Veloso, A.* , Bleuart, A.* , Conrard, L., Orban, T., Bruyr, J., Cabochette, P., Germano, R. F. V., Schevenels, G., Bernard, A., Zindy, E., Demeyer, S., Vanhollebeke, B., Dequiedt, F.* , & Martin, M.*. (27 February 2024). The cytoskeleton adaptor protein Sorbs1 controls the development of lymphatic and venous vessels in zebrafish. BMC Biology, 22 (1), 51. doi:10.1186/s12915-024-01850-z * These authors have contributed equally to this work. |
Lucarelli, E.* , Ongena, L.* , Dubois, L., Galvan, B., Bruyr, J., & Dequiedt, F.*. (17 July 2023). FET fusion oncoproteins hijack the LASR complex to rewire alternative splicing in sarcomas [Poster presentation]. 5th International Caparica Conference in Splicing (SPLICING 2023), Caparica, Portugal. * These authors have contributed equally to this work. |
Lemaitre, F.* , Chakrama, F.* , O'Grady, T., Peulen, O., Rademaker, G., Deward, A., Chabot, B., Piette, J., Colige, A., Lambert, C., Dequiedt, F.* , & Habraken, Y.*. (09 December 2022). The transcription factor c-Jun inhibits RBM39 to reprogram pre-mRNA splicing during genotoxic stress. Nucleic Acids Research, 50 (22), 12768 - 12789. doi:10.1093/nar/gkac1130 * These authors have contributed equally to this work. |
NJOCK, M.-S.* , O'Grady, T.* , Nivelles, O., Lion, M., Jacques, S., Cambier, M., Herkenne, S., Muller, F., Christian, A., REMACLE, C., GUIOT, J., Rahmouni, S., Dequiedt, F.* , & Struman, I.*. (June 2022). Endothelial extracellular vesicles promote tumour growth by tumour-associated macrophage reprogramming. Journal of Extracellular Vesicles, 11 (6), 12228. doi:10.1002/jev2.12228 * These authors have contributed equally to this work. |
O'Grady, T.* , NJOCK, M.-S.* , Lion, M., Bruyr, J., Mariavelle, E., Galvan, B., Boeckx, A., Struman, I.* , & Dequiedt, F.*. (24 March 2022). Sorting and packaging of RNA into extracellular vesicles shape intracellular transcript levels. BMC Biology, 20 (1), 72. doi:10.1186/s12915-022-01277-4 * These authors have contributed equally to this work. |
Duchemin, A., O'Grady, T., Hanache, S., Mereau, A., Thiry, M., Wacheul, L., Michaux, C., Perpète, E., Hervouet, E., Peixoto, P., Ernst, F., Audic, Y., Dequiedt, F., Lafontaine, D., & Mottet, D. (2021). DHX15-independent roles for TFIP11 in U6 snRNA modification, U4/U6.U5 tri-snRNP assembly and pre-mRNA splicing fidelity. Nature Communications. doi:10.1038/s41467-021-26932-2 |
Hanache, S., Duchemin, A., O'Grady, T., Mereau, A., Thiry, M., Wacheul, L., Michaux, C., Perpète, E., Hervouet, E., Peixoto, P., Ernst, F., Audic, Y., Dequiedt, F., Lafontaine, D., & Mottet, D. (17 October 2021). DHX15-independent roles for TFIP11 in U6 snRNA modi!cation, U4/U6.U5 tri-snRNP assembly and pre-mRNA splicing fidelity [Poster presentation]. EMBL. |
Saulnier, O.* , Guedri, K.* , Aynaud, M.-M., Chakraborty, A., Bruyr, J., Pineau, J., O’Grady, T., Mirabeau, O., Grossetête, S., Galvan, B., Claes, M., Hassoun, Z. E. O. G., Sadacca, B., Laud, K., Zaïdi, S., Surdez, D., Baulande, S., Rambout, X., Tirode, F., ... Dequiedt, F.*. (2021). ERG transcription factors have a splicing regulatory function involving RBFOX2 that is altered in the EWS-FLI1 oncogenic fusion. Nucleic Acids Research. doi:10.1093/nar/gkab305 * These authors have contributed equally to this work. |
