Delafosse, A., Calvo, S., Collignon, M.-L., & Toye, D. (12 October 2018). Comparison of hydrodynamics in standard stainless steel and single-use bioreactors by means of an Euler-Lagrange approach. Chemical Engineering Science, 188, 52-64. doi:10.1016/j.ces.2018.01.034 Peer Reviewed verified by ORBi |
de Lamotte, A., Delafosse, A., Calvo, S., Collignon, M.-L., Delvigne, F., & Toye, D. (13 May 2016). Gas-liquid transfer through the liquid free-surface in baffled stirred tanks [Paper presentation]. International conferences "Green chemistry and White biotechnology", Gembloux, Belgium. |
Collignon, M.-L., Delafosse, A., Calvo, S., Martin, C., Marc, A., Toye, D., & Olmos, E. (2016). Large-Eddy Simulations of microcarrier exposure to potentially damaging eddies inside mini-bioreactors. Biochemical Engineering Journal. doi:10.1016/j.bej.2015.10.020 Peer Reviewed verified by ORBi |
Delafosse, A., Collignon, M.-L., Marc, A., Toye, D., & Olmos, E. (30 September 2015). NUMERICAL AND EXPERIMENTAL CHARACTERIZATION OF SOLID-LIQUID HYDRODYNAMICS ENCOUNTERED IN HUMAN MESENCHYMAL STEM CELL CULTURE BIOREACTORS [Paper presentation]. 10th European Congress of Chemical Enginnering (ECCE10). |
Delafosse, A., Calvo, S., Collignon, M.-L., Delvigne, F., Crine, M., & Toye, D. (29 September 2015). Euler–Lagrange approach to model heterogeneities in stirred tank bioreactors – Comparison to experimental flow characterization and particle tracking. Chemical Engineering Science, 134, 457-466. doi:10.1016/j.ces.2015.05.045 Peer Reviewed verified by ORBi |
de Lamotte, A., Delafosse, A., Calvo, S., Collignon, M.-L., & Toye, D. (24 September 2015). Hydrodynamics, mixing and mass transfer in baffled stirred tanks [Paper presentation]. Simulation-Driven Medical Device Innovation Seminar, Zaventem, Belgium. |
de Lamotte, A., Delafosse, A., Calvo, S., Collignon, M.-L., & Toye, D. (September 2015). Surface aeration in baffled stirred tanks: hydrodynamics, mixing and mass transfer characteristics [Poster presentation]. 10th European Congress of Chemical Engineering, Nice, France. |
Delafosse, A., Calvo, S., Collignon, M.-L., & Toye, D. (2015). VALIDATION OF AN EULER-LAGRANGE COMPARTMENT MODEL FOR THE DESIGN OF SCALE-DOWN BIOREACTOR USED IN ANIMAL CELL CULTURES. In Proceeding of the 15th European Conference on Mixing. Peer reviewed |
Delafosse, A., Collignon, M.-L., Marc, A., Toye, D., & Olmos, E. (2015). REVISITING THE DETERMINATION OF HYDROMECHANICAL STRESSES ENCOUNTERED BY MICROCARRIERS IN STEM CELL CULTURE BIOREACTORS. In BMC Proceedings 2015. Peer reviewed |
de Lamotte, A., Delafosse, A., Calvo, S., Collignon, M.-L., & Toye, D. (2015). Hydrodynamics, mixing and mass transfer in baffled stirred tanks. In Proceedings of the 15th European Conference on Mixing. Peer reviewed |
Collignon, M.-L., Martin, C., Toye, D., Marc, A., & Olmos, E. (18 January 2015). CFD Large Eddy Simulation of the hydrodynamics of stirred mini-bioreactors operating with stem cell culture mixing conditions [Poster presentation]. ECI conference: scale-up and manufacturing in cell-based therapies, San Diego, United States. |
Collignon, M.-L., Droissart, L., Delafosse, A., Calvo, S., Vanhamel, S., Rodriguez, R., Claes, T., Moncaubeig, F., Peeters, L., Crine, M., & Toye, D. (15 January 2015). HYDRODYNAMICS IN A DISPOSABLE RECTANGULAR PARALLELEPIPED STIRRED BIOREACTOR WITH ELLIPTIC PENDULUM MOTION PADDLE. Biochemical Engineering Journal, 93. doi:10.1016/j.bej.2014.10.011 Peer Reviewed verified by ORBi |
Calvo, S., Delafosse, A., Crine, M., Toye, D., Collignon, M.-L. (Other coll.), & de Lamotte, A. (Other coll.). (10 September 2014). CFD Comparison of hydrodynamics between BIOSTAT® Cultibag STR and standard Stirred Cell Culture Bioreactors [Poster presentation]. 10th European Symposium on Biochemical Engineering Sciences and 6th International Forum on Industrial Bioprocesses in Collaboration With Acs, LILLE, France. |
