Publications and communications of Lucien Bettendorff

Bettendorff, L. (10 July 2023). Synthetic Thioesters of Thiamine: Promising Tools for Slowing Progression of Neurodegenerative Diseases. International Journal of Molecular Sciences, 24, 11296. doi:10.3390/ijms241411296

Bettendorff, L. (01 November 2022). Neuroprotective effects of thiamine and precursors with higher bioavailability: focus on benfotiamine and dibenzoylthiamine [Paper presentation]. Paper presented at invited conference at the Burke Neurological Institute (Cornell University), White Plains,New York, United States.

Probert, F., Gorlova, A., Deikin, A., Bettendorff, L., Veniaminova, E., Nedorubov, A., Chaprov, K. D., Ivanova, T. A., Anthony, D. C., & Strekalova, T. (November 2022). In FUS[1−359]‐tg mice O,S-dibenzoyl thiamine reduces muscle atrophy, decreases glycogen synthase kinase 3 beta, and normalizes the metabolome. Biomedicine and Pharmacotherapy, 156, 113986. doi:10.1016/j.biopha.2022.113986

Bettendorff, L. (September 2022). Reduced Nucleotides, Thiols and O2 in Cellular Redox Balance: a Biochemist’s View. Antioxidants, 11, 1877. doi:10.3390/antiox11101877

Sambon, M., Pavlova, O., Alhama-Riba, J., Wins, P., Brans, A., & Bettendorff, L. (2022). Product inhibition of mammalian thiamine pyrophosphokinase is an important mechanism for maintaining thiamine diphosphate homeostasis. Biochimica et Biophysica Acta - General Subjects, 1866 (3), 130071. doi:10.1016/j.bbagen.2021.130071

Bettendorff, L. (2021). Update on Thiamine Triphosphorylated Derivatives and Metabolizing Enzymatic Complexes. Biomolecules, 11, 1645. doi:10.3390/biom11111645

Bettendorff, L., & Wins, P. (2021). Biochemistry of thiamine and thiamine phosphate compounds. In J. Jez (Ed.), Encyclopedia of Biological Chemistry, 3rd Edition, vol 1 (pp. 302-313). Elsevier. doi:10.1016/B978-0-12-809633-8.21271-5

Pavlova, O., Stepanenko, S., Chehivska, L., Sambon, M., Bettendorff, L., & Parkhomenko, Y. (2021). Thiamine deficiency in rats affects thiamine metabolism possibly through the formation of oxidized thiamine pyrophosphate. Biochimica et Biophysica Acta - General Subjects, 1865, 129980. doi:10.1016/j.bbagen.2021.129980

Sambon, M., Wins, P., & Bettendorff, L. (2021). Neuroprotective Effects of Thiamine and Precursors with Higher Bioavailability: Focus on Benfotiamine and Dibenzoylthiamine. International Journal of Molecular Sciences, 22, 5418. doi:10.3390/ijms22115418

Bettendorff, L. (2020). Chapter 10: Thiamine. In B. P. Marriott, D. F. Birt, V. A. Stallings, ... A. A. Yares, Present Knowledge in Nutrition, 11th Edition, volume 1 (11th Edition). Amsterdam, Netherlands: Elsevier.

Pavlov, D., Gorlova, A., Bettendorff, L., Kalueff, A. A., Umriukhin, A., Proshin, A., Lysko, A., Landgraf, R., Anthony, D. C., & Strekalova, T. (20 April 2020). Enhanced conditioning of adverse memories in the mouse modified swim test is associated with neuroinflammatory changes - effects that are susceptible to antidepressants. Neurobiology of Learning and Memory, 172, 107227. doi:10.1016/j.nlm.2020.107227

Starling-Soares, B., Carrera-Bastos, P., & Bettendorff, L. (April 2020). The role of the synthetic B1 Vitamin sulbutiamine on health - a review. Journal of Nutrition and Metabolism, 2020 (Article ID 9349063), 1-9. doi:10.1155/2020/9349063

Gibson, G. E., Luchsinger, J. A., Cirio, R., Chen, H., Franchino-Elder, J., Hirsch, J. A., Bettendorff, L., Chen, Z., Flowers, S., Gerber, L., Grandville, T., Schupf, N., Xu, H., Stern, Y., Habeck, C., Jordan, B., & Fonzetti, P. (2020). Benfotiamine and cognitive decline in Alzheimer’s disease: Results of a randomized placebo-controlled phase IIa clinical trial. Journal of Alzheimer's Disease, 78, 989-1010. doi:10.3233/JAD-200896

Mouithys-Mickalad, A., Ceusters, J., Charif, M., Elmoualij, B., Schoumacher, M., Plyte, S., Franck, T., Bettendorff, L., Pirotte, B., Serteyn, D., & De Tullio, P. (2020). Modulation of mitochondrial respiration rate and calcium-induced swelling by new cromakalim analogues. Chemico-Biological Interactions, 331, 109272. doi:10.1016/j.cbi.2020.109272

Sambon, M., Gorlova, A., Demelenne, A., Alhama-Riba, J., Coumans, B., Lakaye, B., Wins, P., Fillet, M., Anthony, D. C., Strekalova, T., & Bettendorff, L. (2020). Dibenzoylthiamine has powerful antioxidant and anti-inflammatory properties in cultured cells and in mouse models of stress and neurodegeneration. Biomedicines, 8, 361. doi:10.3390/biomedicines8090361

Veniaminova, E., Oplatchikova, M., Bettendorff, L., Kotenkova, E., Lysko, A., Vasilevskaya, E., Kalueff, A. V., Fedulova, L., Umriukhin, A., Lesch, K.-P., Anthony, D. C., & Strekalova, T. (2020). Prefrontal cortex inflammation and liver pathologies accompany cognitive T and motor deficits following Western diet consumption in non-obese female mice. Life Sciences, 241, 117163. doi:10.1016/j.lfs.2019.117163

Bettendorff, L. (20 August 2019). Current status of research on thiamine: anti-neuroinflammatory and anti-oxidant properties yield new therapeutic perspectives [Paper presentation]. Conférence au “Symposium and Workshop on “Inflammation and oxidative stress in translational research: new models and treatments”.

Gorlova, A., Pavlov, D., Anthony, D. C., Ponomarev, E., Sambon, M., Shafarevich, I., Babaevskaya, D., Proshin, A., Lesch, K.-P., Bettendorff, L., & Strekalova, T. (2019). Thiamine and benfotiamine counteract stress-induced aggression, normalize AMPA receptor expression and plasticity markers, and reduce oxidative stress in mice. Neuropharmacology, 156, 107543. doi:10.1016/j.neuropharm.2019.02.025

Pavlov, D., Bettendorff, L., Gorlova, A., Olkhovik, A., Kalueff, A., Ponomarev, E., Inozemtsev, A., Chekhonin, V., Lesch, K.-P., Anthony, D. C., & Strekalova, T. (2019). Neuroinflammation and aberrant hippocampal plasticity in a mouse model of emotional stress evoked by exposure to ultrasound of alternating frequencies. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 90, 104-116. doi:10.1016/j.pnpbp.2018.11.014

Sambon, M., NAPP, A., Demelenne, A., Vignisse, J., Wins, P., Fillet, M., & Bettendorff, L. (2019). Thiamine and benfotiamine protect neuroblastoma cells against paraquat and ß- amyloid toxicity by a coenzyme-independent mechanism. Heliyon, 5, 01710. doi:10.1016/j.heliyon.2019.e01710

Bakker, J., Balthazart, J., Baron, F., Beguin, Y., Bettendorff, L., Blanpain, C., Bureau, F., Caers, J., Cani, P., Cataldo, D., Cornil, C., Clercx, C., Cloots, R., Colige, A., Daube, G., De Backer, O., de Kerchove d'Exaerde, A., Desmecht, D., Desmet, C., ... Wittamer, V. (2018). La souris, le patient, et le faux expert. Décryptage d'une mystification. Le Vif. L'Express.

