Profil

Collignon Marie-Laure

See author's contact details
Main Referenced Co-authors
Toye, Dominique  (46)
Delafosse, Angélique  (38)
Crine, Michel  (34)
Delvigne, Frank  (16)
Calvo, Sébastien  (14)
Main Referenced Keywords
CFD (9); Mixing (9); Bioreactor (6); Hydrodynamics (5); Particle Image Velocimetry (5);
Main Referenced Unit & Research Centers
Laboratoire de Génie Chimique (18)
Department of Chemical Engineering / Products, Environment and Processes (PEPs) (1)
Laboratoire Réactions et Génie des Procédés de l'Université de Lorraine (1)
Laboratoire Réactions et Génie des Procédés, UMR 7274 CNRS -Université de Lorraine (1)
Laboratoire de Génie Chimique (LGC) (1)
Main Referenced Disciplines
Chemical engineering (45)
Biotechnology (4)
Civil engineering (1)

Publications (total 50)

The most downloaded
3628 downloads
Collignon, M.-L. (2007). Etude du mélange par PIV et PLIF dans un bioréacteur de culture cellulaire [Master’s dissertation, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/5008 https://hdl.handle.net/2268/5008

The most cited

97 citations (Scopus®)

Delafosse, A., Calvo, S., Collignon, M.-L., Delvigne, F., Crine, M., Thonart, P., & Toye, D. (17 March 2014). CFD-based Compartment model for description of mixing in bioreactors. Chemical Engineering Science, 106, 76-85. doi:10.1016/j.ces.2013.11.033 https://hdl.handle.net/2268/158425

Delafosse, A., Calvo, S., Collignon, M.-L., & Toye, D. (12 October 2018). Comparison of hydrodynamics in standard stainless steel and single-use bioreactors by means of an Euler-Lagrange approach. Chemical Engineering Science, 188, 52-64. doi:10.1016/j.ces.2018.01.034
Peer Reviewed verified by ORBi

de Lamotte, A., Delafosse, A., Calvo, S., Collignon, M.-L., Delvigne, F., & Toye, D. (13 May 2016). Gas-liquid transfer through the liquid free-surface in baffled stirred tanks [Paper presentation]. International conferences "Green chemistry and White biotechnology", Gembloux, Belgium.

Collignon, M.-L., Delafosse, A., Calvo, S., Martin, C., Marc, A., Toye, D., & Olmos, E. (2016). Large-Eddy Simulations of microcarrier exposure to potentially damaging eddies inside mini-bioreactors. Biochemical Engineering Journal. doi:10.1016/j.bej.2015.10.020
Peer Reviewed verified by ORBi

Delafosse, A., Collignon, M.-L., Marc, A., Toye, D., & Olmos, E. (30 September 2015). NUMERICAL AND EXPERIMENTAL CHARACTERIZATION OF SOLID-LIQUID HYDRODYNAMICS ENCOUNTERED IN HUMAN MESENCHYMAL STEM CELL CULTURE BIOREACTORS [Paper presentation]. 10th European Congress of Chemical Enginnering (ECCE10).

Delafosse, A., Calvo, S., Collignon, M.-L., Delvigne, F., Crine, M., & Toye, D. (29 September 2015). Euler–Lagrange approach to model heterogeneities in stirred tank bioreactors – Comparison to experimental flow characterization and particle tracking. Chemical Engineering Science, 134, 457-466. doi:10.1016/j.ces.2015.05.045
Peer Reviewed verified by ORBi

de Lamotte, A., Delafosse, A., Calvo, S., Collignon, M.-L., & Toye, D. (24 September 2015). Hydrodynamics, mixing and mass transfer in baffled stirred tanks [Paper presentation]. Simulation-Driven Medical Device Innovation Seminar, Zaventem, Belgium.

de Lamotte, A., Delafosse, A., Calvo, S., Collignon, M.-L., & Toye, D. (September 2015). Surface aeration in baffled stirred tanks: hydrodynamics, mixing and mass transfer characteristics [Poster presentation]. 10th European Congress of Chemical Engineering, Nice, France.