Vandermeulen, C., O'Grady, T., Wayet, J., Galvan, B., Maseko, S. B., Cherkaoui, M., Desbuleux, A., Coppin, G., Olivet, J., Ben Ameur, L., Kataoka, K., Ogawa, S., Hermine, O., Marcais, A., Thiry, M., Mortreux, F., Calderwood, M. A., Van Weyenbergh, J., Peloponese, J.-M., ... Twizere, J.-C. (2021). The HTLV-1 viral oncoproteins Tax and HBZ reprogram the cellular mRNA splicing landscape. PLoS Pathogens, 17 (9), 1009919. doi:10.1371/journal.ppat.1009919 |
Dequiedt, F., & Cherrier, T. (September 2020). Refining the Class IIa HDAC/MEF2 Paradigm in Muscle Biology: More than Meets the Eye. Journal of Cellular Signaling, 1 (4). |
GUIOT, J., Cambier, M., Boeckx, A., HENKET, M., Nivelles, O., GESTER, F., LOUIS, E., MALAISE, M., Dequiedt, F., LOUIS, R., Struman, I.* , & NJOCK, M.-S.*. (05 August 2020). Macrophage-derived exosomes attenuate fibrosis in airway epithelial cells through delivery of antifibrotic miR-142-3p. Thorax, 75 (10), 870-881. doi:10.1136/thoraxjnl-2019-214077 * These authors have contributed equally to this work. |
Pérez-Boza, J., Boeckx, A., Lion, M., Dequiedt, F., & Struman, I. (2020). hnRNPA2B1 inhibits the exosomal export of miR‑503 in endothelial cells. Cellular and Molecular Life Sciences. doi:10.1007/s00018-019-03425-6 |
Hassoun, Z. E. O., Dequiedt, F., & Galvan, B. (20 February 2019). A new view of Ewing's sarcoma : testing the provocative hypothesis that post-transcriptional mechanisms of mRNA processing contribute to the oncogenic properties of EWS-Fli1 fusion [Poster presentation]. 4th course on Post-Transcriptional Gene Regulation, Paris, France. |
Hanache, S., Duchemin, A., Peixoto, P., Hervouet, E., Dequiedt, F., & Mottet, D. (01 February 2019). Phospho-Dependant Regulation Of TFIP11 Splicing Factor [Poster presentation]. BACR. |
Veloso, A., Martin, M., Bruyr, J., O'Grady, T., Deroanne, C., Mottet, D., Twizere, J.-C., Cherrier, T.* , & Dequiedt, F.*. (2019). Dephosphorylation of HDAC4 by PP2A-Bdelta unravels a new role for the HDAC4/MEF2 axis in myoblast fusion. Cell death & disease, 10 (7), 512. doi:10.1038/s41419-019-1743-6 * These authors have contributed equally to this work. |
Gusareva, E. S., Twizere, J.-C., Sleegers, K., Dourlen, P., Abisambra, J. F., Meier, S., Cloyd, R., Weiss, B., Dermaut, B., Bessonov, K., van der Lee, S. J., Carrasquillo, M. M., Katsumata, Y., Cherkaoui, M., Asselbergh, B., Ikram, M. A., Mayeux, R., Farrer, L. A., Haines, J. L., ... Van Steen, K. (2018). Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer's disease. Neurobiology of Aging, 72, 188.e3-188.e12. doi:10.1016/j.neurobiolaging.2018.08.001 |
Molina Ortiz, P.* , Orban, T.* , Martin, M., Habets, A., Dequiedt, F.* , & Schurmans, S.*. (2018). Rasa3 controls turnover of endothelial cell adhesion and vascular lumen integrity by a Rap1-dependent mechanism. PLoS Genetics. doi:10.1371/journal.pgen.1007195 * These authors have contributed equally to this work. |
Njock, M.-S., GUIOT, J., HENKET, M., Nivelles, O., Thiry, M., Dequiedt, F., Corhay, J.-L., Louis, R., & Struman, I. (2018). Sputum exosomes: promising biomarkers for idiopathic pulmonary fibrosis. Thorax. doi:10.1136/thoraxjnl-2018-211897 |
Hendrick, E., Peixoto, P., Blomme, A., Polese, C., Matheus, N., Cimino, J., Frère, A., Mouithys-Mickalad, A., Serteyn, D., Bettendorff, L., Elmoualij, B., De Tullio, P., Eppe, G., Dequiedt, F., Castronovo, V., & Mottet, D. (2017). Metabolic inhibitors accentuate the anti-tumoral effect of HDAC5 inhibition. Oncogene. doi:10.1038/onc.2017.103 |
