Publications and communications of Emmanuel Di Valentin

Jassin, M.* , Chloé Onkelinx* , Caers, J.* , Nguyen, T. T.* , E Silva, B., Bocuzzi, V., Marcion, G., Ehx, G., Baron, F., & Di Valentin, E. (15 February 2024). CAR-T and nanoCAR-T for multiple myeloma: Does smaller mean smarter ? [Poster presentation]. EBMT - EHA 6th European CAR T-cell Meeting, Valence, Spain.

Jassin, M.* , Chloé Onkelinx* , Caers, J.* , Nguyen, T. T.* , E Silva, B., Bocuzzi, V., Marcion, G., Ehx, G., Baron, F., & Di Valentin, E. (06 February 2024). CAR-T and nanoCAR-T for multiple myeloma: Does smaller mean smarter ? [Poster presentation]. Séminaire Télévie 2024.

Bou Malham, V., Benzoubir, N., Vaquero, J., Desterke, C., Agnetti, J., Song, P. X., Gonzalez-Sanchez, E., Arbelaiz, A., Jacques, S., Di Valentin, E., Rahmouni, S., Tan, T. Z., Samuel, D., Thiery, J. P., Sebagh, M., Fouassier, L., & Gassama-Diagne, A. (2023). Intrinsic cancer cell phosphoinositide 3-kinase δ regulates fibrosis and vascular development in cholangiocarcinoma. Liver International. doi:10.1111/liv.15751

Beauvois, A.* , Gazon, H.* , Chauhan, P. S., Jamakhani, M., Jacques, J.-R., Thiry, M., Dejardin, E., Di Valentin, E., Twizere, J.-C., Péloponèse, J.-M., Njock, M.-S., Yasunaga, J.-I., Matsuoka, M., Hamaïdia, M.* , & Willems, L.*. (2023). The helicase-like transcription factor redirects the autophagic flux and restricts human T-cell leukemia virus type 1 infection. Proceedings of the National Academy of Sciences of the United States of America, 120 (31), 2216127120. doi:10.1073/pnas.2216127120

BOEMER, F., JOSSE, C., LUIS, G., Di Valentin, E., Thiry, J., CELLO, C., CABERG, J.-H., DADOUMONT, C., HARVENGT, J., Lumaka, A., BOURS, V., & DEBRAY, F.-G. (18 February 2022). Novel Loss of Function Variant in BCKDK Causes a Treatable Developmental and Epileptic Encephalopathy. International Journal of Molecular Sciences, 23 (4), 2253. doi:10.3390/ijms23042253

Agnetti, J.* , Vanessa Bou Malham* , Christophe Desterke* , Nassima Benzoubir, Juan Peng Wang, Sophie Jacques, Rahmouni, S., Di Valentin, E., Tuan Zea Tan, Didier Samuel, Jean Paul Thiery, & Ama Gassama-Diagne. (2022). PI3Kδ activity controls 1 plasticity and discriminates between EMT and stemness based on distinct TGF signalling. Communications Biology, 5, 740. doi:10.1038/s42003-022-03637-w

Chiavarina, B., Costanza, B., Ronca, R., Blomme, A., Rezzola, S., Chiodelli, P., Giguelay, A., Belthier, G., Doumont, G., Van Simaeys, G., Lacroix, S., Yokobori, T., Erkhem-Ochir, B., Balaguer, P., Cavailles, V., Fabbrizio, E., Di Valentin, E., Gofflot, S., Detry, O., ... Turtoi, A. (January 2021). Metastatic colorectal cancer cells maintain the TGFβ program and use TGFBI to fuel angiogenesis. Theranostics, 11 (4), 1626-1640. doi:10.7150/thno.51507

Jacques, S., Arjomand, A., Perée, H., COLLINS, P., Mayer, A., Lavergne, A., Wéry, M., Mni, M., Hego, A., Thuillier, V., Becker, G., Bahri, M. A., Plenevaux, A., Di Valentin, E., Oury, C., MOUTSCHEN, M., Delvenne, P., Paquot, N., & Rahmouni, S. (2021). Dual‑specificity phosphatase 3 deletion promotes obesity, non‑alcoholic steatohepatitis and hepatocellular carcinoma. Scientific Reports, 11, 5817. doi:10.1038/s41598-021-85089-6