Delafosse, A., Calvo, S., Collignon, M.-L., & Toye, D. (2015). VALIDATION OF AN EULER-LAGRANGE COMPARTMENT MODEL FOR THE DESIGN OF SCALE-DOWN BIOREACTOR USED IN ANIMAL CELL CULTURES. In Proceeding of the 15th European Conference on Mixing.
Peer reviewed

Delafosse, A., Collignon, M.-L., Marc, A., Toye, D., & Olmos, E. (2015). REVISITING THE DETERMINATION OF HYDROMECHANICAL STRESSES ENCOUNTERED BY MICROCARRIERS IN STEM CELL CULTURE BIOREACTORS. In BMC Proceedings 2015.
Peer reviewed

de Lamotte, A., Delafosse, A., Calvo, S., Collignon, M.-L., & Toye, D. (2015). Hydrodynamics, mixing and mass transfer in baffled stirred tanks. In Proceedings of the 15th European Conference on Mixing.
Peer reviewed

Collignon, M.-L., Martin, C., Toye, D., Marc, A., & Olmos, E. (18 January 2015). CFD Large Eddy Simulation of the hydrodynamics of stirred mini-bioreactors operating with stem cell culture mixing conditions [Poster presentation]. ECI conference: scale-up and manufacturing in cell-based therapies, San Diego, United States.

Collignon, M.-L., Droissart, L., Delafosse, A., Calvo, S., Vanhamel, S., Rodriguez, R., Claes, T., Moncaubeig, F., Peeters, L., Crine, M., & Toye, D. (15 January 2015). HYDRODYNAMICS IN A DISPOSABLE RECTANGULAR PARALLELEPIPED STIRRED BIOREACTOR WITH ELLIPTIC PENDULUM MOTION PADDLE. Biochemical Engineering Journal, 93. doi:10.1016/j.bej.2014.10.011
Peer Reviewed verified by ORBi

Calvo, S., Delafosse, A., Crine, M., Toye, D., Collignon, M.-L. (Other coll.), & de Lamotte, A. (Other coll.). (10 September 2014). CFD Comparison of hydrodynamics between BIOSTAT® Cultibag STR and standard Stirred Cell Culture Bioreactors [Poster presentation]. 10th European Symposium on Biochemical Engineering Sciences and 6th International Forum on Industrial Bioprocesses in Collaboration With Acs, LILLE, France.

Collignon, M.-L., Martin, C., Blanchard, F., Toye, D., Marc, A., & Olmos, E. (07 September 2014). RANS and Large Eddy Simulation of the hydrodynamics inside mini-bioreactors designed for stem cell culture [Paper presentation]. 10th European Symposium on Biochemical Engineering Sciences (ESBES) and 6th International Forum on Industrial Bioprocesses (IFIBiop), Lille, France.

Collignon, M.-L. (10 July 2014). Outils d’étude pour caractériser l’impact de l’ hydrodynamique sur la culture de cellules animales adhérentes cultivées sur microporteurs en bioréacteurs à cuve agitée [Paper presentation]. Journée interdisciplinarité du CNRS sur le thème « Bioprocédés et Bioproduction : environnement – énergie - santé », Paris, France.

Collignon, M.-L. (17 April 2014). Mise en suspension et contraintes hydrodynamiques sur microporteurs en procédés de cultures adhérentes [Paper presentation]. Ecole thématique CNRS: Ingénierie des biosystèmes: de la cellule au bioréacteur, Nancy, France.

Delafosse, A., Calvo, S., Collignon, M.-L., Delvigne, F., Crine, M., Thonart, P., & Toye, D. (17 March 2014). CFD-based Compartment model for description of mixing in bioreactors. Chemical Engineering Science, 106, 76-85. doi:10.1016/j.ces.2013.11.033
Peer Reviewed verified by ORBi

Collignon, M.-L., Delafosse, A., Delvigne, F., Thonart, P., Crine, M., & Toye, D. (2013). Développement d'un dispositif de trajectographie optique nécessaire pour la caractérisation expérimentale par une approche Euler-Lagrange des écoulements dans des bioréacteurs à cuve agitée. In Récents Progrès en Génie des Procédés. Paris, France: Ed. SFGP.
Peer reviewed