Rademaker, G., Hennequière, V., Nokin, M.-J., LOVINFOSSE, P., Durieux, F., GOFFLOT, S., Bellier, J., Costanza, B., Herfs, M., Peiffer, R., Bettendorff, L., Deroanne, C., Thiry, M., Delvenne, P., Hustinx, R., Bellahcene, A., Castronovo, V., & Peulen, O. (April 2018). Myoferlin controls mitochondrial structure and activity in pancreatic ductal adenocarcinoma, and affects tumor aggressiveness. Oncogene, 37 ((32)), 4398-4412. doi:10.1038/s41388-018-0287-z

Rademaker, G., Hennequière, V., Brohée, L., Nokin, M.-J., LOVINFOSSE, P., Durieux, F., Bellier, J., Costanza, B., Herfs, M., Bettendorff, L., Deroanne, C., Delvenne, P., HUSTINX, R., Bellahcene, A., Castronovo, V., & Peulen, O. (2018). Myoferlin controls mitochondrial structure and activity in pancreatic ductal adenocarcinoma and affects tumor aggressiveness [Poster presentation]. Bioforum Uliège.

Rademaker, G., Hennequière, V., Brohée, L., Nokin, M.-J., LOVINFOSSE, P., Durieux, F., GOFFLOT, S., Bellier, J., Costanza, B., Herfs, M., Peiffer, R., Anania, S., Bettendorff, L., Deroanne, C., Thiry, M., Delvenne, P., HUSTINX, R., Bellahcene, A., Castronovo, V., & Peulen, O. (2018). Myoferlin controls mitochondrial structure and activity in pancreatic cancer and affects tumor aggressiveness [Poster presentation]. Belgian Association for Cancer Research Congress.

Tapias, V., Jainuddin, S., Ahuja, M., Stack, C., Elipenahli, C., Vignisse, J., Gerges, M., Starkova, N., Xu, H., Starkov, A. A., Bettendorff, L., Hushpulian, D. M., Smirnova, N. A., Gazaryan, I. G., Kaidery, N. A., Wakade, S., Calingasan, N. Y., Thomas, B., Gibson, G. E., ... Beal, M. F. (2018). Benfotiamine Treatment Activates the Nrf2/ARE Pathway and is Neuroprotective in a Transgenic Mouse Model of Tauopathy. Human Molecular Genetics, 27 (16), 2874-2892. doi:10.1093/hmg/ddy201

Whitfield, K. C., Bourassa, M. W., Adamolekun, B., Bergeron, G., Bettendorff, L., Brown, K. H., Cox, L., Fattal-Valevski, A., Fischer, P. R., Frank, E. L., Hiffler, L., Hlaing, L. M., Jefferds, M. E., Kapner, H., Kounnavong, S., Mousavi, M. P. S., Roth, D. E., Tsaloglou, M.-N., Wieringa, F., & Combs, G. F. J. (2018). Thiamine deficiency disorders: diagnosis, prevalence, and a roadmap for global control programs. Annals of the New York Academy of Sciences, 1430, 3-43. doi:10.1111/nyas.13919

Amorim, C., Andris, F., Arckens, L., Arnould, T., Aron, S., Bakker, J., Balligand, M., Balthazart, J., Baron, F., Beck, B., Beguin, Y., Behets, C., Bellefroid, E., Bertrand, L., Bettendorff, L., Bindels, L., Blankert, B., Blanpain, C., Bondue, A., ... Wittamer, V. (2017). L’expérimentation animale reste indispensable (OPINION). La Libre Belgique.

Rademaker, G., Hennequière, V., Brohée, L., Nokin, M.-J., LOVINFOSSE, P., Durieux, F., GOFFLOT, S., Bellier, J., Costanza, B., Herfs, M., Peiffer, R., Bettendorff, L., Deroanne, C., Delvenne, P., Hustinx, R., Bellahcene, A., Castronovo, V., & Peulen, O. (22 September 2017). Myoferlin controls mitochondrial structure in pancreatic ductal adenocarcinoma, and affects tumor aggressiveness [Poster presentation]. Second U-CRC Symposium, Bruxelles, Belgium.

Hendrick, E., Peixoto, P., Blomme, A., Polese, C., Matheus, N., Cimino, J., Frère, A., Mouithys-Mickalad, A., Serteyn, D., Bettendorff, L., Elmoualij, B., De Tullio, P., Eppe, G., Dequiedt, F., Castronovo, V., & Mottet, D. (2017). Metabolic inhibitors accentuate the anti-tumoral effect of HDAC5 inhibition. Oncogene. doi:10.1038/onc.2017.103

Bettendorff, L. (26 January 2017). Thiamine, biological forms and function [Paper presentation]. Technical Consultation on Global Prevalence and Disease Burden of Thiamine Deficiency – Workshop 1, New York, United States.

Bettendorff, L. (2017). Thiamine: Biological forms and function [Paper presentation]. Technical consultation on global prevalence and disease burden of thiamine deficiency - workshop 1, New York, United States.

Markova, N.* , Bazhenova, N.* , Anthony, D. C., Vignisse, J., Svistunov, A., Lesch, K.-P., Bettendorff, L.* , & Strekalova, T.*. (2017). Thiamine and benfotiamine improve cognition and ameliorate GSK-3β-associated stressinduced behaviours in mice. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 75, 148-156. doi:10.1016/j.pnpbp.2016.11.001

Markova, N., Shevtsova, S., Vignisse, J., Zubareva, O., Anthony, D., Bettendorff, L., Lesch, K., & Strekalova, T. (2017). Modified swim test as a model of enhanced contextual conditioning during depression: expression of GSK3 beta and effects of antidepressant treatment [Poster presentation]. 12th Göttingen Meeting of the German Neuroscience Society, Göttingen, Germany.

Pavlov, D., Markova, N., Bettendorff, L., Chekhonin, V., Pomytkin, I., Lioudyno, V., Svistunov, A., Ponomarev, E., Lesch, K.-P., & Strekalova, T. (2017). Elucidating the functions of brain GSK3α: possible synergy with GSK3β upregulation and reversal by antidepressant treatment in a mouse model of depressive-like behaviour. Behavioural Brain Research, 335, 122-127. doi:10.1016/j.bbr.2017.08.018

Sambon, M., Wins, P., & Bettendorff, L. (2017). Thiamine and lipophilic thiamine precursors protect against oxidative damage in cultured neuroblastoma cells [Poster presentation]. 12th National Congress of the Belgian Society for Neuroscience, Ghent, Belgium. doi:10.3389/conf.fnins.2017.94.00102

Sambon, M., Wins, P., & Bettendorff, L. (2017). Dibenzoylthiamine, a lipophilic thiamine precursor, protects against oxidative damage in neuroblastoma cells [Poster presentation]. ISN-ESN Biennal Meeting, Paris, France.

