Publications and communications of Carole Charlier

Tang, L., Swedlund, B., Dupont, S., Harland, C., Costa Monteiro Moreira, G., Durkin, K., Artesi, M., Mullaart, E., Sartelet, A., Karim, L., Coppieters, W., Georges, M., & Charlier, C. (09 March 2024). GWAS reveals determinants of mobilization rate and dynamics of an active endogenous retrovirus of cattle. Nature Communications, 15 (1), 2154. doi:10.1038/s41467-024-46434-1

Gualdrón Duarte, J. L., Yuan, C., Gori, A.-S., Moreira, G. C. M., Takeda, H., Coppieters, W., Charlier, C., Georges, M., & Druet, T. (28 November 2023). Sequenced-based GWAS for linear classification traits in Belgian Blue beef cattle reveals new coding variants in genes regulating body size in mammals. Genetics, Selection, Evolution, 55 (1), 83. doi:10.1186/s12711-023-00857-4

Lee, Y. L., Bouwman, A. C., Harland, C., Bosse, M., Costa Monteiro Moreira, G., Veerkamp, R. F., Mullaart, E., CAMBISANO, N., Groenen, M. A. M., Karim, L., Coppieters, W., Georges, M., & Charlier, C. (2023). The rate of de novo structural variation is increased in in vitro-produced offspring and preferentially affects the paternal genome. Genome Research. doi:10.1101/gr.277884.123

Yuan, C., Tang, L., Lopdell, T., Petrov, V. A., Oget-Ebrad, C., Moreira, G. C. M., Gualdrón Duarte, J. L., Sartelet, A., Cheng, Z., Salavati, M., Wathes, D. C., Crowe, M. A., GplusE Consortium, Coppieters, W., Littlejohn, M., Charlier, C., Druet, T., Georges, M.* , & Takeda, H.*. (October 2023). An organism-wide ATAC-seq peak catalog for the bovine and its use to identify regulatory variants. Genome Research, 33 (10), 1848 - 1864. doi:10.1101/gr.277947.123

Salavati, M., Clark, R., Becker, D., Kühn, C., Plastow, G., Dupont, S., Costa Monteiro Moreira, G., Charlier, C., & Clark, E. L. (2023). Improving the annotation of the cattle genome by annotating transcription start sites in a diverse set of tissues and populations using CAGE sequencing. G3: Genes, Genomes, Genetics. doi:10.1093/g3journal/jkad108

Lee, Y. L., Bosse, M., Takeda, H., Moreira, G. C. M., Karim, L., Druet, T., Oget-Ebrad, C., Coppieters, W., Veerkamp, R. F., Groenen, M. A. M., Georges, M., Bouwman, A. C., & Charlier, C. (01 May 2023). High-resolution structural variants catalogue in a large-scale whole genome sequenced bovine family cohort data. BMC Genomics, 24 (1), 225. doi:10.1186/s12864-023-09259-8

Gualdron Duarte, J. L., Gori, A.-S., Costa Monteiro Moreira, G., Georges, M., Charlier, C., & Druet, T. (08 July 2022). Sequence-based multi-trait genome-wide association study for linear classification traits in Belgian Blue beef cattle [Paper presentation]. World Congress on Genetics Applied to Livestock Production, Rotterdam, Netherlands.

Lee, Y. L., Bosse, M., Coppieters, W., Veerkamp, R., Karim, L., Oget, C., Druet, T., Groenen, M., Georges, M., Bouwman, A., & Charlier, C. (08 July 2022). Rare CNVs in the bovine genome are not captured well by 50K density genotyping array SNPs [Paper presentation]. World Congress on Genetics Applied to Livestock Production, Rotterdam, Netherlands.

Oget, C., Costa Monteiro Moreira, G., Karim, L., Coppieters, W., Charlier, C., Georges, M., & Druet, T. (08 July 2022). Fine-Scale Study of Meiotic Recombination in Cattle [Paper presentation]. World Congress on Genetics Applied to Livestock Production, Rotterdam, Netherlands.

Rombouts, T., Druet, T., Gualdron Duarte, J. L., Ahariz, N., Karim, L., Coppieters, W., De Smet, S., Georges, M., & Charlier, C. (08 July 2022). A hypomorphic mutation in the ATP2A1 gene increases muscle mass yet compromises meat quality of Belgian Blue cattle [Paper presentation]. World Congress on Genetics Applied to Livestock Production, Rotterdam, Netherlands.

Yuan, C., Tang, L., Lopdell, T., Oget, C., Costa Monteiro Moreira, G., Gualdron Duarte, J. L., Cheng, Z., Salavati, M., Wathes, D. C., Crowe, M. A., GplusE consortium, Coppieters, W., Charlier, C., Druet, T., Georges, M., & Takeda, H. (08 July 2022). Enrichment of causative variants in tissue-specific and shared ATAC-Seq peaks in cattle [Paper presentation]. World Congress on Genetics Applied to Livestock Production, Rotterdam, Netherlands.

Yang, H.* , Wu, J.* , Huang, X., Zhou, Y., Zhang, Y., Liu, M., Liu, Q., Ke, S., He, M., Fu, H., Fang, S., Xiong, X., Jiang, H., Chen, Z., Wu, Z., Gong, H., Tong, X., Huang, Y., Ma, J., ... Huang, L.*. (2022). ABO genotype alters the gut microbiota by regulating GalNAc levels in pigs. Nature. doi:10.1038/s41586-022-04769-z

Meyermans, R., Janssens, S., Coussé, A., Gorssen, W., Hubin, X., Mayeres, P., Veulemans, W., Claerebout, E., Charlier, C., & Buys, N. (15 February 2022). Myostatin mutation causing double muscling could affect increased psoroptic mange sensitivity in dual purpose Belgian Blue cattle. Animal, 16 (3), 100460. doi:10.1016/j.animal.2022.100460

Zhu, Y., Zhou, Z., Huang, T., Zhang, Z., Li, W., Ling, Z., Jiang, T., Yang, J., Yang, S., Xiao, Y., Charlier, C., Georges, M., Yang, B., & Huang, L. (2022). Mapping and analysis of a spatiotemporal H3K27ac and gene expression spectrum in pigs. Science China Life Sciences. doi:10.1007/s11427-021-2034-5

Kadri, N. K., Zhang, J., Oget-Ebrad, C., Wang, Y., Couldrey, C., Spelman, R., Charlier, C., Georges, M., & Druet, T. (2022). High male specific contribution of the X-chromosome to individual global recombination rate in dairy cattle. BMC Genomics, 23 (1), 114. doi:10.1186/s12864-022-08328-8

Tang, L., Harland, C., Durkin, K., Artesi, M., Costa Monteiro Moreira, G., Karim, L., Deckers, M., Mullaart, E., Coppieters, W., Georges, M., & Charlier, C. (11 May 2021). Evidence for inter-individual variation of ERV de novo transposition rate in the male cattle germline [Paper presentation]. The Biology of Genomes, United States.