Collignon, M.-L., Martin, C., Blanchard, F., Toye, D., Marc, A., & Olmos, E. (07 September 2014). RANS and Large Eddy Simulation of the hydrodynamics inside mini-bioreactors designed for stem cell culture [Paper presentation]. 10th European Symposium on Biochemical Engineering Sciences (ESBES) and 6th International Forum on Industrial Bioprocesses (IFIBiop), Lille, France. |
Collignon, M.-L. (10 July 2014). Outils d’étude pour caractériser l’impact de l’ hydrodynamique sur la culture de cellules animales adhérentes cultivées sur microporteurs en bioréacteurs à cuve agitée [Paper presentation]. Journée interdisciplinarité du CNRS sur le thème « Bioprocédés et Bioproduction : environnement – énergie - santé », Paris, France. |
Collignon, M.-L. (17 April 2014). Mise en suspension et contraintes hydrodynamiques sur microporteurs en procédés de cultures adhérentes [Paper presentation]. Ecole thématique CNRS: Ingénierie des biosystèmes: de la cellule au bioréacteur, Nancy, France. |
Delafosse, A., Calvo, S., Collignon, M.-L., Delvigne, F., Crine, M., Thonart, P., & Toye, D. (17 March 2014). CFD-based Compartment model for description of mixing in bioreactors. Chemical Engineering Science, 106, 76-85. doi:10.1016/j.ces.2013.11.033 Peer Reviewed verified by ORBi |
Collignon, M.-L., Delafosse, A., Delvigne, F., Thonart, P., Crine, M., & Toye, D. (2013). Développement d'un dispositif de trajectographie optique nécessaire pour la caractérisation expérimentale par une approche Euler-Lagrange des écoulements dans des bioréacteurs à cuve agitée. In Récents Progrès en Génie des Procédés. Paris, France: Ed. SFGP. Peer reviewed |
Calvo, S., Delafosse, A., Collignon, M.-L., Crine, M., & Toye, D. (2013). Caractérisation expérimentale et modélisation des conditions de mise en suspension homogène d’un solide dans une cuve agitée industrielle. In Récents Progrès en Génie des Procédés (Cd-ROM). Peer reviewed |
Calvo, S., Delafosse, A., Collignon, M.-L., Crine, M., & Toye, D. (August 2013). Experimental characterisation and modelling of homogeneous solid suspension in an industrial stirred tank. Advances in Mechanical Engineering, Volume 2013. doi:10.1155/2013/329264 Peer Reviewed verified by ORBi |
Calvo, S., Delafosse, A., Collignon, M.-L., Crine, M., & Toye, D. (24 April 2013). CFD Modelisation of homogeneous distribution of solid particles in a stirred tank [Poster presentation]. 9th European Congress of Chemical Engineering / 2nd European Congress of Applied Biotechnology, The Hague, Netherlands. |
Collignon, M.-L., Delafosse, A., Delvigne, F., Thonart, P., Crine, M., & Toye, D. (10 September 2012). Development of optical trajectography device for the lagangian study of turbulent flow inside a stirred tank used in pharmaceutical industry [Poster presentation]. 14th European Conference on Mixing, Warsaw, Poland. |
Collignon, M.-L. (2012). Etude de l'hydrodynamique au sein d'un bioréacteur à cuve agitée utilisé pour la culture de cellules animales adhérentes sur microporteurs: Caractérisation expérimentale et théorique des écoulements via des outils eulériens et lagrangiens [Doctoral thesis, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/124023 |
Collignon, M.-L., Droissart, L., Delafosse, A., Vanhamel, S., Rodriguez, R., Claes, T., Moncaubeig, F., Peeters, L., Crine, M., & Toye, D. (2011). Etude de l’écoulement au sein d’un bioréacteur parallélépipédique à usage unique à agitation pendulo-elliptique. In Récents Progrès en Génie des procédés - A la croisée des sciences et des cultures, pour relever les défis industriels du XXIème siècle. Paris, France: Ed. SFGP. Peer reviewed |
Delafosse, A., Delvigne, F., Collignon, M.-L., Crine, M., Thonart, P., & Toye, D. (2011). Modèle hybride Euler-Lagrange pour la description des hétérogénéités dans les bioréacteurs. In SFGP (Ed.), Récents Progrès en Génie des Procédés - N° 101 - Des procédés au service du produit au coeur de l'Europe - Actes du XIIIème Congrès de la société Française de Génie des Procédés - Du 29 Nov. au 1er Décembre 2011 - Lille Grand Palais, FRANCE. Lavoisier Technique et Documentation. Peer reviewed |
