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Florence Xavier

Main Referenced Co-authors
Pirotte, Bernard  (13)
De Tullio, Pascal  (8)
Lebrun, P. (8)
Goffin, Eric  (3)
Lebrun, Philippe (3)
Main Referenced Keywords
Drug Discovery (3); Animals (2); Aorta/physiology (2); Benzopyran derivatives (2); Biochemistry (2);
Main Referenced Disciplines
Pharmacy, pharmacology & toxicology (14)

Publications (total 14)

The most downloaded
7 downloads
Pirotte, B., De Tullio, P., Nguyen, Q.-A., Somers, F., Fraikin, P., Florence, X., Wahl, P., Hansen, J. B., & Lebrun, P. (2010). Chloro-Substituted 3-Alkylamino-4H-1,2,4-benzothiadiazine 1,1-Dioxides as ATP-Sensitive Potassium Channel Activators: Impact of the Position of the Chlorine Atom on the Aromatic Ring on Activity and Tissue Selectivity. Journal of Medicinal Chemistry, 53, 147-154. doi:10.1021/jm9010093 https://hdl.handle.net/2268/29980

The most cited

36 citations (Scopus®)

Sebille, S., Gall, D., De Tullio, P., Florence, X., Lebrun, P., & Pirotte, B. (2006). Design, Synthesis and Pharmacological Evaluation of R/S-3,4-Dihydro-2,2-Dimethyl-6-Halo-4-(Phenylaminocarbonylamino)-2H-1-Benzopyrans: Towards Tissue-Selective Pancreatic Beta-Cells KATP Channel Openers Structually Related to (+/-)-Cromakalim. Journal of Medicinal Chemistry, 49, 4690-4697. doi:10.1021/jm060161z https://hdl.handle.net/2268/23359

Pirotte, B., Florence, X., Goffin, E., Leleux, F., & Lebrun, P. (2022). Research Advancements on Fluorinated and Non-Fluorinated 4- Phenyl(thio)ureido-Substituted 2,2-Dimethylchromans Acting as Inhibitors of Insulin Release and Smooth Muscle Relaxants. Medicinal chemistry (Shariqah (United Arab Emirates)), 18 (8), 884-894. doi:10.2174/1573406418666220221145500
Peer reviewed

Pirotte, B., Florence, X., Goffin, E., & Lebrun, P. (01 March 2019). 2,2-Dimethyl-3,4-dihydro-2H-1,4-benzoxazines as isosteres of 2,2-dimethylchromans acting as inhibitors of insulin release and vascular smooth muscle relaxants. MedChemComm, 10 (3), 431-438. doi:10.1039/c8md00593a
Peer Reviewed verified by ORBi

Pirotte, B., Florence, X., Goffin, E., & Lebrun, P. (2017). Deciphering Structure-Activity Relationships in a Series of 2,2-Dimethylchromans Acting as Inhibitors of Insulin Release and Smooth Muscle Relaxants. ChemMedChem, 12 (21), 1810-1817. doi:10.1002/cmdc.201700409
Peer Reviewed verified by ORBi

Rousseau, A., Florence, X., Pirotte, B., Varenne, A., Gareil, P., Villemin, D., Chiap, P., Crommen, J., Fillet, M., & Servais, A.-C. (March 2010). Development and validation of a nonaqueous capillary electrophoretic method for the enantiomeric purity determination of a synthetic intermediate of new R/S-3,4-dihydro-2,2-dimethyl-2H-1-benzopyrans using a single-isomer anionic cyclodextrin derivative and an ionic liquid [Poster presentation]. 25th International Symposium on MicroScale Bioseparations (MSB 2010), Prague, Czechia.

