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Laschet Céline

Main Referenced Co-authors
Hanson, Julien  (24)
Pirotte, Bernard  (19)
Dupuis, Nadine  (18)
Geubelle, Pierre  (18)
Soni, Arvind  (11)
Main Referenced Keywords
Screening (4); G Protein-Coupled Receptor (3); Gi pathway (3); GPR22 (3); GPCR (2);
Main Referenced Unit & Research Centers
Giga-Signal Transduction - ULiège [BE] (2)
Molecular Pharmacology - Medicinal Chemistry (2)
Centre Interfacultaire de Recherche du Médicament - CIRM (1)
GIGA - molecular biology of disease (1)
Main Referenced Disciplines
Biochemistry, biophysics & molecular biology (18)
Pharmacy, pharmacology & toxicology (9)
Endocrinology, metabolism & nutrition (4)
Biotechnology (1)
Life sciences: Multidisciplinary, general & others (1)

Publications (total 24)

The most downloaded
213 downloads
Laschet, C., Dupuis, N., & Hanson, J. (15 March 2019). A dynamic and screening-compatible nanoluciferase-based complementation assay enables profiling of individual GPCR-G protein interactions. Journal of Biological Chemistry, 294 (11), 4079-4090. doi:10.1074/jbc.RA118.006231 https://hdl.handle.net/2268/230684

The most cited

68 citations (Scopus®)

Laschet, C., Dupuis, N., & Hanson, J. (July 2018). The G Protein-Coupled Receptors Deorphanization Landscape. Biochemical Pharmacology, 153, 62-74. doi:10.1016/j.bcp.2018.02.016 https://hdl.handle.net/2268/220327

Stäubert, C., Wozniak, M., Dupuis, N., Laschet, C., Pillaiyar, T., & Hanson, J. (2022). Superconserved receptors expressed in the brain: Expression, function, motifs and evolution of an orphan receptor family. Pharmacology & Therapeutics, 108217. doi:10.1016/j.pharmthera.2022.108217
Peer reviewed

Laschet, C., Dupuis, N., & Hanson, J. (15 March 2019). A dynamic and screening-compatible nanoluciferase-based complementation assay enables profiling of individual GPCR-G protein interactions. Journal of Biological Chemistry, 294 (11), 4079-4090. doi:10.1074/jbc.RA118.006231
Peer Reviewed verified by ORBi

Abboud, D., Daly, A., Laschet, C., Pirotte, B., BECKERS, A., & Hanson, J. (05 July 2018). GPR101 orphan receptor: a novel cause of growth hormone deregulation [Paper presentation]. World Congress of Basic and Clinical Pharmacology WCP 2018- IUPHAR, Kyoto, Japan.

Laschet, C., Dupuis, N., & Hanson, J. (July 2018). The G Protein-Coupled Receptors Deorphanization Landscape. Biochemical Pharmacology, 153, 62-74. doi:10.1016/j.bcp.2018.02.016
Peer Reviewed verified by ORBi

Geubelle, P., Gilissen, J., Laschet, C., Dilly, S., Huart, J., Jouret, F., Pirotte, B., & Hanson, J. (13 September 2017). Development of original ligands for SUCNR1 [Poster presentation]. International Symposium on GPCRs and G-proteins, Bonn, Königswinter, Germany.

Laschet, C., Dupuis, N., Geubelle, P., Abboud, D., & Hanson, J. (September 2017). Targeted mutagenesis of orphan GPCRs of the SREB family [Poster presentation]. International Symposium on GPCRs and G-proteins, Bonn, Germany.

Abboud, D., Daly, A., Laschet, C., Pirotte, B., BECKERS, A., & Hanson, J. (07 July 2017). Pharmacology of GPR101 [Paper presentation]. Transardennaise de l'hypophyse, Liège, Belgium.

Dupuis, N., Laschet, C., Franssen, D., Martyna, S., Gilissen, J., Geubelle, P., Soni, A., Parent, A.-S., Pirotte, B., Chevigné, A., Twizere, J.-C., & Hanson, J. (01 June 2017). Activation of the orphan G protein-coupled receptor GPR27 by surrogate ligands promotes β-arrestin 2 recruitment. Molecular Pharmacology, 91 (6), 595-608. doi:10.1124/mol.116.107714
Peer Reviewed verified by ORBi

Geubelle, P., Gilissen, J., Dilly, S., POMA, L., Dupuis, N., Laschet, C., Abboud, D., Inoue, A., Jouret, F., Pirotte, B., & Hanson, J. (May 2017). Identification and pharmacological characterization of succinate receptor agonists. British Journal of Pharmacology, 174 (9), 796-808. doi:10.1111/bph.13738
Peer Reviewed verified by ORBi

Abboud, D., Daly, A., Dupuis, N., Laschet, C., Geubelle, P., Pirotte, B., BECKERS, A., & Hanson, J. (May 2017). GPR101 orphan GPCR: a novel cause of growth hormone deregulation [Poster presentation]. 19th European Congress of Endocrinology, Lisbon, Portugal.