Tapias, V., Jainuddin, S., Ahuja, M., Stack, C., Elipenahli, C., Vignisse, J., Gerges, M., Starkova, N., Xu, H., Starkov, A. A., Bettendorff, L., Hushpulian, D. M., Smirnova, N. A., Gazaryan, I. G., Kaidery, N. A., Wakade, S., Calingasan, N. Y., Thomas, B., Gibson, G. E., ... Beal, F. M. (2017). Benfotiamine Treatment Activates Nrf2/ARE Pathway and is Neuroprotective in a Transgenic Mouse Model of Tauopathy [Poster presentation]. 47th Annual Meeting 2017 of the Society for Neuroscience, Washington DC, United States.

Vignisse, J., Sambon, M., Gorlova, A., Pavlov, D., Caron, N., Malgrange, B., Shevtsova, E., Svistunov, A., Anthony, D. C., Markova, N., Bazhenova, N., Coumans, B., Lakaye, B., Wins, P., Strekalova, T., & Bettendorff, L. (2017). Thiamine and benfotiamine prevent stress-induced suppression of hippocampal neurogenesis in mice exposed to predation without affecting brain thiamine diphosphate levels. Molecular and Cellular Neuroscience, 82, 126-136. doi:10.1016/j.mcn.2017.05.005

Bunik, V., Mkrtchyan, G., Grabarska, A., Oppermann, H., Daloso, D., Araujo, W. L., Juszczak, M., Rzeski, W., Bettendorff, L., Fernie, A. R., Meixensberger, J., Stepulak, A., & Gaunitz, F. (March 2016). Inhibition of mitochondrial 2-oxoglutarate dehydrogenase impairs viability of cancer cells in a cell-specific metabolismdependent manner. Oncotarget, 7 (26400), 26421. doi:10.18632/oncotarget.8387

Mkrtchyan, G., Graf, A., Bettendorff, L., & Bunik, V. (2016). Cellular thiamine status is coupled to function of mitochondrial 2-oxoglutarate dehydrogenase. Neurochemistry International, 101, 66-75. doi:10.1016/j.neuint.2016.10.009

Mkrtchyan, G., Aleshin, V., Parkhomenko, Y., Kaehne, T., Di Salvo, M. L., Parroni, A., Contestabile, R., Vovk, A., Bettendorff, L., & Bunik, V. (2015). Molecular mechanisms of the non-coenzyme action of thiamin in brain: biochemical, structural and pathway analysis. Scientific Reports, 5, 12583. doi:10.1038/srep12583

Bettendorff, L., Lakaye, B., Kohn, G., & Wins, P. (25 May 2014). In search of a physiological role for thiamine triphosphate and the 25-kDa thiamine triphosphatase [Paper presentation]. 8th International Conference on Thiamine: From Catalysis to Pathology, Liège, Belgium.

Kohn, G., Ectors, F., Lakaye, B., & Bettendorff, L. (May 2014). 25KDa-Thiamine triphosphatase is essential for spermatozoid development in mice [Poster presentation]. 8th International Conference on Thiamine: From Catalysis to Pathology, Liège, Belgium.

Markova, N., Shevtsova, E., Vignisse, J., Zubareva, O., Trofimov, A., Steinbusch, H., Bachurin, S., Bettendorff, L., & Strekalova, T. (May 2014). Thiamine and benfotiamine improve memory, decrease depressive-like behavior and reduce brain expression of GSK3 beta in mice [Poster presentation]. 8th International Conference on Thiamine: From Catalysis to Pathology, Liège, Belgium.

Vignisse, J., Caron, N., Malgrange, B., & Bettendorff, L. (May 2014). Benfotiamine increases cell proliferation in adult mouse hippocampus [Poster presentation]. 8th International Conference on Thiamine: From Catalysis to Pathology, Liège, Belgium.

Bettendorff, L. (2014). Chapter 7: Thiamine. In J. Zemplini, J. W. Suttie, J. F. Gregory, ... P. J. Stover (Eds.), Handbook of Vitamins, 5th Edition (5th Edition, pp. 267-323). CRC Press Taylor & Francis Group.

Bettendorff, L., & Wins, P. (2014). Thiamine triphosphate: a ubiquitous molecule in search of a physiological role. Metabolic Brain Disease, 29, 1069-1082. doi:10.1007/s11011-014-9509-4

Vignisse, J., Steinbusch, H. W. M., Grigoriev, V., Bolkunov, A., Prochin, A., Bettendorff, L., Bachurin, S., & Strekalova, T. (2014). Concomitant manipulation of NMDA- and AMPA-receptors to produce pro-cognitive drug effects. European Neuropsychopharmacology, 24, 309-320. doi:10.1016/j.euroneuro.2013.06.010

Bettendorff, L., & Wins, P. (May 2013). Biological functions of thiamine derivatives: Focus on non-coenzyme roles. OA Biochemistry, 1 (1), 10.

Bettendorff, L., & Wins, P. (2013). Biochemistry of thiamine and thiamine phosphate compounds. In W. J. Lennarz & M. D. Lane (Eds.), The Encyclopedia of Biological Chemistry, vol 1 (2nd edition, pp. 202-209). Waltham, United States - Massachusetts: Academic Press.

Bunik, Parkhomenko, Y., Kaehne, T., Mkrtchyan, G., Vovk, A., & Bettendorff, L. (March 2013). Thiamine and thiazolium binding proteome includes DJ-1, amyloid beta and several membrane proteins [Poster presentation]. AD/PD 2013 - The 11th International Conference on Alzheimer's & Parkinson's Diseases, Florence, Italy.

Bettendorff, L., & Wins, P. (2013). Thiamine triphosphatase and the CYTH family of proteins. FEBS Journal, 280 (24), 6443–6455.

Delvaux, D., Kerff, F., Murty, M. R. V. S., Lakaye, B., Czerniecki, J., Kohn, G., Wins, P., Herman, R., Gabelica, V., Heuze, F., Tordoir, X., Marée, R., Matagne, A., Charlier, P., De Pauw, E., & Bettendorff, L. (2013). Structural Determinants of Specificity and Catalytic Mechanism in mammalian 25-kDa Thiamine Triphosphatase. Biochimica et Biophysica Acta - General Subjects, 1830, 4513-4523. doi:10.1016/j.bbagen.2013.05.014

Gigliobianco, T., GANGOLF, M., Lakaye, B., Pirson, B., von Ballmoos, C., Wins, P., & Bettendorff, L. (January 2013). An alternative role of FoF1-ATP synthase in Escherichia coli: synthesis of thiamine triphosphate. Scientific Reports, 3 (1071). doi:10.1038/srep01071

Graf, A., Trofimova, L., Loshinskaja, A., Mkrtchyan, G., Strokina, A., Lovat, M., Tylicki, A., Strumilo, S., Bettendorff, L., & Bunik, V. I. (2013). Up-regulation of 2-oxoglutarate dehydrogenase as a stress response. International Journal of Biochemistry and Cell Biology, 45, 175-189. doi:10.1016/j.biocel.2012.07.002

Kohn, G., Delvaux, D., Lakaye, B., Servais, A.-C., Scholer, G., Fillet, M., Elias, B., Derochette, J.-M., Crommen, J., Wins, P., & Bettendorff, L. (12 September 2012). High inorganic triphosphatase activities in bacteria and mammalian cells: Identification of the enzymes involved. PLoS ONE, 7 (9), 43879. doi:10.1371/journal.pone.0043879

Theatre, E., Frederix, K., Guilmain, W., Delierneux, C., Lecut, C., Bettendorff, L., BOURS, V., & Oury, C. (August 2012). Overexpression of CD39 in mouse airways promotes bacteria induced inflammation. Journal of Immunology, 189 (4), 1966-1974. doi:10.4049/jimmunol.1102600

Vignisse, J., Steinbusch, H. W. M., Griegoriev, V., Bettendorff, L., Bolkunov, A., Nunes, J., Bachurin, S., & Strekalova, T. (17 July 2012). Simultaneous versus solitary pharmacological manipulation of NMDA- and AMPA- receptors: effects of new drugs on contextual learning and its extinction [Paper presentation]. 8th FENS Forum of Neuroscience, Barcelona, Spain.