Fettweis, G., Di Valentin, E., L'homme, L., Lassence, C., Dequiedt, F., Fillet, M., Coupienne, I., & Piette, J. (2017). RIP3 antagonizes a TSC2-mediated pro-survival pathway in glioblastoma cell death. Biochimica et Biophysica Acta. doi:10.1016/j.bbamcr.2016.10.014 |
Bacquelaine Veloso, A., Dequiedt, F., Bruyr, J., & Orban, T. (2016). Study of Developmental and Molecular Processes Sorbs1 Regulated by using a combination of in vitro and in vivo models. PSI GIGA ULg. |
Lebrun, M., riva, L., lambert, J., Rambout, X., Thiry, M., blondeau, C., Twizere, J.-C., Dequiedt, F., & Sadzot-Delvaux, C. (20 May 2016). Role of Varicella Zoster virus ORF9p in the secondary egress : importance of its interaction with the cellular Adaptin Protein-1 [Poster presentation]. 2015 Colorado Alphaherpesvirus Latency Society Symposium, Vail, United States - Colorado. |
Daakour, S., Hajingabo, L. J., Kerselidou, D., Devresse, A., Kettmann, R., Simonis, N., Dequiedt, F., & Twizere, J.-C. (2016). Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBWX7 common interactor. BMC Cancer, 16 (1), 335. doi:10.1186/s12885-016-2374-2 |
Rambout, X., Detiffe, C., Bruyr, J., Mariavelle, E., Cherkaoui, M., Brohee, S., Demoitie, P., Lebrun, M., Soin, R., Lesage, B., Guedri, K., Beullens, M., Bollen, M., Farazi, T. A., Kettmann, R., Struman, I., Hill, D. E., Vidal, M., Kruys, V., ... Dequiedt, F. (2016). The transcription factor ERG recruits CCR4-NOT to control mRNA decay and mitotic progression. Nature Structural and Molecular Biology. doi:10.1038/nsmb.3243 |
Vidlickova, I., Dequiedt, F., Jelenska, L., Sedlakova, O., Pastorek, M., Stuchlik, S., Pastorek, J., Zatovicova, M., & Pastorekova, S. (2016). Apoptosis-induced ectodomain shedding of hypoxia-regulated carbonic anhydrase IX from tumor cells: a double-edged response to chemotherapy. BMC Cancer, 16 (1), 239. doi:10.1186/s12885-016-2267-4 |
Pastorek, M., Simko, V., Takacova, M., Barathova, M., Bartosova, M., Hunakova, L., Sedlakova, O., Hudecova, S., Krizanova, O., Dequiedt, F., Pastorekova, S., & Sedlak, J. (2015). Sulforaphane reduces molecular response to hypoxia in ovarian tumor cells independently of their resistance to chemotherapy. International Journal of Oncology, 47 (1), 51-60. doi:10.3892/ijo.2015.2987 |
Daher, J., Martin, M., Rousseau, A., Nuyens, V., Fayyad-Kazan, H., Van Antwerpen, P., Courbebaisse, G., Martiat, P., Badran, B., Dequiedt, F., Zouaoui Boudjeltia, K., & Vanhamme, L. (2014). Myeloperoxidase Oxidized LDL Interferes with Endothelial Cell Motility through miR-22 and Heme Oxygenase 1 Induction: Possible Involvement in Reendothelialization of Vascular Injuries. Mediators of Inflammation. doi:10.1155/2014/134635 |
Amand, M., Erpicum, C., BAJOU, K., Cerignoli, F., Blacher, S., Martin, M., Dequiedt, F., Drion, P., Singh, P., Zurashvili, T., Vandereyken, M., Musumeci, L., Mustelin, T., Moutschen, M., Gilles, C., Noël, A., & Rahmouni, S. (2014). DUSP3/VHR is a pro-angiogenic atypical dual-specificity phosphatase. Molecular Cancer. doi:10.1186/1476-4598-13-108 |
Juvenal Hajingabo, L., Daakour, S., Martin, M., Grausenburger, R., Panzer-Grumayer, R., Dequiedt, F., Simonis, N., & Twizere, J.-C. (2014). Predicting interactome networks perturbations in human cancer: application to gene fusions in acute lymphoblastic leukemia. Molecular Biology of the Cell. doi:10.1091/mbc.E14-06-1038 |
