Publications and communications of Jean-Claude Twizere

Colinet, M.* , Chiver, I.* , Bonafina, A., Masset, G., Almansa Amores, D., Di Valentin, E., Twizere, J.-C., Nguyen, L.* , & Espuny Camacho, I. M.*. (2024). SARS-CoV2 infection triggers reactive astrocyte states and inflammatory conditions in long-term Human Cortical Organoids. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/316470.

Lambourne, L., Mattioli, K., Santoso, C., Sheynkman, G., Inukai, S., Kaundal, B., Berenson, A., Spirohn-Fitzgerald, K., Bhattacharjee, A., Rothman, E., Shrestha, S., Laval, F., Yang, Z., Bisht, D., Sewell, J. A., Li, G., Prasad, A., Phanor, S., Lane, R., ... Fuxman Bass, J. I. (2024). Widespread variation in molecular interactions and regulatory properties among transcription factor isoforms. bioRxiv : the preprint server for biology. doi:10.1101/2024.03.12.584681

Nelson, D. R., Mystikou, A., Jaiswal, A., Rad-Menendez, C., Preston, M. J., De Boever, F., El Assal, D. C., Daakour, S., Lomas, M. W., Twizere, J.-C., Green, D. H., Ratcliff, W. C., & Salehi-Ashtiani, K. (2024). Macroalgal deep genomics illuminate multiple paths to aquatic, photosynthetic multicellularity. Molecular Plant. doi:10.1016/j.molp.2024.03.011

Amnah Salem Jumah Mohamed Alzahmi, Daakour, S., Nelson, D., Al-Khairy, D., Twizere, J.-C., & Salehi-Ashtiani, K. (23 February 2024). Enhancing algal production strategies: strain selection, AI-informed cultivation, and mutagenesis. Frontiers in Sustainable Food Systems, 8. doi:10.3389/fsufs.2024.1331251

Laval, F., Coppin, G., Twizere, J.-C., & Vidal, M. (24 May 2023). Homo cerevisiae-Leveraging Yeast for Investigating Protein-Protein Interactions and Their Role in Human Disease. International Journal of Molecular Sciences, 24 (11), 9179. doi:10.3390/ijms24119179

Bruyere, D., RONCARATI, P., Lebeau, A., Lerho, T., Poulain, F., Hendrick, E., Pilard, C., Reynders, C., Ancion, M., Luyckx, M., Renard, M., Jacob, Y., Twizere, J.-C., Peiffer, R., Peulen, O., Delvenne, P., Hubert, P., McBride, A., Gillet, N., ... Herfs, M. (2023). Human papillomavirus E6/E7 oncoproteins promote radiotherapy-mediated tumor suppression by globally hijacking host DNA damage repair. Theranostics, 13 (3), 1130 - 1149. doi:10.7150/thno.78091

Al-Khairy, D., Fu, W., Alzahmi, A. S., Twizere, J.-C., Amin, S. A., Salehi-Ashtiani, K., & Mystikou, A. (23 November 2022). Closing the Gap between Bio-Based and Petroleum-Based Plastic through Bioengineering. Microorganisms, 10 (12), 2320. doi:10.3390/microorganisms10122320

Bouhtit, F., Najar, M., Rahmani, S., Melki, R., Najimi, M., Sadki, K., Boukhatem, N., Twizere, J.-C., Meuleman, N., Lewalle, P., Lagneaux, L., & Merimi, M. (August 2022). Bioscreening and pre-clinical evaluation of the impact of bioactive molecules from Ptychotis verticillata on the multilineage potential of mesenchymal stromal cells towards immune- and inflammation-mediated diseases. Inflammation Research, 71 (7-8), 887-898. doi:10.1007/s00011-022-01573-3

Lebeau, A.* , Bruyère, D.* , RONCARATI, P., Peixoto, P., Hervouet, E., COBRAIVILLE, G., Taminiau, B., Masson, M., Gallego, C., Mazzucchelli, G., Smargiasso, N., Fleron, M., Baiwir, D., Hendrick, E., Pilard, C., Lerho, T., Reynders, C., Ancion, M., GREIMERS, R., ... Herfs, M. (28 February 2022). HPV infection alters vaginal microbiome through down-regulating host mucosal innate peptides used by Lactobacilli as amino acid sources. Nature Communications, 13 (1), 1076. doi:10.1038/s41467-022-28724-8

