Publications and communications of Rachelle Franzen

Schumacher, N., Pieltain, A., Thelen, N., Gailly, P., Muccioli, G., Arthur-Farraj, P., Vandenbosch, R., & Franzen, R. (July 2023). Role of Cyclin-dependent kinase 7 in Schwann cell development and myelination [Poster presentation]. XVI European Meeting on Glial Cells in Health and Disease, Berlin, Germany.

Schumacher, N., Masar, N., Pieltain, A., Thelen, N., Vandenbosch, R., & Franzen, R. (06 September 2022). Cyclin-dependent kinase 7, a potential new modulator of myelin lipid and protein constitution, promotes Schwann cell myelination in the peripheral nervous system [Poster presentation]. GIGA Day 2022.

Dion, V.* , Schumacher, N.* , Masar, N., Pieltain, A., Tocquin, P., LESOINNE, P., Malgrange, B., Vandenbosch, R.* , & Franzen, R.*. (2022). Cyclin-dependent kinase 7 contributes to myelin maintenance in the adult central nervous system and promotes myelin gene expression. Glia. doi:10.1002/glia.24186
* These authors have contributed equally to this work.

Dion, V., Pieltain, A., Malgrange, B., Vandenbosch, R., & Franzen, R. (July 2019). Cdk7: role in oligodendrocyte differentiation and in myelination [Poster presentation]. XIV European meeting on Glial cells in health and disease, Porto, Portugal.

Boerboom, A., Reusch, C., Pieltain, A., Chariot, A., & Franzen, R. (October 2017). KIAA1199: a novel regulator of MEK/ERK-induced Schwann cell dedifferentiation. Glia, 65 (10), 1682-1696. doi:10.1002/glia.23188

Franzen, R. (28 August 2017). KIAA1199: a novel regulator of MEK/ERK-induced Schwann cell dedifferentiation [Paper presentation]. ISN Satellite meeting on myelin biology, Island of Embiez, France.

Bartholomé, O., Van Den Ackerveken, P., Sanchez Gil, J., de la Brassinne Bonardeaux, O., Leprince, P., Franzen, R., & Rogister, B. (2017). Puzzling Out Synaptic Vesicle 2 Family Members Functions. Frontiers in Molecular Neuroscience. doi:10.3389/fnmol.2017.00148

Boerboom, A., Dion, V., CHARIOT, A., & Franzen, R. (2017). Molecular Mechanisms Involved in Schwann Cell Plasticity. Frontiers in Molecular Neuroscience. doi:10.3389/fnmol.2017.00038

Boerboom, A., Dion, V., Pieltain, A., Shostak, K., Chariot, A., & Franzen, R. (May 2016). KIAA1199 links ErbB signalling to Schwann cell development and plasticity [Poster presentation]. Gordon seminar + conference Myelin.

Cantinieaux, D., Franzen, R., & Schoenen, J. (2016). Impact model of spinal cord injury. In M. Janowski (Ed.), Experimental Neurosurgery in Animal Models (pp. 107-110). New-York, United States: Humana Press. doi:10.1007/978-1-4939-3730-1_7

Dion, V., Boerboom, A., Pieltain, A., Chariot, A., & Franzen, R. (2016). Remyelination in the adult central nervous system: A possible role for Elongator [Poster presentation]. Gordon Research Conferences - Myelin.

Neirinckx, V., Agirman, G., Coste, C., Marquet, A., Dion, V., Rogister, B., Franzen, R., & Wislet, S. (November 2015). Adult bone marrow mesenchymal and neural crest stem cells are chemoattractive and accelerate motor recovery in a mouse model of spinal cord injury. Stem Cell Research and Therapy, 6 (211). doi:10.1186/s13287-015-0202-2

Neirinckx, V., Agirman, G., Coste, C., Rogister, B., Franzen, R., & Wislet, S. (2015). Exploring the secretome of bone marrow mesenchymal and neural crest-derived stem cells for treating spinal cord injuries. Cytotherapy. doi:10.1016/j.jcyt.2015.03.502

Boerboom, A., Dion, V., Pieltain, A., Chariot, A., & Franzen, R. (May 2015). KIAA1199 is involved in Schwann cell survival and differentiation [Poster presentation]. Belgian Society for Neuroscience 2015.

