Blackman, G., Fastrez, S., Gathy, C., Bebrone, C., Vandegaart, H., & Duysens, G. (22 July 2021). Composition comprising at least one detergent component and at least one enzyme component for removing biofilms. |
Gavara, L., Sevaille, L., De Luca, F., Mercuri, P., Bebrone, C., Feller, G., Legru, A., Cerboni, G., Tanfoni, S., Baud, D., Cutolo, G., Bestgen, B., Chelini, G., Verdirosa, F., Sannio, F., Pozzi, C., Benvenuti, M., Kwapien, K., Fischer, M., ... Hernandez, J.-F. (2020). 4-Amino-1,2,4-triazole-3-thione-derived Schiff bases as metallo-beta-lactamase inhibitors. European Journal of Medicinal Chemistry, 208, 112720. doi:10.1016/j.ejmech.2020.112720 |
Parilti, R., Caprasse, J., Riva, R., Alexandre, M., Vandegaart, H., Bebrone, C., Dupont-Gillain, C., Howdle, S. M., & Jérôme, C. (15 December 2018). Antimicrobial peptide encapsulation and sustained release from polymer network particles prepared in supercritical carbon dioxide. Journal of Colloid and Interface Science, 532, 112-117. doi:10.1016/j.jcis.2018.07.125 |
Bebrone, C., Alexandre, M., Vandegaart, H., Duysens, G., & Nicaise, D. (16 November 2017). Composition principalement peptidique pour la détection de l'amiante. |
Bebrone, C., Vandegaart, H., & Nicaise, D. (23 February 2017). Asbestos detection. |
Sevaille, L., Gavara, L., Bebrone, C., De Luca, F., Nauton, L., Achard, M., Mercuri, P., Tanfoni, S., Borgianni, L., Guyon, C., Lonjon, P., Turan-Zitouni, G., Dzieciolowski, J., Becker, K., Bénard, L., Condon, C., Maillard, L., Martinez, J., Frère, J.-M., ... Hernandez, J.-F. (2017). 1,2,4-Triazole-3-thione Compounds as Inhibitors of Dizinc Metallo-β-lactamases. ChemMedChem, 12, 972-985. doi:10.1002/cmdc.201700186 |
Bebrone, C., & Van de Weerdt, C. (2016). Le biomimétisme moléculaire : du concept universitaire à l'application industrielle [Paper presentation]. Liège Créative, Liège, Belgium. |
Camporeale, G., Moreno-Couranjou, M., Bonot, S., Mauchauffé, R., Boscher, N., Bebrone, C., Van de Weerdt, C., Cauchie, H.-M., Favia, P., & Choquet, P. (15 May 2015). Atmospheric-Pressure Plasma Deposited Epoxy-Rich Thin Films as Platforms for Biomolecule Immobilization-Application for Anti-Biofouling and Xenobiotic-Degrading Surfaces. Plasma Processes and Polymers, 12 (11), 1208-1219. doi:10.1002/ppap.201400206 |
Kupper, M. B., Herzog, K., Bennink, S., Schlömer, P., Bogaerts, P., Glupczynski, Y., Fischer, R., Bebrone, C.* , & Hoffmann, K.*. (13 April 2015). The three-dimensional structure of VIM-31a metallo-blactamase from Enterobacter cloacae in its native and oxidized form. FEBS Journal, 282 (12), 2352-2360. doi:10.1111/febs.13283 * These authors have contributed equally to this work. |
Bebrone, C. (2014). Fonctionnaliser les surfaces avec des biomolécules fonctionnelles: vers de nouveaux matériaux bioactifs [Paper presentation]. Congrès dentaire de la Société Francophone des Biomatériaux Dentaires, Liège, Belgium. |
Bebrone, C. (2013). Zinc Beta-lactamase superfamily. In R. Kretsinger, V. Uversky, ... E. Permyakov (Eds.), Encyclopedia of Metalloproteins. Springer. |
Bebrone, C., Bogaerts, P., Delbrück, H., Bennink, S., Kupper, M., Rezende de Castro, R., Glupczynski, Y., & Hoffmann, K. (January 2013). GES-18, a new carbapenem-hydrolyzing GES-Type β-lactamase from pseudomonas aeruginosa that contains Ile80 and Ser170 residues. Antimicrobial Agents and Chemotherapy, 57(1), 396-401. doi:10.1128/AAC.01784-12 |
