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Rosu Frédéric

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Main Referenced Co-authors
De Pauw, Edwin  (52)
Gabelica, Valérie  (51)
Antoine, Rodolphe (12)
Dugourd, Philippe (12)
Broyer, Michel (9)
Main Referenced Keywords
mass spectrometry (45); DNA (37); noncovalent (20); G-quadruplex (19); spectroscopy (12);
Main Referenced Unit & Research Centers
Giga-Systems Biology and Chemical Biology - ULiège [BE] (25)
CART - Centre Interfacultaire d'Analyse des Résidus en Traces - ULiège [BE] (17)
DER Chimie (1)
Laboratoire de Spectrométrie de Masse (1)
Mass Spectrometry Laboratory (MSLab) (1)
Main Referenced Disciplines
Chemistry (51)
Biochemistry, biophysics & molecular biology (27)
Physics (6)
Physical, chemical, mathematical & earth Sciences: Multidisciplinary, general & others (2)
Oncology (1)

Publications (total 57)

The most downloaded
7813 downloads
Rosu, F., Pirotte, S., De Pauw, E., & Gabelica, V. (2006). Positive and negative ion mode ESI-MS and MS/MS for studying drug-DNA complexes. International Journal of Mass Spectrometry, 253 (3), 156-171. doi:10.1016/j.ijms.2005.11.027 https://hdl.handle.net/2268/362

The most cited

242 citations (Scopus®)

Smargiasso, N., Rosu, F., Hsia, W., Colson, P., Baker, E. S., Bowers, M. T., De Pauw, E., & Gabelica, V. (2008). G-Quadruplex DNA Assemblies: Loop Length, Cation Identity, and Multimer Formation. Journal of the American Chemical Society, 130 (31), 10208-10216. doi:10.1021/ja801535e https://hdl.handle.net/2268/397

Rosu, F., Gabelica, V., De Pauw, E., Antoine, R., Broyer, M., & Dugourd, P. (May 2012). UV Spectroscopy of DNA Duplex and Quadruplex Structures in the Gas Phase. Journal of Physical Chemistry. A, 116, 5383−5391. doi:10.1021/jp302468x
Peer Reviewed verified by ORBi

Rosu, F., De Pauw, E., Gabelica, V., Antoine, R., & Dugourd, P. (22 January 2012). IR and UV spectroscopy of DNA Higher-Order Structures in the gas phase [Paper presentation]. IBBI 2012: Isolated biomolecules and biomolecular interactions.

Joly, L., Rosu, F., & Gabelica, V. (2012). d(TG(n)T) DNA sequences do not necessarily form tetramolecular G-quadruplexes. Chemical Communications, 48 (67), 8386-8. doi:10.1039/c2cc33316c
Peer Reviewed verified by ORBi

Zhou, J., Bourdoncle, A., Rosu, F., Gabelica, V., & Mergny, J.-L. (2012). Tri-G-Quadruplex: Controlled Assembly of a G-Quadruplex Structure from Three G-Rich Strands. Angewandte Chemie International Edition. doi:10.1002/anie.201205390
Peer Reviewed verified by ORBi

Echterbille, J., Quinton, L., Rosu, F., Gilles, N., & De Pauw, E. (11 October 2011). Disulfide bond assignement and folding characterization of peptide toxins by Ion Mobility Mass Spectrometry [Paper presentation]. MS Technology Day of Waters Corporation, Bruxelles, Belgium.

Echterbille, J., Quinton, L., De Pauw, E., Rosu, F. (Other coll.), & Gilles, N. (Other coll.). (29 April 2011). Disulfide bonds assignment and folding characterization of peptide toxins by Ion Mobility Mass Spectrometry [Paper presentation]. Meeting annuel de la Société Belge de Spectrométrie de Masse, Mons, Belgium.

Largy, E., Hamon, F., Rosu, F., Gabelica, V., De Pauw, E., Guedin, A., Mergny, J.-L., & Teulade-Fichou, M.-P. (2011). Tridentate N-Donor Palladium(II) Complexes as Efficient Coordinating Quadruplex DNA Binders. Chemistry, 17 (47), 13274-13283. doi:10.1002/chem.201102300
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Echterbille, J., Quinton, L., Rosu, F., & De Pauw, E. (2011). Disulfide bond assignment and folding characterization of peptide toxins by Ion Mobility Mass Spectrometry [Poster presentation]. 59th Conference on Mass Spectrometry and Allied Topics, Denver, United States - Colorado.