Alemu, S. W., Kadri, N. K., Harland, C., Faux, P., Charlier, C., Caballero, A., & Druet, T. (2021). An evaluation of inbreeding measures using a whole-genome sequenced cattle pedigree. Heredity, 126, 410-423. doi:10.1038/s41437-020-00383-9

Artesi, M.* , Hahaut, V.* , Cole, B.* , Lambrechts, L., Ashrafi, F., Marçais, A., Hermine, O., Griebel, P., Arsic, N., van der Meer, F., Burny, A., Bron, D., BIANCHI, E., DELVENNE, P., BOURS, V., Charlier, C., Georges, M., Vandekerckhove, L.* , Van den Broeke, A.* , & Durkin, K.*. (2021). PCIP-seq: simultaneous sequencing of integrated viral genomes and their integration sites with long reads. Genome Biology, 22, 97. doi:10.1186/s13059-021-02307-0

Costa Monteiro Moreira, G., Tang, L., Dupont, S., Young-Lim, L., Harland, C., Karim, L., Coppieters, W., Georges, M., & Charlier, C. (2021). LIVE (EPI)GENOMIC BATTLE BETWEEN UNFIXED TRANSPOSABLE ELEMENTS AND THEIR COGNATE piRNA CLUSTERS IN CATTLE TESTES [Paper presentation]. The Biology of Genomes.

Lee, Y.-L., Takeda, H., Costa Monteiro Moreira, G., Karim, L., Mullaart, E., Coppieters, W., Appeltant, R., Veerkamp, R. F., Groenen, M. A. M., Georges, M., Bosse, M., Druet, T., Bouwman, A. C., & Charlier, C. (2021). A 12 kb multi-allelic copy number variation encompassing a GC gene enhancer is associated with mastitis resistance in dairy cattle. PLoS Genetics, 17 (7), 1009331. doi:10.1371/journal.pgen.1009331

Reynolds, E. G. M., Neeley, C., Lopdell, T. J., Keehan, M., Dittmer, K., Harland, C. S., Couldrey, C., Johnson, T. J. J., Tiplady, K., Worth, G., Walker, M., Davis, S. R., Sherlock, R. G., Carnie, K., Harris, B. L., Charlier, C., Georges, M., Spelman, R. J., Garrick, D. J., & Littlejohn, M. D. (2021). Non-additive association analysis using proxy phenotypes identifies novel cattle syndromes. Nature Genetics, 53 (7), 949-954. doi:10.1038/s41588-021-00872-5

Young-Lim, L., Costa Monteiro Moreira, G., Karim, L., Mullart, E., Coppieters, W., Veerkamp, R., Groenen, M., Bosse, M., Bouwman, A., Georges, M., & Charlier, C. (2021). Pedigree-based de novo rate estimation for structural variation in the cattle germline [Poster presentation]. The Biology of Genomes.

Lee, Y.-L., Takeda, H., Costa Monteiro Moreira, G., Karim, L., Bosse, M., Bouwan, A., Mullaart, E., Coppieters, W., Georges, M., Druet, T., & Charlier, C. (02 December 2020). Fine resolution CNV catalogue from deeply sequenced cattle genomes [Paper presentation]. EAAP annual meeting.

Tang, L., Harland, C., Durkin, K., Artesi, M., Costa Monteiro Moreira, G., Karim, L., Deckers, M., Mullaart, E., Coppieters, W., Georges, M., & Charlier, C. (06 October 2020). INTER-INDIVIDUAL VARIATION OF DE NOVO ERV TRANSPOSITION RATE IN THE CATTLE GERMLINE [Poster presentation]. Transposable Elements, United States.

Artesi, M., Tamma, N., Deckers, M., Karim, L., Coppieters, W., Van den Broeke, A., Georges, M., Charlier, C., & Durkin, K. (2020). Colour-sidedness in Gloucester cattle is associated with a complex structural variant impacting regulatory elements downstream of KIT. Animal Genetics. doi:10.1111/age.12932

Costa Monteiro Moreira, G., Tang, L., Dupont, S., Harland, C., Karim, L., Coppieters, W., Georges, M., & Charlier, C. (2020). BIRTH OF POLYMORPHIC PIRNA CLUSTERS DRIVEN BY TRANSPOSABLE ELEMENT INSERTIONS IN THE MALE CATTLE GERMLINE [Poster presentation]. Transposable Elements Meeting.

Gualdron Duarte, J. L., Gori, A.-S., Hubin, X., Lourenco, D., Charlier, C., Misztal, I., & Druet, T. (2020). Performances of Adaptive MultiBLUP, Bayesian regressions, and weighted-GBLUP approaches for genomic predictions in Belgian Blue beef cattle. BMC Genomics, 21 (1), 545. doi:10.1186/s12864-020-06921-3

Zhang, J., Kadri, N. K., Mullaart, E., Spelman, R., Fritz, S., Boichard, D., Charlier, C., Georges, M., & Druet, T. (2020). Genetic architecture of individual variation in recombination rate on the X chromosome in cattle. Heredity, 125 (5), 304-316. doi:10.1038/s41437-020-0341-9

Gualdron Duarte, J. L., Gori, A.-S., Hubin, X., Charlier, C., & Druet, T. (30 August 2019). Exploring different strategies to implement a weighted single-step GBLUP in Belgian Blue beef cattle [Paper presentation]. 70th annual meeting of the European Association for Animal Production, Gent, Belgium.

