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Thiry Justine

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Main Referenced Co-authors
Evrard, Brigitte  (31)
Krier, Fabrice  (16)
Hubert, Philippe  (13)
Ziemons, Eric  (13)
Netchacovitch, Lauranne  (12)
Main Referenced Keywords
Hot melt extrusion (3); Hot-Melt Extrusion (3); nanomedicine (3); Raman spectroscopy (3); Accuracy profile (2);
Main Referenced Unit & Research Centers
Centre Interfacultaire de Recherche du Médicament - CIRM (23)
CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège [BE] (8)
Center for Education and Research on Macromolecules (CERM) (4)
CESAM - Complex and Entangled Systems from Atoms to Materials - ULiège [BE] (1)
Main Referenced Disciplines
Pharmacy, pharmacology & toxicology (30)
Materials science & engineering (3)
Chemistry (3)
Engineering, computing & technology: Multidisciplinary, general & others (1)
Veterinary medicine & animal health (1)

Publications (total 35)

The most downloaded
24 downloads
Netchacovitch, L., Thiry, J., De Bleye, C., Chavez, P.-F., Krier, F., Sacre, P.-Y., Evrard, B., Hubert, P., & Ziemons, E. (September 2015). Vibrational spectroscopy and microspectroscopy analyzing qualitatively and quantitatively pharmaceutical hot melt extrudates. Journal of Pharmaceutical and Biomedical Analysis, 113, 21-33. doi:10.1016/j.jpba.2015.01.051 https://hdl.handle.net/2268/178226

The most cited

122 citations (Scopus®)

Thiry, J., Krier, F., & Evrard, B. (01 February 2015). A Review of Pharmaceutical Extrusion: Critical Process Parameters and Scaling-up. International Journal of Pharmaceutics, 479 (1), 227-240. doi:10.1016/j.ijpharm.2014.12.036 https://hdl.handle.net/2268/175676

Kok, M., Thiry, J., Evrard, B., Nys, G., & Fillet, M. (12 September 2017). Sampling only 10 μL of whole blood to study the bioavailability of itraconazole formulations in rats [Paper presentation]. International Symposium on Electro- and Liquid Phase- Separation Techniques (ITP), Sopot, Poland.

Netchacovitch, L., Thiry, J., De Bleye, C., Dumont, E., Cailletaud, J., Sacre, P.-Y., Evrard, B., Hubert, P., & Ziemons, E. (26 April 2017). Global approach for the validation of an in-line Raman spectroscopic method to determine the API content in real-time during a hot-melt extrusion process. Talanta, 171, 45-52. doi:10.1016/j.talanta.2017.04.060
Peer Reviewed verified by ORBi

Thiry, J., Nuozzi, A., Emmerechts, C., Beeckman, E., Krier, F., & Evrard, B. (04 April 2017). Development of an original thermoforming apparatus to be coupled to hot melt extrusion for the continuous production of itraconazole-based amorphous solid dispersions [Paper presentation]. 2nd European Meeting on Pharmaceutics, Krakow, Poland.

Thiry, J., Kok, M., Collard, L., Frere, A., Krier, F., Fillet, M., & Evrard, B. (01 March 2017). Bioavailability enhancement of itraconazole-based solid dispersions produced by hot melt extrusion in the framework of the Three Rs rule. European Journal of Pharmaceutical Sciences, 99, 1-8. doi:10.1016/j.ejps.2016.12.001
Peer Reviewed verified by ORBi

Thiry, J., Evrard, B., Nys, G., Fillet, M., & Kok, M. (2017). Sampling only ten microliters of whole blood for the quantification of poorly soluble drugs: Itraconazole as case study. Journal of Chromatography. A, 1479, 161-168. doi:10.1016/j.chroma.2016.12.009
Peer Reviewed verified by ORBi

Thiry, J., Krier, F., Ratwatte, S., Thomassin, J.-M., Jérôme, C., & Evrard, B. (01 January 2017). Hot-Melt Extrusion as a Continuous Manufacturing Process to Form Ternary Cyclodextrin Inclusion Complexes. European Journal of Pharmaceutical Sciences, 96, 590-597. doi:10.1016/j.ejps.2016.09.032
Peer Reviewed verified by ORBi

Netchacovitch, L., Dumont, E., Cailletaud, J., Thiry, J., De Bleye, C., Sacre, P.-Y., Boiret, M., Evrard, B., Hubert, P., & Ziemons, E. (2017). Development of an analytical method for crystalline content determination in amorphous solid dispersions produced by Hot-Melt Extrusion using transmission Raman spectroscopy: A feasibility study. International Journal of Pharmaceutics, 530 (1-2), 249-255. doi:10.1016/j.ijpharm.2017.07.052
Peer Reviewed verified by ORBi