Rosu, F., Gabelica, V., Poncelet, H., & De Pauw, E. (2010). Tetramolecular G-quadruplex formation pathways studied by electrospray mass spectrometry. Nucleic Acids Research. doi:10.1093/nar/gkq208
Peer Reviewed verified by ORBi

Gabelica, V., Rosu, F., Joly, L., De Pauw, E., Matheis, K., Kappes, M. M., Giuliani, A., Miloslavljevic, A., Refregiers, M., Nahon, L., Antoine, R., & Dugourd, P. (2010). Electronic spectroscopy of nucleic acids in the gas phase [Paper presentation]. 240th ACS National Meeting, Boston, United States.

Rosu, F., Gabelica, V., Smargiasso, N., Mazzucchelli, G., Shin-ya, K., & De Pauw, E. (2010). Cation Involvement in Telomestatin Binding to G-Quadruplex DNA. Journal of Nucleic Acids, 121259. doi:10.4061/2010/121259
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Collie, G. W., Parkinson, G. N., Neidle, S., Rosu, F., De Pauw, E., & Gabelica, V. (2010). Electrospray Mass Spectrometry of Telomeric RNA (TERRA) Reveals the Formation of Stable Multimeric G-Quadruplex Structures. Journal of the American Chemical Society, 132 (27), 9328–9334. doi:10.1021/ja100345z
Peer Reviewed verified by ORBi

Morsa, D., Gabelica, V., Rosu, F., Remacle, F., & De Pauw, E. (2010). Internal energy content of ions in a travelling wave ion guide [Paper presentation]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.

Rosu, F., Gabelica, V., Joly, L., Gregoire, G., & De Pauw, E. (2010). Zwitterionic i-motif structures are preserved in DNA negatively charged ions produced by electrospray mass spectrometry. Physical Chemistry Chemical Physics, 12, 13448-13454. doi:10.1039/c0cp00782j
Peer Reviewed verified by ORBi

Gabelica, V., Amato, J., Oliviero, G., Rosu, F., & De Pauw, E. (04 June 2009). A simple method for determination of electrospray response factors of noncovalent complexes: application to DNA G-quadruplex binding and self-assembly [Paper presentation]. 57th ASMS Conference on Mass Spectrometry, Philadelphia, United States.

Gabelica, V., Rosu, F., & De Pauw, E. (2009). A Simple Method to Determine Electrospray Response Factors of Noncovalent Complexes. Analytical Chemistry, 81 (16), 6708-6715. doi:10.1021/ac900785m
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Smargiasso, N., Gabelica, V., Damblon, C., Rosu, F., De Pauw, E., Teulade-Fichou, M.-P., Rowe, J. A., & Claessens, A. (2009). Putative DNA G-quadruplex formation within the promoters of Plasmodium falciparum var genes. BMC Genomics, 10, 362. doi:10.1186/1471-2164-10-362
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Gabelica, V., Rosu, F., Gregoire, G., Schermann, J.-P., Desfrançois, C., Lemaire, J., Tabarin, T., Antoine, R., Broyer, M., Dugourd, P., & De Pauw, E. (03 June 2008). IR and UV spectroscopic signatures of DNA higher-order structures in the gas phase [Paper presentation]. 56th ASMS Conference on Mass Spectrometry, Denver (CO), United States.

Gabelica, V., Rosu, F., De Pauw, E., Antoine, R., Tabarin, T., Broyer, M., Dugourd, P., Matheis, K., & Kappes, M. M. (15 April 2008). Electron Photodetachment of DNA Polyanions: Photoelectron Spectroscopy and UV Action Spectroscopy [Paper presentation]. IBBI 08 Conference: “Isolated Biomolecules and Biomolecular Interactions”, Valladolid, Spain.

Gabelica, V., Rosu, F., Gregoire, G., Gillet, J.-C., Poullly, J.-C., Lecomte, F., Schermann, J.-P., Desfrançois, C., Lemaire, J., Tabarin, T., Antoine, R., Broyer, M., Dugourd, P., & De Pauw, E. (15 February 2008). IR and UV spectroscopy of DNA ions stored in a quadrupole ion trap mass spectrometer [Paper presentation]. Annual Meeting of the Belgian Society for Mass Spectrometry, Beerse, Belgium.