Dion, V., Boerboom, A., Pieltain, A., Chariot, A., & Franzen, R. (2015). Role of Elongator in central nervous system remyelination [Poster presentation]. Belgian Society for Neuroscience 2015.

Neirinckx, V., Agirman, G., Marquet, A., Coste, C., Dion, V., Rogister, B., Franzen, R., & Wislet, S. (17 November 2014). Specific properties of bone marrow mesenchymal and neural crest-derived stem cells: Relevance in spinal cord injury therapy [Poster presentation]. Neuroscience 2014, Washington DC, United States.

Neirinckx, V., Agirman, G., Rogister, B., Franzen, R., & Wislet, S. (25 September 2014). Bone marrow mesenchymal and neural crest-derived stem cells have distinct secretomes, which are both relevant for spinal cord injury therapy [Paper presentation]. 9th Congress of the International Society for NeuroImmunoModulation.

Neirinckx, V., Coste, C., Franzen, R., Gothot, A., Rogister, B., & Wislet, S. (28 August 2014). Neutrophil contribution to spinal cord injury and repair. Journal of Neuroinflammation, 11 (1). doi:10.1186/s12974-014-0150-2

Kaux, J.-F., Drion, P., Libertiaux, V., Colige, A., HOFFMANN, A., Nusgens, B., Forthomme, B., LE GOFF, C., Franzen, R., Rickert, M., Crielaard, J.-M., & Croisier, J.-L. (April 2014). Eccentric training improves tendon biomechanical properties: a rat model. British Journal of Sports Medicine, 48 (7), 155. doi:10.1136/bjsports-2014-093494.155

Neirinckx, V., CANTINIEAUX, D., Coste, C., Rogister, B., Franzen, R., & Wislet, S. (2014). Spinal Cord Injuries – How Could Adult Mesenchymal and Neural Crest Stem Cells Take Up the Challenge? Stem Cells. doi:10.1002/stem.1579

Neirinckx, V., Rogister, B., Franzen, R., & Wislet, S. (2014). Bone marrow stromal stem cells transplantation in mice with acute spinal cord injury. Methods in Molecular Biology, 1213. doi:10.1007/978-1-4939-1453-1_21

CANTINIEAUX, D., QUERTAINMONT, R., Blacher, S., Rossi, L., Wanet, T., Noël, A., BROOK, G., Schoenen, J., & Franzen, R. (2013). Conditioned Medium from Bone marrow-derived Mesenchymal Stem Cells improves recovery after Spinal Cord Injury in rats: an original strategy to avoid cell transplantation. PLoS ONE, 8 (8), 69515. doi:10.1371/journal.pone.0069515

Kaux, J.-F., Drion, P., Libertiaux, V., Colige, A., HOFFMANN, A., Nusgens, B., Forthomme, B., Besançon, B., LE GOFF, C., Franzen, R., Defraigne, J.-O., Cescotto, S., Rickert, M., Crielaard, J.-M., & Croisier, J.-L. (January 2013). Eccentric training improves tendon biomechanical properties: a rat model. Journal of Orthopaedic Research, 31 (1), 119-124. doi:10.1002/jor.22202

Boerboom, A., Chaballe, L., Close, P., Schoenen, J., Chariot, A., & Franzen, R. (October 2012). Acetylation and Wallerian degeneration [Poster presentation]. Belgian Brain Congress 2012.

Kaux, J.-F., Drion, P., Croisier, J.-L., Besançon, B., Libertiaux, V., FORTHOMME, B., Colige, A., LE GOFF, C., Franzen, R., Defraigne, J.-O., Cescotto, S., Rickert, M., & Crielaard, J.-M. (2012). Influence of type of contraction upon tendinous tissue during training: animal model. In R. Meeusen, J. Duchateau, B. Roelands, M. Klass, B. De Geus, S. Daubry, ... E. Tsolakidis (Eds.), Book of Abstracts of the 17th annual Congress of the ECSS (pp. 630). ECSS.