Blibek, K., Fujii, N., Legros, S., Boxus, M., Dewulf, J.-F., Zimmermann, P., Kettmann, R., Borg, J.-P., Dequiedt, F., & Twizere, J.-C. (29 June 2013). Inhibition of Tax transformation activity using a small molecule targetting Tax/PDZ domain interactions [Poster presentation]. 16th International Conference on Human Retrovirology : HTLV and Related Viruses, Montréal, Québec., Canada. |
Blibek, K., Fujii, N., Legros, S., Boxus, M., Dewulf, J.-F., Zimmermann, P., Kettmann, R., Dequiedt, F., & Twizere, J.-C. (29 June 2013). Inhibition of Tax transformation activity using a small molecule targetting Tax/PDZ domain interactions [Poster presentation]. 16th International Conference on Human Retrovirology: HTLV and Related Viruses HTLV, Montréal, Québec., Canada. |
Blibek, K., Rambout, X., beaufays, J., Lins, L., Dequiedt, F., & Twizere, J.-C. (29 June 2013). An interaction map for HTLV-1 Tax and PDZ-containing proteins [Poster presentation]. 16th International Conference on Human Retrovirology : HTLV and Related Viruses, Montréal, Québec., Canada. |
Cherrier, T., Le Douce, V., Eilebrecht, S., Riclet, R., Marban, C., Dequiedt, F., Goumon, Y., Paillart, J.-C., Mericskay, M., Parlakian, A., Bausero, P., Abbas, W., Herbein, G., Kurdistani, S. K., Grana, X., Van Driessche, B., Schwartz, C., Candolfi, E., Benecke, A. G., ... Rohr, O. (2013). CTIP2 is a negative regulator of P-TEFb. Proceedings of the National Academy of Sciences of the United States of America, 110 (31), 12655-60. doi:10.1073/pnas.1220136110 |
Condé, C., Rambout, X., Lebrun, M., Lecat, A., Di Valentin, E., Dequiedt, F., Piette, J., Gloire, G., & Legrand, S. (2012). The inositol phosphatase SHIP-1 inhibits NOD2-induced NF-κB activation by disturbing the interaction of XIAP with RIP2. PLoS ONE. doi:10.1371/journal.pone.0041005 |
Sabatel, H., Di Valentin, E., Gloire, G., Dequiedt, F., Piette, J., & Habraken, Y. (2012). Phosphorylation of p65(RelA) on Ser547 by ATM represses NF-κB-dependent transcription of specific genes after genotoxic stress. PLoS ONE. doi:10.1371/journal.pone.0038246 |
Simonis, N., Rual, J.-F., Lemmens, I., Boxus, M., Hirozane-Kishikawa, T., GATOT, J.-S., Dricot, A., Hao, T., Vertommen, D., Legros, S., Daakour, S., Klitgord, N., Martin, M., Willaert, J.-F., Dequiedt, F., Navratil, V., Cusick, M. E., Burny, A., Van Lint, C., ... Twizere, J.-C. (2012). Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses. Retrovirology, 9, 26. doi:10.1186/1742-4690-9-26 |
Legros, S., Boxus, M., GATOT, J.-S., Van Lint, C., Kruys, V., Kettmann, R., Twizere, J.-C., & Dequiedt, F. (2011). The HTLV-1 Tax protein inhibits formation of stress granules by interacting with histone deacetylase 6. Oncogene. doi:10.1038/onc.2011.120 |
Chanaz, S.-S., Fabre, A., Dequiedt, F., Restouin, A., Castellano, R., Garbi, S., Roche, P., Morelli, X., Brunel, J.-M., & Collette, Y. (2010). Modified Cap Group Suberoylanilide Hydroxamic Acid Histone Deacetylase Inhibitor Derivatives Reveal Improved Selective Antileukemic Activity. Journal of Medicinal Chemistry, 53(8), 3038-47. doi:10.1021/jm901358y |
Martin, M., Kettmann, R., & Dequiedt, F. (2010). Recent insights into Protein Phosphatase 2A structure and regulation : The reason why PP2A is no longer considered as a lazy passive housekeeping enzyme. Biotechnologie, Agronomie, Société et Environnement, 14 (1), 243-252. |