Olivet, J., Maseko, S. B., Volkov, A. N., Salehi-Ashtiani, K., Das, K., Calderwood, M. A., Twizere, J.-C.* , & Gorgulla, C.*. (2022). A systematic approach to identify host targets and rapidly deliver broad-spectrum antivirals. Molecular Therapy. doi:10.1016/j.ymthe.2022.02.015

Caillet-Saguy, C., Durbesson, F., Rezelj, V. V., Gogl, G., Tran, Q. D., Twizere, J.-C., Vignuzzi, M., Vincentelli, R., & Wolff, N. (2021). Host PDZ-containing proteins targeted by SARS-CoV-2. FEBS Journal. doi:10.1111/febs.15881

Lim, H. J., Yoon, H., Kim, H., Kang, Y.-W., Kim, J.-E., Kim, O. Y., Lee, E.-Y., Twizere, J.-C., Rak, J., & Kim, D.-K. (2021). Extracellular Vesicle Proteomes Shed Light on the Evolutionary, Interactive, and Functional Divergence of Their Biogenesis Mechanisms. Frontiers in Cell and Developmental Biology, 9, 734950. doi:10.3389/fcell.2021.734950

Vandermeulen, C., O'Grady, T., Wayet, J., Galvan, B., Maseko, S. B., Cherkaoui, M., Desbuleux, A., Coppin, G., Olivet, J., Ben Ameur, L., Kataoka, K., Ogawa, S., Hermine, O., Marcais, A., Thiry, M., Mortreux, F., Calderwood, M. A., Van Weyenbergh, J., Peloponese, J.-M., ... Twizere, J.-C. (2021). The HTLV-1 viral oncoproteins Tax and HBZ reprogram the cellular mRNA splicing landscape. PLoS Pathogens, 17 (9), 1009919. doi:10.1371/journal.ppat.1009919

Luck, K., Kim, D.-K., Lambourne, L., Spirohn, K., Begg, B. E., Bian, W., Brignall, R., Cafarelli, T., Campos-Laborie, F. J., CHARLOTEAUX, B., Choi, D., Coté, A. G., Daley, M., Deimling, S., Desbuleux, A., Dricot, A., Gebbia, M., Hardy, M. F., Kishore, N., ... Calderwood, M. A. (2020). A reference map of the human binary protein interactome. Nature, 580 (7803), 402-408. doi:10.1038/s41586-020-2188-x

Choi, S. G., Olivet, J., Cassonnet, P., Vidalain, P.-O., Luck, K., Lambourne, L., Spirohn, K., Lemmens, I., Dos Santos, M., Demeret, C., Jones, L., Rangarajan, S., Bian, W., Coutant, E. P., Janin, Y. L., van der Werf, S., Trepte, P., Wanker, E. E., De Las Rivas, J., ... Jacob, Y. (2019). Maximizing binary interactome mapping with a minimal number of assays. Nature Communications, 10 (1), 3907. doi:10.1038/s41467-019-11809-2

Veloso, A., Martin, M., Bruyr, J., O'Grady, T., Deroanne, C., Mottet, D., Twizere, J.-C., Cherrier, T.* , & Dequiedt, F.*. (2019). Dephosphorylation of HDAC4 by PP2A-Bdelta unravels a new role for the HDAC4/MEF2 axis in myoblast fusion. Cell death & disease, 10 (7), 512. doi:10.1038/s41419-019-1743-6

Bruyère, D., Lebeau, A., RONCARATI, P., Hendrick, E., Masson, M., Twizere, J.-C., Pilard, C., Hubert, P., DELVENNE, P., & Herfs, M. (28 May 2018). Deciphering the radiosensitivity of HPV-positive tumors [Poster presentation]. EDT-Immunology day 2018, Liège, Belgium.

