Publications and communications of Bernard Pirotte

Bay, Y., Egeberg Jeppesen, M., Frydenvang, K., Francotte, P., Pirotte, B., Pickering, D. S., Kristensen, A. S., & Kastrup, J. S. (2024). The positive allosteric modulator BPAM344 and L-glutamate introduce an active-like structure of the ligand-binding domain of GluK2. FEBS Letters. doi:10.1002/1873-3468.14824

Colson, T., Piette, M., Bay, Y., Pickering, D. S., Kristensen, A. S., Baudino, G., Tchekounang Tchonwa, I. F., Pochet, L., Goffin, E., Lesenfants, C., Kastrup, J. S., Pirotte, B., & Francotte, P. (31 January 2024). Advances in Targeting Kainic Acid Receptors: Developing Selective Positive Allosteric Modulators from the 1,2,4-Benzothiadiazine 1,1-Dioxide scaffold [Poster presentation]. CIRM Day 2024, Liège, Belgium.

Lesenfants, C., Goffin, E., Colson, T., Chaaya, N., Leroy, C., Garigliany, M.-M., Chavatte, P., Reboud-Ravaux, M., Pirotte, B., El Amri, C., & Francotte, P. (31 January 2024). RATIONAL DESIGN OF COUMARIN DERIVATIVES WITH A BASIC MOIETY FOR INHIBITING THE SERINE PROTEASE TMPRSS2: AN INNOVATIVE APPROACH TO COMBAT THE ENTRY OF SELECTED RESPIRATORY VIRUSES [Poster presentation]. CIRM Day, Liège, Belgium.

Bay, Y., Venskutonytė, R., Frantsen, S. M., Thorsen, T. S., Musgaard, M., Frydenvang, K., Francotte, P., Pirotte, B., Biggin, P. C., Kristensen, A. S., Boesen, T., Pickering, D. S., Gajhede, M., & Kastrup, J. S. (2023). Small-molecule positive allosteric modulation of homomeric kainate receptors GluK1-3: development of screening assays and insight into GluK3 structure. FEBS Journal. doi:10.1111/febs.17046

Mvondo Mbala, J.-G., Thierry Mawete, D., Makiese, A., Kwiraviwe, L., Pangu, K., Nguimi, E., Cimanga Kanyanga, R., Pieters, L., Degotte, G., Frederich, M., Matondo, A., Van Pelt, N., Caljon, G., Pirotte, B., Mbala Mavinga, B., Bambi-Nyanguile, S.-M., & Mvondo, G. (24 December 2023). Synthesis and pharmacological evaluation of fluoro/chloro-substituted acetyl and benzoyl esters of quinine as antimalarial agents. Results in Chemistry, 7, 101284. doi:10.1016/j.rechem.2023.101284

Francotte, P., Bay, Y., Goffin, E., Colson, T., Lesenfants, C., Dorosz, J., Laulumaa, S., Fraikin, P., De Tullio, P., Beaufour, C., Botez, I., Pickering, D., Frydenvang, K., Danober, L., Skov Kristensen, A., Sandholm Kastrup, J., & Pirotte, B. (09 December 2023). Exploring thienothiadiazine dioxides as isosteric analogues of benzo-and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulators. European Journal of Medicinal Chemistry, 264, 116036. doi:10.1016/j.ejmech.2023.116036

Lesenfants, C., Leroy, C., Goffin, E., Colson, T., Chaaya, N., Garigliany, M.-M., Chavatte, P., Reboud-Ravaux, M., Pirotte, B., El Amri, C., & Francotte, P. (08 December 2023). EXPLORING COUMARIN DERIVATIVES AS NOVEL ANTIVIRAL AGENTS TARGETING TMPRSS2: A MULTIDISCIPLINARY APPROACH FOR RESPIRATORY VIRAL DISEASE TREATMENT [Poster presentation]. MedChem 2023, Bruxelles, Belgium.

Colson, T., Piette, M., Bay, Y., Pickering, D. S., Kristensen, A. S., Goffin, E., Lesenfants, C., Kastrup, J. S., Pirotte, B., & Francotte, P. (19 October 2023). Glutamate Regulation: Synthesis of Selective Positive Allosteric Modulators of the Kainic Acid Receptors belonging to 1,2,4-Benzothiadiazine 1,1-Dioxides [Poster presentation]. SRC 2023 Scientific Day, Louvain-La-Neuve, Belgium.

Lesenfants, C., Leroy, C., Goffin, E., Colson, T., Garigliany, M.-M., Chavatte, P., Reboud, M., Pirotte, B., El Amri, C., & Francotte, P. (19 October 2023). Design of original serine protease inhibitors to combat viral respiratory infections: a synthetic pathway for new coumarinic compounds [Poster presentation]. 2023 SRC Scientific Day, Louvain-la-Neuve, Belgium.

Colson, T., Valembois, S., Leroy, C., Bay, Y., Pickering, D. S., Kristensen, A. S., Pirotte, B., Kastrup, J. S., & Francotte, P. (07 September 2023). Design of potentiators targeting the allosteric pocket of the kainate subtype glutamate receptors [Poster presentation]. 10th EFMC Young Medicinal Chemist Symposium (EFMC-YMCS), Zagreb, Croatia.

Oury, C., Meyers, S., Jacques, N., Leeten, K., Jiang, Z., MUSUMECI, L., Lox, M., Debuisson, M., Goffin, E., Pirotte, B., Delvenne, P., Nchimi Longang, A., Hubert, C., Heptia, M., Hubert, P., Kuijpers, M. J. E., Vanassche, T., Martinod, K., Verhamme, P., & Lancellotti, P. (2023). Protective Effect of Ticagrelor Against Infective Endocarditis Induced by Virulent Staphylococcus aureus in Mice. JACC: Basic to Translational Science. doi:10.1016/j.jacbts.2023.02.003

Goffin, E., Fraikin, P., Abboud, D., De Tullio, P., Beaufour, C., Botez, I., Hanson, J., Danober, L., Francotte, P., & Pirotte, B. (15 March 2023). New insights in the development of positive allosteric modulators of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors belonging to 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides: Introduction of (mono/difluoro)methyl groups at the 2-position of the thiadiazine ring. European Journal of Medicinal Chemistry, 250, 115221. doi:10.1016/j.ejmech.2023.115221

Arslan, D., Schoumacher, M., Dilly, S., Elmoualij, B., Zorzi, D., Quatresooz, P., Lambert, V., Noël, A., Pirotte, B., & De Tullio, P. (2023). Design, Synthesis, and Evaluation of Novel Pyruvate Dehydrogenase Kinase Inhibitors. Medicinal Chemistry, 19 (3), 276-296. doi:10.2174/1573406418666220819102627

Degotte, G., Pendeville-Samain, H., Di Chio, C., Ettari, R., Pirotte, B., Frederich, M., & Francotte, P. (2023). Dimeric polyphenols to pave the way for new antimalarial drugs. RSC Medicinal Chemistry. doi:10.1039/d2md00392a

Pirotte, B., Francotte, P., El Amri, C., Reboud-Ravaux, M., Chaaya, N., & Lesenfants, C. (2023). Substituted aryl esters of coumarin-3-carboxylic acid and their use as transmembrane serine protease 2 inhibitors and pharmaceutical composition.

Abboud, D., Daly, A., Dupuis, N., Bahri, M. A., Inoue, A., Chevigné, A., Ectors, F., Plenevaux, A., Pirotte, B., Beckers, A., & Hanson, J. (April 2022). Deciphering the role of the GPR101 orphan receptor in growth hormone hypersecretion [Poster presentation]. Keystone Symposia Conference, GPCRs: An Odyssey from Structure, Signaling and Regulation to Therapeutics, Snowbird, United States.

Mechouche, N., Bouhedja, M., Habila, T., Stiti, M. Z., Faury, G., Pirotte, B., & Khelili, S. (March 2022). Synthesis and evaluation of the pharmacological activity of open analogues of cromakalim carrying urea and thiourea moieties. International Journal of Research in Pharmacy and Chemistry, 12, 6-24. doi:10.33289/ijrpc.12.1.2022.12(4)

Colson, T., Bay, Y., Pickering, D. S., Møllerud, S., Frydenvang, K., Pirotte, B., Mulle, C., Kristensen, A. S., Kastrup, J. S., & Francotte, P. (02 February 2022). Design and synthesis of key intermediates giving access to potentiators for the kainate subtype glutamate receptors [Poster presentation]. CIRM Day, Liège, Belgium.

Lesenfants, C., Goffin, E., Pirotte, B., Dammicco, S., & Francotte, P. (02 February 2022). Contribution to the synthesis of positive allosteric modulators of AMPA receptors for potential use in the early diagnosis of neurodegenerative diseases [Poster presentation]. CIRM Day, Liège, Belgium.

Abboud, D., Daly, A., Dupuis, N., Bahri, M. A., Inoue, A., Chevigné, A., Ectors, F., Plenevaux, A., Pirotte, B., Beckers, A., & Hanson, J. (February 2022). Deciphering the role of the GPR101 orphan receptor in growth hormone hypersecretion [Paper presentation]. CIRM day, Liege, Belgium.

Degotte, G., Pirotte, B., Francotte, P., & Frederich, M. (2022). Potential of caffeic acid derivatives as antimalarial leads. Letters in Drug Design and Discovery, 19, 823-836.

Pirotte, B., Florence, X., Goffin, E., Leleux, F., & Lebrun, P. (2022). Research Advancements on Fluorinated and Non-Fluorinated 4- Phenyl(thio)ureido-Substituted 2,2-Dimethylchromans Acting as Inhibitors of Insulin Release and Smooth Muscle Relaxants. Medicinal chemistry (Shariqah (United Arab Emirates)), 18 (8), 884-894. doi:10.2174/1573406418666220221145500

Colson, T., Valembois, S., Bay, Y., Pickering, D. S., Møllerud, S., Frydenvang, K., Pirotte, B., Mulle, C., Kristensen, A. S., Kastrup, J. S., & Francotte, P. (19 November 2021). Design of selective ligands for the kainate subtype receptors [Poster presentation]. MedChem 2021, Liège, Belgium.