Calvo, S., Delafosse, A., Collignon, M.-L., Crine, M., & Toye, D. (2013). Caractérisation expérimentale et modélisation des conditions de mise en suspension homogène d’un solide dans une cuve agitée industrielle. In Récents Progrès en Génie des Procédés (Cd-ROM).
Peer reviewed

Calvo, S., Delafosse, A., Collignon, M.-L., Crine, M., & Toye, D. (August 2013). Experimental characterisation and modelling of homogeneous solid suspension in an industrial stirred tank. Advances in Mechanical Engineering, Volume 2013. doi:10.1155/2013/329264
Peer Reviewed verified by ORBi

Calvo, S., Delafosse, A., Collignon, M.-L., Crine, M., & Toye, D. (24 April 2013). CFD Modelisation of homogeneous distribution of solid particles in a stirred tank [Poster presentation]. 9th European Congress of Chemical Engineering / 2nd European Congress of Applied Biotechnology, The Hague, Netherlands.

Collignon, M.-L., Delafosse, A., Delvigne, F., Thonart, P., Crine, M., & Toye, D. (10 September 2012). Development of optical trajectography device for the lagangian study of turbulent flow inside a stirred tank used in pharmaceutical industry [Poster presentation]. 14th European Conference on Mixing, Warsaw, Poland.

Collignon, M.-L. (2012). Etude de l'hydrodynamique au sein d'un bioréacteur à cuve agitée utilisé pour la culture de cellules animales adhérentes sur microporteurs: Caractérisation expérimentale et théorique des écoulements via des outils eulériens et lagrangiens [Doctoral thesis, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/124023

Collignon, M.-L., Droissart, L., Delafosse, A., Vanhamel, S., Rodriguez, R., Claes, T., Moncaubeig, F., Peeters, L., Crine, M., & Toye, D. (2011). Etude de l’écoulement au sein d’un bioréacteur parallélépipédique à usage unique à agitation pendulo-elliptique. In Récents Progrès en Génie des procédés - A la croisée des sciences et des cultures, pour relever les défis industriels du XXIème siècle. Paris, France: Ed. SFGP.
Peer reviewed

Delafosse, A., Delvigne, F., Collignon, M.-L., Crine, M., Thonart, P., & Toye, D. (2011). Modèle hybride Euler-Lagrange pour la description des hétérogénéités dans les bioréacteurs. In SFGP (Ed.), Récents Progrès en Génie des Procédés - N° 101 - Des procédés au service du produit au coeur de l'Europe - Actes du XIIIème Congrès de la société Française de Génie des Procédés - Du 29 Nov. au 1er Décembre 2011 - Lille Grand Palais, FRANCE. Lavoisier Technique et Documentation.
Peer reviewed

Collignon, M.-L., Degand, A., Delafosse, A., Delvigne, F., Thonart, P., & Toye, D. (29 November 2011). Mise au point d’un dispositif de trajectographie optique pour l’étude lagrangienne des écoulements dans une cuve agitée utilisée dans l’industrie pharmaceutique [Poster presentation]. 13ème Congrès de la Société Française du Génie des Procédés, Lille, France.

Delvigne, F., Brognaux, A., Gorret, N., Delafosse, A., Collignon, M.-L., Toye, D., Crine, M., & Thonart, P. (29 November 2011). Prise en compte l'état de la membrane cellulaire sur la réponse de biocapteurs fluorescents pour la détection de défaut d'écoulement au niveau des bioréacteurs : vers une intégration du "sécrétome" dans la problématique de l'extrapolation [Paper presentation]. 12ème congrès de la Société Française de génie des procédés, Lille, France.

Delafosse, A., Delvigne, F., Collignon, M.-L., Crine, M., Thonart, P., & Toye, D. (15 November 2011). Hybrid Euler-Lagrange approach to model concentration heterogeneities in stirred tank bioreactors [Paper presentation]. Fifth International Conference on Advanced COmputational Methods in ENgineering (ACOMEN2011), Liège, Belgium.