Delbrück, H., Bogaerts, P., Kupper, M., Rezende de Castro, R., Bennik, S., Glupczynski, Y., Galleni, M., Hoffmann, K., & Bebrone, C. (November 2012). Kinetic and crystallographic studies of extended-spectrum GES-11, GES-12, and GES-14 β-lactamases. Antimicrobial Agents and Chemotherapy, 56(11), 5618-5625. doi:10.1128/AAC.01272-12 |
Bebrone, C., Garau, G., Garcia-Saez, I., Chantalat, L., Carfi, A., & Dideberg, O. (2012). X-RAY STRUCTURES AND MECHANISMS OF METALLO-beta-LACTAMASES. In J.-M. Frère (Ed.), Beta-Lactamases (Molecular Anatomy and Physiology of Proteins). Nova Science Publishers. |
Bogaerts, P., Bebrone, C., Huang, T.-D., Bouchahrouf, W., DeGheldre, Y., Deplano, A., Hoffmann, K., & Glupczynski, Y. (June 2012). Detection and characterization of VIM-31, a new variant of VIM-2 with Tyr224His and His252Arg mutations, in a clinical isolate of Enterobacter cloacae. Antimicrobial Agents and Chemotherapy, 56(6), 3283-3287. doi:10.1128/AAC.06249-11 |
Bebrone, C., Bogaerts, P., Delbrück, H., Rezende de Castro, R., Kupper, M. B., Glupczynski, G., & Hoffmann, K. (2012). Biochemical characterisation of GES-18 carbapenemase with an additional Val80Ile substitution compared to GES-5 [Poster presentation]. 22th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Londres, United Kingdom. |
Bogaerts, P., Bebrone, C., Te-Din, H., Bouchahrouf, W., DeGheldre, Y., Hoffmann, K., & Glupczynski, G. (2012). Detection and characterization of a new VIM-31 variant in Enterobacter cloacae [Poster presentation]. 22th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Londres, United Kingdom. |
Kupper, M., Bauvois, C., Frère, J.-M., Galleni, M., & Bebrone, C. (January 2012). The CphAII protein from Aquifex aeolicus exhibits a metal-dependent phosphodiesterase activity. Extremophiles: Life Under Extreme Conditions, 16(1), 45-55. doi:10.1007/s00792-011-0404-1 |
El Garch, F., Bogaerts, P., Bebrone, C., Galleni, M., & Glupczynski, Y. (October 2011). OXA-198, an acquired carbapenem-hydrolyzing class D beta-lactamase from Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy, 55(10), 4828-4833. doi:10.1128/AAC.00522-11 |
Horsfall, L., Izougarhane, Y., Lassaux, P., Selevsek, N., Liénard, B., Poirel, L., Kupper, M., Hoffmann, K., Frère, J.-M., Galleni, M., & Bebrone, C. (April 2011). Broad antibiotic resistance profile of the subclass B3 metallo-β-lactamase GOB-1, a di-zinc enzyme. FEBS Journal, 278(8), 1252-1263. doi:10.1111/j.1742-4658.2011.08046.x |
Bebrone, C., Delbrück, H., Kupper, M. B., Ervenich, D., Hoffmann, K., & Galleni, M. (2011). The C221D mutation leads to a modification of the Metallo-beta-Lactamase fold of CphA [Poster presentation]. IAP P6/19 project: PROFUSA meeting, Liège, Belgium. |
Bebrone, C., Delbrück, H., Kupper, M. B., Galleni, M., & Hoffmann, K. (2011). The structure of the C221D mutant of the subclass B2 CphA metallo-beta-lactamase shows a modification of the typical alpha beta beta alpha fold [Poster presentation]. 11th β-lactamase meeting, Leonessa, Italy. |
Bebrone, C., Kupper, M. B., Dehareng, D., Frère, J.-M., Hoffmann, K., & Galleni, M. (2011). The CphAII protein from Aquifex aeolicus possesses a metal-dependent phosphodiesterase activity [Poster presentation]. 11th β-lactamase meeting, Leonessa, Italy. |