Bettendorff, L. (2012). Chapter 17: Thiamin. In J. W. Erdman, Jr, I. A. MacDonald, ... S. H. Zeisel (Eds.), Present Knowledge in Nutrition (10th Edition, pp. 261-279). Blackwell Publishing Ltd.

Bettendorff, L. (2012). Thiamine : a link with Alzheimer’s disease ? [Paper presentation]. invited conference at the School for Mental Health and Neuroscience, University of Maastricht, Maastricht, Netherlands.

Bettendorff, L. (2012). Chapter 5: The chemistry, biochemistry and metabolism of thiamin (vitamin B1). In V. R. Preedy (Ed.), B Vitamins and Folate: Chemistry, Analysis, Function and Effects (pp. 71-92). Cambridge, United Kingdom: RSC Publishing. doi:10.1039/ 9781849733694

Bettendorff, L. (2012). Chapter 17: Thiamin (E-book). In J. W. Erdman, Jr, I. A. MacDonald, ... S. H. Zeisel (Eds.), Present Knowledge in Nutrition (E-book) (10th Edition, pp. 435-465). Wiley-Blackwell.

Bettendorff, L., Delvaux, D., Kohn, G., Wins, P., & Lakaye, B. (2012). Molecular evolution of the CYTH superfamily of proteins [Poster presentation]. 22nd IUBMB & 37th FEBS Congress, Seville, Spain, September 4-9, 2012, Sevilla, Spain.

Hills, J. I., Golub, M. S., Bettendorff, L., & Keen, C. L. (2012). The effect of thiamin tetrahydrofurfuryl disulfide on behavior of juvenile DBA/2J mice. Neurotoxicology and Teratology, 34, 242-252. doi:10.1016/j.ntt.2011.07.006

Trofimova, L. K., Araùjo, W. L., Strokina, A. A., Fernie, A. R., Bettendorff, L., & Bunik, V. I. (2012). Consequences of the α-Ketoglutarate Dehydrogenase Inhibition for Neuronal Metabolism and Survival: Implications for Neurodegenerative Diseases. Current Medicinal Chemistry, 19, 5895-5906. doi:10.2174/092986712804143367

Binet, A., Delvaux, D., & Bettendorff, L. (2011). Une invitée surprise.

Vignisse, J., Liégeois, J.-F., Wins, P., & Bettendorff, L. (July 2011). Thiamin derivatives in the brain of a mouse model of Alzheimer's disease and in cultured Neuroblastoma cells treated with benfotiamine [Poster presentation]. FENS/IBRO Summer School 2011: Metabolic Aspects of Chronic Brain Diseases, Gunzburg, Germany.

Bettendorff, L. (2011). Unusual thiamine derivatives : Clues to non-cofactor roles of thiamine in prokaryote and eukaryote cell function [Paper presentation]. Invited conference at the Institut des Sciences de la Vie (ISV), Université Catholique de Louvain, Louvain-la-Neuve, Belgium.

Bettendorff, L. (2011). Dérivés triphosphorylés inhabituels à l’interface entre le métabolisme des nucléotides et le métabolisme énergétique des cellules [Paper presentation]. Invited conference at the Institut de Génétique et Microbiologie, Université Paris-Sud XI, Orsay, France.

Delvaux, D., Murty, M. R. V. S., Gabelica, V., Lakaye, B., Lunin, V. V., Skarina, T., Onopriyenko, O., Kohn, G., Wins, P., De Pauw, E., & Bettendorff, L. (2011). A specific inorganic triphosphatase from Nitrosomonas europaea: structure and catalytic mechanism. Journal of Biological Chemistry, 286, 34023-34035. doi:10.1074/jbc.M111.233585

Gangolf, M., Czerniecki, J., Radermecker, M., Detry, O., NISOLLE, M., JOUAN, C., Martin, D., Chantraine, F., Lakaye, B., Wins, P., Grisar, T., & Bettendorff, L. (October 2010). Thiamine Status in Humans and Content of Phosphorylated Thiamine Derivatives in Biopsies and Cultured Cells. PLoS ONE, 5 (10), 13616. doi:10.1371/journal.pone.0013616

Gigliobianco, T., Lakaye, B., Wins, P., Elmoualij, B., Zorzi, W., & Bettendorff, L. (May 2010). Adenosine thiamine triphosphate accumulates in Escherichia coli cells in response to specific conditions of metabolic stress. BMC Microbiology, 10, 148. doi:10.1186/1471-2180-10-148

Bettendorff, L. (2010). Synthesis of thiamine triphosphate in brain mitochondria and E. coli: possible role of FoF1-ATPase [Paper presentation]. Invited conference at the MRC Mitochondrial Biology Unit (Director John Walker, Prix Nobel de Chimie 1997), Cambridge, United Kingdom.

Gangolf, M., Wins, P., Thiry, M., Elmoualij, B., & Bettendorff, L. (2010). Thiamine triphosphate synthesis in rat brain occurs in mitochondria and is coupled to the respiratory chain. Journal of Biological Chemistry, 285, 583-594. doi:10.1074/jbc.M109.054379

Bettendorff, L. (2009). Thiamine triphosphate and adenosine thiamine triphosphate: metabolism and physiological significance [Paper presentation]. The 2nd International Workshop-Cum-Training Course on Molecular Medicine and Drug Research, Karachi, Pakistan.

Bettendorff, L., & Wins, P. (2009). Thiamin diphosphate in biological chemistry: new aspects of thiamin metabolism, especially triphosphate derivatives acting other than as cofactors. FEBS Journal, 276 (11), 2917-2925. doi:10.1111/j.1742-4658.2009.07019.x

Frederich, M., Delvaux, D., Gigliobianco, T., GANGOLF, M., Dive, G., Mazzucchelli, G., Elias, B., De Pauw, E., Angenot, L., Wins, P., & Bettendorff, L. (2009). Thiaminylated adenine nucleotides — chemical synthesis, structural characterization and natural occurrence. FEBS Journal, 276 (12), 3256–3268. doi:10.1111/j.1742-4658.2009.07040.x

Bettendorff, L. (2008). Thiamine phosphate derivatives at the interface of cell bioenergetics and nucleotide metabolism: potential implications in aging and neurodegeneration [Paper presentation]. Invited conference at the CNCM Meeting : Towards the discovery of Basic Mechanisms of Neurological Diseases, Liège, Belgium.