Niemi, M., Gazon, H., JUSZCZAK, D., FADEUR, M., CAMBY, S., MEURIS, C., THYS, M., JACQUES, J., HENKET, M., BEGUIN, Y., Rahmouni, S., Lebrun, M., MOUTSCHEN, M., Misset, B., DARCIS, G., GUIOT, J., AZARZAR, S., DELLOT, P., GOFFLOT, S., ... HUYNEN, P. (Other coll.). (2021). Mapping the human genetic architecture of COVID-19. Nature, 600, 472-477. doi:10.1038/s41586-021-03767-x

Dedobbeleer, M., Willems, E., Lambert, J., LOMBARD, A., Di Gregorio, M., Lumapat, P. N., Di Valentin, E., Freeman, S., Goffart, N., Scholtes, F., & Rogister, B. (2020). MKP1 phosphatase is recruited by CXCL12 in glioblastoma cells and plays a role in DNA strand breaks repair. Carcinogenesis. doi:10.1093/carcin/bgz151

Lombard, A., Di Gregorio, M., COPPIETERS, N., Di Valentin, E., Hego, A., Martin, D., & Rogister, B. (2020). Communicating hydrocephalus associated to ventral leptomeningeal invasion leads to precocious death in a glioblastoma orthotopic xenograft model. Neuro-Oncology Advances.

Rademaker, G., Costanza, B., Anania, S., Agirman, F., Maloujahmoum, N., Di Valentin, E., Goval, J.-J., Bellahcene, A., Castronovo, V., & Peulen, O. (June 2019). Myoferlin contributes to the metastatic phenotype of pancreatic cancer cells by enhancing their migratory capacity through the control of oxidative phosphorylation. Cancers, 11 (6). doi:10.3390/cancers11060853

LOMBARD, A., Dedobbeleer, M., DEWANDRE, Q., REUTER, G., Freeman, S., Di Valentin, E., MARTIN, D., & ROGISTER, B. (November 2018). Deciphering the response of subventricular zone-nested glioblastoma cells after surgery [Poster presentation]. Society for NeuroOncology (SNO), New Orleans, United States - Louisiana.

Trussart, C., Pirlot, C., Di Valentin, E., Piette, J., & Habraken, Y. (2018). Melanoma antigen-D2 controls cell cycle progression and modulates the DNA damage response. Biochemical Pharmacology. doi:10.1016/j.bcp.2018.01.035

Fettweis, G., Di Valentin, E., L'homme, L., Lassence, C., Dequiedt, F., Fillet, M., Coupienne, I., & Piette, J. (2017). RIP3 antagonizes a TSC2-mediated pro-survival pathway in glioblastoma cell death. Biochimica et Biophysica Acta. doi:10.1016/j.bbamcr.2016.10.014

Goffart, N.* , LOMBARD, A.* , Lallemand, F., Kroonen, J., Nassen, J., Di Valentin, E., Berendsen, S., Dedobbeleer, M., Willems, E., Robe, P., Bours, V., Martin, D., Martinive, P., Maquet, P., & Rogister, B. (2017). CXCL12 mediates glioblastoma resistance to radiotherapy in the subventricular zone. Neuro-Oncology, 19 (1), 66-77. doi:10.1093/neuonc/now136

Blomme, A., Costanza, B., De Tullio, P., Thiry, M., Van Simaeys, G., Boutry, S., Doumont, G., Di Valentin, E., Hirano, T., Yokobori, T., GOFFLOT, S., Peulen, O., Bellahcene, A., Sherer, F., Le Goff, C., Cavalier, E., Mouithys-Mickalad, A., Jouret, F., CUSUMANO, G., ... Turtoi, A. (2016). Myoferlin regulates cellular lipid metabolism and promotes metastases in triple-negative breast cancer. Oncogene. doi:10.1038/onc.2016.369

Peixoto, P.* , Blomme, A.* , Costanza, B.* , Ronca, R., Rezzola, S., Palacios, A., SCHOYSMAN, L., Boutry, S., Goffart, N., Peulen, O., Maris, P., Di Valentin, E., Hennequière, V., BIANCHI, E., Henry, A., Meunier, P., Rogister, B., MULLER, R., Delvenne, P., ... Turtoi, A. (2016). HDAC7 inhibition resets STAT3 tumorigenic activity in human glioblastoma independently of EGFR and PTEN: new opportunities for selected targeted therapies. Oncogene. doi:10.1038/onc.2015.506

Pirlot, C., Thiry, M., Trussart, C., Di Valentin, E., Piette, J., & Habraken, Y. (2016). Melanoma antigen-D2: a nucleolar protein undergoing delocalization during cell cycle and after cellular stress. BBA Molecular Cell Research, 1853 (3), 581-595. doi:10.1016/j.bbamcr.2015.12.010

Pirlot, C., Thiry, M., Trussart, C., Di Valentin, E., Piette, J., & Habraken, Y. (03 November 2015). Melanoma antigen D2, a substrate of ATM, is a nucleolar protein that shuttles with cell cycle and cellular stress [Poster presentation]. PI3K-like protein kinases, Milan, Italy.