El Garch, F., Bogaerts, P., Bebrone, C., Galleni, M., & Glupczynski, G. (2011). Identification of OXA-198, a new carbapenem hydrolyzing class D beta-lactamase, in Pseudomonas aeruginosa [Poster presentation]. 21th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Milan, Italy. |
Naik, A. D., Beck, J., Dirtu, M. M., Bebrone, C., Tinant, B., Robeyns, K., Marchand-Brynaert, J., & Garcia, Y. (2011). Zinc complexes with 1,2,4-triazole functionalized amino acid derivatives: Synthesis, structure and beta-lactamase assay [Poster presentation]. EDT-CHIM-Liege meeting, Liège, Belgium. |
Naik, A., Beck, J., Dîrtu, M., Bebrone, C., Tinant, B., Robeyns, K., Marchand-Brynaerts, J., & Garcia, Y. (2011). Zinc complexes with 1,2,4-triazole functionalized amino acid derivatives: Synthesis, structure and b-lactamase assay. Inorganica Chimica Acta, 368, 21-28. doi:10.1016/j.ica.2010.12.017 |
Weide, T., Saldanha, S. A., Minond, D., Spicer, T., Fotsing, J., Spaargaren, M., Frère, J.-M., Bebrone, C., Sharpless, B., Hodder, P., & Fokin, V. (July 2010). NH-1,2,3-Triazole-based Inhibitors of the VIM-2 Metallo-β- Lactamase: Synthesis and Structure-Activity Studies. ACS Medicinal Chemistry Letters, 1(4), 150-154. |
Bebrone, C., Lassaux, P., Vercheval, L., Sohier, J., Jehaes, A., Sauvage, E., & Galleni, M. (16 April 2010). Current challenges in antimicrobial chemotherapy: focus on beta-lactamase inhibition. Drugs, 70(6), 651-679. doi:10.2165/11318430-000000000-00000 |
Lassaux, P., Delbrück, H., Gulea, M., Kupper, M., Hoffmann, K., Galleni, M., & Bebrone, C. (2010). Interactions mediating the positioning of mercapto-phosphonate inhibitors in the active site of metallo-beta-lactamases [Paper presentation]. ECCMID, Vienne, Austria. |
Lassaux, P., Hamel, M., Gulea, M., Delbrück, H., Mercuri, P., Horsfall, L., Dehareng, D., Kupper, M., Frère, J.-M., Hoffmann, K., Galleni, M., & Bebrone, C. (2010). Mercaptophosphonate Compounds as Broad-Spectrum Inhibitors of the Metallo-β-lactamases. Journal of Medicinal Chemistry, 53, 4862–4876. doi:10.1021/jm100213c |
Minond, D., Saldanha, S. A., Spaargaren, M., Spicer, T., Fotsing, J. R., Weide, T., Fokin, V. V., Sharpless, K. B., Galleni, M., Bebrone, C., Lassaux, P., & Hodder, P. (15 July 2009). Inhibitors of VIM-2 by screening pharmacologically active and click-chemistry compound libraries. Bioorganic and Medicinal Chemistry, 17, 5027-37. doi:10.1016/j.bmc.2009.05.070 |
Beck, J., Vercheval, L., Bebrone, C., Herteg-Fernea, A., Lassaux, P., & Marchand-Brynaert, J. (01 July 2009). Discovery of novel lipophilic inhibitors of OXA-10 enzyme (class D beta-lactamase) by screening amino analogs and homologs of citrate and isocitrate. Bioorganic and Medicinal Chemistry Letters, 19, 3593-7. doi:10.1016/j.bmcl.2009.04.149 |
Bebrone, C., Delbrück, H., Kupper, M., Schlömer, P., Willmann, C., Frère, J.-M., Fisher, R., Galleni, M., & Hoffmann, K. (2009). The structure of the di-zinc subclass B2 metallo-beta-lactamase CphA reveals that the second inhibitory zinc ion binds in the "histidine" site. Antimicrobial Agents and Chemotherapy. doi:10.1128/AAC.00288-09 |