Degotte, G., Pirotte, B., Pendeville-Samain, H., Frederich, M., & Francotte, P. (19 November 2021). Pharmacomodulation of Ellagic Acid to Identify New Antimalarial Candidates [Poster presentation]. MedChem 2021, Liège, Belgium.

Abboud, D., Daly, A., Dupuis, N., Bahri, M. A., Inoue, A., Chevigné, A., Ectors, F., Plenevaux, A., Pirotte, B., BECKERS, A., & Hanson, J. (October 2021). Deciphering the role of the GPR101 orphan receptor in growth hormone hypersecretion [Poster presentation]. 5th ERNEST meeting, Bari, Italy.

LANCELLOTTI, P., Oury, C., Pirotte, B., MUSUMECI, L., Jacques, N., & Goffin, E. (23 September 2021). Preparation of pyrimidine derivatives for prevention and treatment of Gram-negative bacterial infection, contamination and fouling.

Degotte, G., Pirotte, B., Frederich, M., & Francotte, P. (2021). Polyhydroxybenzoic acid derivatives as potential new antimalarial agents. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft. doi:10.1002/ardp.202100190

Etse, K. S., Dorosz, J., Mc Lain Christensen, Thomas, J.-Y., Botez Pop, I., Goffin, E., Colson, T., Lestage, P., Danober, L., Pirotte, B., Sandholm Katrup, J., & Francotte, P. (09 July 2021). Development of Thiochroman Dioxide Analogues of Benzothiadiazine Dioxides as New Positive Allosteric Modulators of α-Amino-3- hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors. ACS Chemical Neurosciences, 12 (14), 2679-2692. doi:10.1021/acschemneuro.1c00255

Abboud, D., Daly, A., Dupuis, N., Bahri, M. A., Inoue, A., Chevigné, A., Ectors, F., Plenevaux, A., Pirotte, B., BECKERS, A., & Hanson, J. (July 2021). GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11 [Poster presentation]. 1st Transatlantic ECI GPCR symposium.

Degotte, G., Pirotte, B., Pendeville-Samain, H., Duwez, L., Frederich, M., & Francotte, P. (28 May 2021). Gallic acid dimerization to open the way for new antimalarial drugs [Paper presentation]. One-Day FNRS Med Chem Meeting, Louvain-La-Neuve, Belgium.

Degotte, G., Pirotte, B., Pendeville-Samain, H., Duwez, L., Frederich, M., & Francotte, P. (26 May 2021). Gallic acid dimerization to open the way for new antimalarial drugs [Poster presentation]. 3rd CIRMDay, Liège, Belgium.

Abboud, D., Daly, A., Dupuis, N., Bahri, M. A., Inoue, A., Chevigné, A., Ectors, F., Plenevaux, A., Pirotte, B., BECKERS, A., & Hanson, J. (May 2021). GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11 [Paper presentation]. FASEB, The Growth Hormone (GH)/ Prolactin (PRL) Family in Biology & Disease Conference.

Abboud, D., Daly, A., Dupuis, N., Bahri, M. A., Inoue, A., Chevigné, A., Ectors, F., Plenevaux, A., Pirotte, B., Beckers, A., & Hanson, J. (April 2021). GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11 [Paper presentation]. 4th ERNEST meeting.

Abboud, D., Daly, A., Dupuis, N., Bahri, M. A., Inoue, A., Chevigné, A., Ectors, F., Plenevaux, A., Pirotte, B., BECKERS, A., & Hanson, J. (April 2021). GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11 [Paper presentation]. Belgian Society of Physiology and Pharmacology.

Abboud, D., Daly, A., Dupuis, N., Bahri, M. A., Inoue, A., Chevigné, A., Ectors, F., Plenevaux, A., Pirotte, B., BECKERS, A., & Hanson, J. (April 2021). GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11 [Poster presentation]. American Society for Pharmacology and Experimental Therapeutics (ASPET), GPCR colloquium.

Degotte, G., Pirotte, B., Francotte, P., & Frederich, M. (2021). Overview of natural antiplasmodials from the last decade to inspire medicinal chemistry. Current Medicinal Chemistry. doi:10.2174/0929867328666210329112354

Abboud, D., Daly, A., Dupuis, N., Bahri, M. A., Inoue, A., Chevigné, A., Ectors, F., Plenevaux, A., Pirotte, B., Beckers, A., & Hanson, J. (November 2020). GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11 [Paper presentation]. GDR3545.

Oury, C., Pirotte, B., MUSUMECI, L., Jacques, N., Goffin, E., & LANCELLOTTI, P. (22 October 2020). New pyrimidine derivatives for prevention and treatment of gram negative bacterial infection, contamination and fouling.

Abboud, D., Daly, A., Dupuis, N., Bahri, M. A., Inoue, A., Chevigné, A., Ectors, F., Plenevaux, A., Pirotte, B., Beckers, A., & Hanson, J. (21 September 2020). GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11. Nature Communications, 11 (1), 4752. doi:10.1038/s41467-020-18500-x

Etse, K. S., Comeron Lamela, L., Zaragoza, G., & Pirotte, B. (30 June 2020). Synthesis, crystal structure, Hirshfeld surface and interaction energies analysis of 5-methyl-1,3-bis(3-nitrobenzyl)pyrimidine-2,4(1H,3H)-dione. European Journal of Chemistry, 11/2, 91-99. doi:10.5155/eurjchem.11.2.91-99.1973

Stiti, M. Z., Belghobsi, M., Habila, T., Goffin, E., De Tullio, P., Pirotte, B., Faury, G., & Khelili, S. (March 2020). Synthesis and vasodilator activity of new 1,4-dihyropyridines bearing sulfonylurea, urea and thiourea moieties. Chemical Papers, 74 (3), 915 - 928. doi:10.1007/s11696-019-00925-4

Degotte, G., Pirotte, B., Frederich, M., & Francotte, P. (20 February 2020). Pharmacomodulation of natural compounds: medicinal chemistry in antimalarial purposes [Poster presentation]. ChemCys 2020, Blankenberg, Belgium.

Matute Matute, A. F., Tabart, J., CHERAMY-BIEN, J.-P., Pirotte, B., Kevers, C., Auger, C., Schini-Kerth, V., Dommes, J., Defraigne, J.-O., & PINCEMAIL, J. (22 January 2020). Compared Phenolic Compound Contents of 22 Commercial Fruit and Vegetable Juices: Relationship to Ex-Vivo Vascular Reactivity and Potential In Vivo Projection. Antioxidants, 9 (2), 92. doi:10.3390/antiox9020092

Abboud, D., Daly, A., Dupuis, N., Bahri, M. A., Inoue, A., Chevigné, A., Ectors, F., Plenevaux, A., Pirotte, B., BECKERS, A., & Hanson, J. (2020). GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11 [Paper presentation]. 9TH GDR3545 GPCR INTERNATIONAL MEETING.

Conlon, T., John-Schuster, G., Heide, D., Pfister, D., Lehmann, M., Hu, Y., Ertuz, Z., Lopez, M., Ansari, M., Strunz, M., Mayr, C., Cimineiri, C., Costa, R., Kohlhepp, M. S., Guillot, A., Günes, G., Jeridi, A., Funk, M., Beroshvili, G., ... Yildirim, A. Ö. (2020). Inhibition of LTβR-signalling activates Wnt-induced regeneration in lung. Nature. doi:10.1038/s41586-020-2882-8

Goffin, E., Jacques, N., Musumeci, L., Nchimi Longang, A., Oury, C., Lancellotti, P., & Pirotte, B. (2020). Synthesis of ticagrelor analogues belonging to 1,2,3-triazolo[4,5-d]pyrimidines and study of their antiplatelet and antibacterial activity. European Journal of Medicinal Chemistry, 208, 112767. doi:10.1016/j.ejmech.2020.112767

Hanke, S., Tindall, C. A., Pippel, J., Ulbricht, D., Pirotte, B., Reboud-Ravaux, M., Heiker, J. T., & Sträter, N. (2020). Structural Studies on the Inhibitory Binding Mode of Aromatic Coumarinic Esters to Human Kallikrein-Related Peptidase 7. Journal of Medicinal Chemistry, 63 (11), 5723-5733. doi:10.1021/acs.jmedchem.9b01806

Mouithys-Mickalad, A., Ceusters, J., Charif, M., Elmoualij, B., Schoumacher, M., Plyte, S., Franck, T., Bettendorff, L., Pirotte, B., Serteyn, D., & De Tullio, P. (2020). Modulation of mitochondrial respiration rate and calcium-induced swelling by new cromakalim analogues. Chemico-Biological Interactions, 331, 109272. doi:10.1016/j.cbi.2020.109272

Arslan, D., LAMBERT, V., Noël, A., Pirotte, B., De Tullio, P., Zorzi, D. (Other coll.), & Hansen, S. (Other coll.). (11 December 2019). From Metabolomics Study of Age Related Macular Degeneration (AMD) to the Development of New Pyruvate Dehydrogenase Kinase (PDK) Inhibitors [Poster presentation]. 2nd CIRM-day.

Degotte, G., Lempereur, D., Adubofour, Y., Pirotte, B., Frederich, M., & Francotte, P. (11 December 2019). Dimerisation of gallic acid for malaria treatment [Poster presentation]. CIRMDay, Liège, Belgium.