Alemu, S., Kadri, N., Charlier, C., & Druet, T. (27 August 2019). Benchmarking inbreeding coefficient estimators with a whole-genome sequenced Holstein pedigree [Paper presentation]. 70th EAAP Annual Meeting, Ghent, Belgium.

Artesi, M., Hahaut, V., Ashrafi, F., Marcais, A., Hermine, O., Griebel, P., Arsic, N., van der Meer, F., Burny, A., Bron, D., Charlier, C., Georges, M., Van den Broeke, A., & Durkin, K. (2019). Pooled CRISPR Inverse PCR sequencing (PCIP-seq): simultaneous sequencing of retroviral insertion points and the associated provirus in thousands of cells with long reads 558130. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/237583. doi:10.1101/558130

Georges, M., Charlier, C., & Hayes, B. (2019). Harnessing genomic information for livestock improvement. Nature Reviews. Genetics. doi:10.1038/s41576-018-0082-2

Kadri, N. K., Harland, C., Charlier, C., Karim, L., Cambisano, N., Deckers, M., Mullaart, E., Coppieters, W., Georges, M., & Druet, T. (2018). High resolution mapping of cross-over events in cattle using NGS data. In Proceedings of the World Congress on Genetics Applied to Livestock Production.

Harland, C., Charlier, C., Karim, L., Cambisano, N., Deckers, M., Mni, M., Mullaart, E., Coppieters, W., & Georges, M. (2017). Frequency of mosaicism points towards mutation-prone early cleavage cell divisions in cattle. BioRxiv. doi:10.1101/079863

Druet, T., Sartelet, A., Hubin, X., Tamma, N., Georges, M., & Charlier, C. (August 2017). Identification and management of recessive genetic defects in Belgian Blue beef cattle [Paper presentation]. 68th Annual Meeting of the European Federation of Animal Science, Tallinn, Estonia.

Rosewick, N.* , Durkin, K.* , Artesi, M.* , Marçais, A., Hahaut, V., Griebel, P., Avettand-Fenoel, V., Burny, A., Charlier, C., Hermine, O., Georges, M., & Van den Broeke, A. (23 May 2017). Cis-perturbation of cancer drivers by the HTLV-1/BLV proviruses is an early determinant of leukemogenesis. Nature Communications, 8. doi:10.1038/ncomms15264

Agerholm, J. S., McEvoy, F. J., Heegaard, S., Charlier, C., Jagannathan, V., & Drogemuller, C. (2017). A de novo missense mutation of FGFR2 causes facial dysplasia syndrome in Holstein cattle. BMC Genetics, 18 (1), 74. doi:10.1186/s12863-017-0541-3

Charlier, C., Li, W., Harland, C., Littlejohn, M., Coppieters, W., Creagh, F., Davis, S., Druet, T., Faux, P., Guillaume, F., Karim, L., Keehan, M., Kadri, N. K., Tamma, N., Spelman, R., & Georges, M. (19 September 2016). NGS- based reverse genetic screen for common embryonic lethal mutations compromising fertility in livestock. Genome Research, 26:1-9. doi:10.1101/gr.207076.116

Sartelet, A., Harland, C., Tamma, N., Karim, L., Bayrou, C., Li, W., Ahariz, N., Coppieters, W., Georges, M., & Charlier, C. (07 July 2016). A stop-gain in the laminin, alpha 3 gene causes recessive junctional epidermolysis bullosa in Belgian Bleu cattle [Paper presentation]. XXIXth World Buiatrics Congress, Dublin, Ireland.

Kadri, N. K., Harland, C., Faux, P., Cambisano, N., Karim, L., Coppieters, W., Fritz, S., Mullaart, E., Boichard, D., Spelman, R., Charlier, C., Georges, M., & Druet, T. (15 June 2016). Sequence-based association analysis identifies coding and non-coding variants in HFM1, MLH3, MSH4, MSH5, RNF212 and RNF212B with large effects on male and female recombination rate in cattle [Poster presentation]. 5th International Congress on Quantitative Genetics, Madison, United States.

Kadri, N. K., Harland, C., Faux, P., Cambisano, Karim, L., Coppieters, W., Fritz, S., Mullaart, E., Boichard, D., Spelman, R., Charlier, C., Georges, M., & Druet, T. (11 May 2016). HIGHER MALE THAN FEMALE RECOMBINATION RATE LARGELY CONTROLLED BY MISSENSE VARIANTS IN RNF212, MLH3, HFM1, MSH5 AND MSH4 IN CATTLE [Poster presentation]. Cold Spring Harbor meetings: the biology of genomes.

Li, W.* , Sartelet, A.* , Tamma, N., Coppieters, W., Georges, M., & Charlier, C. (February 2016). Reverse genetic screen for loss-of-function mutations uncovers a frame-shifting deletion in the melanophilin gene accountable for a distinctive coat-color in Belgian Blue Cattle. Animal Genetics, 47 (1), 110-113. doi:10.1111/age.12383

Duff, J. P., Passant, S., Wessels, M., Charlier, C., Hateley, G., & Irvine, R. M. (2016). Calf health: Cholesterol deficiency causing calf illthrift and diarrhoea. Veterinary Record, 178 (17), 424-5. doi:10.1136/vr.i2265

Kadri, N. K., Harland, C., Faux, P., Cambisano, N., Karim, L., Coppieters, W., Fritz, S., Mullaart, E., Baurain, D., Boichard, D., Spelman, R., Charlier, C., Georges, M., & Druet, T. (2016). Coding and noncoding variants in HFM1, MLH3, MSH4, MSH5, RNF212, and RNF212B affect recombination rate in cattle. Genome Research, 26 (10), 1323-1332. doi:10.1101/gr.204214.116

Xu, X., Ectors, F., Davis, E. E., Pirottin, D., Cheng, H., Farnir, F., Hadfield, T., Cockett, N., Charlier, C., Georges, M., & Takeda, H. (16 October 2015). Ectopic Expression of Retrotransposon-Derived PEG11/RTL1 Contributes to the Callipyge Muscular Hypertrophy. PLoS ONE, 10 (10), 0140594. doi:10.1371/journal.pone.0140594

Sartelet, A.* , Harland, C.* , Tamma, N., Karim, L., Bayrou, C., Li, W., Ahariz, N., Coppieters, W., Georges, M., & Charlier, C. (October 2015). A stop-gain in the laminin, alpha 3 gene causes recessive junctional epidermolysis bullosa in Belgian Blue cattle. Animal Genetics, 46 (5), 566-570. doi:10.1111/age.12342

Rosewick, N., Durkin, K., Marçais, A., Artesi, M., Hermine, O., Charlier, C., Georges, M., & Van den Broeke, A. (28 August 2015). HTLV-1/BLV antisense-RNA dependent host gene perturbation in pre-leukemic and leukemic clones. Retrovirology, 12 (1).