Delvigne, F., Delafosse, A., Collignon, M.-L., Toye, D., Crine, M., & Thonart, P. (25 September 2011). Potential use of GFP microbial biosensors for the detection of mixing imperfections and cell viability in bioreactors [Paper presentation]. 1st european congress on applied biotechnology, Berlin, Germany.

Collignon, M.-L., Delafosse, A., Crine, M., & Toye, D. (18 September 2011). Study of turbulent flow inside a stirred tank used in animal cell culture [Paper presentation]. 7th International Symposium on Mixing in Industrial Processes, ISMIP 7, Pekin, China.

Delvigne, F., Brognaux, A., Gorret, N., Delafosse, A., Collignon, M.-L., Toye, D., Crine, M., & Thonart, P. (2011). Taking into account cell membrane permeability to account for the response of GFP microbial biosensors : integrating the secretome in the scaling-up procedures. Récents Progrès en Génie des Procédés, 101, 1-7.
Peer reviewed

Delvigne, F.* , Brognaux, A.* , Gorret, N., Neubauer, P., Delafosse, A., Collignon, M.-L., Toye, D., Crine, M., Boxus, M., & Thonart, P. (2011). Characterization of the response of GFP microbial biosensors sensitive to substrate limitation in scale-down bioreactors. Biochemical Engineering Journal, 55 (2), 131-139. doi:10.1016/j.bej.2011.03.016
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Delafosse, A., Collignon, M.-L., Dossin, D., Crine, M., & Toye, D. (2011). Estimation of the turbulent kinetic energy dissipation in a culture cell stirred tank bioreactor. Chemical Engineering Science, 66 (8), 1728-1737. doi:10.1016/j.ces.2011.01.011
Peer Reviewed verified by ORBi

Collignon, M.-L., Delafosse, A., Crine, M., & Toye, D. (2011). Reply to "Comments on Collignon et al. (Chem. Eng. Sci. 65 (2010) 5929-5941)". Chemical Engineering Science, 6, 1324-1325. doi:10.1016/j.ces.2010.12.038
Peer Reviewed verified by ORBi

Delafosse, A., Delvigne, F., Collignon, M.-L., Crine, M., Thonart, P., & Toye, D. (2011). Description of concentration heterogeneities in a stirred-tank bioreactor by mean of an Euler- Lagrange model [Paper presentation]. 8th European Congress of Chemical Engineering – ECCE8”, Berlin, Germany, 25-29 septembre 2011, Berlin, Germany.

Collignon, M.-L., Delafosse, A., Crine, M., & Toye, D. (15 November 2010). AXIAL IMPELLER SELECTION FOR ANCHORAGE DEPENDENT ANIMAL CELL CULTURE IN STIRRED BIOREACTORS: METHODOLOGY BASED ON THE IMPELLER COMPARISON AT JUST-SUSPENDED SPEED OF ROTATION. Chemical Engineering Science, 65 (22), 5929-5941. doi:10.1016/j.ces.2010.08.027
Peer Reviewed verified by ORBi

Collignon, M.-L., Droissart, L., Delafosse, A., Vanhamel, S., Rodriguez, R., Claes, T., Moncaubeig, F., Peeters, L., Crine, M., & Toye, D. (August 2010). Study of hydrodynamics inside a single use parallelepiped stirred bioreactor equipped with an elliptic motion paddle [Paper presentation]. Organisation conjointe: 19th Congress of Chemical and Process Engineering(CHISA) ; 7th European Congress of Chemical Engineering (ECCE-7), Prague, République Tchèque, 28 août - 1 septembre 2010, Prague, Czechia.