Thiry, J., Lebrun, P., Vinassa, C., Adam, M., Netchacovitch, L., Ziemons, E., Hubert, P., Krier, F., & Evrard, B. (30 December 2016). Continuous Production of Itraconazole-based Solid Dispersions by Hot Melt Extrusion: Preformulation, Optimization and Design Space Determination. International Journal of Pharmaceutics, 515 (1-2), 114-124. doi:10.1016/j.ijpharm.2016.10.003
Peer Reviewed verified by ORBi

Thiry, J., Krier, F., Ratwatte, S., Thomassin, J.-M., Jérôme, C., & Evrard, B. (16 November 2016). Hot-Melt Extrusion as a Continuous Manufacturing Process to Form Ternary Cyclodextrin Inclusion Complexes [Poster presentation]. AAPS 2016 Denver.

Thiry, J., Kok, M., Collard, L., Frère, A., Krier, F., Fillet, M., & Evrard, B. (15 November 2016). Original study of the bioavailability enhancement of itraconazole-based solid dispersions produced by hot melt extrusion in the framework of the three Rs rule [Poster presentation]. AAPS 2016 Denver.

Thiry, J. (2016). Development of a continuous hot melt extrusion process for manufacturing solid oral dosage forms containing a BCS II drug [Doctoral thesis, Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/314951

Netchacovitch, L., Thiry, J., De Bleye, C., Dumont, E., Sacre, P.-Y., Evrard, B., Hubert, P., & Ziemons, E. (17 October 2016). Determination of the analytical performances of an in-line Raman spectroscopic method monitoring a hot-melt extrusion process [Paper presentation]. 19th Forum of Pharmaceutical Sciences, Bruxelles, Belgium.

Ergül, Z., Vanslambrouck, S., Thiry, J., Debuigne, A., Lecomte, P., Jérôme, C., & Riva, R. (12 September 2016). Polyphosphoester containing amphiphilic block copolymers as drug nanocarriers [Poster presentation]. PAI Annual Meeting, Liège, Belgium.

Netchacovitch, L., Thiry, J., De Bleye, C., Dumont, E., Dispas, A., Hubert, C., Krier, F., Sacre, P.-Y., Evrard, B., Hubert, P., & Ziemons, E. (July 2016). A simple calibration approach based on film-casting for confocal Raman microscopy to support the development of a Hot-Melt Extrusion process. Talanta, 154, 392-399. doi:10.1016/j.talanta.2016.03.080
Peer Reviewed verified by ORBi

Grimard, J., Dewasme, L., Thiry, J., Krier, F., Evrard, B., & Vande Wouwer, A. (June 2016). Modeling, sensitivity analysis and parameter identification of a twin screw extruder [Paper presentation]. 11th IFAC Symposium on Dynamics and Control of Process Systems, including Biosystems.

Yilmaz-Ergül, Z., Vanslambrouck, S., Thiry, J., Debuigne, A., Lecomte, P., Jérôme, C., & Riva, R. (23 May 2016). Polyphosphoester containing amphiphilic block copolymers as drug nanocarriers [Poster presentation]. Belgian Polymer Group (BPG) Annual Meeting, Hasselt, Belgium.

Thiry, J., Krier, F., Ratwatte, S., Thomassin, J.-M., Jérôme, C., & Evrard, B. (06 April 2016). Hot Melt Extrusion as a New Method to Form Inclusion Complexes with Cyclodextrins [Paper presentation]. 10th PBP World Meeting, Glasgow, United Kingdom.

Ergül, Z., Vanslambrouck, S., Cajot, S., Thiry, J., Debuigne, A., Lecomte, P., Jérôme, C., & Riva, R. (2016). Core cross-linked micelles of polyphosphoester containing amphiphilic block copolymers as drug nanocarriers. RSC Advances, 6 (48), 42081-42088. doi:10.1039/C6RA07422G
Peer Reviewed verified by ORBi

Thiry, J., Broze, G., Pestieau, A., Tatton, A., Baumans, F., Damblon, C., Krier, F., & Evrard, B. (2016). Investigation of a suitable in vitro dissolution test for itraconazole-based solid dispersions. European Journal of Pharmaceutical Sciences. doi:10.1016/j.ejps.2016.02.002
Peer Reviewed verified by ORBi

Thiry, J., Lebrun, P., Netchacovitch, L., Ziemons, E., Hubert, P., Krier, F., & Evrard, B. (23 November 2015). Production of Itraconazole/Soluplus® Extrudates: Optimization of Both Formulation and Hot-Melt Extrusion Process Through a Single Design of Experiment [Paper presentation]. Biopharmacy Day 2015, Leuven, Belgium.