Kadri, N. K., Harland, C., Coppieters, W., Fritz, S., Boichard, D., Spelman, R., Schrooten, C., Mullaart, E., Charlier, C., Georges, M., & Druet, T. (05 May 2015). Higher male than female recombination rate in cattle is controlled by genetic variants effective in both sexes [Poster presentation]. Cold Spring Harbord meeting - The biology of genomes.

Kadri, N. K., Harland, C., Coppieters, W., Fritz, S., Boichard, D., Spelman, R., Schrooten, C., Mullaart, E., Charlier, C., Georges, M., & Druet, T. (February 2015). Scanning the genome for QTL affecting the recombination process in the male and female cattle germline [Poster presentation]. Gordon Research Conference: Quantitative Genetics & Genomics, Lucca, Italy.

Sartelet, A.* , Li, W.* , Pailhoux, E., Richard, C., Tamma, N., Karim, L., Fasquelle, C., Druet, T., Coppieters, W., Georges, M., & Charlier, C. (2015). Genome-wide next-generation DNA and RNA sequencing reveals a mutation that perturbs splicing of the phosphatidylinositol glycan anchor biosynthesis class H gene (PIGH) and causes arthrogryposis in Belgian Blue cattle. BMC Genomics, 16 (316). doi:10.1186/s12864-015-1528-y

Cheng, H., Xu, X., Hadfield, T., Cockett, N., Charlier, C., Georges, M., & Takeda, H. (30 October 2014). Experimental evaluation does not reveal a direct effect of microRNA from the callipyge locus on DLK1 expression. BMC Genomics, 15, 944. doi:10.1186/1471-2164-15-944

Druet, T., Ahariz, N., Cambisano, N., Tamma, N., Michaux, C., Coppieters, W., Charlier, C., & Georges, M. (17 October 2014). Selection in action: dissecting the molecular underpinnings of the increasing muscle mass of Belgian Blue Cattle [Paper presentation]. First FARAH-day.

Sartelet, A., Chapon, S., Fasquelle, C., Tamma, N., Georges, M., & Charlier, C. (27 June 2014). AN INTEGRATED APPROACH FOR THE MANAGEMENT OF INHERITED DISORDERS IN BELGIAN BLUE CATTLE BREED IN BELGIUM [Paper presentation]. Congreso Internacional ANEMBE de Medecina Bovina & IX ECBHM Symposium, Oviedo, Spain.

Druet, T., Ahariz, N., Cambisano, N., Tamma, N., Michaux, C., Coppieters, W., Charlier, C., & Georges, M. (2014). Selection in action: dissecting the molecular underpinnings of the increasing muscle mass of Belgian Blue Cattle. BMC Genomics, 15 (1), 796. doi:10.1186/1471-2164-15-796

Kumar Kadri, N., Sahana, G., Charlier, C., Iso-Touru, T., Guldbrandtsen, B., Karim, L., Sander Nielsen, U., Panitz, F., Pedersen Aamand, G., Schulman, N., Georges, M., Vilkki, J., Sandø Lund, M., & Druet, T. (January 2014). A 660-Kb Deletion with Antagonistic Effects on Fertility and Milk Production Segregates at High Frequency in Nordic Red Cattle: Additional Evidence for the Common Occurrence of Balancing Selection in Livestock. PLoS Genetics, 10 (1), 1004049. doi:10.1371/journal.pgen.1004049

Sartelet, A.* , Stauber, T.* , Coppieters, W., Ludwig, C. F., Fasquelle, C., Druet, T., Zhang, Z., Ahariz, N., Cambisano, N., Jentsch, T. J., & Charlier, C. (January 2014). A missense mutation accelerating the gating of the lysosomal Cl-/H+-exchanger ClC-7/Ostm1 causes osteopetrosis with gingival hamartomas in cattle. Disease Models and Mechanisms, 7, 119-128. doi:10.1242/dmm.012500

Sartelet, A., Li, W., Pailhoux Eric, Tamma, N., Karim, L., Fasquelle, C., Druet, T., Coppieters, W., Georges, M., & Charlier, C. (2013). A splice-acceptor site variant in the bovine PIGH gene causes glycosylphosphatidyl inositol deficiency and lethal arthrogryposis syndrome. In C. Bayrou, J.-F. Cabaraux, C. Delguste, T. Jauniaux, A. Sartelet, ... D. Votion (Eds.), Proccedings of the 3rd Scientific Meetingof the Faculty of Veterinary Medecine (pp. 27). Liège, Belgium: Presses de la Faculté de Médecine Vétérinaire.

Sartelet, A., Tamma, N., Chapon, S., & Charlier, C. (October 2013). Rilouke, une cellule de surveillance des défauts génétiques dans la race blanc bleu belge. Point Vétérinaire, 339, 54-59.

Sartelet, A., Li, W., Pailhoux, E., Tamma, N., Karim, L., Fasquelle, C., Druet, T., Coppieters, W., Georges, M., & Charlier, C. (29 August 2013). A splice-acceptor site variant in the bovine PIGH gene causes glycosylphosphatidyl inositol deficiency and lethal arthrogryposis syndrome [Poster presentation]. Buiatrissima - 8th ECBHM Symposium, Berne, Switzerland.

Druet, T., Ahariz, N., Cambisano, N., Géron, S., Coppieters, W., Charlier, C., & Georges, M. (February 2013). Scan for selective sweeps associated with muscular devolpment in Belgian Blue beef cattle [Poster presentation]. The Quantitative Genetics & Genomics Gordon Research Conference.