Bebrone, C., Delbrück, H., Wilmann, C., Galleni, M., Frère, J.-M., & Hoffmann, K. (2009). The structure of the di-zinc form of the subclass B2 CphA metallo-β-lactamase reveals that the second zinc ion binds in the Histidine site [Poster presentation]. “Penicillin-recognizing enzymes: from enzyme kinetics to protein folding” symposium, Liège, Belgium. |
Beck, J., Gharbi, S., Herteg-Fernea, A., Vercheval, L., Bebrone, C., Lassaux, P., Zervosen, A., & Marchand-Brynaert, J. (2009). Aminophosphonic Acids and Aminobis(phosphonic acids) as Potential Inhibitors of Penicillin-Binding Proteins. European Journal of Organic Chemistry, (1), 85-97. doi:10.1002/ejoc.200800812 |
Bebrone, C. (2008). Emerging antimicrobial resistance: mechanisms, management and control [Paper presentation]. Alpha Bacterialnet, Florence/Sienne, Italy. |
Bebrone, C., Anne, C., Kerff, F., Garau, G., De Vriendt, K., Lantin, R., Devreese, B., Van Beeumen, J., Dideberg, O., Frère, J.-M., & Galleni, M. (2008). Mutational analysis of the zinc- and substrate-binding sites in the CphA metallo-beta-lactamase from Aeromonas hydrophila. Biochemical Journal, 414 (1), 151-9. doi:10.1042/BJ20080375 |
Bebrone, C., Delbrück, H., Kupper, M. B., Galleni, M., Frère, J.-M., & Hoffmann, K. (2008). The structure of the di-zinc form of the subclass B2 CphA metallo-β-lactamase reveals that the second zinc binds in the Histidine site [Poster presentation]. International congress on Biocatalysis BIOCAT, Hambourg, Germany. |
Hubert, S., Rigali, S., Bebrone, C., Kupper, M. B., Hoffmann, K., Vanhulle, S., & Frère, J.-M. (2008). Analysis of the enzymatic component of ligninolytic system of Pycnoporus sanguineus PS7 [Poster presentation]. International congress on Biocatalysis BIOCAT, Hambourg, Germany. |
Bebrone, C. (15 December 2007). Metallo-beta-lactamases (classification, activity, genetic organization, structure, zinc coordination) and their superfamily. Biochemical Pharmacology, 74 (12), 1686-1701. doi:10.1016/j.bcp.2007.05.021 |
Lassaux, P., Hamel, M., Gulea, M., Mercuri, P., Horsfall, L., Bebrone, C., Gaumont, A.-C., Frère, J.-M., & Galleni, M. (2007). Mercapto-phosphonate compounds as broad-spectrum inhibitors of the metallo-beta-lactamases. International Journal of Antimicrobial Agents, 29 (Supplément 2), 95. |
De Vriendt, K., Van Driessche, G., Devreese, B., Bebrone, C., Anne, C., Frère, J.-M., Galleni, M., & Van Beeumen, J. (February 2006). Monitoring the zinc affinity of the metallo-beta-lactamase CphA by automated nanoESI-MS. Journal of the American Society for Mass Spectrometry, 17 (2), 180-188. doi:10.1016/j.jasms.2005.10.007 |
Trovaslet, M., Bebrone, C., Enaud, E., Hubert, S., Nouaimeh, N., Pamplona, M., Lorenzini, B., Bols, C.-M., Frère, J.-M., & Corbisier, A.-M. (2006). Kinetic activation of Pycnoporus sanguineus laccase in presence of dyes [Poster presentation]. 3rd European Meeting in Oxizymes, Oeiras, Portugal. |
Bebrone, C., Anne, C., De Vriendt, K., Devreese, B., Rossolini, G. M., Van Beeumen, J., Frère, J.-M., & Galleni, M. (05 August 2005). Dramatic broadening of the substrate profile of the Aeromonas hydrophila CphA metallo-beta-lactamase by site-directed mutagenesis. Journal of Biological Chemistry, 280 (31), 28195-28202. doi:10.1074/jbc.M414052200 |