Bettendorff, L. (2008). A tale of two molecules : on the physiological significance of thiamine triphosphate and adenosine thiamine triphosphate [Paper presentation]. The 7th International Conference on Mechansims and Physiology of Thiamine, Wittenberg, Germany.

Gangolf, M., Wins, P., Thiry, M., & Bettendorff, L. (2008). Evidence for a mitochondrial synthesis of thiamine triphosphate in the rat brain [Paper presentation]. 7th International Conference on mechanisms and physiology of thiamine, Lutherstadt Wittenburg, Germany.

Gigliobianco, T., Lakaye, B., Makarchikov, A. F., Wins, P., & Bettendorff, L. (2008). Adenylate Kinase-Independent Thiamine Triphosphate Accumulation under Severe Energy Stress in Escherichia Coli. BMC Microbiology, 8, 16. doi:10.1186/1471-2180-8-16

Song, J., Bettendorff, L., Tonelli, M., & Markley, J. L. (2008). Structural basis for the catalytic mechanism of mammalian 25 kDa thiamine triphosphatase. Journal of Biological Chemistry, 283, 10939-10948. doi:10.1074/jbc.M709675200

Theatre, E., de Leval, L., Bettendorff, L., Bours, V., & Oury, C. (2008). Overexpression of airway CD39 in transgenic mice enhances lipopolysaccharide-induced inflammation. Purinergic Signalling, 4, 113.

Volvert, M.-L., Seyen, S., Piette, M., Evrard, B., Gangolf, M., Plumier, J.-C., & Bettendorff, L. (2008). Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives. BMC Pharmacology, 8, 10. doi:10.1186/1471-2210-8-10

Bettendorff, L. (2007). Thiamine triphosphate and adenosine thiamine triphosphate: New signals in bacterial stress response ? [Paper presentation]. Minisymposium: Biosynthesis of Vitamine, Brussels, Belgium.

Bettendorff, L. (2007). New evidence for a non-cofactor role of thiamine phosphate derivatives [Paper presentation]. Invited conference at the Katholieke Universiteit Leuven, Department of molecular Cell Biology, Leuven, Belgium.

Bettendorff, L. (2007). At the crossroad of thiamine degradation and biosynthesis. Nature Chemical Biology, 3 (8), 454-455. doi:10.1038/nchembio0807-454

Bettendorff, L., Wirtzfeld, B., Makarchikov, A. F., Mazzucchelli, G., Frederich, M., Gigliobianco, T., Gangolf, M., De Pauw, E., Angenot, L., & Wins, P. (2007). Discovery of a natural thiamine adenine nucleotide. Nature Chemical Biology, 3 (4), 211-212. doi:10.1038/nchembio867

Makarchikov, A. F., Brans, A., & Bettendorff, L. (2007). Thiamine Diphosphate Adenylyl Transferase from E. Coli: Functional Characterization of the Enzyme Synthesizing Adenosine Thiamine Triphosphate. BMC Biochemistry, 8, 17. doi:10.1186/1471-2091-8-17

Szyniarowski, P., Bettendorff, L., & Schweingruber, M. E. (2006). The antitrypanosomal drug melarsoprol competitively inhibits thiamin uptake in mouse neuroblastoma cells. Cell Biology and Toxicology, 22 (3), 183-187. doi:10.1007/s10565-006-0034-z

Makarchikov, A. F., & Bettendorff, L. (2005). Distrribution of specific thiamine triphosphatase in biological objects. News of Biomedical Sciences, 2, 55-60.

Szyniarowski, P., Lakaye, B., Czerniecki, J., Makarchikov, A. F., Wins, P., Margineanu, I., Coumans, B., Grisar, T., & Bettendorff, L. (2005). Pig tissues express a catalytically inefficient 25-kDa thiamine triphosphatase: Insight in the catalytic mechanisms of this enzyme. Biochimica et Biophysica Acta - General Subjects, 1725 (1), 93-102. doi:10.1016/j.bbagen.2005.05.026

Bettendorff, L. (2004). Thiamine triphosphate from bacteria to mammals : a new molecule involved in stress response [Paper presentation]. Invited conference at the Forschungszentrum Juelich (Allemagne), Institut für Biotechnologie und Institut für Molekulare Enzymtechnologie, Juelich, Germany.

Bettendorff, L. (2004). Le triphosphate de thiamine : une nouvelle molécule de signalisation ? [Paper presentation]. Invited Conference at the University of Luxembourg, Campus Limpertsberg, Luxembourg, Luxembourg.

Bettendorff, L., & Wins, P. (2004). New perspectives on the cellular role of thiamine triphosphate and thiamine triphosphatase. In M. S. Patel & F. Jordan (Eds.), Thiamine: catalytic mechanisms and role in normal and disease states (pp. 43-56). New York, United States: Maecel Dekker.

Czerniecki, J., Chanas, G., Verlaet, M., Bettendorff, L., Makarchikov, A. F., Leprince, P., Wins, P., Grisar, T., & Lakaye, B. (2004). Neuronal localization of the 25-kDa specific thiamine triphosphatase in rodent brain. Neuroscience, 125 (4), 833-840. doi:10.1016/j.neuroscience.2004.02.033

Lakaye, B., Makarchikov, A. F., Wins, P., Margineanu, I., Roland, S., Lins, L., Aichour, R., Lebeau, L., Elmoualij, B., Zorzi, W., Coumans, B., Grisar, T., & Bettendorff, L. (2004). Human recombinant thiamine triphosphatase: purification, secondary structure and catalytic properties. International Journal of Biochemistry and Cell Biology, 36 (7), 1348-1364. doi:10.1016/j.biocel.2003.11.013

Lakaye, B., Verlaet, M., Dubail, J., Czerniecki, J., Bontems, S., Makarchikov, A. F., Wins, P., Piette, J., Grisar, T., & Bettendorff, L. (2004). Expression of 25 kDa thiamine triphosphatase in rodent tissues using quantitative PCR and characterization of its mRNA. International Journal of Biochemistry and Cell Biology, 36 (10), 2032-2041. doi:10.1016/j.biocel.2004.03.004

Lakaye, B., Wirtzfeld, B., Wins, P., Grisar, T., & Bettendorff, L. (2004). Thiamine triphosphate, a new signal required for optimal growth of Escherichia coli during amino acid starvation. Journal of Biological Chemistry, 279 (17), 17142-17147. doi:10.1074/jbc.M313569200

Makarchikov, A. F., & Bettendorff, L. (2004). A study of the quantitative content of thiamine triphosphate in different biological objects by high-performance liquid chromatography. News of Biomedical Sciences, 2, 70-76.

Bettendorff, L., Nghiem, H. O., Wins, P., & Lakaye, B. (2003). A general method for the chemical synthesis of gamma-P-32-labeled or unlabeled nucleoside 5 '-triphosphates and thiamine triphosphate. Analytical Biochemistry, 322 (2), 190-197. doi:10.1016/j.ab.2003.08.013

Makarchikov, A. F., Lakaye, B., Gulyai, I. E., Czerniecki, J., Coumans, B., Wins, P., Grisar, T., & Bettendorff, L. (2003). Thiamine triphosphate and thiamine triphosphatase activities: from bacteria to mammals. Cellular and Molecular Life Sciences, 60 (7), 1477-1488. doi:10.1007/s00018-003-3098-4

Nguyen, L., Malgrange, B., Breuskin, I., Bettendorff, L., Moonen, G., Belachew, S., & Rigo, J.-M. (2003). Autocrine/paracrine activation of the GABA(A) receptor inhibits the proliferation of neurogenic polysialylated neural cell adhesion molecule-positive (PSA-NCAM+) precursor cells from postnatal striatum. Journal of Neuroscience, 23 (8), 3278-94. doi:10.1523/jneurosci.23-08-03278.2003

Ruelle, V., Zorzi, W., Elmoualij, B., Pierard, O., Heinen, E., Lakaye, B., Bettendorff, L., Rees, J., Voorhees, K., & De Pauw, E. (2003). Fingerprint matching of genetically modified E.coli strains by MALDI-TOF Mass Spectrometry of whole cells using a k-nearest-neighbors approach [Poster presentation]. 8th Conference on Food Microbiology. 19-20 Juin 2003. Liège – Belgique.