Trussart, C., Orban, T., Di Valentin, E., Piette, J., & Habraken, Y. (06 February 2015). The phosphorylation of RelA on Ser547 does not modulate NF-kB activation after TNFa treatment like after a genotoxic stress [Poster presentation]. DISCOLBEL meeting in KUL, Louvain, Belgium.

Goffart, N., KROONEN, J., Di Valentin, E., Dedobbeleer, M., Denne, A., Martinive, P., & Rogister, B. (2015). Adult mouse subventricular zones stimulate glioblastoma stem cells specific invasion through CXCL12/CXCR4 signaling. Neuro-Oncology, 17 (1), 81-94. doi:10.1093/neuonc/nou144

Maris, P., Blomme, A., Palacios, A. P., Costanza, B., Bellahcene, A., BIANCHI, E., GOFFLOT, S., Drion, P., Trombino, G. E., Di Valentin, E., CUSUMANO, G., MAWEJA, S., JERUSALEM, G., Delvenne, P., LIFRANGE, E., Castronovo, V., & Turtoi, A. (2015). Asporin Is a Fibroblast-Derived TGF-beta1 Inhibitor and a Tumor Suppressor Associated with Good Prognosis in Breast Cancer. PLoS Medicine, 12 (9), 1001871. doi:10.1371/journal.pmed.1001871

Fettweis, G., Coupienne, I., Fillet, M., Lassence, C., Di Valentin, E., & Piette, J. (October 2014). TSC2 and 14-3-3 proteins down-regulate a RIP3 dependent PDT-induced Necroptosis in Glioblastoma [Poster presentation]. Keystone Symposia : "Cell death Signaling in Cancer and the Immune System".

Trussart, C., Orban, T., Di Valentin, E., Piette, J., & Habraken, Y. (29 August 2014). Promoter specific regulation of NF-kappaB by RelA phosphorylation on Ser547 [Poster presentation]. Discobel meeting.

Turtoi, A., Blomme, A., Debois, D., SOMJA, J., Delvaux, D., Patsos, G., Di Valentin, E., Peulen, O., MUTIJIMA NZARAMBA, E., De Pauw, E., Delvenne, P., DETRY, O., & Castronovo, V. (March 2014). Organized Proteomic Heterogeneity in Colorectal Cancer Liver Metastases and Implications for Therapies. Hepatology, 59 (3), 924-934. doi:10.1002/hep.26608

Lebrun, M., Thelen, N., Thiry, M., Riva, L., Ote, I., Condé, C., Vandevenne, P., Di Valentin, E., BONTEMS, S., & Sadzot-Delvaux, C. (2014). Varicella-zoster virus induces the formation of dynamic nuclear capsid aggregates. Virology, 454-455, 311-27. doi:10.1016/j.virol.2014.02.023

Trussart, C., Orban, T., Sabatel, H., Di Valentin, E., Piette, J., & Habraken, Y. (January 2014). Promotor specific regulation of NF-kappaB mediated transcription by the phosphorylation of p65 on Ser547 [Poster presentation]. Metabolism 2014: Alterations of metabolic pathways as therapeutic targets, Esh-sur-Alzette, Luxembourg.

Condé, C., Rambout, X., Lebrun, M., Lecat, A., Di Valentin, E., Dequiedt, F., Piette, J., Gloire, G., & Legrand, S. (2012). The inositol phosphatase SHIP-1 inhibits NOD2-induced NF-κB activation by disturbing the interaction of XIAP with RIP2. PLoS ONE. doi:10.1371/journal.pone.0041005

Lebrun, M., Riva, L., Ote, I., Vandevenne, P., Di Valentin, E., Thiry, M., BONTEMS, S., & Sadzot-Delvaux, C. (2012). Varicella-Zoster virus (VZV) capsids trapped in PML-bodies: antiviral defense or stress response? [Poster presentation]. GIGA-DAY.