Bebrone, C. (2005). Caractérisation des résidus impliqués dans le mécanisme d’action et la spécificité de la beta-lactamase de classe B Cpha [Doctoral thesis, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/301353 |
Garau, G., Bebrone, C., Anne, C., Galleni, M., Frère, J.-M., & Dideberg, O. (28 January 2005). A metallo-beta-lactamase enzyme in action: Crystal structures of the monozinc carbapenemase CphA and its complex with biapenem. Journal of Molecular Biology, 345 (4), 785-795. doi:10.1016/j.jmb.2004.10.070 |
Bebrone, C. (2005). CphA, un exemple pratique de beta-lactamase à zinc [Paper presentation]. Séminaire IRMW, Bruxelles, Belgium. |
Garau, G., Garcia-Saez, I., Bebrone, C., Anne, C., Mercuri, P., Galleni, M., Frère, J.-M., & Dideberg, O. (July 2004). Update of the standard numbering scheme for class B beta-lactamases. Antimicrobial Agents and Chemotherapy, 48 (7), 2347-2349. doi:10.1128/AAC.48.7.2347-2349.2004 |
Bebrone, C., Anne, C., & Galleni, M. (2003). Modification of the specificity of the CphA metallo- β-lactamase produced by Aeromonas hydrophila by site-directed mutagenesis [Poster presentation]. Bioforum, Liège, Belgium. |
Vanhove, M., Zakhem, M., Devreese, B., Franceschini, N., Anne, C., Bebrone, C., Amicosante, G., Rossolini, G. M., Van Beeumen, J., Frère, J.-M., & Galleni, M. (2003). Role of Cys221 and Asn116 in the zinc-binding sites of the Aeromonas hydrophila metallo-beta-lactamase. Cellular and Molecular Life Sciences, 60 (11), 2501-9. doi:10.1007/s00018-003-3092-x |
De Seny, D., Prosperi, C., Bebrone, C., Rossolini, G. M., Page, M. I., Noel, P., Frère, J.-M., & Galleni, M. (01 May 2002). Mutational analysis of the two zinc-binding sites of the Bacillus cereus 569/H/9 metallo-beta-lactamase. Biochemical Journal, 363 (Pt 3), 687-696. doi:10.1042/bj3630687 |
Bebrone, C., Anne, C., & Galleni, M. (2002). Molecular evolution of the Aeromonas hydrophila CphA metallo-β-lactamase [Poster presentation]. Engineering enzymes for biocatalysis by using directed evolution, Paris, France. |
Bebrone, C., Moali, C., Mahy, F., Rival, S., Docquier, J.-D., Rossolini, G. M., Fastrez, J., Pratt, R. F., Frère, J.-M., & Galleni, M. (June 2001). Centa as a Chromogenic Substrate for Studying Beta-Lactamases. Antimicrobial Agents and Chemotherapy, 45 (6), 1868-71. doi:10.1128/AAC.45.6.1868-1871.2001 |
Bebrone, C. (2001). Modification of the specificity of CphA metallo-beta-lactamase by site-directed and random mutagenesis [Paper presentation]. EU-network meeting on zinc ion containing beta-lactamases, Sienne, Italy. |
Bebrone, C., Fastrez, J., Frère, J.-M., & Galleni, M. (2001). Centa as a chromogenic substrate for the study of β-lactamases [Poster presentation]. Bioforum, Liège, Belgium. |
Bebrone, C. (2000). Study of the Aeromonas hydrophila class B2 metallo-beta-lactamase: catalytic mechanism and specificity [Paper presentation]. EU-network meeting on zinc ion containing beta-lactamases, Copenhague, Denmark. |
Bebrone, C. (1999). Etude du mécanisme d’action de la beta-lactamase à zinc de Bacillus cereus [Master’s dissertation, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/301354 |
Bebrone, C. (1999). Mutational study of the two zinc binding sites of the Bacillus cereus 569/H/9 metallo-beta-lactamase [Paper presentation]. EU-Network meeting on zinc ion containing beta-lactamases, Saarbrücken, Germany. |