Wins, P., Margineanu, I., Penelle, J., Angenot, L., Grisar, T., & Bettendorff, L. (2003). Bisindole alkaloids from Strychnos guianensis are effective antagonists of nicotinic acetylcholine receptors in cultured human TE671 cells. Naunyn-Schmiedeberg's Archives of Pharmacology, 367 (3), 253-259. doi:10.1007/s00210-003-0692-9

Bettendorff, L. (2002). Relevance of molecular biology to Psychopharmacology [Paper presentation]. Euron courses 2002, Workshop on Psychoimmunology, Psychoendodrinology & Psychopharmacology, Kerkgrade, Netherlands.

Bettendorff, L. (2002). New perspectives on the cellular role of thiamine triphosphate and thiamine triphosphatase [Paper presentation]. International Conference on Thiamin, its Biochemistry and structural Biology, Newark, United States.

Bettendorff, L., Lakaye, B., Margineanu, I., Grisar, T., & Wins, P. (2002). ATP-driven, Na(+)-independent inward Cl- pumping in neuroblastoma cells. Journal of Neurochemistry, 81 (4), 792-801. doi:10.1046/j.1471-4159.2002.00858.x

Lakaye, B., Makarchikov, A. F., Antunes, A. F., Zorzi, W., Coumans, B., De Pauw, E., Wins, P., Grisar, T., & Bettendorff, L. (2002). Molecular characterization of a specific thiamine triphosphatase widely expressed in mammalian tissues. Journal of Biological Chemistry, 277 (16), 13771-13777. doi:10.1074/jbc.M111241200

Makarchikov, A. F., Luchko, A. A., Bettendorff, L., Lakaye, B., & Wins, P. (2002). Study of the role of ionogenic amino-acid residues in catalytic activity of thiamine triphosphatase from bovine kidney by means of chemical modification. News of Biomedical Sciences, 3, 66-70.

Makarchikov, A. F., Wins, P., Janssen, E., Wieringa, B., Grisar, T., & Bettendorff, L. (2002). Adenylate kinase 1 knockout mice have normal thiamine triphosphate levels. BBA Molecular Cell Research, 1592 (2), 117-121. doi:10.1016/S0167-4889(02)00277-X

Nghiêm, H. O., Bettendorff, L., & Changeux, J.-P. (2000). Specific phosphorylation of Torpedo 43 rapsyn by endogenous kinase(s) with thiamine triphosphate as the phosphate donor. FASEB Journal, 14, 543-554. doi:10.1096/fasebj.14.3.543

Bettendorff, L. (1999). Thiamine triphosphate, a new modulator of protein activity [Paper presentation]. 1st EURON symposium "Neuroscience at eight Euregio Universities", Maastricht, Netherlands.

Bettendorff, L., & Wins, P. (1999). Thiamine derivatives in excitable tissues: Metabolism, deficiency and neurodegenerative diseases. In S. G. Pandalai (Ed.), Recent Research Developments in Neurochemistry, vol 2, part 1 (pp. 37-62). Trivandrum, India: Research Signpost.

Grisar, T., Lakaye, B., Thomas, E., Bettendorff, L., & Minet, A. (1999). The Molecular Neuron-Glia Couple and Epileptogenesis. Advances in Neurology, 79, 591-602.

Grisar, T., Lakaye, B., Thomas, E., Bettendorff, L., & Minet, A. (1999). The molecular neuron-glia couple and epileptogenesis. In A. V. Delgado-Escueta, W. A. Wilson, R. W. Olsen, ... R. J. Porter (Eds.), Jasper's Basic Mechanisms of the Epilepsies, 3rd edition. Philadelphia, United States - Pennsylvania: Lippincott Williams & Wilkins.

Bettendorff, L. (1997). Low thiamine status in human brain: a post-mortem study in control and demented patients [Paper presentation]. Joint Meeting of the International Society for Neurochemistry and the American Society for Neurochemistry, Boston, United States.

Bettendorff, L., Goessens, G., & Sluse, F. (1997). Reversibility of thiamine deficiency-induced partial necrosis and mitochondrial uncoupling by addition of thiamine to neuroblastoma cell suspensions. Molecular and Cellular Biochemistry, 174 (1-2), 121-4. doi:10.1023/A:1006842609998

Bettendorff, L., Mastrogiacomo, F., Wins, P., Kish, S. J., Grisar, T., & Ball, M. J. (1997). Low Thiamine Diphosphate Levels in Brains of Patients with Frontal Lobe Degeneration of the Non-Alzheimer's Type. Journal of Neurochemistry, 69 (5), 2005-2010. doi:10.1046/j.1471-4159.1997.69052005.x

Bettendorff, L. (1996). A Non-Cofactor Role of Thiamine Derivatives in Excitable Cells? Archives of Physiology and Biochemistry, 104 (6), 745-751. doi:10.1076/apab.104.6.745.12916

Bettendorff, L., Mastrogiacomo, F., Kish, S. J., & Grisar, T. (1996). Thiamine, Thiamine Phosphates, and Their Metabolizing Enzymes in Human Brain. Journal of Neurochemistry, 66 (1), 250-8. doi:10.1046/j.1471-4159.1996.66010250.x

Bettendorff, L., Mastrogiacomo, F., LaMarche, J., Dozic, S., & Kish, S. J. (1996). Brain Levels of Thiamine and Its Phosphate Esters in Friedreich's Ataxia and Spinocerebellar Ataxia Type 1. Movement Disorders, 11 (4), 437-439. doi:10.1002/mds.870110415

Bettendorff, L., Sallanon-Moulin, M., Touret, M., Wins, P., Margineanu, I., & Schoffeniels, E. (1996). Paradoxical Sleep Deprivation Increases the Content of Glutamate and Glutamine in Rat Cerebral Cortex. Sleep, 19 (1), 65-71. doi:10.1093/sleep/19.1.65

Mastrogiacomo, F., Bettendorff, L., Grisar, T., & Kish, S. J. (1996). Brain thiamine, its phosphate esters, and its metabolizing enzymes in Alzheimer's disease. Annals of Neurology, 39, 585-591. doi:10.1002/ana.410390507

Mastrogiacomo, F., LaMarche, J., Dozic, S., Lindsay, G., Bettendorff, L., Robitaille, Y., Schut, L., & Kish, S. J. (1996). Immunoreactive levels of α-ketoglutarate dehydrogenase subunits in Friedreich's ataxia and spinocerebellar ataxia type 1. Neurodegeneration: A Journal for Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration, 5, 27-33. doi:10.1006/neur.1996.0004

Mastrogiacomo, F., Lindsay, J. G., Bettendorff, L., Rice, J., & Kish, S. J. (1996). Brain protein and alpha-ketoglutarate dehydrogenase complex activity in Alzheimer's disease. Annals of Neurology, 39, 592-598. doi:10.1002/ana.410390508

Bettendorff, L. (1995). Thiamine Homeostasis in Neuroblastoma Cells. Neurochemistry International, 26 (3), 295-302. doi:10.1016/0197-0186(94)00123-C

Bettendorff, L. (1995). La thiamine et ses dérivés dans le métabolisme, l'excitabilité et les processus abiotrophiques des cellules nerveuses [Post doctoral thesis, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/126931

Bettendorff, L. (1995). A non-cofactor role of thiamine and its derivatives in excitable cells [Paper presentation]. International Symposium: The Land of Bioelectrogenesis Revisited, Liege, Belgium.