Quertainmont, R., Cantinieaux, D., Botman, O., SID, S., Schoenen, J., & Franzen, R. (2012). Mesenchymal Stem Cell Graft Improves Recovery after Spinal Cord Injury in Adult Rats through Neurotrophic and Pro-Angiogenic Actions. PLoS ONE, 7 (6), 39500. doi:10.1371/journal.pone.0039500

Chaballe, L., Close, P., SEMPELS, M., DELSTANCHE, S., FANIELLE, J., Moons, L., Carmeliet, P., Schoenen, J., Chariot, A., & Franzen, R. (March 2011). Involvement of placental growth factor in Wallerian degeneration. Glia, 59 (3), 379-396. doi:10.1002/glia.21108

Kaux, J.-F., Drion, P., Croisier, J.-L., Besançon, B., Libertiaux, V., Forthomme, B., Colige, A., LE GOFF, C., Franzen, R., Defraigne, J.-O., Cescotto, S., Rickert, M., & Crielaard, J.-M. (2011). Influence sur le tissu tendino(-musculaire) du mode de contraction en entraînement : modèle animal. In M. Julia, D. Hirt, J.-L. Croisier, P. Codine, ... C. Hérisson (Eds.), Tendon et jonction tendino-musculaire - De la biomécanique aux applications thérapeutiques (pp. 31-40). Issy-les-Moulineaux, France: Elsevier - Masson.

Chaballe, L., Schoenen, J., & Franzen, R. (2011). Placental growth factor: a tissue modelling factor with therapeutic potentials in neurology? Acta Neurologica Belgica, 111 (1), 10-7.

Hugnot, J.-P., & Franzen, R. (2011). The spinal cord ependymal region: A stem cell niche in the caudal central nervous system. Frontiers in Bioscience: A Journal and Virtual Library, (16), 1044-1059. doi:10.2741/3734

Scholtes, F., Theunissen, E., Phan Ba, R., Adriaensens, P., Brook, G., Franzen, R., Gelan, J., Schoenen, J., & Martin, D. (2011). Post-mortem assessment of rat spinal cord injury and white matter sparing using inversion recovery-supported proton density magnetic resonance imaging. Spinal Cord, 1-7. doi:10.1038/sc.2010.129

Kaux, J.-F., Drion, P., Besançon, B., Libertiaux, V., Croisier, J.-L., Forthomme, B., Colige, A., Le Goff, C., Franzen, R., Defraigne, J.-O., Cescotto, S., Rickert, M., & Crielaard, J.-M. (25 November 2010). Intrinsic modification of tendon structure after concentric or excentric training [Poster presentation]. 6th International Congress of EFOST, Brussels, Belgium.

Kaux, J.-F., Drion, P., Besançon, B., Libertiaux, V., Croisier, J.-L., Forthomme, B., Colige, A., Le Goff, C., Franzen, R., Defraigne, J.-O., Cescotto, S., Rickert, M., & Crielaard, J.-M. (2010). Influence du mode de contraction sur le tendon : modèle animal. In 3ème Congrès Commun SFMS - SFTS (pp. 62).

Kaux, J.-F., Drion, P., Besançon, B., Libertiaux, V., Croisier, J.-L., Forthomme, B., Colige, A., Le Goff, C., Franzen, R., Defraigne, J.-O., Cescotto, S., Rickert, M., & Crielaard, J.-M. (2010). Influence of the contraction mode on the tendon structure - Rat model. In 2nd Congress of European College of Sport & Exercise Physicians - Conference Brochure 2010: Abstracts and CVs (pp. 27).

Chaballe, L., Close, P., Sempels, M., Delstanche, S., Fanielle, J., Moons, L., Carmeliet, P., Schoenen, J., Chariot, A., & Franzen, R. (September 2010). Involvement of Placental growth factor in Wallerian degeneration [Poster presentation]. Belgian Brain Congress, Bruxelles, Belgium.