Gusareva, E. S., Twizere, J.-C., Sleegers, K., Dourlen, P., Abisambra, J. F., Meier, S., Cloyd, R., Weiss, B., Dermaut, B., Bessonov, K., van der Lee, S. J., Carrasquillo, M. M., Katsumata, Y., Cherkaoui, M., Asselbergh, B., Ikram, M. A., Mayeux, R., Farrer, L. A., Haines, J. L., ... Van Steen, K. (2018). Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer's disease. Neurobiology of Aging, 72, 188.e3-188.e12. doi:10.1016/j.neurobiolaging.2018.08.001

Jamet, A., Dervyn, R., Lapaque, N., Bugli, F., Perez-Cortez, N. G., Blottière, H. M., Twizere, J.-C., Sanguinetti, M., Posteraro, B., Serror, P., & Maguin, E. (2017). The Enterococcus faecalis virulence factor ElrA interacts with the human Four-And-A-Half LIM Domains Protein. Scientific Reports, 7 (1). doi:10.1038/s41598-017-04875-3

Lebrun, M., riva, L., lambert, J., Rambout, X., Thiry, M., blondeau, C., Twizere, J.-C., Dequiedt, F., & Sadzot-Delvaux, C. (20 May 2016). Role of Varicella Zoster virus ORF9p in the secondary egress : importance of its interaction with the cellular Adaptin Protein-1 [Poster presentation]. 2015 Colorado Alphaherpesvirus Latency Society Symposium, Vail, United States - Colorado.

Daakour, S., Hajingabo, L. J., Kerselidou, D., Devresse, A., Kettmann, R., Simonis, N., Dequiedt, F., & Twizere, J.-C. (2016). Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBWX7 common interactor. BMC Cancer, 16 (1), 335. doi:10.1186/s12885-016-2374-2

Rambout, X., Detiffe, C., Bruyr, J., Mariavelle, E., Cherkaoui, M., Brohee, S., Demoitie, P., Lebrun, M., Soin, R., Lesage, B., Guedri, K., Beullens, M., Bollen, M., Farazi, T. A., Kettmann, R., Struman, I., Hill, D. E., Vidal, M., Kruys, V., ... Dequiedt, F. (2016). The transcription factor ERG recruits CCR4-NOT to control mRNA decay and mitotic progression. Nature Structural and Molecular Biology. doi:10.1038/nsmb.3243

Kerselidou, D., Daakour, S., & Twizere, J.-C. (October 2015). Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBW7 common interactor [Poster presentation]. The Notch Meeting IX.

Zune, Q., Delepierre, A., Gofflot, S., Bauwens, J., Twizere, J.-C., Punt, P. J., Francis, F., Bawin, T., Toye, D., & Delvigne, F. (2015). A fungal biofilm reactor based on metal structured packing improves the quality of a Gla::GFP fusion protein produced by Aspergillus oryzae. Applied Microbiology and Biotechnology. doi:10.1007/s00253-015-6608-z

Bridoux, L., Bergiers, I., Draime, A., Halbout, M., Deneyer, N., Twizere, J.-C., & Rezsohazy, R. (2015). KPC2 relocalizes HOXA2 to the cytoplasm and decreases its transcriptional activity. Biochimica et Biophysica Acta, 1849 (10), 1298-311. doi:10.1016/j.bbagrm.2015.08.006

Mansour, M. R., Reed, C., Eisenberg, A. R., Tseng, J.-C., Twizere, J.-C., Daakour, S., Yoda, A., Rodig, S. J., Tal, N., Shochat, C., Berezovskaya, A., DeAngelo, D. J., Sallan, S. E., Weinstock, D. M., Izraeli, S., Kung, A. L., Kentsis, A., & Look, A. T. (2015). Targeting oncogenic interleukin-7 receptor signalling with N-acetylcysteine in T cell acute lymphoblastic leukaemia. British Journal of Haematology, 168 (2), 230-8. doi:10.1111/bjh.13115

Vandermeulen, C., Hajingabo, L.-J., & Twizere, J.-C. (2015). Comparative Interactome of HIV-1 Tat and Human T Lymphotropic Virus Type-1 Tax and the Cellular Transcriptional Machinery. AIDS Research and Human Retroviruses, 31 (12), 1204-5. doi:10.1089/aid.2014.0377

Juvenal Hajingabo, L., Daakour, S., Martin, M., Grausenburger, R., Panzer-Grumayer, R., Dequiedt, F., Simonis, N., & Twizere, J.-C. (2014). Predicting interactome networks perturbations in human cancer: application to gene fusions in acute lymphoblastic leukemia. Molecular Biology of the Cell. doi:10.1091/mbc.E14-06-1038