Sartelet, A., Li, W., Pailhoux, E., Tamma, N., Karim, L., Fasquelle, C., Druet, T., Coppieters, W., Georges, M., & Charlier, C. (28 January 2013). A splice-acceptor site variant in the bovine PIGH gene causes glycosylphosphatidyl inositol deficiency and lethal arthrogryposis syndrome [Poster presentation]. GIGA-DAY, Liège, Belgium.

Druet, T., Perez-Pardal, L., Charlier, C., & Gautier, M. (2013). Identification of large selective sweeps associated with major genes in cattle. Animal Genetics, 44 (6), 758-62. doi:10.1111/age.12073

Dupuis, M.-C., Zhang, Z., Durkin, K., Charlier, C., Lekeux, P., & Georges, M. (2013). Detection of copy number variants in the horse genome and examination of their association with recurrent laryngeal neuropathy. Animal Genetics. doi:10.1111/j.1365-2052.2012.02373.x

Sartelet, A., Stauber, T., Coppieters, W., Fasquelle, C., Druet, T., Zhang, Z., Ahariz, N., Cambisano, N., Jentsch, T., Georges, M., & Charlier, C. (19 October 2012). A missense mutation in the ClC-7 chloride channel causes hamartomas with osteopetrosis in cattle [Paper presentation]. 2nd FMC Scientific day, Liège, Belgium.

Sartelet, A.* , Klingbeil, P.* , Franklin, C., Fasquelle, C., Geron, S., Isacke, C., Georges, M., & Charlier, C. (October 2012). Allelic heterogeneity of Crooked Tail Syndrome: result of balancing selection? Animal Genetics, 43 (5), 604-607. doi:10.1111/j.1365-2052.2011.02311.x

Guillaume, F., Zhang, Z., Sartelet, A., Charlier, C., Georges, M., Farnir, F., & Druet, T. (20 June 2012). Development of a method for haplotype-based association analysis of binary traits in structured populations [Poster presentation]. 4th International Conference on Quantitative Genetics: Understanding Variation in Complex Traits, Edinburgh, United Kingdom.

Zhang, Z., Guillaume, F., Sartelet, A., Charlier, C., Georges, M., Farnir, F., & Druet, T. (June 2012). Ancestral haplotype-based association mapping with generalized linear mixed models accounting for stratification. Bioinformatics, 28 (19), 2467-2473. doi:10.1093/bioinformatics/bts348

Sartelet, A., Druet, T., Michaux, C., Fasquelle, C., Geron, S., Tamma, N., Zhang, Z., Coppieters, W., Georges, M., & Charlier, C. (15 March 2012). A splice site variant in the bovine RNF11 gene compromises growth and regulation of the inflammatory response. PLoS Genetics, 15 (3), 1002581. doi:10.1371/journal.pgen.1002581

Durkin, K., Coppieters, W., Drogemuller, C., Ahariz, N., Cambisano, N., Druet, T., Fasquelle, C., Haile, A., Horin, P., Huang, L., Kamatani, Y., Karim, L., Lathrop, M., Moser, S., Oldenbroek, K., Rieder, S., Sartelet, A., Solkner, J., Stalhammar, H., ... Charlier, C. (02 February 2012). Serial translocation by means of circular intermediates underlies colour sidedness in cattle. Nature, 482 (7383), 81-4. doi:10.1038/nature10757

Charlier, C., Agerholm, J. S., Coppieters, W., Karlskov-Mortensen, P., Li, W., de Jong, G., Fasquelle, C., Karim, L., Cirera, S., Cambisano, N., Ahariz, N., Mullaart, E., Georges, M., & Fredholm, M. (2012). A deletion in the bovine FANCI gene compromises fertility by causing fetal death and brachyspina. PLoS ONE, 7 (8), 43085. doi:10.1371/journal.pone.0043085

Sandor, C., Li, W., Coppieters, W., Druet, T., Charlier, C., & Georges, M. (2012). Genetic variants in REC8, RNF212, and PRDM9 influence male recombination in cattle. PLoS Genetics, 8 (7), 1002854. doi:10.1371/journal.pgen.1002854

Voz, M., Coppieters, W., Manfroid, I., Baudhuin, A., Von Berg, V., Charlier, C., Meyer, D., Driever, W., Martial, J., & Peers, B. (2012). Fast Homozygosity Mapping and Identification of a Zebrafish ENU-Induced Mutation by Whole-Genome Sequencing. PLoS ONE, 7 (4), 34671. doi:10.1371/journal.pone.0034671

Sartelet, A., Druet, T., Michaux, C., Fasquelle, C., Géron, S., Tamma, N., Zhang, Z., Coppieters, W., Georges, M., & Charlier, C. (09 December 2011). A splice site mutation in the bovine RNF11 gene is responsible of growth retardation and increased susceptibility to inflammatory diseases [Paper presentation]. 1st FMV Scientific Day, Liège, Belgium.

Sartelet, A., Druet, T., Zhang, Z., Michaux, C., Fasquelle, C., Géron, S., Coppieters, W., Georges, M., & Charlier, C. (10 October 2011). A splice site mutation in the bovine RNF11 gene is responsible of growth retardation and increased susceptibility to inflammatory diseases [Poster presentation]. 4th International Symposium on Animal Functional Genomics, Dublin, Ireland.

Durkin, K., Cambisano, N., Ahariz, N., Fasquelle, C., Karim, L., Sartelet, A., Baurain, D., Drogemüller, C., Leeb, T., Coppieters, W., Georges, M., & Charlier, C. (May 2011). Molecular dissection of the color-sided phenotype in cattle reveals a novel mechanism of chromosome evolution involving circular shuttling intermediates. Chromosome Research, 19 (S1), 18.

Durkin, K., Cambisano, N., Ahariz, N., Fasquelle, C., Karim, L., Sartelet, A., Drogemüller, C., Leeb, T., Coppieters, W., Georges, M., & Charlier, C. (May 2011). Molecular dissection of the color-sided pehnotype in cattle reveals a novel mechanism of chromosome evolution involving circular shuttling intermediates [Poster presentation]. The Biology Of Genomes, Cold Spring Harbor, United States - New York.