Bettendorff, L., Goessens, G., Sluse, F., Wins, P., Bureau, M., Laschet, J., & Grisar, T. (1995). Thiamine Deficiency in Cultured Neuroblastoma Cells: Effect on Mitochondrial Function and Peripheral Benzodiazepine Receptors. Journal of Neurochemistry, 64 (5), 2013-2021. doi:10.1046/j.1471-4159.1995.64052013.x

Bettendorff, L., Margineanu, I., Wins, P., & Grisar, T. (1995). An Atypical Anion Transporter Functioning at Acid pH in Neuroblastoma Cells. Biochemical and Biophysical Research Communications, 207 (1), 375-381. doi:10.1006/bbrc.1995.1198

Bettendorff, L., Sluse, F., Goessens, G., Wins, P., & Grisar, T. (1995). Thiamine Deficiency--Induced Partial Necrosis and Mitochondrial Uncoupling in Neuroblastoma Cells Are Rapidly Reversed by Addition of Thiamine. Journal of Neurochemistry, 65 (5), 2178-2184. doi:10.1046/j.1471-4159.1995.65052178.x

Bettendorff, L. (1994). Transport and metabolism of thiamine [Paper presentation]. Invited Conference et the Laboratory of Microbiology (Prof. M.E. Schweingruber), Bern, Switzerland.

Bettendorff, L. (1994). Thiamine in Excitable Tissues: Reflections on a Non-Cofactor Role. Metabolic Brain Disease, 9 (3), 183-209. doi:10.1007/BF01991194

Bettendorff, L. (1994). The Compartmentation of Phosphorylated Thiamine Derivatives in Cultured Neuroblastoma Cells. Biochimica et Biophysica Acta, 1222 (1), 7-14. doi:10.1016/0167-4889(94)90019-1

Bettendorff, L., Hennuy, B., De Clerck, A., & Wins, P. (1994). Chloride Permeability of Rat Brain Membrane Vesicles Correlates with Thiamine Triphosphate Content. Brain Research, 652 (1), 157-160. doi:10.1016/0006-8993(94)90331-X

Bettendorff, L., & Wins, P. (1994). Mechanism of Thiamine Transport in Neuroblastoma Cells. Inhibition of a High Affinity Carrier by Sodium Channel Activators and Dependence of Thiamine Uptake on Membrane Potential and Intracellular Atp. Journal of Biological Chemistry, 269 (20), 14379-14385.

Bettendorff, L., Wins, P., & Lesourd, M. (1994). Subcellular Localization and Compartmentation of Thiamine Derivatives in Rat Brain. Biochimica et Biophysica Acta, 1222 (1), 1-6. doi:10.1016/0167-4889(94)90018-3

Bettendorff, L., Hennuy, B., Wins, P., & Schoffeniels, E. (1993). Thiamin and Derivatives as Modulators of Rat Brain Chloride Channels. Neuroscience, 52 (4), 1009-1017. doi:10.1016/0306-4522(93)90547-S

Bettendorff, L., Kolb, H.-A., & Schoffeniels, E. (1993). Thiamine Triphosphate Activates an Anion Channel of Large Unit Conductance in Neuroblastoma Cells. Journal of Membrane Biology, 136 (3), 281-8. doi:10.1007/BF00233667

Bettendorff, L., Peeters, M., Wins, P., & Schoffeniels, E. (1993). Metabolism of Thiamine Triphosphate in Rat Brain: Correlation with Chloride Permeability. Journal of Neurochemistry, 60 (2), 423-434. doi:10.1111/j.1471-4159.1993.tb03168.x

Bettendorff, L. (1991). Application of High-Performance Liquid Chromatography to the Study of Thiamine Metabolism and in Particular Thiamine Triphosphatase. Journal of Chromatography. A, 566 (2), 397-408. doi:10.1016/0378-4347(91)80256-C

Bettendorff, L., Longree, I., Wins, P., & Schoffeniels, E. (1991). Solubilization of Thiamine Triphosphatase from the Electric Organ of Electrophorus Electricus. Biochimica et Biophysica Acta - General Subjects, 1073 (1), 69-76. doi:10.1016/0304-4165(91)90184-I

Bettendorff, L., Peeters, M., Jouan, C., Wins, P., & Schoffeniels, E. (1991). Determination of Thiamin and Its Phosphate Esters in Cultured Neurons and Astrocytes Using an Ion-Pair Reversed-Phase High-Performance Liquid Chromatographic Method. Analytical Biochemistry, 198 (1), 52-59. doi:10.1016/0003-2697(91)90505-N

Bettendorff, L. (1990). Application of high-performance liquid chromatography to the study of thiamine metabolism and in particular thiamine triphosphatase [Paper presentation]. First International Symposium on Applications of HPLC in Enzyme Chemistry, Verona, Italy.

Bettendorff, L., Weekers, L., Wins, P., & Schoffeniels, E. (1990). Injection of Sulbutiamine Induces an Increase in Thiamine Triphosphate in Rat Tissues. Biochemical Pharmacology, 40 (11), 2557-2560. doi:10.1016/0006-2952(90)90099-7

Bettendorff, L., Wins, P., & Schoffeniels, E. (1990). Regulation of Ion Uptake in Membrane Vesicles from Rat Brain by Thiamine Compounds. Biochemical and Biophysical Research Communications, 171 (3), 1137-1144. doi:10.1016/0006-291X(90)90803-U

Bettendorff, L., Grandfils, C., Wins, P., & Schoffeniels, E. (1989). Thiamine Triphosphatase in the Membranes of the Main Electric Organ of Electrophorus Electricus: Substrate-Enzyme Interactions. Journal of Neurochemistry, 53 (3), 738-746. doi:10.1111/j.1471-4159.1989.tb11767.x

Bettendorff, L., Schoffeniels, E., Naquet, R., Silva-Barrat, C., Riche, D., & Menini, C. (1989). Phosphorylated Thiamine Derivatives and Cortical Activity in the Baboon Papio Papio: Effect of Intermittent Light Stimulation. Journal of Neurochemistry, 53 (1), 80-87. doi:10.1111/j.1471-4159.1989.tb07297.x

De Rycker, C., Grandfils, C., Bettendorff, L., & Schoffeniels, E. (1989). Solubilization of Sodium Channel from Human Brain. Journal of Neurochemistry, 52 (2), 349-53. doi:10.1111/j.1471-4159.1989.tb09128.x

Bettendorff, L. (1988). Triphosphate de thiamine et bioélectrogenèse [Doctoral thesis, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/126930