Rosu, F., De Pauw, E., Gabelica, V., Antoine, R., & Dugourd, P. (2008). Photodissociation spectroscopy of cationic porphyrins in the gas phase. Influence of the complexation with DNA. Comparison with solution phase. In R. D. Beck, M. Drabbels, ... T. R. Rizzo (Eds.), Contributions 16th Symposium on Atomic and Surface Physics and Related Topics (pp. 210-211). Innsbruck, Austria: Innsbruck University Press.

Mazzucchelli, G., Gabelica, V., Smargiasso, N., Fleron, M., Ashimwe, W., Rosu, F., De Pauw-Gillet, M.-C., Riou, J.-F., & De Pauw, E. (2008). Proteome alteration induced by hTERT transfection of human fibroblast cells. Proteome Science, 6 (1), 12. doi:10.1186/1477-5956-6-1
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Monchaud, D., Allain, C., Bertrand, H., Smargiasso, N., Rosu, F., Gabelica, V., De Cian, A., Mergny, J.-L., & Teulade-Fichou, M.-P. (2008). Ligands playing musical chairs with G-quadruplex DNA: A rapid and simple displacement assay for identifying selective G-quadruplex binders. Biochimie, 90 (8), 1207-1223. doi:10.1016/j.biochi.2008.02.019
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Amato, J., Gabelica, V., Borbone, N., Rosu, F., De Pauw, E., Oliviero, G., Piccialli, G., & Mayol, L. (2008). A short C-rich PNA fragment capable to form novel G-quadruplex-PNA complexes. Nucleic Acids Symposium Series, 52, 167-168. doi:10.1093/nass/nrn085
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Amato, J., Oliviero, G., Borbone, N., D'Errico, S., Piccialli, G., Mailliet, P., Rosu, F., De Pauw, E., & Gabelica, V. (2008). Ligand binding to tetra-end-linked (TGGGGT)4 G-quadruplexes: an electrospray mass spectroscopy study. Nucleic Acids Symposium Series, 52, 165-166. doi:10.1093/nass/nrn084
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Smargiasso, N., Rosu, F., Baker, E., Bowers, M., Colson, P., De Pauw, E., & Gabelica, V. (2008). Novel G-Quadruplex Higher Order Assemblies Revealed by Electrospray Ionization Mass Spectrometry.

Rosu, F., Gabelica, V., De Pauw, E., Mailliet, P., & Mergny, J.-L. (2008). Cooperative 2:1 Binding of a Bisphenothiazine to Duplex DNA. Chembiochem: A European Journal of Chemical Biology, 9, 849-852. doi:10.1002/cbic.200700572
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Mazzucchelli, G., Gabelica, V., Smargiasso, N., Rosu, F., De Pauw-Gillet, M.-C., Riou, J.-F., & De Pauw, E. (2008). Proteomic analysis of telomerase inhibition by telomere specific ligands. Anticancer Research, 28 (5c), 3257-3258.
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Gabelica, V., Rosu, F., De Pauw, E., Antoine, R., Tabarin, T., Broyer, M., & Dugourd, P. (2008). Photodetachment and photodissociation mass spectrometry of DNA multiply charged ions. In R. D. Beck, M. Drabbels, ... T. R. Rizzo (Eds.), Contributions 16th Symposium on Atomic and Surface Physics and Related Topics (pp. 22-24). Innsbruck University Press.

Rosu, F., De Pauw, E., & Gabelica, V. (2008). Electrospray Mass Spectrometry to Study Drug-Nucleic Acids Interactions. Biochimie, 90 (7), 1074-1087. doi:10.1016/j.biochi.2008.01.005
Peer Reviewed verified by ORBi

Smargiasso, N., Rosu, F., Hsia, W., Colson, P., Baker, E. S., Bowers, M. T., De Pauw, E., & Gabelica, V. (2008). G-Quadruplex DNA Assemblies: Loop Length, Cation Identity, and Multimer Formation. Journal of the American Chemical Society, 130 (31), 10208-10216. doi:10.1021/ja801535e
Peer Reviewed verified by ORBi

Gabelica, V., Rosu, F., De Pauw, E., Lemaire, J., Gillet, J.-C., Poully, J.-C., Lecomte, F., Grégoire, G., Schermann, J.-P., & Desfrançois, C. (2008). Infrared Signature of DNA G-Quadruplexes in the Gas Phase. Journal of the American Chemical Society, 130 (6), 1810-1. doi:10.1021/ja077321w
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Rosu, F., Poncelet, H., Teulade-Fichou, M.-P., De Pauw, E., & Gabelica, V. (07 September 2007). Exploring the Formation Pathways of DNA G-Quadruplex Architectures [Paper presentation]. 2nd European Conference on Chemistry for Life Sciences, Wroclaw, Poland.