Georges, M., Coppieters, W., Charlier, C., Agerholm, J. S., & Fredholm, M. (April 2011). a genetic marker test for brachyspina and fertility in cattle.

Charlier, C., Sartelet, A., Fasquelle, C., Michaux, C., Mullaart, E., Agerholm, J. S., Fredholm, M., & Georges, M. (February 2011). Identification of disease-­causing mutations allows for unbiased estimation of their overlooked pleïotropic effects on related quantitative traits [Poster presentation]. Gordon Research Conferences on Quantitative Genetics & Genomics, Galvestone, United States - Texas.

Dupuis, M.-C., Zhang, Z., Druet, T., Denoix, J.-M., Charlier, C., Lekeux, P., & Georges, M. (2011). Results of a haplotype-based GWAS for recurrent laryngeal neuropathy in the horse. Mammalian Genome. doi:10.1007/s00335-011-9337-3

Georges, M., & Charlier, C. (19 May 2010). Method and kit for detecting genetic perdisposition for crooked tail syndrome (CTS) in bovine individuals.

Sartelet, A., Fasquelle, C., Tamma, N., Coppieters, W., Georges, M., & Charlier, C. (2010). A direct link between growth retardation and inflammation? Identification of a splice site mutation in the bovine RNF11 gene. New Biotechnology, (supplement 1), 63.

Sartelet, A., Druet, T., Coppieters, W., Georges, M., & Charlier, C. (April 2010). Towards positional identification of susceptibility loci for White Heifer disease in Belgian Blue Cattle (poster). New Biotechnology, 27 (Supplement 1), 79.

Battaille, G., Lavoué, R., Peeters, D., Farnir, F., Georges, M., Charlier, C., & Lequarré, A.-S. (2010). Genetic analysis of a glomerulonephropathy segregating in a pedigree of French Mastiff. In Proceedings of 32nd Annual Conference of the International Society of Animal Genetics.

Caiment, F., Charlier, C., Hadfield, T., Cockett, N., Georges, M.* , & Baurain, D.*. (2010). Assessing the effect of the CLPG mutation on the microRNA catalog of skeletal muscle using high-throughput sequencing. Genome Research, 20 (12), 1651-62. doi:10.1101/gr.108787.110

Hiard, S., Charlier, C., Coppieters, W., Georges, M., & Baurain, D. (2010). Patrocles: a database of polymorphic miRNA-mediated gene regulation in vertebrates. Nucleic Acids Research, 38 (Database), 640-D651. doi:10.1093/nar/gkp926

Takeda, H., Charlier, C., Farnir, F., & Georges, M. (2010). Demonstrating polymorphic miRNA-mediated gene regulation in vivo: application to the g+6223G->A mutation of Texel sheep. RNA, 16 (9), 1854-63. doi:10.1261/rna.2131110

Hiard, S., Charlier, C., Coppieters, W., Georges, M., & Baurain, D. (December 2009). Patrocles: a database of polymorphic miRNA-mediated gene regulation in vertebrates [Poster presentation]. BBC09, the fifth Benelux Bioinformatics Conference, Liège, Belgium.

Baurain, D., Hiard, S., Coppieters, W., Charlier, C., & Georges, M. (29 September 2009). Patrocles: a database of polymorphic miR-mediated gene regulation in vertebrates [Paper presentation]. La face cachée des microRNA, Liège, Belgium.

Fasquelle, C.* , Sartelet, A.* , Li, W., Dive, M., Tamma, N., Michaux, C., Druet, T., Huijbers, I. J., Isacke, C. M., Coppieters, W., Georges, M., & Charlier, C. (2009). Balancing selection of a frame-shift mutation in the MRC2 gene accounts for the outbreak of the Crooked Tail Syndrome in Belgian Blue Cattle. PLoS Genetics, 5 (9), 1000666. doi:10.1371/journal.pgen.1000666

Katrincsakova, B., Takeda, H., Urbankova, H., Michaux, L., Jarosova, M., Vandenberghe, P., Georges, M., Charlier, C., & Wlodarska, I. (2009). Methylation analysis of the imprinted DLK1-GTL2 domain supports the random parental origin of the IGH-involving del(14q) in B-cell malignancies. Epigenetics, 4 (7), 469-75. doi:10.4161/epi.4.7.9924

Sartelet, A., Dive, M., Touati, K., Rollin, F., Georges, M., & Charlier, C. (10 July 2008). Crooked tail and muscular hypertrophy syndrome, an emerging inherited defect in Belgian blue breed [Paper presentation]. XXVth World Buiatrics Congress, Budapest, Hungary.

Hiard, S., Baurain, D., Coppieters, W., Tordoir, X., Charlier, C., & Georges, M. (July 2008). Patrocles: a database of polymorphic miRNA-mediated gene regulation [Poster presentation]. XX International Congress of Genetics, Berlin, Germany.

Hiard, S., Baurain, D., Coppieters, W., Tordoir, X., Charlier, C., & Georges, M. (03 March 2008). Patrocles: a database of polymorphic miRNA-mediated gene regulation [Paper presentation]. EADGENE miRNAs workshop and miRNAs in Health and Disease 2 / Satellite Course "A primer in miRNA biology", Liège, Belgium.

Charlier, C., Coppieters, W., Rollin, F., Desmecht, D., Agerholm, J. S., Cambisano, N., Carta, E., Dardano, S., Dive, M., Fasquelle, C., Frennet, J.-C., Hanset, R., Hubin, X., Jorgensen, C., Karim, L., Kent, M., Harvey, K., Pearce, B. R., Simon, P., ... Georges, M. (2008). Highly effective SNP-based association mapping and management of recessive defects in livestock. Nature Genetics, 40 (4), 449-54. doi:10.1038/ng.96

Pirottin, D., Takeda, H., Tamma, N., Delcombel, R., Georges, M., & Charlier, C. (2008). A mouse model for polar overdominance ? In XX International Congress of Genetics.

Rollin, F., Vandeputte, S., Guyot, H., Touati, K., Desmecht, D., Charlier, C., & Georges, M. (2008). Congenital muscular dystony in the Belgian Blue breed [Paper presentation]. XXV World Buiatrics Congress, Budapest, Hungary.