Lecat, A., Di Valentin, E., Somja, J., Jourdan, S., Fillet, M., Kufer, T., Habraken, Y., Sadzot-Delvaux, C., Louis, E., Delvenne, P., Piette, J., & Legrand-Poels, S. (2012). The c-jun N-terminal Kinase (JNK)-binding Protein (JNKBP1) Acts as a Negative Regulator of NOD2 Protein Signaling by Inhibiting Its Oligomerization Process. Journal of Biological Chemistry, 287 (35), 29213-26. doi:10.1074/jbc.M112.355545

Rubio, N., Coupienne, I., Di Valentin, E., Heirman, I., Grooten, J., Piette, J., & Agostinis, P. (2012). Spatiotemporal autophagic degradation of oxidatively damaged organelles after photodynamic stress is amplified by mitochondrial reactive oxygen species. Autophagy, 8 (9), 1312-24. doi:10.4161/auto.20763

Sabatel, H., Di Valentin, E., Gloire, G., Dequiedt, F., Piette, J., & Habraken, Y. (2012). Phosphorylation of p65(RelA) on Ser547 by ATM represses NF-κB-dependent transcription of specific genes after genotoxic stress. PLoS ONE. doi:10.1371/journal.pone.0038246

Riva, L., Lebrun, M., BONTEMS, S., Di Valentin, E., Piette, J., & Sadzot-Delvaux, C. (July 2011). Determination of the biological function of the Varicella Zoster Virus ORF9p [Poster presentation]. 36th Annual International Herpesvirus Workshop / Varicella Zoster Virus satellite meeting, Gdansk, Poland.

Vandevenne, P., Lebrun, M., El Mjiyad, N., Ote, I., Di Valentin, E., Habraken, Y., Dortu, E., Piette, J., & Sadzot-Delvaux, C. (February 2011). The varicella-zoster virus ORF47 kinase interferes with host innate immune response by inhibiting the activation of IRF3. PLoS ONE, 9 (2). doi:10.1371/journal.pone.0016870

Lecat, A., Di Valentin, E., Fillet, M., Piette, J., & Legrand-Poels, S. (27 January 2011). identification of new parterns of the NOD2 protein [Poster presentation]. cell signalomics 2011, Luxembourg, Luxembourg.

Bogaert, P., Naessens, T., De Koker, S., Hennuy, B., Hacha, J., Smet, M., Cataldo, D., Di Valentin, E., Piette, J., Tournoy, K. G., & Grooten, J.-M. (2011). Inflammatory signatures for eosinophilic versus neutrophilic allergic pulmonary inflammation reveal critical regulatory checkpoints. American Journal of Physiology - Lung Cellular and Molecular Physiology, sous presse. doi:10.1152/ajplung.00202.2010

Garbacki, N., Di Valentin, E., Huynh-Thu, V. A., Geurts, P., Irrthum, A., Crahay, C., Arnould, T., Deroanne, C., Piette, J., Cataldo, D., & Colige, A. (2011). MicroRNAs Profiling in Murine Models of Acute and Chronic Asthma: A Relationship with mRNAs Targets. PLoS ONE. doi:10.1371/journal.pone.0016509

Lecat, A., Di Valentin, E., Fillet, M., Rambout, X., Twizere, J.-C., Dequiedt, F., Piette, J., & Legrand-Poels, S. (28 January 2010). NOD2 interactome [Poster presentation]. inflammation 2010, Luxembourg, Luxembourg.

Charlier, E., Condé, C., Zhang, J., Deneubourg, L., Di Valentin, E., Rahmouni, S., Chariot, A., Agostinis, P., Pang, P.-C., Haslam, S., Dell, A., Penninger, J., Erneux, C., Piette, J., & Gloire, G. (2010). SHIP-1 inhibits CD95/APO-1/Fas-induced apoptosis in primary T lymphocytes and T leukemic cells by promoting CD95 glycosylation independently of its phosphatase activity. Leukemia. doi:10.1038/leu.2010.9

Lecat, A., Di Valentin, E., Piette, J., & Legrand-Poels, S. (April 2009). identification of new parterns of the NOD2 protein in an invasion model of intestinal epithelial cells by salmonella typhimurium [Poster presentation]. Biomedica, Liège, Belgium.