Abboud, D., Daly, A., Dupuis, N., Pirotte, B., BECKERS, A., & Hanson, J. (December 2019). GPR101 orphan receptor in XLAG syndrome [Paper presentation]. CIRM day.

Degotte, G., Pirotte, B., Frederich, M., & Francotte, P. (22 November 2019). Total synthesis approach: development of new antimalarial compounds [Poster presentation]. MedChem 2019, Bruxelles, Belgium.

Etse, K. S., Zaragoza, G., & Pirotte, B. (30 September 2019). Crystal structure and Hirshfeld surface analysis of N-(2-(N-methylsulfamoyl)phenyl)formamide: Degradation product of 2-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide. European Journal of Chemistry, 10 (3), 189-194. doi:10.5155/eurjchem.10.3.189-194.1903

Degotte, G., Pirotte, B., Frederich, M., & Francotte, P. (05 September 2019). Pharmacomodulation of ellagic acid: a total synthesis approach [Poster presentation]. EFMC Young Medicinal Chemist, Athènes, Greece.

Oury, C., LANCELLOTTI, P., & Pirotte, B. (22 August 2019). Pyrimidine derivatives for prevention and treatment of bacterial infections.

Oury, C., LANCELLOTTI, P., & Pirotte, B. (21 August 2019). Pyrimidine derivatives for prevention and treatment of bacterial infection.

Abboud, D., Daly, A., Dupuis, N., Pirotte, B., BECKERS, A., & Hanson, J. (July 2019). Pharmacology of GPR101 orphan receptor [Paper presentation]. Transardennaise de l’hypophyse.

Schoumacher, M., LAMBERT, V., Hansen, S., leenders, J., govaerts, B., Pirotte, B., Rakic, J.-M., Noël, A., & De Tullio, P. (23 June 2019). New insight in Metabolomics based study of Age Related Macular Degeneration (AMD): Lipoprotein profile and patients follow-up [Poster presentation]. Metabolomics 2019, The Hague, Netherlands.

Abboud, D., Daly, A., Dupuis, N., Pirotte, B., BECKERS, A., & Hanson, J. (May 2019). GPR101 orphan receptor in XLAG syndrome [Paper presentation]. Belgian Society of Physiology and Pharmacology.

Degotte, G., Halleux, A., Pirotte, B., Francotte, P., & Frederich, M. (May 2019). Design of new antimalarials inspired by ellagic acid through a total synthesis approach [Poster presentation]. Phytoday, Bruxelles, Belgium.

Lancellotti, P., Musumeci, L., Jacques, N., Servais, L., Goffin, E., Pirotte, B., & Oury, C. (2019). Antibacterial Activity of Ticagrelor in Conventional Antiplatelet Dosages Against Antibiotic-Resistant Gram-Positive Bacteria. JAMA Cardiology. doi:10.1001/jamacardio.2019.1189

Pirotte, B., Florence, X., Goffin, E., & Lebrun, P. (01 March 2019). 2,2-Dimethyl-3,4-dihydro-2H-1,4-benzoxazines as isosteres of 2,2-dimethylchromans acting as inhibitors of insulin release and vascular smooth muscle relaxants. MedChemComm, 10 (3), 431-438. doi:10.1039/c8md00593a

Manos-Turvey, A., Becker, G., Francotte, P., Serrano Navacerrada, M. E., Luxen, A., Pirotte, B., Plenevaux, A., & Lemaire, C. (11 February 2019). Fully Automated Synthesis and Evaluation of [ 18 F]BPAM121: Potential of an AMPA Receptor Positive Allosteric Modulator as PET Radiotracer. ChemMedChem, 14 (7), 788-795. doi:10.1002/cmdc.201800816

Habila, T., Belghobsi, M., Stiti, M.-Z., Goffin, E., De Tullio, P., Faury, G., Pirotte, B., & Khelili, S. (2019). Synthesis and vasodilator activity of 3,4-dihydropyrimidin-2(1H)-ones bearing urea, thiourea, and sulfonylurea moieties. Canadian Journal of Chemistry, 97 (1), 20 - 28. doi:10.1139/cjc-2018-0239

Harrouche, K., Lahouel, A., Belghobsi, M., Pirotte, B., & Khelili, S. (2019). Synthesis, characterization, and investigation of the antioxidant activity of some 1,2,4-benzothiadiazine-1,1-dioxides bearing sulfonylthioureas moieties. Canadian Journal of Chemistry, 97 (12), 824 - 832. doi:10.1139/cjc-2019-0194

Laulumaa, S., Hansen, K. V., Masternak, M., Drapier, T., Francotte, P., Pirotte, B., Frydenvang, K., & Kastrup, J. S. (2019). Crystal Structures of Potent Dimeric Positive Allosteric Modulators at the Ligand-Binding Domain of the GluA2 Receptor. ACS Medicinal Chemistry Letters, 10 (3), 243-247. doi:10.1021/acsmedchemlett.8b00369

Arslan, D., LAMBERT, V., Noël, A., Pirotte, B., De Tullio, P., Schoumacher, M. (Other coll.), Hansen, S. (Other coll.), & Elmoualij, B. (Other coll.). (19 December 2018). From Metabolomics Study of Age Related Macular Degeneration (AMD) to the Development of New Pyruvate Dehydrogenase Kinase (PDK) Inhibitors [Paper presentation]. 1st CIRM DAY.

Abboud, D., Daly, A., Dupuis, N., Pirotte, B., BECKERS, A., & Hanson, J. (December 2018). GPR101 orphan receptor in XLAG syndrome [Paper presentation]. CIRM day.

Degotte, G., Halleux, A., Hans, A., Jansen, O., Ledoux, A., Desdemoustier, P., Pirotte, B., Francotte, P., & Frederich, M. (December 2018). Preparation of ellagic acid derivatives through a total synthesis approach to improve bioavailability [Poster presentation]. 1st CIRM Day, Liège, Belgium.

Arslan, D., LAMBERT, V., Elmoualij, B., Noël, A., Pirotte, B., De Tullio, P., Schoumacher, M. (Other coll.), & Hansen, S. (Other coll.). (23 November 2018). From Metabolomics Study of Age Related Macular Degeneration (AMD) to the Development of New Pyruvate Dehydrogenase Kinase Inhibitors (PDK) [Poster presentation]. MedChem 2018 New Avenues in Kinase Drug Discovery: a Bright Future ?.

Degotte, G., Francotte, P., Frederich, M., Halleux, A., Hans, A., Jansen, O., Ledoux, A., Desdemoustier, P., & Pirotte, B. (November 2018). Pharmacomodulation of ellagic acid, a promising antiplasmodial agent, to improve its bioavailability [Poster presentation]. 30th International Symposium on the Chemistry of Natural Products and the 10th International Conference on Biodiversity, Athens, Greece.

Abboud, D., Daly, A., Laschet, C., Pirotte, B., BECKERS, A., & Hanson, J. (05 July 2018). GPR101 orphan receptor: a novel cause of growth hormone deregulation [Paper presentation]. World Congress of Basic and Clinical Pharmacology WCP 2018- IUPHAR, Kyoto, Japan.

Abboud, D., Daly, A., Dupuis, N., Pirotte, B., BECKERS, A., & Hanson, J. (July 2018). The orphan receptor GPR101 as a novel cause of growth hormone deregulation [Poster presentation]. 18th International Union of Basic and Clinical Pharmacology (IUPHAR) congress.

Schoumacher, M., LAMBERT, V., Hansen, S., Leenders, J., Govaerts, B., Pirotte, B., Rakic, J.-M., Noël, A., & De Tullio, P. (24 June 2018). NMR-Based metabolomics study of Age-related Macular Degeneration (AMD): from pre-clinic model to new target discovery [Poster presentation]. Metabolomics 2017, Seattle, United States.

Courtois, A., Makrygiannis, G., CHERAMY-BIEN, J.-P., Purnelle, A., Pirotte, B., Dogné, J.-M., Hanson, J., Defraigne, J.-O., Drion, P., & SAKALIHASAN, N. (2018). Therapeutic Applications of Prostaglandins and Thromboxane A2 Inhibitors in Abdominal Aortic Aneurysms. Current Drug Targets. doi:10.2174/1389450119666171227224314

Drapier, T., Geubelle, P., Bouckaert, C., Nielsen, L., Laulumaa, S., Goffin, E., Dilly, S. A., Francotte, P., Hanson, J., Pochet, L., Kastrup, J., & Pirotte, B. (2018). Enhancing Action of Positive Allosteric Modulators through the Design of Dimeric Compounds. Journal of Medicinal Chemistry. doi:10.1021/acs.jmedchem.8b00250

Goffin, E.* , Drapier, T.* , Probst Larsen, A., Geubelle, P., Ptak, C. P., Laulumaa, S., Rovinskaja, K., Gilissen, J., De Tullio, P., Olsen, L., Frydenvang, K., Pirotte, B., Hanson, J., Oswald, R. E., Sandholm Kastrup, J., & Francotte, P. (2018). 7‐Phenoxy-Substituted 3,4-Dihydro‐2H‐1,2,4-benzothiadiazine 1,1- Dioxides as Positive Allosteric Modulators of α‐Amino-3-hydroxy-5- methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency. Journal of Medicinal Chemistry, 61, 251-264. doi:10.1021/acs.jmedchem.7b01323

Schoumacher, M., LAMBERT, V., Hansen, S., Leenders, J., Govaerts, B., Pirotte, B., Rakic, J.-M., Noël, A., & De Tullio, P. (02 October 2017). New Translational Metabolomics Exploration of Age-Related Macular Degeneration: From Patients to Functional Implication of Lactate [Poster presentation]. SMMAP 2017, Paris, France.