Foret, A., Quertainmont, R., Botman, O., Bouhy, D., AMABILI, P., Brook, G., Schoenen, J., & Franzen, R. (February 2010). Stem cells in the adult rat spinal cord: Plasticity after injury and treadmill training exercise. Journal of Neurochemistry, 112 (3), 762-772. doi:10.1111/j.1471-4159.2009.06500.x

Chaballe, L., Wouters, M., Fanielle, J., Moons, L., Carmeliet, P., Schoenen, J., & Franzen, R. (11 May 2009). Expression and role of Placental Growth Factor (PLGF) in the inflammatory context resulting from nerve injury, the Wallerian Degeneration [Poster presentation]. Belgian Society for Neurosciences, Liège, Belgium.

MONTZKA, K., Lassonczyk, N., Tschöke, B., Neuss, S., Führmann, T., Franzen, R., Smeets, R., Brook, G., & Wöltje, M. (March 2009). Neural differentiation potential of human bone marrow-derived mesenchymal stromal cells: misleading marker gene expression. BMC Neuroscience, 10, 16. doi:10.1186/1471-2202-10-16

Chaballe, L., Wouters, M., Sempels, M., Moons, L., Carmeliet, P., Schoenen, J., & Franzen, R. (November 2008). Expression and role of Placental Growth Factor (PLGF) in the inflammatory context resulting from nerve injury, the Wallerian Degeneration [Poster presentation]. Neuroscience.

Chaballe, L., Wouters, M., Sempels, M., Moons, L., Carmeliet, P., Schoenen, J., & Franzen, R. (October 2008). Expression and role of Placental Growth Factor (PLGF) in the inflammatory context resulting from nerve injury, the Wallerian Degeneration [Poster presentation]. Belgian Brain Congress, Ostende, Belgium.

Chaballe, L., Wouters, M., Sempels, M., Moons, L., Carmeliet, P., Schoenen, J., & Franzen, R. (July 2008). Expression and role of Placental Growth Factor (PLGF) in the inflammatory context resulting from nerve injury, the Wallerian Degeneration [Poster presentation]. 6th Forum of European Neuroscience, Genève, Switzerland.

Scholtes, F., Franzen, R., Poirrier, A.-L., Schoenen, J., & Martin, D. (08 March 2008). Recruitment of preserved spinal cord parenchyma after spinal cord injury in order to increase locomotor recovery [Poster presentation]. Réunion annuelle de la Société Belge de Neurochirurgie, LIEGE, Belgium.

Scholtes, F., Phan-Ba, R., Theunissen, E., Adriaensens, P., Brook, G., Franzen, R., Bouhy, D., Gelan, J., Martin, D., & Schoenen, J. (2008). Rapid, postmortem 9.4 T MRI of spinal cord injury: correlation with histology and survival times. Journal of Neuroscience Methods, 174 (2), 157-67. doi:10.1016/j.jneumeth.2008.06.038

Chaballe, L., Delstanche, S., Wouters, M., Moons, L., Carmeliet, P., Schoenen, J., & Franzen, R. (07 May 2007). Role of Placental Growth Factor (PLGF) in the inflammatory context resulting from nerve injury, the Wallerian Degeneration [Poster presentation]. Belgian Society for Neurosciences, Antwerpen, Belgium.

Chaballe, L., Wouters, M., Moons, L., Carmeliet, P., Schoenen, J., & Franzen, R. (10 November 2006). Role of Placental Growth Factor (PLGF) in the inflammatory context resulting from nerve injury, the Wallerian Degeneration [Poster presentation]. Neurobelgium, Genval, Belgium.

Bouhy, D., Malgrange, B., Multon, S., Poirrier, A.-L., Scholtes, F., Schoenen, J., & Franzen, R. (June 2006). Delayed GM-CSF treatment stimulates axonal regeneration and functional recovery in paraplegic rats via an increased BDNF expression by endogenous macrophages. FASEB Journal, 20 (8), 12391241. doi:10.1096/fj.05-4382fje

Bouhy, D., Malgrange, B., Multon, S., POIRRIER, A.-L., Scholtes, F., Schoenen, J., & Franzen, R. (2006). Delayed Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) treatment promotes axonal regeneration and functional recovery in paraplegic rats via an increased BDNF expression by endogenous macrophages [Poster presentation]. Bioforum, Liège, Belgium.