Di Valentin, E., Crahay, C., Garbacki, N., Hennuy, B., Guéders, M., Noël, A., Foidart, J.-M., Grooten, J., Colige, A., Piette, J., & Cataldo, D. (February 2009). New asthma biomarkers: lessons from murine models of acute and chronic asthma. American Journal of Physiology - Lung Cellular and Molecular Physiology, 296 (2), 185-97. doi:10.1152/ajplung.90367.2008

Garbacki, N., Di Valentin, E., Piette, J., Cataldo, D., Crahay, C., & Colige, A. (2009). Matrix metalloproteinase 12 silencing: A therapeutic approach to treat pathological lung tissue remodeling? Pulmonary Pharmacology and Therapeutics, 22 (4), 267-278. doi:10.1016/j.pupt.2009.03.001

Habran, L., El Mjiyad, N., Di Valentin, E., Sadzot-Delvaux, C., Bontems, S., & Piette, J. (October 2007). The varicella-zoster virus immediate-early 63 protein affects chromatin-controlled gene transcription in a cell-type dependent manner. BMC Molecular Biology, 8, 99. doi:10.1186/1471-2199-8-99

Vandevenne, P., El Mjiyad, N., Ote, I., Joris-Gerards, A., Di Valentin, E., Bontems, S., Piette, J., & Sadzot-Delvaux, C. (2007). Caractérisation de la réponse immunitaire unnée au virus de la varicelle et du zona (VZV): implication du Toll-like récepteur 3 [Poster presentation]. IXème Journées Francophones de Virologie, Paris, France.

Sadzot-Delvaux, C., Di Valentin, E., & Bontems, S. (2006). Le virus de la varicelle et du zona : un alphaherpesvirus pas vraiment comme les autres. Virologie, 10 (3), 219-232.

Di Valentin, E., Bontems, S., Habran, L., Jolois, O., Markine-Goriaynoff, N., Vanderplasschen, A., Sadzot-Delvaux, C., & Piette, J. (March 2005). Varicella-zoster virus IE63 protein represses the basal transcription machinery by disorganizing the pre-initiation complex. Biological Chemistry, 386 (3), 255-267. doi:10.1515/BC.2005.031

Habran, L., Bontems, S., Di Valentin, E., Sadzot-Delvaux, C., & Piette, J. (2005). Varicella-zoster virus IE63 protein phosphorylation by roscovitine-sensitive cyclin-dependent kinases modulates its cellular localization and activity. Journal of Biological Chemistry, 280 (32), 29135-43. doi:10.1074/jbc.M503312200

Bontems, S., Di Valentin, E., Baudoux, L., Rentier, B., Sadzot-Delvaux, C., & Piette, J. (07 June 2002). Phosphorylation of varicella-zoster virus IE63 protein by casein kinases influences its cellular localization and gene regulation activity. Journal of Biological Chemistry, 277 (23), 21050-21060. doi:10.1074/jbc.M111872200

Bontems, S., Di Valentin, E., Baudoux, L., Sadzot-Delvaux, C., Rentier, B., & Piette, J. (2002). Phosphorylation of varicella-zoster virus IE63 protein by casein kinases influences its cellular localization and gene regulation activity [Poster presentation]. Cell signaling, transcription and translation as therapeutic targets, Luxembourg, Luxembourg.

Hamers, C., Di Valentin, E., Dumont, C., Lambot, M., Joris, E., Genicot, B., & Pastoret, P.-P. (January 2002). Virus neutralising antibodies against 22 bovine viral diarrhoea virus isolates in vaccinated calves. Veterinary Journal, 163 (1), 61-67. doi:10.1053/tvjl.2001.0638

BONTEMS, S., Di Valentin, E., Baudoux, L., Sadzot-Delvaux, C., Rentier, B., & Piette, J. (July 2001). Role of phosphorylation of varicella)zoster virus (VZV) IE63 protein on its cellular localization and activity [Poster presentation]. 26th International Herpesvirus workshop, Regensburg, Germany.

Di Valentin, E., Bontems, S., Baudoux, L., Sadzot-Delvaux, C., Rentier, B., & Piette, J. (July 2001). Cellular localization and regulatory properties of VZV Immediate early proteins in neuronal and non-neuronal cells [Poster presentation]. 26th International Herpesvirus workshop, Regensburg, Germany.

Bontems, S., Di Valentin, E., Baudoux, L., Sadzot-Delvaux, C., Rentier, B., & Piette, J. (2001). Importance de la phosphorylation de la protéine IE63 du virus de la varicelle et di zona (VZV) sur sa localisation et son activité [Poster presentation]. Bioforum, Liège, Belgium.

Hamers, C., Di Valentin, E., Dumont, C., Lambot, M., Joris, E., Genicot, B., & Pastoret, P.-P. (December 2000). Virus Neutralizing Antibodies against a Panel of 18 Bvdv Isolates in Calves Vaccinated with Rispoval Rs-Bvd. Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health, 47 (10), 721-6. doi:10.1046/j.1439-0450.2000.00405.x