Arslan, D., Schoumacher, M., Pirotte, B., De Tullio, P., Hansen, S. (Other coll.), LAMBERT, V. (Other coll.), Elmoualij, B. (Other coll.), & Noël, A. (Other coll.). (14 September 2017). From Metabolomics Study of Age-Related Macular Degeneration (AMD) to the Development of New Pyruvate Dehydrogenase Kinase Inhibitors (PDK) [Poster presentation]. 31éme ournée Franco-Belge de Pharmacochimie, SPA, Belgium.

Geubelle, P., Gilissen, J., Laschet, C., Dilly, S., Huart, J., Jouret, F., Pirotte, B., & Hanson, J. (13 September 2017). Development of original ligands for SUCNR1 [Poster presentation]. International Symposium on GPCRs and G-proteins, Bonn, Königswinter, Germany.

Manos-Turvey, A., Lemaire, C., Becker, G., Plenevaux, A., Luxen, A., Pirotte, B., & Francotte, P. (August 2017). Design and Synthesis of [18F]BPAM121, a PET-Probe Targeting AMPA-subtype Glutamatergic Receptors [Poster presentation]. EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry, Vienne, Austria.

Abboud, D., Daly, A., Laschet, C., Pirotte, B., BECKERS, A., & Hanson, J. (07 July 2017). Pharmacology of GPR101 [Paper presentation]. Transardennaise de l'hypophyse, Liège, Belgium.

Manos-Turvey, A., Lemaire, C., Becker, G., Plenevaux, A., Luxen, A., Francotte, P., & Pirotte, B. (July 2017). Synthesis of [18F]BPAM121: An AMPAR Modulator with Potential as a PET Probe [Poster presentation]. RICT 2017, Drug Discovery and Selection, 53rd International Conference on Medicinal Chemistry, Toulouse, France.

Schnekenburger, M., Goffin, E., Lee, J.-Y., Jang, J. Y., Mazumder, A., Ji, S., Rogister, B., Bouider, N., Lefranc, F., Miklos, W., Mathieu, V., De Tullio, P., Kim, K.-W., Dicato, M., Berger, W., Han, B., Kiss, R., Pirotte, B., & Diederich, M. (08 June 2017). Discovery and Characterization of R/S-N-3-Cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea, a New Histone Deacetylase Class III Inhibitor Exerting Antiproliferative Activity against Cancer Cell Lines. Journal of Medicinal Chemistry, 60 (11), 4714-4733. doi:10.1021/acs.jmedchem.7b00533

Dupuis, N., Laschet, C., Franssen, D., Martyna, S., Gilissen, J., Geubelle, P., Soni, A., Parent, A.-S., Pirotte, B., Chevigné, A., Twizere, J.-C., & Hanson, J. (01 June 2017). Activation of the orphan G protein-coupled receptor GPR27 by surrogate ligands promotes β-arrestin 2 recruitment. Molecular Pharmacology, 91 (6), 595-608. doi:10.1124/mol.116.107714

Larsen, A. P., Fièvre, S., Frydenvang, K., Francotte, P., Pirotte, B., Kastrup, J. S., & Mulle, C. (June 2017). Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors. Molecular Pharmacology, 91, 576-585. doi:10.1124/mol.116.107599

Manos-Turvey, A., Lemaire, C., Deverdenne, F., Luxen, A., Francotte, P., & Pirotte, B. (June 2017). [18F]BPAM121: An AMPAR Modulator with Potential as a PET Probe [Poster presentation]. Royal Society of Chemistry Medicinal Chemistry Residential School, Loughborough, United Kingdom.

Abboud, D., Daly, A., Dupuis, N., Laschet, C., Geubelle, P., Pirotte, B., BECKERS, A., & Hanson, J. (May 2017). GPR101 orphan GPCR: a novel cause of growth hormone deregulation [Poster presentation]. 19th European Congress of Endocrinology, Lisbon, Portugal.

Geubelle, P., Gilissen, J., Dilly, S., POMA, L., Dupuis, N., Laschet, C., Abboud, D., Inoue, A., Jouret, F., Pirotte, B., & Hanson, J. (May 2017). Identification and pharmacological characterization of succinate receptor agonists. British Journal of Pharmacology, 174 (9), 796-808. doi:10.1111/bph.13738

Abboud, D., Daly, A., Dupuis, N., Laschet, C., Geubelle, P., Pirotte, B., BECKERS, A., & Hanson, J. (April 2017). GPR101 orphan GPCR: a novel cause of growth hormone deregulation [Poster presentation]. Belgian Society of Physiology and Pharmacology, Bruxelles, Belgium.

Pirotte, B., Florence, X., Goffin, E., & Lebrun, P. (2017). Deciphering Structure-Activity Relationships in a Series of 2,2-Dimethylchromans Acting as Inhibitors of Insulin Release and Smooth Muscle Relaxants. ChemMedChem, 12 (21), 1810-1817. doi:10.1002/cmdc.201700409

Abboud, D., Dupuis, N., Laschet, C., Geubelle, P., Pirotte, B., & Hanson, J. (November 2016). GPR101 orphan GPCR: a novel cause of growth hormone deregulation [Poster presentation]. Fifth annual meeting of the CNRS GDR-3545, G Protein-coupled Receptors: from Physiology to Drugs (RCPG-Physio-Med), Tours, France.

Dupuis, N., Franssen, D., Laschet, C., Geubelle, P., Soni, A., Abboud, D., Twizere, J.-C., Pirotte, B., & Hanson, J. (26 September 2016). Small molecule ligands for the orphan GPR27 [Poster presentation]. GLISTEN meeting 2016 in Prague.

Schoumacher, M., LAMBERT, V., Hansen, S., Leenders, J., Govaerts, B., Pirotte, B., Rakic, J.-M., Noël, A., & De Tullio, P. (27 June 2016). New Insight into exudative Age-related Macular Degeneration (AMD): A Metabolomics Approach [Poster presentation]. Metabolomics 2016, Dublin, Ireland.

Krintel, C.* , Francotte, P.* , Pickering, D. S., Juknaite, L., Pøhlsgaard, J., Olsen, L., Frydenvang, K., Goffin, E., Pirotte, B., & Kastrup, J. (07 June 2016). Enthalpy-Entropy Compensation in the Binding of Modulators at Ionotropic Glutamate Receptor GluA2. Biophysical Journal, 110, 2397-2406. doi:10.1016/j.bpj.2016.04.032

Drapier, T., Geubelle, P., Bouckaert, C., Goffin, E., Dilly, S., Hanson, J., Pochet, L., Kastrup, J. S., Francotte, P., & Pirotte, B. (26 May 2016). DESIGN OF HIGH-AFFINITY LIGANDS FOR THE BENZOTHIADIAZINE ALLOSTERIC BINDING SITE OF THE AMPA RECEPTORS [Poster presentation]. JFB 2016 : 30èmes Journées Franco-Belges de Pharmacochimie 25-27 May 2016 Amboise (France), Amboise, France.

Geubelle, P., Gilissen, J., Dilly, S., Jouret, F., Pirotte, B., & Hanson, J. (26 May 2016). Development of original ligands for SUCNR1 [Poster presentation]. 30èmes JFB de Pharmacochimie, Amboise, France.

Arslan, D., Schoumacher, M., Pirotte, B., De Tullio, P., Hansen, S. (Other coll.), LAMBERT, V. (Other coll.), Elmoualij, B. (Other coll.), & Noël, A. (Other coll.). (May 2016). From Metabolomics Study of Age-Related Macular Degeneration (AMD) to the Development of New Pyruvate Dehydrogenase Kinase Inhibitors (PDK) [Poster presentation]. JFB 2016 : 30èmes Journées Franco-Belges de Pharmacochimie, Amboise, France.

Schoumacher, M., De Tullio, P., LAMBERT, V. (Other coll.), Hansen, S. (Other coll.), Leenders, J. (Other coll.), Govaerts, B. (Other coll.), Pirotte, B. (Other coll.), RAKIC, J.-M. (Other coll.), & Noël, A. (Other coll.). (May 2016). From Metabolomics to Identification of a new therapeutic approach for Age-Related Macular Degeneration (AMD) [Poster presentation]. JFB 2016 : 30èmes Journées Franco-Belges de Pharmacochimie, Amboise, France.

Tabart, J., Shini-Kerth, V., PINCEMAIL, J., Kevers, C., Pirotte, B., Defraigne, J.-O., & Dommes, J. (22 April 2016). Effect of Ribes nigrum leaf extracts on endothelium-dependent vasorelaxation [Poster presentation]. New frontiers in oxidative stress and redox regulation - groupe de contact FNRS "Oxidative Processes and Antioxidants", Louvain-La-Neuve, Belgium.

Dupuis, N., Gilissen, J., Derj, A., Soni, A., Geubelle, P., Laschet, C., Piron, C., Twizere, J.-C., Pirotte, B., & Hanson, J. (25 January 2016). Identification of small molecule ligands for the orphan GPCR GPR27 [Poster presentation]. GIGA-DAY 2016.

Geubelle, P., Gilissen, J., Dupuis, N., Derj, A., Laschet, C., Soni, A., Pirotte, B., & Hanson, J. (25 January 2016). Design, synthesis and identification of ligands for SUCNR1 and GPR22 [Paper presentation]. 2016 GIGA Day - Signal transduction pathways in health and disease, Liège, Belgium.

Laschet, C., Dupuis, N., Derj, A., Gilissen, J., Geubelle, P., Soni, A., Pirotte, B., & Hanson, J. (25 January 2016). Targeted and random mutagenesis of orphan GPCRs of the SREB family [Poster presentation]. GIGA-Day.