Bouhy, D., Malgrange, B., Multon, S., POIRRIER, A.-L., Scholtes, F., Schoenen, J., & Franzen, R. (2006). Delayed Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) treatment promotes axonal regeneration and functional recovery in paraplegic rats via an increased BDNF expression by endogenous macrophages [Poster presentation]. Society for Neurosciences, Atlanta, United States - Georgia.

Multon, S., Pardutz, A., Mosen, J., Hua, M. T., de Fays, C., Honda, S. I., Harada, N., Bohotin, C., Franzen, R., & Schoenen, J. (March 2005). Lack of estrogen increases pain in the trigeminal formalin model: a behavioural and immunocytochemical study of transgenic ArKO mice. Pain, 114 (1-2), 257-265. doi:10.1016/j.pain.2004.12.030

Franzen, R., Bouhy, D., & Schoenen, J. (May 2004). Nervous system injury: focus on the inflammatory cytokine 'granulocyte-macrophage colony stimulating factor'. Neuroscience Letters, 361 (1-3), 76-78. doi:10.1016/j.neulet.2003.12.018

Poirrier, A.-L., Nyssen, Y., Scholtes, F., Multon, S., Rinkin, C., Weber, G., Bouhy, D., Brook, G., Schoenen, J., & Franzen, R. (15 January 2004). Repetitive transcranial magnetic stimulation improves open field locomotor recovery after low but not high thoracic spinal cord compression-injury in adult rats. Journal of Neuroscience Research, 75 (2), 253-261. doi:10.1002/jnr.10852

Buss, A., Brook, G. A., Kakulas, B., Martin, D., Franzen, R., Schoenen, J., Noth, J., & Schmitt, A. B. (January 2004). Gradual loss of myelin and formation of an astrocytic scar during Wallerian degeneration in the human spinal cord. Brain: a Journal of Neurology, 127 (Part 1), 34-44. doi:10.1093/brain/awh001

Bohotin, C., Scholsem, M., Bohotin, V., Franzen, R., & Schoenen, J. (13 November 2003). Vagus nerve stimulation attenuates heat- and formalin-induced pain in rats. Neuroscience Letters, 351 (2), 79-82. doi:10.1016/S0304-3940(03)00908-X

Multon, S.* , Franzen, R.* , Poirrier, A.-L., Scholtes, F., & Schoenen, J. (August 2003). The effect of treadmill training on motor recovery after a partial spinal cord compression-injury in the adult rat. Journal of Neurotrauma, 20 (8), 699-706. doi:10.1089/089771503767869935
* These authors have contributed equally to this work.

Brook, G. A., Scholtes, F., Franzen, R., Malgrange, B., Leprince, P., Schoenen, J., & Noth, J. (2002). Axonal regeneration of adult mouse dorsal root ganglion (DRG) neurons following microtransplantation into the gray matter of adult rat brains. Glia, (Suppl. 1), 88.

POIRRIER, A.-L., Nyssen, Y., Scholtes, F., Brook, G., Multon, S., Malchair, P., RINKIN, C., Franzen, R., & Schoenen, J. (2002). Effects of repetitive high frequency transcranial magnetic stimulations on functional recovery after a compression-injury of rat spinal cord : relation with the segmental level of compression [Paper presentation]. Winter Meeting of the Belgian Neurological Society, Liege, Belgium.

POIRRIER, A.-L., Nyssen, Y., Scholtes, F., Brook, G., Multon, S., Malchair, P., RINKIN, C., Van Langenacker, M., Bouhy, D., Franzen, R., & Schoenen, J. (2002). Effects of repetitive high frequency transcranial magnetic stimulations (rTMS) on functional recovery after a compression-injury of rat spinal cord : relationship with the segmental level of compression [Poster presentation]. Third Forum of European Neurosciences, Paris, France.