Rosu, F., Nguyen, C.-H., De Pauw, E., & Gabelica, V. (2007). Ligand binding mode to duplex and triplex DNA assessed by combining electrospray tandem mass spectrometry and molecular modeling. Journal of the American Society for Mass Spectrometry, 18 (6), 1052-1062. doi:10.1016/j.jasms.2007.03.010
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Gabelica, V., Rosu, F., Tabarin, T., Kinet, C., Antoine, R., Broyer, M., De Pauw, E., & Dugourd, P. (2007). Base-dependent electron photodetachment from negatively charged DNA strands upon 260-nm laser irradiation. Journal of the American Chemical Society, 129 (15), 4706-4713. doi:10.1021/ja068440z
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Gros, J., Rosu, F., Amrane, S., De Cian, A., Gabelica, V., Lacroix, L., & Mergny, J.-L. (2007). Guanines are a quartet's best friend: impact of base substitutions on the kinetics and stability of tetramolecular quadruplexes. Nucleic Acids Research, 35 (9), 3064-3075. doi:10.1093/nar/gkm111
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Gabelica, V., Rosu, F., De Pauw, E., Antoine, R., Tabarin, T., Broyer, M., & Dugourd, P. (2007). Electron photodetachment dissociation of DNA anions with covalently or noncovalently bound chromophores. Journal of the American Society for Mass Spectrometry, 18 (11), 1990-2000. doi:10.1016/j.jasms.2007.08.007
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Gabelica, V., Tabarin, T., Kinet, C., Antoine, R., Rosu, F., Compagnon, I., Broyer, M., De Pauw, E., & Dugourd, P. (13 September 2006). Formation de radicaux anions d'ADN par irradiation laser UV et visible et nouveaux canaux de dissociation [Paper presentation]. 23èmes Journées Françaises de Spectrométrie de Masse, Nantes, France.

Mazzucchelli, G., Smargiasso, N., Rosu, F., Gabelica, V., Colson, P., Teulade- Fichou, M.-P., De Pauw-Gillet, M.-C., & De Pauw, E. (30 May 2006). G-quadruplex targeting drugs: from the gas phase structure of non covalent complexes to in vitro activity [Paper presentation]. 54th ASMS Conference, Seattle, United States.

Schulz, E., Karas, M., Rosu, F., & Gabelica, V. (2006). Influence of the matrix on analyte fragmentation in atmospheric pressure MALDI. Journal of the American Society for Mass Spectrometry, 17 (7), 1005-1013. doi:10.1016/j.jasms.2006.03.009
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Rosu, F., Pirotte, S., De Pauw, E., & Gabelica, V. (2006). Positive and negative ion mode ESI-MS and MS/MS for studying drug-DNA complexes. International Journal of Mass Spectrometry, 253 (3), 156-171. doi:10.1016/j.ijms.2005.11.027
Peer Reviewed verified by ORBi

Gabelica, V., Tabarin, T., Antoine, R., Rosu, F., Compagnon, I., Broyer, M., De Pauw, E., & Dugourd, P. (2006). Electron photodetachment dissociation of DNA polyanions in a quadrupole ion trap mass spectrometer. Analytical Chemistry, 78 (18), 6564-6572. doi:10.1021/ac060753p
Peer Reviewed verified by ORBi