Frederich, M., Pirotte, B., Fillet, M., & De Tullio, P. (2016). Metabolomics as a Challenging Approach for Medicinal Chemistry and Personalized Medicine. Journal of Medicinal Chemistry, 59 (19), 8649–8666. doi:10.1021/acs.jmedchem.5b01335

Gilissen, J., Jouret, F., Pirotte, B., & Hanson, J. (2016). Insight into SUCNR1 (GPR91) structure and function. Pharmacology and Therapeutics. doi:10.1016/j.pharmthera.2016.01.008

Harrouche, K., Renard, J., Bouider, N., De Tullio, P., Goffin, E., Lebrun, P., Faury, G., Pirotte, B., & Khelili, S. (2016). Synthesis, characterization and biological evaluation of benzothiazoles and tetrahydrobenzothiazoles bearing urea or thiourea moieties as vasorelaxants and inhibitors of the insulin releasing process. European Journal of Medicinal Chemistry, 115, 352-360. doi:10.1016/j.ejmech.2016.03.028

Larsen, A., Francotte, P., Frydenvang, K., Tapken, D., Goffin, E., Fraikin, P., Caignard, D., Lestage, P., Danober, L., Pirotte, B., & Kastrup, J. (2016). Synthesis and Pharmacology of Mono-, Di-, and Trialkyl-Substituted 7-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides Combined with X-ray Structure Analysis to Understand the Unexpected Structure-Activity Relationship at AMPA Receptors. ACS Chemical Neurosciences, 7, 378-390. doi:10.1021/acschemneuro.5b00318

Pirotte, B., Florence, X., Goffin, E., Medeiros, M., De Tullio, P., & Lebrun, P. (2016). 4-Phenylureido/thioureido-substituted 2,2-dimethylchroman analogs of cromakalim bearing a bulky 'carbamate' moiety at the 6-position as potent inhibitors of glucose-sensitive insulin secretion. European Journal of Medicinal Chemistry, 121, 338-351. doi:10.1016/j.ejmech.2016.05.042

Tabart, J., Schini-Kerth, V., PINCEMAIL, J., Kevers, C., Pirotte, B., Defraigne, J.-O., & Dommes, J. (2016). The leaf extract of Ribes nigrum L. is a potent stimulator of the endothelial formation of NO in cultured endothelial cells and porcine coronary artery rings. Journal of Berry Research, 6, 277-289. doi:10.3233/JBR-160129

Arslan, D., Schoumacher, M., Pirotte, B., De Tullio, P., Hansen, S. (Other coll.), LAMBERT, V. (Other coll.), Elmoualij, B. (Other coll.), & Noël, A. (Other coll.). (12 November 2015). FROM METABOLOMICS STUDY OF AGE RELATED MACULAR DEGENERATION (AMD) TO THE DEVELOPMENT OF NEW PDK INHIBITORS [Poster presentation]. International Gazi Pharma Symposium Series, Antalya, Turkey.

Deverdenne, F., Claes, G., Goffin, E., Plenevaux, A., Pirotte, B., Luxen, A., & Francotte, P. (05 June 2015). Design and synthesis of PET-probes targeting AMPA-subtype receptors [Poster presentation]. 29èmes Journées franco-belges de Pharmacochimie, Spa, Belgium.

Geubelle, P., Gilissen, J., Dupuis, N., Derj, A., Laschet, C., Soni, A., Pirotte, B., & Hanson, J. (05 June 2015). Identification, Design and Evaluation of Pharmacological tools for the orphan GPCR GPR22 [Paper presentation]. 29ème Journées Franco-Belge de Pharmacochimie, Spa, Belgium.

Drapier, T., Francotte, P., Pirotte, B., Goffin, E. (Other coll.), Hanson, J. (Other coll.), Dilly, S. (Other coll.), & Kastrup, J. (Other coll.). (04 June 2015). Design, synthesis and pharmacological evaluation of dimeric ligands for the benzothiadiazine dioxide allosteric binding site of the AMPA receptors [Paper presentation]. 29ème Journées Franco-Belge de Pharmacochimie, Spa, Belgium.

Schoumacher, M., Arslan, D., De Tullio, P., Hansen, S. (Other coll.), LAMBERT, V. (Other coll.), Elmoualij, B. (Other coll.), Noël, A. (Other coll.), & Pirotte, B. (Other coll.). (June 2015). From Metabolic Study of Age-Related Macular Degeneration (AMD) to Development of New PDH Kinase Inhibitors [Poster presentation]. 29ème Journées Franco-Belge de Pharmacochimie, Spa, Belgium.

Deverdenne, F., Claes, G., Goffin, E., Plenevaux, A., Pirotte, B., Luxen, A., & Francotte, P. (13 May 2015). Design and synthesis of PET-probes targeting AMPA subtype receptors [Poster presentation]. The Bioforum 2015 of BioLiège, Liège, Belgium.

Dupuis, N., Gilissen, J., Derj, A., Laschet, C., Geubelle, P., Soni, A., Piron, C., Twizere, J.-C., Pirotte, B., & Hanson, J. (27 January 2015). ßarrestin coupling of the orphan GPCR GPR27 [Poster presentation]. GIGA-day 2015, Liege, Belgium.

Geubelle, P., Gilissen, J., Dupuis, N., Derj, A., Laschet, C., Soni, A., Pirotte, B., & Hanson, J. (27 January 2015). Identification, Design and Evaluation of Pharmacological tools for the orphan GPCR GPR22 [Poster presentation]. 2015 GIGA Day: Current Advances in Medical Genetics and Genomics, Liège, Belgium.

Bouider, N., Fhayli, W., Ghandour, Z., Boyer, M., Harrouche, K., Florence, X., Pirotte, B., Lebrun, P., Faury, G., & Khelili, S. (2015). Design and synthesis of new potassium channel activators derived from the ring opening of diazoxide: Study of their vasodilatory effect, stimulation of elastin synthesis and inhibitory effect on insulin release. Bioorganic and Medicinal Chemistry, 23, 1735-1746. doi:10.1016/j.bmc.2015.02.043

Cieckiewicz, E., Mathieu, V., Angenot, L., Gras, T., Dejaegher, B., De Tullio, P., Pirotte, B., & Frederich, M. (2015). Semisynthesis and in Vitro Photodynamic Activity Evaluations of Halogenated and Glycosylated Derivatives of Pheophorbide a. European Journal of Organic Chemistry, 2015 (27), 6061-6074. doi:10.1002/ejoc.201500387

Gilissen, J., Geubelle, P., Dupuis, N., Laschet, C., Pirotte, B., & Hanson, J. (2015). Forskolin-free cAMP assay for Gi-coupled receptors. Biochemical Pharmacology. doi:10.1016/j.bcp.2015.09.010

Tan, X., Soualmia, F., Furio, L., Renard, J.-F., Kempen, I., Qin, L., Pagano, M., Pirotte, B., El Amri, C., Hovnanian, A., & Reboud-Ravaux, M. (2015). Toward the First Class of Suicide Inhibitors of Kallikreins Involved in Skin Diseases. Journal of Medicinal Chemistry, 58, 598-612. doi:10.1021/jm500988d

Nørholm, A.-B., Francotte, P., Goffin, E., Botez-Pop, I., Danober, L., Lestage, P., Pirotte, B., Olsen, L., & Oostenbrink, C. (24 November 2014). Thermodynamic Characterization of New Positive Allosteric Modulators Binding to the Glutamate Receptor A2 Ligand-Binding Domain: Combining Experimental and Computational Methods Unravels Differences in Driving Forces. Journal of Chemical Information and Modeling, 54 (12), 3404-3416. doi:10.1021/ci500559b

Geubelle, P., Gilissen, J., Dupuis, N., Derj, A., Laschet, C., Soni, A., Pirotte, B., & Hanson, J. (21 November 2014). Identification, Design and Evaluation of Pharmacological tools for the orphan GPCR GPR22 [Poster presentation]. MedChem 2014 New Vistas in GPCR Research: the Dawn of an Exciting Drug Discovery Era?, Braine-L'Alleud, Belgium.

Laschet, C., Dupuis, N., Derj, A., Gilissen, J., Geubelle, P., Soni, A., Pirotte, B., & Hanson, J. (21 November 2014). Understanding the pharmacology and signaling pathways of the orphan G protein coupled receptor GPR85/SREB2 [Poster presentation]. Annual one-day meeting on medicinal chemistry.

Francotte, P.* , Nørholm, A.-B.* , Deva, T., Olsen, L., Frydenvang, K., Goffin, E., Fraikin, P., De Tullio, P., Challal, S., Thomas, J.-Y., Iop, F., Louis, C., Botez-Pop, I., Lestage, P., Danober, L., Kastrup, J. S., & Pirotte, B. (06 November 2014). Positive Allosteric Modulators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors Belonging to 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-pyridothiadiazine Dioxides and Diversely Chloro-Substituted 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides. Journal of Medicinal Chemistry, 57 (22), 9539-9553. doi:10.1021/jm501268r

Dupuis, N., Gilissen, J., Derj, A., Laschet, C., Geubelle, P., Soni, A., Twizere, J.-C., Pirotte, B., & Hanson, J. (October 2014). Identifying ligands for orphan receptors: test screening of a SOSA library with a complementation assay for orphan GPCR GPR27 [Poster presentation]. third annual meeting of the GDR3545, Montpellier, France.

Arslan, D., Pirotte, B., De Tullio, P., Charif, M. (Other coll.), Dilly, S. (Other coll.), Hansen, S. (Other coll.), LAMBERT, V. (Other coll.), Elmoualij, B. (Other coll.), & Noël, A. (Other coll.). (09 September 2014). AGE-RELATED MACULAR DEGENERATION (AMD): FROM METABOLOMICS APPROACH TO THE INHIBITION OF PDK AS A NEW THERAPEUTIC TARGET [Poster presentation]. XXIII International Symposium on Medicinal Chemistry (EFMC-ISMC 2014), Lisbonne, Portugal.