Hiard, S., Tordoir, X., Coppieters, W., Charlier, C., & Georges, M. (12 November 2007). Compiling polymorphic miRNA-target interactions: the Patrocles database [Poster presentation]. Benelux Bioinformatics Conference 2007, Leuven, Belgium.

Hiard, S., Tordoir, X., Coppieters, W., Charlier, C., & Georges, M. (15 February 2007). Compiling polymorphic miRNA-target interactions: the Patrocles database [Poster presentation]. Bioinformatics and Modeling : From genomes to network, Liège, Belgium.

Georges, M., Coppieters, W., & Charlier, C. (2007). Polymorphic miRNA-mediated gene regulation: contribution to phenotypic variation and disease. Current Opinion in Genetics and Development, 17 (3), 166-76. doi:10.1016/j.gde.2007.04.005

Pirottin, D., Caiment, F., Takeda, H., Tamma, N., Georges, M., & Charlier, C. (2007). A mouse model for polar overdominance ? In Workshop RiboReg, Carry le Rouet, France, 2007.

Vandeputte, S., Brihoum, M., Hubin, X., Georges, M., Charlier, C., Desmecht, D., Guyot, H., & Rollin, F. (15 October 2006). Congenital muscular dystonia (CMD): a new congenital pathology in Belgian Blue calves [Paper presentation]. XXIV World Buiatrics Congress, Nice, France.

Georges, M., Clop, A., Marcq, F., Takeda, H., Pirottin, D., Tordoir, X., Hiard, S., Bibé, B., Bouix, J., Caiment, F., Eychenne, F., Larzul, C., Laville, E., Meish, F., Milenkovic, D., Tobin, J., & Charlier, C. (June 2006). Polymorphic miRNA-target interactions : A Novel Source of Phenotypic Variation. Cold Spring Harbor Symposia on Quantitative Biology, 71, 343-350. doi:10.1101/sqb.2006.71.056

Takeda, H., Caiment, F., Smit, M., Hiard, S., Tordoir, X., Cockett, N., Georges, M.* , & Charlier, C.*. (23 May 2006). The callipyge mutation enhances bidirectional long-range DLK1-GTL2 intergenic transcription in cis. Proceedings of the National Academy of Sciences of the United States of America, 103 (21), 8119-8124. doi:10.1073/pnas.0602844103

Clop, A.* , Marcq, F.* , Takeda, H.* , Pirottin, D.* , Tordoir, X., Bibe, B., Bouix, J., Caiment, F., Elsen, J.-M., Eychenne, F., Larzul, C., Laville, E., Meish, F., Milenkovic, D., Tobin, J., Charlier, C., & Georges, M. (2006). A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep. Nature Genetics, 38 (7), 813-8. doi:10.1038/ng1810

Pirottin, D., Takeda, H., Georges, M., & Charlier, C. (2006). A mouse model for polar overdominance ? In Conférences Monod : Epigenetic Perspectives from Multiple Organisms.

Davis, E., Caiment, F., Tordoir, X., Cavaille, J., Ferguson-Smith, A., Cockett, N., Georges, M., & Charlier, C. (10 May 2005). Erratum to : RNAi-mediated allelic trans-interaction at the imprinted Rtl1/Peg11 locus (vol 15, pg 746, 2005). Current Biology, 15 (9), 884. doi:10.1016/j.cub.2005.02.060

Cockett, N. E., Smit, M. A., Bidwell, C. A., SEGERS, K., Hadfield, T. L., Snowder, G. D., Georges, M., & Charlier, C. (2005). The callipyge mutation and other genes that affect muscle hypertrophy in sheep. Genetics, Selection, Evolution, 37 Suppl 1, 65-81. doi:10.1051/gse:2004032

Smit, M. A., Tordoir, X., Gyapay, G., Cockett, N. E., Georges, M.* , & Charlier, C.*. (2005). BEGAIN: a novel imprinted gene that generates paternally expressed transcripts in a tissue- and promoter-specific manner in sheep. Mammalian Genome, 16 (10), 801-14. doi:10.1007/s00335-004-2415-z

Davis, E., Jensen, C., Schroder, H. D., Farnir, F., Shay-Hadfield, T., Kliem, A., Cockett, N., Georges, M.* , & Charlier, C.*. (26 October 2004). Ectopic expression of DLK1 protein in skeletal muscle of padumnal heterozygotes causes the callipyge phenotype. Current Biology, 14 (20), 1858-1862. doi:10.1016/j.cub.2004.09.079

Georges, M., Charlier, C., Smit, M., Davis, E., Shay, T., Tordoir, X., Takeda, H., Caiman, F., & Cockett, N. (2004). Toward molecular understanding of polar overdominance at the ovine callipyge locus. In B. Stillman & D. Stewart (Eds.), "Epigenetics” Cold Spring Harbor Symposium on Quantitative Biology (pp. 477-483). Cold Spring Harbor Laboratory Press. doi:10.1101/sqb.2004.69.477

Georges, M., Charlier, C., & Cockett, N. (2003). The callipyge locus: evidence for the trans interaction of reciprocally imprinted genes. Trends in Genetics, 19, 248-252. doi:10.1016/S0168-9525(03)00082-9

Singh, N. A., Westenskow, P., Charlier, C., Pappas, C., Leslie, J., Dillon, J., Anderson, V. E., Sanguinetti, M. C., & Leppert, M. F. (2003). KCNQ2 and KCNQ3 potassium channel genes in benign familial neonatal convulsions: expansion of the functional and mutation spectrum. Brain: a Journal of Neurology, 126 (Pt 12), 2726-37. doi:10.1093/brain/awg286

Smit, M.* , SEGERS, K.* , Carrascosa, L. G., Shay, T., Baraldi, F., Gyapay, G., Snowder, G., Georges, M.* , Cockett, N.* , & Charlier, C.*. (2003). Mosaicism of Solid Gold supports the causality of a noncoding A-to-G transition in the determinism of the callipyge phenotype. Genetics, 163 (1), 453-6.