Collignon, M.-L., Degand, A., Delafosse, A., Delvigne, F., Thonart, P., & Toye, D. (29 November 2011). Mise au point d’un dispositif de trajectographie optique pour l’étude lagrangienne des écoulements dans une cuve agitée utilisée dans l’industrie pharmaceutique [Poster presentation]. 13ème Congrès de la Société Française du Génie des Procédés, Lille, France. |
Delvigne, F., Brognaux, A., Gorret, N., Delafosse, A., Collignon, M.-L., Toye, D., Crine, M., & Thonart, P. (29 November 2011). Prise en compte l'état de la membrane cellulaire sur la réponse de biocapteurs fluorescents pour la détection de défaut d'écoulement au niveau des bioréacteurs : vers une intégration du "sécrétome" dans la problématique de l'extrapolation [Paper presentation]. 12ème congrès de la Société Française de génie des procédés, Lille, France. |
Delafosse, A., Delvigne, F., Collignon, M.-L., Crine, M., Thonart, P., & Toye, D. (15 November 2011). Hybrid Euler-Lagrange approach to model concentration heterogeneities in stirred tank bioreactors [Paper presentation]. Fifth International Conference on Advanced COmputational Methods in ENgineering (ACOMEN2011), Liège, Belgium. |
Delvigne, F., Delafosse, A., Collignon, M.-L., Toye, D., Crine, M., & Thonart, P. (25 September 2011). Potential use of GFP microbial biosensors for the detection of mixing imperfections and cell viability in bioreactors [Paper presentation]. 1st european congress on applied biotechnology, Berlin, Germany. |
Collignon, M.-L., Delafosse, A., Crine, M., & Toye, D. (18 September 2011). Study of turbulent flow inside a stirred tank used in animal cell culture [Paper presentation]. 7th International Symposium on Mixing in Industrial Processes, ISMIP 7, Pekin, China. |
Delvigne, F., Brognaux, A., Gorret, N., Delafosse, A., Collignon, M.-L., Toye, D., Crine, M., & Thonart, P. (2011). Taking into account cell membrane permeability to account for the response of GFP microbial biosensors : integrating the secretome in the scaling-up procedures. Récents Progrès en Génie des Procédés, 101, 1-7. Peer reviewed |
Delvigne, F.* , Brognaux, A.* , Gorret, N., Neubauer, P., Delafosse, A., Collignon, M.-L., Toye, D., Crine, M., Boxus, M., & Thonart, P. (2011). Characterization of the response of GFP microbial biosensors sensitive to substrate limitation in scale-down bioreactors. Biochemical Engineering Journal, 55 (2), 131-139. doi:10.1016/j.bej.2011.03.016 Peer Reviewed verified by ORBi * These authors have contributed equally to this work. |
Delafosse, A., Collignon, M.-L., Dossin, D., Crine, M., & Toye, D. (2011). Estimation of the turbulent kinetic energy dissipation in a culture cell stirred tank bioreactor. Chemical Engineering Science, 66 (8), 1728-1737. doi:10.1016/j.ces.2011.01.011 Peer Reviewed verified by ORBi |
Collignon, M.-L., Delafosse, A., Crine, M., & Toye, D. (2011). Reply to "Comments on Collignon et al. (Chem. Eng. Sci. 65 (2010) 5929-5941)". Chemical Engineering Science, 6, 1324-1325. doi:10.1016/j.ces.2010.12.038 Peer Reviewed verified by ORBi |
Delafosse, A., Delvigne, F., Collignon, M.-L., Crine, M., Thonart, P., & Toye, D. (2011). Description of concentration heterogeneities in a stirred-tank bioreactor by mean of an Euler- Lagrange model [Paper presentation]. 8th European Congress of Chemical Engineering – ECCE8”, Berlin, Germany, 25-29 septembre 2011, Berlin, Germany. |
Collignon, M.-L., Delafosse, A., Crine, M., & Toye, D. (15 November 2010). AXIAL IMPELLER SELECTION FOR ANCHORAGE DEPENDENT ANIMAL CELL CULTURE IN STIRRED BIOREACTORS: METHODOLOGY BASED ON THE IMPELLER COMPARISON AT JUST-SUSPENDED SPEED OF ROTATION. Chemical Engineering Science, 65 (22), 5929-5941. doi:10.1016/j.ces.2010.08.027 Peer Reviewed verified by ORBi |
Collignon, M.-L., Droissart, L., Delafosse, A., Vanhamel, S., Rodriguez, R., Claes, T., Moncaubeig, F., Peeters, L., Crine, M., & Toye, D. (August 2010). Study of hydrodynamics inside a single use parallelepiped stirred bioreactor equipped with an elliptic motion paddle [Paper presentation]. Organisation conjointe: 19th Congress of Chemical and Process Engineering(CHISA) ; 7th European Congress of Chemical Engineering (ECCE-7), Prague, République Tchèque, 28 août - 1 septembre 2010, Prague, Czechia. |