Dupuis, N., Gilissen, J., Derj, A., Soni, A., Twizere, J.-C., Pirotte, B., & Hanson, J. (16 July 2014). Ligand-independent Identification of orphan GPCR Signaling pathways [Paper presentation]. World Congress of basic & clinical Pharmacology, Cape Town, South Africa.

LAMBERT, V., Dufour, G., Chiap, P., Evrard, B., Noël, A., Pirotte, B., & De Tullio, P. (23 June 2014). NMR in the Pharmaceutical and Biomedical areas for identification and quantification of drugs and metabolomics applications [Paper presentation]. Drug Analysis 2014, Liège, Belgium.

Deverdenne, F., Goffin, E., Plenevaux, A., Pirotte, B., Luxen, A., & Francotte, P. (05 June 2014). Design and synthesis of high-affinity ligands of AMPA receptors and study of their Fluorine-18 radiolabeling [Poster presentation]. 28èmes Journées franco-belges de Pharmacochimie, Metz, France.

Dupuis, N., Gilissen, J., Derj, A., Soni, A., Twizere, J.-C., Pirotte, B., & Hanson, J. (05 June 2014). LIGAND-INDEPENDENT IDENTIFICATION OF ORPHAN GPCR ARRESTIN BINDING [Poster presentation]. 23èmes Journées franco-belges de Pharmacochimie, Metz, France.

Arslan, D., Pirotte, B., De Tullio, P., Charif, M. (Other coll.), Dilly, S. (Other coll.), Hansen, S. (Other coll.), LAMBERT, V. (Other coll.), Elmoualij, B. (Other coll.), & Noël, A. (Other coll.). (June 2014). Inhibition of PDH Kinase as a new therapeutic target for Age-related Macular Degeneration (AMD) [Poster presentation]. 28e Journées franco-belges de Pharmacochimie, Communauté de Metz Métropole, France.

Drapier, T., Goffin, E., Hanson, J., Dilly, S., Francotte, P., Kastrup, J., & Pirotte, B. (June 2014). DESIGN OF HIGH-AFFINITY LIGANDS FOR THE BENZOTHIADIAZINE ALLOSTERIC BINDING SITE OF THE AMPA RECEPTORS [Poster presentation]. 28èmes Journées franco-belges de Pharmacochimie, Metz, France.

Dupuis, N., Gilissen, J., Derj, A., Soni, A., Twizere, J.-C., Pirotte, B., & Hanson, J. (04 April 2014). Ligand-independent Identification of orphan GPR27 Signaling pathways [Poster presentation]. Physphar 2014.

DUBOIS, N., Counerotte, S., Goffin, E., Pirotte, B., & Charlier, C. (April 2014). Validation analytique d'une méthode chromatographique destinée à rechercher et à identifier les opiacés naturels ou (semi) synthétiques. Annales de Biologie Clinique, 72 (2), 197-206. doi:10.1684/abc.2014.0944

Derj, A., Dupuis, N., Gilissen, J., Soni, A., Pirotte, B., Chevigné, A., & Hanson, J. (27 January 2014). Unraveling the signaling and dimerization properties of CXCR3 isoforms and their interplay with CXCR7 in the context of glioblastoma pathology [Poster presentation]. GIGA Day 2014, Liège, Belgium.

Dupuis, N., Gilissen, J., Derj, A., Soni, A., Twizere, J.-C., Pirotte, B., & Hanson, J. (14 January 2014). Development of a luciferase complementation assay for ligand screening on orphan GPCR GPR27 [Poster presentation]. GIGA-DAY 2014.

Florence, X., Desvaux, V., Goffin, E., De Tullio, P., Pirotte, B., & Lebrun, P. (2014). Influence of the alkylsulfonylamino substituent located at the 6-position of 2,2-dimethylchromans structurally related to cromakalim: From potassium channel openers to calcium entry blockers? European Journal of Medicinal Chemistry, 80, 36-46. doi:10.1016/j.ejmech.2014.04.024

Noerholm, A.-B., Francotte, P., Goffin, E., Botez, L., Danober, L., Lestage, P., Pirotte, B., Kastrup, J. S., Olsen, L., & Oostenbrink, C. (2014). Thermodynamic Characterization of New Positive Allosteric Modulators Binding to the Glutamate Receptor A2 Ligand-Binding Domain: Combining Experimental and Computational Methods Unravels Differences in Driving Forces. Journal of Chemical Information and Modeling, 54, 3404-3416.

Renard, J.-F., Lecomte, F., Hubert, P., de Leval, X., & Pirotte, B. (2014). N-(3-Arylaminopyridin-4-yl)alkanesulfonamides as pyridine analogs of nimesulide: Cyclooxygenases inhibition, anti-inflammatory studies and insight on metabolism. European Journal of Medicinal Chemistry, 74, 12-22. doi:10.1016/j.ejmech.2013.12.033

Dupuis, N., Gilissen, J., Twizere, J.-C., Pirotte, B., & Hanson, J. (18 October 2013). Development of an original β-arrestin complementation assay for orphan GPCR GPR27(SREB1) ligand and signaling pathways determination [Poster presentation]. Autumn Meeting of Belgian Society of Physiology and Pharmacology.

Nørholm, A.-B., Francotte, P., Olsen, L., Krintel, C., Frydenvang, K., Goffin, E., Challal, S., Danober, L., Botez-Pop, I., Lestage, P., Pirotte, B., & Kastrup, J. S. (16 October 2013). Synthesis, Pharmacological and Structural Characterization, and Thermodynamic Aspects of GluA2-Positive Allosteric Modulators with a 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxide Scaffold. Journal of Medicinal Chemistry, 56 (21), 8736–8745. doi:10.1021/jm4012092

Francotte, P., Goffin, E., Fraikin, P., Graindorge, E., Lestage, P., Danober, L., Challal, S., Rogez, N., Nosjean, O., Caignard, D.-H., Pirotte, B., & De Tullio, P. (03 October 2013). Development of Thiophenic Analogues of Benzothiadiazine Dioxides as New Powerful Potentiators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid (AMPA) Receptors. Journal of Medicinal Chemistry, 56 (20), 7838-7850. doi:10.1021/jm400676g

Bambi Nyanguile, S.-M., Hanson, J., OOMS, A., Alpan, L., Kolh, P., dogné, J.-M., & Pirotte, B. (July 2013). Synthesis and pharmacological evaluation of 2-aryloxy/arylamino-5-cyanobenzenesulfonylureas as novel thromboxane A2 receptor antagonists. European Journal of Medicinal Chemistry, 65, 32-40. doi:10.1016/j.ejmech.2013.04.033

Arslan, D., Dilly, S., LAMBERT, V., Hansen, S., RAKIC, J.-M., Noël, A., Govaerts, B., Pirotte, B., & De Tullio, P. (06 June 2013). Age-related Macular Degeneration (AMD): from Metabolomics approach to the inhibition of PDH Kinase as a new therapeutic target [Poster presentation]. 27e Journées franco-belges de Pharmacochimie, Lille, France.

Dupuis, N., Gilissen, J., Pirotte, B., & Hanson, J. (06 June 2013). Identification of chemical probes and signaling pathways for the orphan GPCR GPR27 [Poster presentation]. 27èmes Journées franco-belges de Pharmacochimie & 21èmes Conférences européennes du GP2A, Lille, France.

LAMBERT, V., Hansen, S., Rousseau, R., Govaerts, B., Pirotte, B., RAKIC, J.-M., Noël, A., & De Tullio, P. (23 May 2013). Age-related Macular Degeneration Study: A Metabolomics Approach [Paper presentation]. First Belgian-Netherlands Joint Symposium on Metabolomics: Transational approaches in Metabolomics, Spa, Belgium.

Esters, V., Karangwa, C., Tits, M., Francotte, P., Pirotte, B., Servais, A.-C., Fillet, M., Crommen, J., Robbrecht, E., MINET, A., Grisar, T., Angenot, L., & Frederich, M. (March 2013). Unusual Amino Acids and Monofluoroacetate from Dichapetalum michelsonii (Umutambasha), a Toxic Plant from Rwanda. Planta Medica, 79, 334-337. doi:10.1055/s-0032-1328283

Dupuis, N., Gilissen, J., Pirotte, B., & Hanson, J. (28 January 2013). Chemical probes and signaling pathways for the orphan GPCR GPR27 [Poster presentation]. Giga-Day 2013.

Gilissen, J., Pirotte, B., Hanson, J., & Dupuis, N. (Other coll.). (28 January 2013). Pharmacological evaluation of succinic acid receptor (SUCNR1) modulators [Poster presentation]. GIGA Day 2013.

Akika, F.-Z., Kihal, N., Habila, T., Avramova, I., Suzer, S., Pirotte, B., & Khelili, S. (2013). Synthesis and characterization of Zn(1-x)NixAl2O4 spinels as a new heterogeneous catalyst of Biginelli's reaction. Bulletin of the Korean Chemical Society, 34, 1445-1453. doi:10.5012/bkcs.2013.34.5.1445

Bambi Nyanguile, S.-M., Mangwala Kimpende, P., Pirotte, B., & Van Meervelt, L. (2013). N-tert-butyl-N'-[5-cyano-2-(4-methylphenoxy)phenylsulfonyl]urea, a new TXA₂ receptor antagonist. Acta Crystallographica. Section C, Crystal Structure Communications, 69, 901-903. doi:10.1107/S010827011301771X

Constant-Urban, C., Charif, M., Goffin, E., VAN HEUGEN, J.-C., Elmoualij, B., CHIAP, P., Mouithys-Mickalad, A., Serteyn, D., Lebrun, P., Pirotte, B., & De Tullio, P. (2013). Triphenylphosphonium salts of 1,2,4-benzothiadiazine 1,1-dioxides related to diazoxide targeting mitochondrial ATP-sensitive potassium channels. Bioorganic and Medicinal Chemistry Letters, 23, 5878-5881. doi:10.1016/j.bmcl.2013.08.091

Hanson, J., Ferreiros, N., Pirotte, B., Geisslinger, G., & Offermanns, S. (2013). Heterologously expressed formyl peptide receptor 2 (FPR2/ALX) does not respond to lipoxin A4. Biochemical Pharmacology, 85, 1795-1802. doi:10.1016/j.bcp.2013.04.019

Mouithys-Mickalad, A., Ceusters, J., Charef, M., Pirotte, B., Ballarini, M., Franck, T., Elmoualij, B., Plyte, S., Fancelli, D., Deby-Dupont, G., De Tullio, P., & Serteyn, D. (2013). Effects of diazoxide, benzothiadiazine and benzopyrane derivatives on mitochondrial proton and electron leaks of cardiomyocytes (H9C2 cell line) [Poster presentation]. 4th World Congress on Targeting Mitochondria 2013 - Berlin, Germany, Berlin, Germany.