Berghmans, S., SEGERS, K., Shay, T., Cockett, N., Georges, M., & Charlier, C. (2001). Breakpoint mapping positions the callipyge gene within a 450-kilobase chromosome segment containing the DLK1 and GTL2 genes. Mammalian Genome, 12 (2), 183-5. doi:10.1007/s003350010246

Charlier, C., SEGERS, K., Karim, L., Shay, T., Gyapay, G., Cockett, N., & Georges, M. (2001). The callipyge (CLPG) mutation enhances the expression of the coregulated DLK1, GTL2, PEG11 and MEG8 genes in cis without affecting their imprinting status. Nature Genetics, 27, 367-369. doi:10.1038/86856

Charlier, C., SEGERS, K., Wagenaar, D., Karim, L., Berghmans, S., Jaillon, O., Shay, T., Weissenbach, J., Cockett, N., Gyapay, G., & Georges, M. (2001). Human - ovine comparative sequencing of a 250 kilobase imprinted domain encompassing the callipyge (clpg) gene and identification of six imprinted transcripts: DLK1, DAT, GTL2, PEG11, antiPEG11 and MEG8. Genome Research, 11, 850-862. doi:10.1101/gr.172701

Paulsen, M., Takada, S., Youngson, N. A., Benchaib, M., SEGERS, K., Ferguson-Smith, A. C., Georges, M., & Charlier, C. (2001). Comparative sequence analysis of the imprinted Dlk1-Gtl2 locus in three mammalian species reveals highly conserved genomic elements and refines comparison with the Igf2-H19 region. Genome Research, 11 (12), 2085-94. doi:10.1101/gr.206901

Shay, T. L., Berghmans, S., SEGERS, K., Meyers, S., Beever, J. E., Womack, J. E., Cockett, N. E., Georges, M., & Charlier, C. (2001). Fine-mapping and construction of a bovine contig spanning the ovine callipyge locus. Mammalian Genome, 12 (2), 141-9. doi:10.1007/s003350010248

SEGERS, K., Vaiman, D., Berghmans, S., Shay, T., Meyers, S., Beever, J., Cockett, N., Charlier, C., & Georges, M. (2000). Construction and characterization of an ovine BAC contig spanning the callipyge locus. Animal Genetics, 31 (6), 352-9. doi:10.1046/j.1365-2052.2000.00676.x

Peiffer, A., Thompson, J., Charlier, C., Otterud, B., Varvil, T., Pappas, C., Barnitz, C., Gruenthal, K., Kuhn, R., & Leppert, M. (1999). A locus for febrile seizures (FEB3) maps to chromosome 2q23-24. Annals of Neurology, 46 (4), 671-8. doi:10.1002/1531-8249(199910)46:4<671::AID-ANA20>3.0.CO;2-5

Singh, N., Charlier, C., Peiffer, A., Stauffer, D., Melis, R., Enoch, M. A., Goldman, D., Rogers, S., Anderson, V. E., & Leppert, M. (1999). Genes for rare idiopathic generalized epilepsies: BFNC. Advances in Neurology, 79, 341-50.

Charlier, C., Singh, N. A., Ryan, S. G., Lewis, T. B., Reus, B. E., Leach, R. J., & Leppert, M. (1998). A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family. Nature Genetics, 18 (1), 53-5. doi:10.1038/ng0198-53

Singh, N. A., Charlier, C., Stauffer, D., DuPont, B. R., Leach, R. J., Melis, R., Ronen, G. M., Bjerre, I., Quattlebaum, T., Murphy, J. V., McHarg, M. L., Gagnon, D., Rosales, T. O., Peiffer, A., Anderson, V. E., & Leppert, M. (1998). A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns. Nature Genetics, 18 (1), 25-9. doi:10.1038/ng0198-25

Dunner, S., Charlier, C., Farnir, F., Brouwers, B., Canon, J., & Georges, M. (1997). Towards interbreed IBD fine mapping of the mh locus: double-muscling in the Asturiana de los Valles breed involves the same locus as in the Belgian Blue cattle breed. Mammalian Genome, 8 (6), 430-5. doi:10.1007/s003359900462

Andersson, L., Archibald, A., Ashburner, M., Audun, S., Barendse, W., Bitgood, J., Bottema, C., Broad, T., Brown, S., Burt, D., Charlier, C., Copeland, N., Davis, S., Davisson, M., Edwards, J., Eggen, A., Elgar, G., Eppig, J. T., Franklin, I., ... Womack, J. (1996). Comparative genome organization of vertebrates. The First International Workshop on Comparative Genome Organization. Mammalian Genome, 7 (10), 717-34. doi:10.1007/s003359900222

Charlier, C., Denys, B., Belanche, J. I., Coppieters, W., Grobet, L., Mni, M., Womack, J., Hanset, R., & Georges, M. (1996). Microsatellite mapping of a major determinant of White Heifer Disease: the bovine roan locus. Mammalian Genome, 7, 138-142. doi:10.1007/s003359900034

Charlier, C., Farnir, F., Berzi, P., Vanmanshoven, P., Brouwers, B., & Georges, M. (1996). IBD mapping of recessive traits in livestock: application to map the bovine syndactyly locus to chromosome 15. Genome Research, 6, 580-589. doi:10.1101/gr.6.7.580

Charlier, C., & Leroy, P. (1996). Comparison of muscular fibers of double muscled Texel and Bleu du Maine [Paper presentation]. Sheep and Goat Commission S 4.36, 47th annual meeting of the EAAP, Lillehammer, Norway.

Charlier, C., Coppieters, W., Farnir, F., Grobet, L., Leroy, P., Michaux, C., Mni, M., Schwers, A., Vanmanshoven, P., Hanset, R., & Georges, M. (1995). The mh gene causing double-muscling in cattle maps to bovine chromosome 2. Mammalian Genome, 6, 788-792. doi:10.1007/BF00539005

Grobet, L., Schwers, A., Charlier, C., Marcq, F., Ectors, F., Touati, K., & Hanset. (1992). Le sexage d'embryons bovins par la technique de l'amplification en chaîne par la polymérase (acp) d'une séquence Y-spécifique bovine. Annales de Médecine Vétérinaire, 136, 119-124.