Shochat, C., Tal, N., Gryshkova, V., Birger, Y., Bandapalli, O. R., Cazzaniga, G., Gershman, N., Kulozik, A. E., Biondi, A., Mansour, M. R., Twizere, J.-C., Muckenthaler, M. U., Ben-Tal, N., Constantinescu, S. N., Bercovich, D., & Izraeli, S. (2014). Novel activating mutations lacking cysteine in type I cytokine receptors in acute lymphoblastic leukemia. Blood, 124 (1), 106-10. doi:10.1182/blood-2013-10-529685

Blibek, K., Fujii, N., Legros, S., Boxus, M., Dewulf, J.-F., Zimmermann, P., Kettmann, R., Borg, J.-P., Dequiedt, F., & Twizere, J.-C. (29 June 2013). Inhibition of Tax transformation activity using a small molecule targetting Tax/PDZ domain interactions [Poster presentation]. 16th International Conference on Human Retrovirology : HTLV and Related Viruses, Montréal, Québec., Canada.

Blibek, K., Fujii, N., Legros, S., Boxus, M., Dewulf, J.-F., Zimmermann, P., Kettmann, R., Dequiedt, F., & Twizere, J.-C. (29 June 2013). Inhibition of Tax transformation activity using a small molecule targetting Tax/PDZ domain interactions [Poster presentation]. 16th International Conference on Human Retrovirology: HTLV and Related Viruses HTLV, Montréal, Québec., Canada.

Blibek, K., Rambout, X., beaufays, J., Lins, L., Dequiedt, F., & Twizere, J.-C. (29 June 2013). An interaction map for HTLV-1 Tax and PDZ-containing proteins [Poster presentation]. 16th International Conference on Human Retrovirology : HTLV and Related Viruses, Montréal, Québec., Canada.

Bergiers, I., Bridoux, L., Nguyen, N., Twizere, J.-C., & Rezsohazy, R. (2013). The homeodomain transcription factor Hoxa2 interacts with and promotes the proteasomal degradation of the E3 ubiquitin protein ligase RCHY1. PLoS ONE, 8 (11), 80387. doi:10.1371/journal.pone.0080387

Lambert, B., Vandeputte, J., Remacle, S., Bergiers, I., Simonis, N., Twizere, J.-C., Vidal, M., & Rezsohazy, R. (2012). Protein interactions of the transcription factor Hoxa1. BMC Developmental Biology, 12, 29. doi:10.1186/1471-213X-12-29

Simonis, N., Rual, J.-F., Lemmens, I., Boxus, M., Hirozane-Kishikawa, T., GATOT, J.-S., Dricot, A., Hao, T., Vertommen, D., Legros, S., Daakour, S., Klitgord, N., Martin, M., Willaert, J.-F., Dequiedt, F., Navratil, V., Cusick, M. E., Burny, A., Van Lint, C., ... Twizere, J.-C. (2012). Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses. Retrovirology, 9, 26. doi:10.1186/1742-4690-9-26

Twizere, J.-C., DEWULF, J.-F., Blibek, K., Legros, S., Boxus, M., Zimmermann, P., FUJII, N., & Kettmann, R. (06 June 2011). Disruption of PDZ protein-protein interactions inhibits Tax transformation and HTLV-1 infection capacities [Poster presentation]. 15th International Conference on Human Retrovirology: HTLV and Related Retroviruses, Leuven, Gembloux, Belgium.

de Barsy, M., Jamet, A., Filopon, D., Nicolas, C., Laloux, G., Rual, J.-F., Muller, A., Twizere, J.-C., Nkengfac, B., Vandenhaute, J., Hill, D. E., Salcedo, S. P., Gorvel, J.-P., Letesson, J.-J., & De Bolle, X. (2011). Identification of a Brucella spp. secreted effector specifically interacting with human small GTPase Rab2. Cellular Microbiology, 13 (7), 1044-58. doi:10.1111/j.1462-5822.2011.01601.x

Legros, S., Boxus, M., GATOT, J.-S., Van Lint, C., Kruys, V., Kettmann, R., Twizere, J.-C., & Dequiedt, F. (2011). The HTLV-1 Tax protein inhibits formation of stress granules by interacting with histone deacetylase 6. Oncogene. doi:10.1038/onc.2011.120