Pirotte, B., De Tullio, P., Florence, X., Goffin, E., Somers, F., Boverie, S., & Lebrun, P. (2013). 1,4,2-Benzo/pyridodithiazine 1,1-Dioxides Structurally Related to the ATP-Sensitive Potassium Channel Openers 1,2,4-Benzo/pyridothiadiazine 1,1-Dioxides Exert a Myorelaxant Activity Linked to a Distinct Mechanism of Action. Journal of Medicinal Chemistry, 56, 3247-3256. doi:10.1021/jm301743b

Pirotte, B., Francotte, P., Goffin, E., & De Tullio, P. (2013). AMPA receptor positive allosteric modulators: a patent review. Expert Opinion on Therapeutic Patents, 23, 615-628. doi:10.1517/13543776.2013.770840

Gilissen, J., Pirotte, B., Hanson, J., & Dupuis, N. (Other coll.). (30 November 2012). Synthesis and pharmacological evaluation of succinic acid receptor (SUCNR1) small molecule modulators [Poster presentation]. MedChem 2012 - From Rapid Dissociation to Irreversible Inhibition - Optimisation of Drug-Target Residence Time.

Francotte, P., Goffin, E., Fraikin, P., Danober, L., Lestage, P., Caignard, D.-H., Challal, S., Rogez, N., Nosjean, O., Lesur, B., Botez, I., Pirotte, B., & De Tullio, P. (September 2012). Design, Synthesis and Biological Evaluation of 4-Cycloalkyl-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides Acting as AMPA Potentiators [Poster presentation]. ISMC2012, Berlin, Germany.

Bambi Nyanguile, S.-M., Hanson, J., Dogné, J.-M., & Pirotte, B. (August 2012). Development of original 2-aryloxy/arylamino-5-cyanobenzenesulfonylureas as thromboxane A2 receptor antagonists [Poster presentation]. 19th EuroQSAR, VIENNE, Austria.

Francotte, P., Goffin, E., Fraikin, P., Danober, L., Lestage, P., Caignard, D.-H., Challal, S., Rogez, N., Nosjean, O., Lesur, B., De Tullio, P., & Pirotte, B. (24 May 2012). Développement d’agents cognitifs agissant par potentialisation des récepteurs AMPA : Design de nouvelles thiénothiadiazine 1,1-dioxydes [Poster presentation]. 26es Journées Franco-Belges de Pharmacochimie, Orléans, France.

Bambi Nyanguile, S.-M., Hanson, J., Dogné, J.-M., & Pirotte, B. (May 2012). Development of original diversely substituted benzenesulfonylureas as thromboxane A2 receptor antagonists [Poster presentation]. 26 eme journées Francobelges de Pharmacochimie, Orléans, France.

Renard, J.-F., Lecomte, F., Arslan, D., Hubert, P., & Pirotte, B. (May 2012). Evaluation de l'impact au niveau pharmacocinétique de modulations structurales de N-(pyrid-4-yl)alcanesulfonamides [Poster presentation]. 26èmes Journées franco-belges de pharmacochimie, Orléans, France.

Gilissen, J., Pirotte, B., & Hanson, J. (2012). Pharmacological evaluation of succinic acid receptor (SUCNR1) small molecule modulators with an intracellular calcium biosensor [Poster presentation]. Giga Day.

Gilissen, J., Pirotte, B., & Hanson, J. (2012). Identification by a SOSA library screening and structure-activity relationships of succinic acid receptor (SUCNR1 or GPR91) agonist [Paper presentation]. 26èmes Journées Franco-belges de Pharmacochimie.

Gilissen, J., Pirotte, B., & Hanson, J. (2012). Design, synthesis and structure-activity relationship study of succinic acid receptor (SUCNR1) modulators [Paper presentation]. Forum des sciences pharmaceutiques.

Goffin, E., Lamoral-Theys, D., Tajeddine, N., De Tullio, P., Mondin, L., Lefranc, F., Gailly, P., ROGISTER, B., Kiss, R., & Pirotte, B. (2012). N-Aryl-N'-(chroman-4-yl)ureas and thioureas display in vitro anticancer activity and selectivity on apoptosis-resistant glioblastoma cells: screening, synthesis of simplified derivatives, and structure-activity relationship analysis. European Journal of Medicinal Chemistry, 54, 834-44. doi:10.1016/j.ejmech.2012.06.050

Hoekstra, W. J., & Pirotte, B. (2012). Tribute to a living legend [letter to the editor]. Current Medicinal Chemistry, 19, 4207.

Khelili, S., Kihal, N., Yekhlef, M., De Tullio, P., Lebrun, P., & Pirotte, B. (2012). Synthesis and pharmacological activity of N-(2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)-4H-1,2,4-benzothiadiazine-3-carboxamides 1,1-dioxides on rat uterus, rat aorta and rat pancreatic β-cells. European Journal of Medicinal Chemistry, 54, 873-878. doi:10.1016/j.ejmech.2012.05.011

Krintel, C., Frydenvang, K., Olsen, L., Kristensen, M., de Barrios, O., Naur, P., Francotte, P., Pirotte, B., Gajhede, M., & Kastrup, J. (2012). Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2. Biochemical Journal, 441, 173-178. doi:10.1042/BJ20111221

Francotte, P., De Tullio, P., Pirotte, B., Botez, I., Danober, L., & Lestage, P. (14 July 2011). Preparation of cyclopropyl thiochroman derivatives and their use as AMPA receptor modulators.

Cherdon, C., Rolin, S., Hanson, J., OOMS, A., de Leval, L., Drion, P., michiels, C., Pirotte, B., Mullier, F., SakalihasanN, N., DEFRAIGNE, J., & Dogné, J.-M. (2011). BM-573 INHIBITS THE EARLY ATHEROSCLEROTIC LESIONS IN APO-E DEFICIENT MICE BY BLOCKING TP RECEPTORS AND THROMBOXANE SYNTHASE. In Congress of the International Society of Thrombosis and Hemostasis- 57th Annual SSC Meeting.

Renard, J.-F., Lecomte, F., de Leval, X., Hubert, P., & Pirotte, B. (May 2011). Conception, synthèse et évaluation pharmacologique de N-(pyridin-4-yl)alcanesulfonamides en tant qu'inhibiteurs de cyclooxygénases [Poster presentation]. XVèmes Journées Franco-belges de pharmacochimie, Liège, Belgium.

Servais, A.-C., Rousseau, A., Dive, G., Frederich, M., Pirotte, B., Crommen, J., & Fillet, M. (23 March 2011). Systèmes génériques pour la séparation d’énantiomères de molécules basiques et acides à l’aide de cyclodextrines en électrophorèse capillaire en milieu non aqueux [Paper presentation]. 9ème congrès francophone de l'AfSep sur les sciences séparatives et les couplages (SEP 11), Toulouse, France.

Cherdon, C., Rolin, S., Hanson, J., OOMS, A., de Leval, L., Drion, P., Michiels, C., Pirotte, B., Masereel, B., SakalihasanN, N., DEFRAIGNE, J., & Dogné, J.-M. (2011). BM-573 inhibits the development of early atherosclerotic lesions in Apo E deficient mice by blocking TP receptors and thromboxane synthase. Prostaglandins and Other Lipid Mediators. doi:10.1016/j.prostaglandins.2011.03.001

Ceusters, J., Mouithys-Mickalad, A., De Tullio, P., Elmoualij, B., Plyte, S., Ballarini, M., Fancelli, D., Deby-Dupont, G., Pirotte, B., & Serteyn, D. (2011). MODULATING EFFECT OF THE RESPIRATORY RATE OF CARDIOMYOCYTES (H9C2 CELLS) AND MITOCHONDRIAL SWELLING BY DIAZOXIDE ANALOGUES: STRUCTURE–FUNCTION RELATIONSHIPS [Poster presentation]. 2nd world Congress on Targeting Mitochondria, Berlin, Germany.

De Tullio, P., Servais, A.-C., Fillet, M., Gillotin, F., Somers, F., CHIAP, P., Lebrun, P., & Pirotte, B. (2011). Hydroxylated analogues of ATP-sensitive potassium channel openers belonging to the group of 6- and/or 7-substituted 3-Isopropylamino-4H-1,2,4- benzothiadiazine 1,1-dioxides: Toward an improvement in sulfonylurea receptor 1 selectivity and metabolism stability. Journal of Medicinal Chemistry, 54, 8353-8361. doi:10.1021/jm200786z

Dintilhac, G., Arslan, D., Dilly, S., Danober, L., Botez, I., Lestage, P., Pirotte, B., & De Tullio, P. (2011). New substituted aryl esters and aryl amides of 3,4-dihydro-2H-1,2,4- benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors. MedChemComm, 2, 509. doi:10.1039/c1md00069a

Florence, X., Dilly, S., De Tullio, P., Pirotte, B., & Lebrun, P. (2011). Modulation of the 6-position of benzopyran derivatives and inhibitory effects on the insulin releasing process. Bioorganic and Medicinal Chemistry. doi:10.1016/j.bmc.2011.05.040

Francotte, P., Goffin, E., Fraikin, P., Danober, L., Lestage, P., Caignard, D.-H., De Tullio, P., & Pirotte, B. (2011). Development of cognitive enhancers: design of novel thienothiadiazine 1,1-dioxides acting as AMPA potentiators [Paper presentation]. Giga-day, Liège, Belgium.