Mouton, V., Toussaint, L., Vertommen, D., Gueuning, M.-A., Maisin, L., Havaux, X., Sanchez-Canedo, C., Bertrand, L., Dequiedt, F., Hemmings, B. A., Hue, L., & Rider, M. H. (2010). Heart 6-phosphofructo-2-kinase activation by insulin requires PKB (protein kinase B), but not SGK3 (serum- and glucocorticoid-induced protein kinase 3). Biochemical Journal, 431 (2), 267-75. doi:10.1042/BJ20101089 |
Simboeck, E., Sawicka, A., Zupkovitz, G., Senese, S., Winter, S., Dequiedt, F., Ogris, E., Di Croce, L., Chiocca, S., & Seiser, C. (2010). A phosphorylation switch regulates the transcriptional activation of cell cycle regulator p21 by histone deacetylase inhibitors. Journal of Biological Chemistry. doi:10.1074/jbc.M110.184481 |
Legros, S., Boxus, M., Dewulf, J. F., Dequiedt, F., Kettmann, R., & Twizere, J.-C. (2009). Protein-protein interactions and gene expression regulation in HTLV-1 infected cells. Frontiers in Bioscience: A Journal and Virtual Library, 14, 4138-48. doi:10.2741/3518 |
Martin, M., Kettmann, R., & Dequiedt, F. (2009). Class IIa histone deacetylases: conducting development and differentiation. International Journal of Developmental Biology, 53 (2-3), 291-301. doi:10.1387/ijdb.082698mm |
Twizere, J.-C., Springael, J.-Y., Boxus, M., Burny, A., Dequiedt, F., Dewulf, J.-F., Duchateau, J., Portetelle, D., Urbain, P., Van Lint, C., Green, P. L., Mahieux, R., Parmentier, M., Willems, L., & Kettmann, R. (2007). Human T-cell leukemia virus type-1 Tax oncoprotein regulates G-protein signaling. Blood, 109 (3), 1051-60. doi:10.1182/blood-2006-06-026781 |
Dequiedt, F., Martin, M., Von Blume, J., Vertommen, D., Lecomte, E., Mari, N., Heinen, M.-F., Bachmann, M., Twizere, J.-C., Huang, M. C., Rider, M. H., Piwnica-Worms, H., Seufferlein, T., & Kettmann, R. (2006). New Role For Hpar-1 Kinases Emk And C-Tak1 In Regulating Localization And Activity Of Class Iia Histone Deacetylases. Molecular and Cellular Biology, 26 (19), 7086-7102. doi:10.1128/MCB.00231-06 |
Dequiedt, F., Van Lint, J., Lecomte, E., Van Duppen, V., Seufferlein, T., Vandenheede, J., Wattiez, R., & Kettmann, R. (2005). Phosphorylation Of Histone Deacetylase 7 By Protein Kinase D Mediates T Cell Receptor-Induced Nur77 Expression And Apoptosis. Journal of Experimental Medicine, 201 (5), 793-804. doi:10.1084/jem.20042034 |
Kopacek, J., Barathova, M., Dequiedt, F., Sepelakova, J., Kettmann, R., Pastorek, J., & Pastorekova, S. (2005). Mapk Pathway Contributes To Density- And Hypoxia-Induced Expression Of The Tumor-Associated Carbonic Anhydrase Ix. Biochimica et Biophysica Acta-Gene Structure and Expression, 1729 (1), 41-49. doi:10.1016/j.bbaexp.2005.03.003 |
Wittich, S., Scherf, H., Xie, C., Heltweg, B., Dequiedt, F., Verdin, E., Gerhauser, & Jung, M. (2005). Effect Of Inhibitors Of Histone Deacetylase On The Induction Of Cell Differentiation In Murine And Human Erythroleukemia Cell Lines. Anti-Cancer Drugs, 16 (6), 635-643. doi:10.1097/00001813-200507000-00008 |
Heltweg, B., Dequiedt, F., Marshall, B., Branch, C., Yoshida, M., Nishino, N., Verdin, E., & Jung, M. (2004). Subtype Selective Substrates For Histone Deacetylases. Journal of Medicinal Chemistry, 47 (21), 5235-5243. doi:10.1021/jm0497592 |
Heltweg, B., Dequiedt, F., Verdin, E., & Jung, M. (2003). Nonisotopic substrate for assaying both human zinc and NAD+-dependent histone deacetylases. Analytical Biochemistry, 319 (1), 42-8. doi:10.1016/S0003-2697(03)00276-8 |
Verdin, E., Dequiedt, F., & Kasler, H. G. (2003). Class II histone deacetylases: versatile regulators. Trends in Genetics, 19 (5), 286-93. doi:10.1016/S0168-9525(03)00073-8 |