Collignon, M.-L., Dossin, D., Delafosse, A., Crine, M., & Toye, D. (2010). Quality of mixing in a stirred bioreactor used for animal cells culture: heterogeneities in a lab scale bioreactor and evolution of mixing time with scale up. Biotechnologie, Agronomie, Société et Environnement, 14, 401-407. Peer Reviewed verified by ORBi |
Delafosse, A., Delvigne, F., Collignon, M.-L., Crine, M., Thonart, P., & Toye, D. (2010). Development of a compartment model based on CFD simulations for mixing description in bioreactors. Biotechnologie, Agronomie, Société et Environnement, 14 (2), 517-522. Peer Reviewed verified by ORBi |
Delafosse, A., Delvigne, F., Collignon, M.-L., Crine, M., Thonart, P., & Toye, D. (2010). Stochastic modelling of micro-organisms displacements in a stirred-tank bioreactor [Poster presentation]. 19th Congress of Chemical and Process Engineering (CHISA2010) – 7th European Congress of Chemical Engineering (ECCE7), 28 aout–2 septembre 2010, Prague, Czechia. |
Collignon, M.-L., Dossin, D., Delafosse, A., Crine, M., & Toye, D. (12 December 2009). Study of heterogeneities in laboratory scale and prediction of mixing time evolution during the scale- up of an animal cells culture in a stirred bioreactor [Paper presentation]. Journée d'étude annuelle de l'école doctorale GEPROC sur le thème des Biotechnologies, Gembloux, Belgium. |
Collignon, M.-L., Crine, M., Delafosse, A., & Toye, D. (14 October 2009). Effet de la viscosité sur la structure de l'écoulement et sur le mélange dans un bioréacteur à cuve agitée utilisé en culture de cellules animales [Poster presentation]. 12ème congrès de la Société Française de Génie des Procédés, Marseille, France. |
Collignon, M.-L., Dossin, D., Crine, M., Chaubard, J.-F., Peeters, L., Dessoy, S., & Toye, D. (01 April 2009). Study of the mixing time evolution during the scale-up of an animal cells culture in a stirred tank bioreactor [Poster presentation]. Biomedica, the life science summit, Liège, Belgium. |
Toye, D., Collignon, M.-L., & Crine, M. (05 February 2009). Les outils du génie chimique pour une meilleure maîtrise des procédés biologiques et biotechnologiques [Paper presentation]. « Le biomédical en Sciences appliquées », Liège, Belgium. |
Delafosse, A., Collignon, M.-L., Delvigne, F., Crine, M., Thonart, P., & Toye, D. (2009). CFD-based Compartment model for the description of the heterogeneities experienced by microorganisms in bioreactors [Poster presentation]. Bioproscale symposium, 24 - 27 Novembre 2009, Berlin, Germany. |
Collignon, M.-L., Crine, M., Delafosse, A., & Toye, D. (2009). Effet de la viscosité sur la structure de l'écoulement et sur le mélange dans un bioréacteur à cuve agitée utilisé en culture de cellules animales. In Récents Progrès en Génie des procédés - A la croisée des sciences et des cultures, pour relever les défis industriels du XXIème siècle. Paris, France: Lavoisier Technique et Documentation. Peer reviewed |
Collignon, M.-L., Crine, M., Verdin, E., Chaubard, J.-F., Peeters, L., Dessoy, S., & Toye, D. (20 August 2008). A study of the mixing by PIV and PLIF in bioreactor of cells animals culture [Paper presentation]. Sixth International Symposium on Mixing in Industrial Process Industries, Niagara on the Lake, Canada. |
Collignon, M.-L., Crine, M., Verdin, E., Chaubard, J.-F., Peeters, L., Dessoy, S., & Toye, D. (19 August 2008). A study of the mixing by PIV and PLIF in bioreactor of cells animal culture [Paper presentation]. 6th International Symposium of Mixing in Industrial Processes, ISMIP 6, Niagara Falls, Ontario, Canada. |
Collignon, M.-L., Crine, M., Chaubard, J.-F., Peeters, L., Dessoy, S., & Toye, D. (16 April 2008). Experimental analysis by P.I.V. and P.L.I.F of the local hydrodynamic environment of animal cells cultivated in a stirred tank bioreactor [Poster presentation]. Biomedica, the life science summit, Maastricht, Netherlands. |
Collignon, M.-L. (2007). Etude du mélange par PIV et PLIF dans un bioréacteur de culture cellulaire [Master’s dissertation, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/5008 |