Legros, S., Boxus, M., Dewulf, J. F., Dequiedt, F., Kettmann, R., & Twizere, J.-C. (2009). Protein-protein interactions and gene expression regulation in HTLV-1 infected cells. Frontiers in Bioscience: A Journal and Virtual Library, 14, 4138-48. doi:10.2741/3518

Samuel, S., Twizere, J.-C., Beifuss, K. K., & Bernstein, L. R. (2008). Nucleolin binds specifically to an AP-1 DNA sequence and represses AP1-dependent transactivation of the matrix metalloproteinase-13 gene. Molecular Carcinogenesis, 47 (1), 34-46. doi:10.1002/mc.20358

Florins, A.-F., Gillet, N., Asquith, B., Boxus, M., Burteaux, C., Twizere, J.-C., Urbain, P., Vandermeers, F., Debacq, C., Sanchez-alcaraz, M. T., Schwartz-Cornil, I., Kerkhofs, P., Jean, G., Thewis, A., Hay, J., Mortreux, F., Wattel, E., Reichert, M., Burny, A., ... Willems, L. (2007). Cell dynamics and immune response to BLV infection: a unifying model. Frontiers in Bioscience: A Journal and Virtual Library, 12, 1520-1531. doi:10.2741/2165

Twizere, J.-C., Springael, J.-Y., Boxus, M., Burny, A., Dequiedt, F., Dewulf, J.-F., Duchateau, J., Portetelle, D., Urbain, P., Van Lint, C., Green, P. L., Mahieux, R., Parmentier, M., Willems, L., & Kettmann, R. (2007). Human T-cell leukemia virus type-1 Tax oncoprotein regulates G-protein signaling. Blood, 109 (3), 1051-60. doi:10.1182/blood-2006-06-026781

Dequiedt, F., Martin, M., Von Blume, J., Vertommen, D., Lecomte, E., Mari, N., Heinen, M.-F., Bachmann, M., Twizere, J.-C., Huang, M. C., Rider, M. H., Piwnica-Worms, H., Seufferlein, T., & Kettmann, R. (2006). New Role For Hpar-1 Kinases Emk And C-Tak1 In Regulating Localization And Activity Of Class Iia Histone Deacetylases. Molecular and Cellular Biology, 26 (19), 7086-7102. doi:10.1128/MCB.00231-06

Samuel, S., Twizere, J.-C., & Bernstein, L. R. (2005). YB-1 represses AP1-dependent gene transactivation and interacts with an AP-1 DNA sequence. Biochemical Journal, 388 (Pt 3), 921-8. doi:10.1042/BJ20041497

Twizere, J.-C., Lefebvre, L., Collete, D., Debacq, C., Urbain, P., Heremans, H., Jauniaux, J.-C., Burny, A., Willems, L., & Kettmann, R. (2005). The homeobox protein MSX2 interacts with tax oncoproteins and represses their transactivation activity. Journal of Biological Chemistry, 280 (33), 29804-11. doi:10.1074/jbc.M503674200

Twizere, J.-C., Kruys, V., Lefebvre, L., Vanderplasschen, A., Collete, D., Debacq, C., Lai, W. S., Jauniaux, J.-C., Bernstein, L. R., Semmes, O. J., Burny, A., Blackshear, P. J., Kettmann, R., & Willems, L. (2003). Interaction of retroviral Tax oncoproteins with tristetraprolin and regulation of tumor necrosis factor-alpha expression. Journal of the National Cancer Institute, 95 (24), 1846-59. doi:10.1093/jnci/djg118

Twizere, J.-C., Kerkhofs, P., Burny, A., Portetelle, D., Kettmann, R., & Willems, L. (2000). Discordance between bovine leukemia virus tax immortalization in vitro and oncogenicity in vivo. Journal of Virology, 74 (21), 9895-902. doi:10.1128/JVI.74.21.9895-9902.2000

Willems, L., Grimonpont, C., Kerkhofs, P., Capiau, C., Gheysen, D., Conrath, K., Roussef, R., Mamoun, R., Portetelle, D., Burny, A., Adam, E., Lefebvre, L., Twizere, J.-C., Heremans, H., & Kettmann, R. (1998). Phosphorylation of bovine leukemia virus Tax protein is required for in vitro transformation but not for transactivation. Oncogene, 16 (17), 2165-76. doi:10.1038/sj.onc.1201765