Maquet, V., Martin, D., Scholtes, F., Franzen, R., Schoenen, J., Moonen, G., & Jérôme, R. (May 2001). Poly(D,L-lactide) foams modified by poly(ethylene oxide)-block-poly(D,L-lactide) copolymers and a-FGF: in vitro and in vivo evaluation for spinal cord regeneration. Biomaterials, 22 (10), 1137-1146. doi:10.1016/S0142-9612(00)00357-4

Franzen, R., Tanner, S., Dashiell, S., Rottkamp, C., Hammer, J., & Quarles, R. (Ed.). (2001). Microtubule-associated protein 1B: a neuronal binding partner for myelin-associated glycoprotein. Journal of Cell Biology, 155, 893-898. doi:10.1083/jcb.200108137

Maquet, V., Martin, D., Malgrange, B., Franzen, R., Schoenen, J., Moonen, G., & Jérôme, R. (15 December 2000). Peripheral Nerve Regeneration Using Bioresorbable Macroporous Polylactide Scaffolds. Journal of Biomedical Materials Research. Part A, 52 (4), 639-51. doi:10.1002/1097-4636(20001215)52:4<639::AID-JBM8>3.0.CO;2-G

Franzen, R., Tanner, S., Jaffe, H., & Quarles, R. (Ed.). (2000). Evidence for expression of some Microtubule-associated Protein 1B in neurons as a plasma membrane glycoprotein. Journal of Neurochemistry, 75, 553-562. doi:10.1046/j.1471-4159.2000.0750553.x

Franzen, R., Martin, D., Daloze, A., Moonen, G., & Schoenen, J. (11 May 1999). Grafts of Meningeal Fibroblasts in Adult Rat Spinal Cord Lesion Promote Axonal Regrowth. Neuroreport, 10 (7), 1551-6. doi:10.1097/00001756-199905140-00029

Franzen, R. (1998). Régénération axonale dans le système nerveux central: de la lésion expérimentale à la greffe intramédullaire [Doctoral thesis, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/28398

Franzen, R., Schoenen, J., Leprince, P., Joosten, E., Moonen, G., & Martin, D. (01 February 1998). Effects of Macrophage Transplantation in the Injured Adult Rat Spinal Cord: A Combined Immunocytochemical and Biochemical Study. Journal of Neuroscience Research, 51 (3), 316-27. doi:10.1002/(SICI)1097-4547(19980201)51:3<316::AID-JNR5>3.0.CO;2-J

Brook, G. A., Plate, D., Franzen, R., Martin, D., Moonen, G., Schoenen, J., Schmitt, A. B., Noth, J., & Nacimiento, W. (1998). Spontaneous longitudinally orientated axonal regeneration is associated with the Schwann cell framework within the lesion site following spinal cord compression injury of the rat. Journal of Neuroscience Research, 53 (1), 51-65. doi:10.1002/(SICI)1097-4547(19980701)53:1<51::AID-JNR6>3.0.CO;2-I

Franzen, R., Martin, D., Joosten, E. A. J., Leprince, P., Moonen, G., & Schoenen, J. (1997). Grafting cultured macrophages or fibroblasts in a contusion model of adult rat spinal cord : a combined morphological and biochemical study of neuronal and non-neuronal actors in repair processes [Paper presentation]. Neurology.

Martin, D., Robe, P., Franzen, R., Delree, P., Schoenen, J., Stevenaert, A., & Moonen, G. (01 September 1996). Effects of Schwann Cell Transplantation in a Contusion Model of Rat Spinal Cord Injury. Journal of Neuroscience Research, 45 (5), 588-597. doi:10.1002/(SICI)1097-4547(19960901)45:5<588::AID-JNR8>3.0.CO;2-8

Joosten, E. A., Verhaagh, S., Martin, D., Robe, P., Franzen, R., Hooiveld, M., Doornbos, R., Bartsch, P., & Moonen, G. (1996). Alpha-MSH stimulates neurite outgrowth of neonatal rat corticospinal neurons in vitro. Brain Research, 736 (1-2), 91-8. doi:10.1016/0006-8993(96)00700-7

Humblet, C., Deman, J., Franzen, R., Greimers, R., Boniver, J., & Defresne, M.-P. (May 1995). Spontaneous and Induced Apoptosis after Whole Body Radiation Exposure: Experimental Approaches. Observations in Radio-Induced Thymic Lymphomagenesis. Stem Cells, 13 (Suppl 1), 129-35.