Rousseau, A., Florence, X., Pirotte, B., Varenne, A., Gareil, P., Villemin, D., Chiap, P., Crommen, J., Fillet, M., & Servais, A.-C. (2010). Development and validation of a nonaqueous capillary electrophoretic method for the enantiomeric purity determination of a synthetic intermediate of new 3,4-dihydro-2,2-dimethyl-2H-1-benzopyrans using a single-isomer anionic cyclodextrin derivative and an ionic liquid. Journal of Chromatography. A, 1217 (51), 7949-55. doi:10.1016/j.chroma.2010.07.005
Peer Reviewed verified by ORBi

Pirotte, B., De Tullio, P., Nguyen, Q.-A., Somers, F., Fraikin, P., Florence, X., Wahl, P., Hansen, J. B., & Lebrun, P. (2010). Chloro-Substituted 3-Alkylamino-4H-1,2,4-benzothiadiazine 1,1-Dioxides as ATP-Sensitive Potassium Channel Activators: Impact of the Position of the Chlorine Atom on the Aromatic Ring on Activity and Tissue Selectivity. Journal of Medicinal Chemistry, 53, 147-154. doi:10.1021/jm9010093
Peer Reviewed verified by ORBi

Florence, X. (2009). Design, synthesis and biological evaluation of original cromakalim analogues as ATP-sensitive potassium channel openers [Doctoral thesis, Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/314797

Florence, X., Sebille, S., De Tullio, P., Lebrun, P., & Pirotte, B. (2009). New R/S-3,4-dihydro-2,2-dimethyl-2H-1-benzopyrans as KATP channel openers: modulation of the 4-position. Bioorganic and Medicinal Chemistry, 17, 7723-7731. doi:10.1016/j.bmc.2009.09.041
Peer Reviewed verified by ORBi

Florence, X., De Tullio, P., Pirotte, B., & Lebrun, P. (2009). Original cromakalim analogues as KATP channel openers. Metabolic and Functional Research on Diabetes, 2, 19-44 (A16.
Peer reviewed

Sebille, S., De Tullio, P., Florence, X., Becker, B., Antoine, M.-H., Michaux, C., Wouters, J., Pirotte, B., & Lebrun, P. (2008). new R/S-3,4-dihydro-2,2-dimethyl-6-halo-4-(phenylainothiocarbonylamino)-2H-1-benzopyrans structually related to (+/-)-cromakalim as tissue-selective pancreatic beta-celle KATP channel openers. Bioorganic and Medicinal Chemistry, 16, 5704-5719.
Peer Reviewed verified by ORBi

Khelili, S., Florence, X., Bouhadja, M., Abdelaziz, S., Mechouch, N., Mohamed, Y., De Tullio, P., Lebrun, P., & Pirotte, B. (2008). Synthesis and activity on rat aorta rings and rat pancreatic beta-cells of ring-opened analogues of benzopyran-type potassium channel activators. Bioorganic and Medicinal Chemistry, 16, 6124-6130. doi:10.1016/j.bmc.2008.04.043
Peer Reviewed verified by ORBi

Sebille, S., Gall, D., De Tullio, P., Florence, X., Lebrun, P., & Pirotte, B. (2006). Design, Synthesis and Pharmacological Evaluation of R/S-3,4-Dihydro-2,2-Dimethyl-6-Halo-4-(Phenylaminocarbonylamino)-2H-1-Benzopyrans: Towards Tissue-Selective Pancreatic Beta-Cells KATP Channel Openers Structually Related to (+/-)-Cromakalim. Journal of Medicinal Chemistry, 49, 4690-4697. doi:10.1021/jm060161z
Peer Reviewed verified by ORBi

De Tullio, P., Lebrun, P., Florence, X., Antoine, M. H., Francotte, P., & Pirotte, B. (2006). Selective pancreatic ATP-sensitive potassium channel openers for the treatement of glucose homeostasis disorders. Drugs of the Future, 31, 991-1001. doi:10.1358/dof.2006.031.11.1036837
Peer reviewed

Pirotte, B., De Tullio, P., Antoine, M.-H., Sebille, S., Florence, X., & Lebrun, P. (2005). New insights into the development pf ATP-sensitive potassium channel openers. Expert Opinion on Therapeutic Patents, 15, 497-504. doi:10.1517/13543776.15.5.497
Peer Reviewed verified by ORBi

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