Gabelica, V., Rosu, F., Witt, M., Baykut, G., & De Pauw, E. (2005). Fast gas-phase hydrogen/deuterium exchange observed for a DNA G-quadruplex. Rapid Communications in Mass Spectrometry, 19 (2), 201-208. doi:10.1002/rcm.1772
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Guittat, L., De Cian, A., Rosu, F., Gabelica, V., De Pauw, E., Delfourne, E., & Mergny, J.-L. (2005). Ascididemin and meridine stabilise G-quadruplexes and inhibit telomerase in vitro. Biochimica et Biophysica Acta - General Subjects, 1724 (3), 375-384. doi:10.1016/j.bbagen.2005.04.023
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David-Cordonnier, M. H., Laine, W., Lansiaux, A., Rosu, F., Colson, P., De Pauw, E., MICHEL, S., Tillequin, F., Koch, M., Hickman, J., Pierre, A., & Bailly, C. (2005). Covalent binding of antitumor benzoacronycines to double-stranded DNA induces helix opening and the formation of single-stranded DNA: Unique consequences of a novel DNA-bonding mechanism. Molecular Cancer Therapeutics, 4 (1), 71-80.
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Rosu, F., De Pauw, E., Guittat, L., Alberti, P., Lacroix, L., Mailliet, P., Riou, J.-F., & Mergny, J.-L. (09 September 2003). Selective interaction of ethidium derivatives with quadruplexes: An equilibrium dialysis and electrospray ionization mass spectrometry analysis. Biochemistry, 42 (35), 10361-10371. doi:10.1021/bi034531m
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Guittat, L., Alberti, P., Rosu, F., Van Miert, S., Thetiot, E., Pieters, L., Gabelica, V., De Pauw, E., Ottaviani, A., Riou, J.-F., & Mergny, J.-L. (2003). Interactions of cryptolepine and neocryptolepine with unusual DNA structures. Biochimie, 85 (5), 535-547. doi:10.1016/S0300-9084(03)00035-X
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Gabelica, V., Galic, N., Rosu, F., Houssier, C., & De Pauw, E. (2003). Influence of response factors on determining equilibrium association constants of non-covalent complexes by electrospray ionization mass spectrometry. Journal of Mass Spectrometry, 38 (5), 491-501. doi:10.1002/jms.459
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Rosu, F., Gabelica, V., Shin-ya, K., & De Pauw, E. (2003). Telomestatin-induced stabilization of the human telomeric DNA quadruplex monitored by electrospray mass spectrometry. Chemical Communications, (21), 2702-2703. doi:10.1039/b309394h
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Gabelica, V., Rosu, F., De Pauw-Gillet, M.-C., Colson, P., & De Pauw, E. (September 2002). Introduction de méthodes basées sur la spectrométrie de masse pour l’étude de la reconnaissance moléculaire [Poster presentation]. Journées AFERP, Athène, Greece.

Carrasco, C., Rosu, F., Gabelica, V., Houssier, C., De Pauw, E., Garbay-Jaureguiberry, C., Roques, B., Wilson, W. D., Chaires, J. B., Waring, M. J., & Bailly, C. (2002). Tight binding of the antitumor drug ditercalinium to quadruplex DNA. Chembiochem: A European Journal of Chemical Biology, 3 (12), 1235-1241. doi:10.1002/1439-7633(20021202)3:12<1235::AID-CBIC1235>3.0.CO;2-I
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Rosu, F., Gabelica, V., Houssier, C., & De Pauw, E. (2002). Determination of affinity, stoichiometry and sequence selectivity of minor groove binder complexes with double-stranded oligodeoxynucleotides by electrospray ionization mass spectrometry. Nucleic Acids Research, 30 (16), 82. doi:10.1093/nar/gnf081
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Rosu, F., Gabelica, V., Houssier, C., Colson, P., & De Pauw, E. (2002). Triplex and quadruplex DNA structures studied by electrospray mass spectrometry. Rapid Communications in Mass Spectrometry, 16 (18), 1729-1736. doi:10.1002/rcm.778
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De Pauw-Gillet, M.-C., Colson, P., Bailly, C., Pieters, L., Vlietinck, A. J., Rosu, F., De Pauw, E., & Houssier, C. (June 2001). DNA intercalation, topoisomerase II inhibition and cytotoxic activity of the plant alkaloid neocryptolepine [Poster presentation]. Gordon Conferences, "Biological molecules in gas phase", Boston, United States.

Rosu, F., Gabelica, V., Houssier, C., & De Pauw, E. (2001). Determination of Binding Constants of Oligonucleotide Complexes with Minor Groove Binders by Electrospray Ionization Mass Spectrometry. Comparison with Fluorescence Titration Data. Advances in Mass Spectrometry, 795-796.

Gabelica, V., Rosu, F., Houssier, C., & De Pauw, E. (2000). Gas Phase Thermal Denaturation of an Oligonucleotide Duplex and Its Complexes with Minor Groove Binders. Rapid Communications in Mass Spectrometry, 14 (6), 464-467. doi:10.1002/(SICI)1097-0231(20000331)14:6<464::AID-RCM895>3.0.CO;2-M
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Gabelica, V., De Pauw, E., & Rosu, F. (1999). Interaction between Antitumor Drugs and a Double-Stranded Oligonucleotide Studied by Electrospray Ionization Mass Spectrometry. Journal of Mass Spectrometry, 34 (12), 1328-1337. doi:10.1002/(SICI)1096-9888(199912)34:12<1328::AID-JMS889>3.0.CO;2-F
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