Abboud, D., Daly, A., Dupuis, N., Laschet, C., Geubelle, P., Pirotte, B., BECKERS, A., & Hanson, J. (April 2017). GPR101 orphan GPCR: a novel cause of growth hormone deregulation [Poster presentation]. Belgian Society of Physiology and Pharmacology, Bruxelles, Belgium.

Abboud, D., Dupuis, N., Laschet, C., Geubelle, P., Pirotte, B., & Hanson, J. (November 2016). GPR101 orphan GPCR: a novel cause of growth hormone deregulation [Poster presentation]. Fifth annual meeting of the CNRS GDR-3545, G Protein-coupled Receptors: from Physiology to Drugs (RCPG-Physio-Med), Tours, France.

Dupuis, N., Franssen, D., Laschet, C., Geubelle, P., Soni, A., Abboud, D., Twizere, J.-C., Pirotte, B., & Hanson, J. (26 September 2016). Small molecule ligands for the orphan GPR27 [Poster presentation]. GLISTEN meeting 2016 in Prague.

Laschet, C., Dupuis, N., Soni, A., Geubelle, P., Abboud, D., & Hanson, J. (September 2016). Targeted mutagenesis of orphan GPCRs of the SREB family [Poster presentation]. GLISTEN 2016 in Prague.

Laschet, C., Dupuis, N., Derj, A., Gilissen, J., Geubelle, P., Soni, A., Pirotte, B., & Hanson, J. (25 January 2016). Targeted and random mutagenesis of orphan GPCRs of the SREB family [Poster presentation]. GIGA-Day.

Dupuis, N., Gilissen, J., Derj, A., Soni, A., Geubelle, P., Laschet, C., Piron, C., Twizere, J.-C., Pirotte, B., & Hanson, J. (25 January 2016). Identification of small molecule ligands for the orphan GPCR GPR27 [Poster presentation]. GIGA-DAY 2016.

Geubelle, P., Gilissen, J., Dupuis, N., Derj, A., Laschet, C., Soni, A., Pirotte, B., & Hanson, J. (25 January 2016). Design, synthesis and identification of ligands for SUCNR1 and GPR22 [Paper presentation]. 2016 GIGA Day - Signal transduction pathways in health and disease, Liège, Belgium.

Geubelle, P., Gilissen, J., Dupuis, N., Derj, A., Laschet, C., Soni, A., Pirotte, B., & Hanson, J. (05 June 2015). Identification, Design and Evaluation of Pharmacological tools for the orphan GPCR GPR22 [Paper presentation]. 29ème Journées Franco-Belge de Pharmacochimie, Spa, Belgium.

Geubelle, P., Gilissen, J., Dupuis, N., Derj, A., Laschet, C., Soni, A., Pirotte, B., & Hanson, J. (27 January 2015). Identification, Design and Evaluation of Pharmacological tools for the orphan GPCR GPR22 [Poster presentation]. 2015 GIGA Day: Current Advances in Medical Genetics and Genomics, Liège, Belgium.

Dupuis, N., Gilissen, J., Derj, A., Laschet, C., Geubelle, P., Soni, A., Piron, C., Twizere, J.-C., Pirotte, B., & Hanson, J. (27 January 2015). ßarrestin coupling of the orphan GPCR GPR27 [Poster presentation]. GIGA-day 2015, Liege, Belgium.

Gilissen, J., Geubelle, P., Dupuis, N., Laschet, C., Pirotte, B., & Hanson, J. (2015). Forskolin-free cAMP assay for Gi-coupled receptors. Biochemical Pharmacology. doi:10.1016/j.bcp.2015.09.010
Peer Reviewed verified by ORBi

Geubelle, P., Gilissen, J., Dupuis, N., Derj, A., Laschet, C., Soni, A., Pirotte, B., & Hanson, J. (21 November 2014). Identification, Design and Evaluation of Pharmacological tools for the orphan GPCR GPR22 [Poster presentation]. MedChem 2014 New Vistas in GPCR Research: the Dawn of an Exciting Drug Discovery Era?, Braine-L'Alleud, Belgium.

Laschet, C., Dupuis, N., Derj, A., Gilissen, J., Geubelle, P., Soni, A., Pirotte, B., & Hanson, J. (21 November 2014). Understanding the pharmacology and signaling pathways of the orphan G protein coupled receptor GPR85/SREB2 [Poster presentation]. Annual one-day meeting on medicinal chemistry.

Dupuis, N., Gilissen, J., Derj, A., Laschet, C., Geubelle, P., Soni, A., Twizere, J.-C., Pirotte, B., & Hanson, J. (October 2014). Identifying ligands for orphan receptors: test screening of a SOSA library with a complementation assay for orphan GPCR GPR27 [Poster presentation]. third annual meeting of the GDR3545, Montpellier, France.

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