Thiry, J., Lebrun, P., Netchacovitch, L., Pestieau, A., Ziemons, E., Hubert, P., Krier, F., & Evrard, B. (October 2015). Production of Itraconazole/Soluplus® Extrudates: Optimization of Both Formulation and Hot-Melt Extrusion Process Through a Single Design of Experiment [Poster presentation]. AAPS Orlando 2015.

Netchacovitch, L., Thiry, J., De Bleye, C., Chavez, P.-F., Krier, F., Sacre, P.-Y., Evrard, B., Hubert, P., & Ziemons, E. (September 2015). Vibrational spectroscopy and microspectroscopy analyzing qualitatively and quantitatively pharmaceutical hot melt extrudates. Journal of Pharmaceutical and Biomedical Analysis, 113, 21-33. doi:10.1016/j.jpba.2015.01.051
Peer Reviewed verified by ORBi

Netchacovitch, L., Thiry, J., De Bleye, C., Chavez, P.-F., Krier, F., Sacre, P.-Y., Evrard, B., Hubert, P., & Ziemons, E. (21 May 2015). Analysis of film casting by Raman confocal microscopy: An innovative approach in the framework of drug content and API solid-state determination [Paper presentation]. Forum des jeunes chercheurs, Namur, Belgium.

Thiry, J., Pestieau, A., Krier, F., & Evrard, B. (May 2015). How to choose a suitable dissolution test for BCS II drugs? [Paper presentation]. 18e Forum des Sciences Pharmaceutiques.

Thiry, J., Krier, F., & Evrard, B. (01 February 2015). A Review of Pharmaceutical Extrusion: Critical Process Parameters and Scaling-up. International Journal of Pharmaceutics, 479 (1), 227-240. doi:10.1016/j.ijpharm.2014.12.036
Peer Reviewed verified by ORBi

Thiry, J., Netchacovitch, L., Krier, F., Ziemons, E., Hubert, P., & Evrard, B. (2015). Determination of the Crystal Content within an Itraconazole-based extrudate : Comparison between Differential Scanning Calorimetry and Raman techniques [Poster presentation]. TA Instruments' BeNeLux Users Meeting & Symposium 2015.

Netchacovitch, L., Thiry, J., De Bleye, C., Chavez, P.-F., Sacre, P.-Y., Krier, F., Evrard, B., Hubert, P., & Ziemons, E. (January 2015). Confocal Raman microscopy to support the development of an extrusion process: a quantitative approach based on film casting [Poster presentation]. CHimiometrie XVI, Genève, Switzerland.

Thiry, J., Krier, F., Pestieau, A., & Evrard, B. (December 2014). Selection of a Discriminant Dissolution Test for Extrudates Containing Itraconazole [Poster presentation]. Biopharmacy Day 2014, Vlaardingen, Netherlands.

Thiry, J., Krier, F., Pestieau, A., & Evrard, B. (06 November 2014). Preformulation Study of an Itraconazole-based Oral Dosage Produced by Hot-Melt Extrusion [Poster presentation]. AAPS Annual Meeting San Diego 2014.

Thiry, J., Krier, F., Pestieau, A., & Evrard, B. (03 November 2014). Selection of a Discriminant Dissolution Test for Itraconazole-based Extrudates [Poster presentation]. AAPS Annual Meeting San Diego 2014.

Netchacovitch, L., Thiry, J., De Bleye, C., Sacre, P.-Y., Chavez, P.-F., Krier, F., Evrard, B., Hubert, P., & Ziemons, E. (June 2014). Confocal Raman microscopy to support the development of an extrusion process by qualitative and quantitative analyses [Poster presentation]. Drug Analysis 2014.

Thiry, J., Krier, F., Pestieau, A., & Evrard, B. (May 2014). Production of Itraconazole-based Solid Dispersions Using Hot-Melt Extrusion [Poster presentation]. AFPM 2014, Liège, Belgium.

Thiry, J., Krier, F., Pestieau, A., & Evrard, B. (2014). Production Of Itraconazole-based Solid Dispersions Using Hot-Melt Extrusion: Preformulation Study [Poster presentation]. 9th PBP World Meeting Lisbon 2014.

Krier, F., Mantanus, J., Sacre, P.-Y., Chavez, P.-F., Thiry, J., Pestieau, A., Rozet, E., Ziemons, E., Hubert, P., & Evrard, B. (2013). PAT tools for the control of co-extrusion implants manufacturing process. International Journal of Pharmaceutics, 458, 15-24. doi:10.1016/j.ijpharm.2013.09.040
Peer Reviewed verified by ORBi

Thiry, J., Krier, F., Pestieau, A., & Evrard, B. (2013). Preformulation study of an itraconazole-based drug using hot-melt extrusion [Paper presentation]. 17ème Forum des Sciences Pharmaceutiques.

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