Bettendorff, L., Wins, P., & Schoffeniels, E. (1988). Thiamine Triphosphatase from Electrophorus Electric Organ Is Anion-Dependent and Irreversibly Inhibited by 4,4'-Diisothiocyanostilbene-2,2'disulfonic Acid. Biochemical and Biophysical Research Communications, 154 (3), 942-947. doi:10.1016/0006-291X(88)90230-6

Grandfils, C., Bettendorff, L., de Rycker, C., & Schoffeniels, E. (1988). Synthesis of [Gamma-32p]Thiamine Triphosphate. Analytical Biochemistry, 169 (2), 274-278. doi:10.1016/0003-2697(88)90285-0

Bettendorff, L., Michel-Cahay, C., Grandfils, C., De Rycker, C., & Schoffeniels, E. (1987). Thiamine triphosphate and membrane-associated thiamine phosphatases in the electric organ of Electrophorus electricus. Journal of Neurochemistry, 49, 495-502. doi:10.1111/j.1471-4159.1987.tb02891.x

Bettendorff, L., & Schoffeniels, E. (1987). Activités thiamine triphophatasiques et bioélectrogenèse. Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique, 142 (2-3), 228-236.

Bettendorff, L., Grandfils, C., De Rycker, C., & Schoffeniels, E. (1986). Determination of thiamine and its phosphate esters in human blood serum at femtomole levels. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 382, 297-302.

Grandfils, C., Cesa, D., Bettendorff, L., & De Rycker, C. (03 September 1985). Synthèse de triphosphate de thiamine avec incorporation de phosphore 32 en position gamma [Poster presentation]. XII Forum des Jeunes Chercheurs, Liège, Liège, Belgium.

Michel-Cahay, C., Bettendorff, L., De Rycker, C., Grandfils, C., & Schoffeniels, E. (03 September 1985). Membrane associated thiamine phosphatases in the electric organ of Electrophorus electricus [Poster presentation]. XII Forum des Jeunes Chercheurs, Liège, Liège, Belgium.

Bettendorff, L., Schoffeniels, E., Schmartz, D., Bontemps, J., Dandrifosse, G., & Grandfils, C. (Other coll.). (1985). Determination of thiamine and its phosphate esters by reversed-phase HPLC at femtomole levels. Application to bioelectrogenesis. In J.-P. Changeux, A. Maelicke, ... E. Neumann (Eds.), Molecular Basis of Nerve Activity (pp. 479-490). Berlin, Germany: Walter de Gruyter & Co.

Bontemps, J., Grandfils, C., Bettendorff, L., Dandrifosse, G., & Schoffeniels, E. (1985). High performance gel filtration as a tool for the monitoring of the purification steps of the Na channel protein. Archives Internationales de Physiologie et de Biochimie, 93, 5-B6.

Dandrifosse, G., Grandfils, C., Bettendorff, L., Schoffeniels, E., & Bontemps, J. (1985). Rapid purification procedure of the Na-channel of Electrophorus electricus. In J.-P. Changeux, A. Maelicke, ... E. Neumann (Eds.), Molecular Basis of Nerve Activity (pp. 163-172). Berlin, Germany: Walter de Gruyter & Co.

Dandrifosse, G., Grandfils, C., Bettendorff, L., Schoffeniels, E., & Bontemps, J. (1985). A purification procedure of the tetrodotoxin binding component contained in the electroplaxes of E. electricus. In J. P. Changeux, A. Maelicke, ... E. Neumann (Eds.), Molecular Basis of Nerve Activity (pp. 163-175). Walter de Gruyter et Co.

Grandfils, C., Bettendorff, L., Schoffeniels, E., Bontemps, J., & Dandrifosse, G. (1985). High yield synthesis of a new Na-channel marker, [3H]-ethylenediamine ditetrodotoxin, EDD-TTX. In J.-P. Changeux, A. Maelicke, ... E. Neumann (Eds.), Molecular Basis of Nerve Activity (pp. 153-162). Berlin, Germany: Walter de Gruyter & Co.

Grandfils, C., Bettendorff, L., Schoffeniels, E., Bontemps, J., & Dandrifosse, G. (1985). Dérivés phosphorylés de la thiamine et bioélectrogenèse. Regards sur la biochimie, 4, 65.

Michel-Cahay, C., Bettendorff, L., De Rycker, C., Grandfils, C., & Schoffeniels, E. (1985). Membrane associated thiamin phosphatases in the electric organ of E. electricus. Archives Internationales de Physiologie et de Biochimie, 93, 20.

Bettendorff, L., Grandfils, C., Schoffeniels, E., Bontemps, J., Schmartz, D., & Dandrifosse, G. (October 1984). Determination of thiamine and its phosphate esters by reversed phase HPLC at femtomole levels. Application to bioelectrogenesis [Paper presentation]. International Symposium in Memory of D. Nachmansohon on Molecular Basis of Nerve Activity, Berlin, Germany.

Dandrifosse, G., Grandfils, C., Bettendorff, L., Schoffeniels, E., & Bontemps, J. (1984). A purification procedure of the tetrodotoxin binding component coming from the electroplaxes of E. electricus. In J. P. Changeux, A. Maelicke, ... E. Neumann (Eds.), Molecular Basis of Nerve Activity. Walter de Gruyter et Co.

Grandfils, C., Bettendorff, L., Schoffeniels, E., Bontemps, J., & Dandrifosse, G. (September 1984). Dérivés phosphorylés de la thiamine et bioélectrogenèse [Poster presentation]. Forum des jeunes chercheurs, Grenoble (France), Grenoble, France.

Bontemps, J., Laschet, L., Bettendorff, L., Van Cutsem, J. L., Grandfils, C., Etienne, A., Lombet, J., Grisard, T., Dandrifosse, G., Schoffeniels, E., & Forget, P. (18 May 1984). HPLC in neurochemistry [Poster presentation]. Réunion du groupe de Contact chromatographie, FNRS, Liège, Sart Tilman, Liège, Belgium.

Bettendorff, L., Bontemps, J., Lombet, J., Grandfils, C., Compère, P., Dandrifosse, G., & Schoffeniels, E. (25 February 1984). Experimental evidence of the role of thiamine in nerve conduction as determined by HPLC using pre and post column derivatization techniques [Poster presentation]. 125e Réunion de la Société Belge de Biochimie, Rhode-Saint-Genèse.

Bettendorff, L., Bontemps, J., Lombet, J., Grandfils, C., Compère, P., Dandrifosse, G., & Schoffeniels, E. (1984). Experimental evidence of the role of thiamine in nerve conduction as determined by HPLC using pre- and post-column derivatization techniques. Archives Internationales de Physiologie et de Biochimie, 92, 4.

Bontemps, J., Bettendorff, L., Dandrifosse, G., Schoffeniels, E., & Nevejans, F. (1984). Sensitization of thiamine analysis by the peak compression technique. HRC and CC. Journal of High Resolution Chromatography and Chromatography Communications, 7, 490-491. doi:10.1002/jhrc.1240070810

Bontemps, J., Bettendorff, L., Lombet, J., Dandrifosse, G., Schoffeniels, E., Nevejans, F., Yang, Y., & Verzele, M. (1984). Determination of thiamine and thiamine phosphates as thiochrome derivatives by reversed phase chromatography on polystyrene packing materials. Chromatographia, 18, 424-426. doi:10.1007/BF02262970

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