Collignon, M.-L., Dossin, D., Delafosse, A., Crine, M., & Toye, D. (2010). Quality of mixing in a stirred bioreactor used for animal cells culture: heterogeneities in a lab scale bioreactor and evolution of mixing time with scale up. Biotechnologie, Agronomie, Société et Environnement, 14, 401-407.
Peer Reviewed verified by ORBi

Delafosse, A., Delvigne, F., Collignon, M.-L., Crine, M., Thonart, P., & Toye, D. (2010). Development of a compartment model based on CFD simulations for mixing description in bioreactors. Biotechnologie, Agronomie, Société et Environnement, 14 (2), 517-522.
Peer Reviewed verified by ORBi

Delafosse, A., Delvigne, F., Collignon, M.-L., Crine, M., Thonart, P., & Toye, D. (2010). Stochastic modelling of micro-organisms displacements in a stirred-tank bioreactor [Poster presentation]. 19th Congress of Chemical and Process Engineering (CHISA2010) – 7th European Congress of Chemical Engineering (ECCE7), 28 aout–2 septembre 2010, Prague, Czechia.

Collignon, M.-L., Dossin, D., Delafosse, A., Crine, M., & Toye, D. (12 December 2009). Study of heterogeneities in laboratory scale and prediction of mixing time evolution during the scale- up of an animal cells culture in a stirred bioreactor [Paper presentation]. Journée d'étude annuelle de l'école doctorale GEPROC sur le thème des Biotechnologies, Gembloux, Belgium.

Collignon, M.-L., Crine, M., Delafosse, A., & Toye, D. (14 October 2009). Effet de la viscosité sur la structure de l'écoulement et sur le mélange dans un bioréacteur à cuve agitée utilisé en culture de cellules animales [Poster presentation]. 12ème congrès de la Société Française de Génie des Procédés, Marseille, France.

Collignon, M.-L., Dossin, D., Crine, M., Chaubard, J.-F., Peeters, L., Dessoy, S., & Toye, D. (01 April 2009). Study of the mixing time evolution during the scale-up of an animal cells culture in a stirred tank bioreactor [Poster presentation]. Biomedica, the life science summit, Liège, Belgium.

Toye, D., Collignon, M.-L., & Crine, M. (05 February 2009). Les outils du génie chimique pour une meilleure maîtrise des procédés biologiques et biotechnologiques [Paper presentation]. « Le biomédical en Sciences appliquées », Liège, Belgium.

Delafosse, A., Collignon, M.-L., Delvigne, F., Crine, M., Thonart, P., & Toye, D. (2009). CFD-based Compartment model for the description of the heterogeneities experienced by microorganisms in bioreactors [Poster presentation]. Bioproscale symposium, 24 - 27 Novembre 2009, Berlin, Germany.

Collignon, M.-L., Crine, M., Delafosse, A., & Toye, D. (2009). Effet de la viscosité sur la structure de l'écoulement et sur le mélange dans un bioréacteur à cuve agitée utilisé en culture de cellules animales. In Récents Progrès en Génie des procédés - A la croisée des sciences et des cultures, pour relever les défis industriels du XXIème siècle. Paris, France: Lavoisier Technique et Documentation.
Peer reviewed

Collignon, M.-L., Crine, M., Verdin, E., Chaubard, J.-F., Peeters, L., Dessoy, S., & Toye, D. (20 August 2008). A study of the mixing by PIV and PLIF in bioreactor of cells animals culture [Paper presentation]. Sixth International Symposium on Mixing in Industrial Process Industries, Niagara on the Lake, Canada.

Collignon, M.-L., Crine, M., Verdin, E., Chaubard, J.-F., Peeters, L., Dessoy, S., & Toye, D. (19 August 2008). A study of the mixing by PIV and PLIF in bioreactor of cells animal culture [Paper presentation]. 6th International Symposium of Mixing in Industrial Processes, ISMIP 6, Niagara Falls, Ontario, Canada.

Collignon, M.-L., Crine, M., Chaubard, J.-F., Peeters, L., Dessoy, S., & Toye, D. (16 April 2008). Experimental analysis by P.I.V. and P.L.I.F of the local hydrodynamic environment of animal cells cultivated in a stirred tank bioreactor [Poster presentation]. Biomedica, the life science summit, Maastricht, Netherlands.

Collignon, M.-L. (2007). Etude du mélange par PIV et PLIF dans un bioréacteur de culture cellulaire [Master’s dissertation, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/5008

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