Gilissen, J., Pirotte, B., & Hanson, J. (2011). Synthèse et évaluation pharmacologique de modulateurs du récepteur de l'acide succinique (SUCNR1) [Poster presentation]. 25e Journées franco-belges de pharmacochimie.

Mourlevat, S., Galizzi, J. P., Guigal-Stephan, N., Courtade-Gaïani, S., Rolland-Valognes, G., Rodriguez, M., Barbet, F., Bourrier, C., Catesson, S., Chomel, A., Danober, L., Villain, N., Caignard, D. H., Pirotte, B., Lestage, P., & Lockhart, B. P. (2011). Molecular characterization of the AMPA-receptor potentiator S70340 in rat primary cortical culture: Whole-genome expression profiling. Neuroscience Research, 70, 349-360. doi:10.1016/j.neures.2011.05.004

Pirotte, B., De Tullio, P., Boverie, S., Michaux, C., & Lebrun, P. (2011). Impact of the Nature of the Substituent at the 3-Position of 4H-1,2,4-Benzothiadiazine 1,1-Dioxides on Their Opening Activity toward ATP-Sensitive Potassium Channels. Journal of Medicinal Chemistry, 54, 3188-3199. doi:10.1021/jm200100c

Renard, J.-F., Lecomte, F., de Leval, X., Hubert, P., & Pirotte, B. (January 2011). Pyridine Derivatives of Nimesulide as New Promising Anti-inflammatory Agents [Poster presentation]. Giga Days, Liège, Belgium.

Francotte, P., Goffin, E., Fraikin, P., Danober, L., Lestage, P., Lesur, B., Botez, I., Caignard, D.-H., De Tullio, P., & Pirotte, B. (08 September 2010). Development of cognitive enhancers acting through AMPA potentiation: design of novel thienothiadiazine 1,1-dioxides [Poster presentation]. ISMC2010, Bruxelles, Belgium.

Renard, J.-F., Lecomte, F., de Leval, X., Hubert, P., & Pirotte, B. (21 May 2010). Nouveaux agents anti-inflammatoires en série N-(4-pyridyl)alcanesulfonamide [Paper presentation]. 24èmes JOURNEES FRANCO-BELGES DE PHARMACOCHIMIE, Woluwé-Saint-Lambert, Belgium.

Rousseau, A., Florence, X., Pirotte, B., Varenne, A., Gareil, P., Villemin, D., Chiap, P., Crommen, J., Fillet, M., & Servais, A.-C. (March 2010). Development and validation of a nonaqueous capillary electrophoretic method for the enantiomeric purity determination of a synthetic intermediate of new R/S-3,4-dihydro-2,2-dimethyl-2H-1-benzopyrans using a single-isomer anionic cyclodextrin derivative and an ionic liquid [Poster presentation]. 25th International Symposium on MicroScale Bioseparations (MSB 2010), Prague, Czechia.

Francotte, P., De Tullio, P., Pirotte, B., Danober, L., Lestage, P., & Caignard, D. H. (15 January 2010). Preparation of cycloalkylated benzothiadiazine derivatives and their use as AMPA receptor modulators.

Francotte, P., Goffin, E., Fraikin, P., Lestage, P., Van Heugen, J.-C., Gillotin, F., Danober, L., Thomas, J.-Y., Chiap, P., Caignard, D.-H., Pirotte, B., & De Tullio, P. (2010). New Fluorinated 1,2,4-Benzothiadiazine 1,1-Dioxides: Discovery of an Orally Active Cognitive Enhancer Acting through Potentiation of the 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors. Journal of Medicinal Chemistry, 53, 1700-1711. doi:10.1021/jm901495t

Gillotin, F., Chiap, P., Frederich, M., Van Heugen, J.-C., Francotte, P., Lebrun, P., Pirotte, B., & De Tullio, P. (2010). Coupling of Liquid Chromatography/Tandem Mass Spectrometry and Liquid Chromatography/Solid-Phase Extraction/NMR Techniques for the Structural Identification of Metabolites following In Vitro Biotransformation of SUR1-Selective ATP-Sensitive Potassium Channel Openers. Drug Metabolism and Disposition: the Biological Fate of Chemicals, 38 (2), 232-240. doi:10.1124/dmd.109.028928

Hemmer, M., Kempen, I., De Tullio, P., Frankenne, F., Lambert, V., Blacher, S., Bueb, J.-L., Foidart, J.-M., Noël, A., Tschirhart, E., & Pirotte, B. (2010). New Biological Investigations on 3-Bromophenyl 6-Acetoxymethyl-2-oxo-2H-1-Benzopyran-3-Carboxylate as Anti-angiogenic Agent. Drug Development Research, 71, 1-10. doi:10.1002/ddr.20364

Lamoral-Theys, D., Pottier, L., Kerff, F., Dufrasne, F., Proutiere, F., Wauthoz, N., Neven, P., Ingrassia, L., Antwerpen, P. V., Lefranc, F., Gelbcke, M., Pirotte, B., Kraus, J.-L., Neve, J., Kornienko, A., Kiss, R., & Dubois, J. (2010). Simple di- and trivanillates exhibit cytostatic properties toward cancer cells resistant to pro-apoptotic stimuli. Bioorganic and Medicinal Chemistry, 18 (11), 3823-33. doi:10.1016/j.bmc.2010.04.047

Pirotte, B., De Tullio, P., Nguyen, Q.-A., Somers, F., Fraikin, P., Florence, X., Wahl, P., Hansen, J. B., & Lebrun, P. (2010). Chloro-Substituted 3-Alkylamino-4H-1,2,4-benzothiadiazine 1,1-Dioxides as ATP-Sensitive Potassium Channel Activators: Impact of the Position of the Chlorine Atom on the Aromatic Ring on Activity and Tissue Selectivity. Journal of Medicinal Chemistry, 53, 147-154. doi:10.1021/jm9010093

Pirotte, B., Francotte, P., Goffin, E., fraikin, P., Danober, L., Lesur, B., Botez, I., Caignard, D. H., Lestage, P., & De Tullio, P. (2010). Ring-fused thiadiazines as core structures for the development of potent AMPA receptor potentiators. Current Medicinal Chemistry, 17, 3575-3582. doi:10.2174/092986710792927859

Rousseau, A., Florence, X., Pirotte, B., Varenne, A., Gareil, P., Villemin, D., Chiap, P., Crommen, J., Fillet, M., & Servais, A.-C. (2010). Development and validation of a nonaqueous capillary electrophoretic method for the enantiomeric purity determination of a synthetic intermediate of new 3,4-dihydro-2,2-dimethyl-2H-1-benzopyrans using a single-isomer anionic cyclodextrin derivative and an ionic liquid. Journal of Chromatography. A, 1217 (51), 7949-55. doi:10.1016/j.chroma.2010.07.005

Robert, S., Ghiotto, J., Pirotte, B., David, J. L., Masereel, B., Pochet, L., & Dogne, J. M. (November 2009). Is thrombin generation the new rapid, reliable and relevant pharmacological tool for the development of anticoagulant drugs? [Paper presentation]. Congress of the Belgian Society of Thrombosis and Hemostasis (BSTH 2009), Liège, Belgium.

Francotte, P., De Tullio, P., Pirotte, B., Danober, L., Lestage, P., & Caignard, D.-H. (07 July 2009). Preparation of cycloalkylated benzothiadiazine derivatives and their use as AMPA receptor modulators.

Florence, X., De Tullio, P., Pirotte, B., & Lebrun, P. (June 2009). Original cromakalim analogues as KATP channel openers [Paper presentation]. 2nd International Brussels Pancreatic Islet Symposium, Bruxelles, Belgium.

Florence, X., De Tullio, P., Lebrun, P., & Pirotte, B. (May 2009). Les canaux potassiques ATP-dépendants: nouvelles cibles potentielles pour le traitement de divers troubles métaboliques [Poster presentation]. 23èmes Journées Franco-Belges de Pharmacochimie, Mons, Belgium.

Francotte, P., Fraikin, P., Goffin, E., Danober, L., Lestage, P., Caignard, D. H., Lesur, B., Botez, I., Van Heugen, J.-C., Chiap, P., Pirotte, B., & De Tullio, P. (May 2009). Stabilisation métabolique par introduction d’atomes de fluor : application aux benzothiadiazine 1,1-dioxydes agissant en tant que potentialisateurs AMPA [Poster presentation]. 23èmes Journées Franco-Belges de Pharmacochimie, Mons, Belgium.

Hemmer, M., Bambi Nyanguile, S.-M., De Tullio, P., Konradowski, E., Frankenne, Noël, A., Foidart, J.-M., Bueb, J. L., Tschirhart, E., & Pirotte, B. (May 2009). Conception, synthèse et évaluation biologique de dérivés coumariniques en tant qu’agents anti-cancéreux potentiels [Poster presentation]. 23èmes Journées Franco-Belges de Pharmacochimie, Mons, Belgium.

Renard, J.-F., Arslan, D., Garbacki, N., De Leval, X., & Pirotte, B. (May 2009). Developpement d’inhibiteurs de cyclooxygénases: les analogues pyridiniques du nimésulide [Poster presentation]. 23èmes Journées Franco-Belges de Pharmacochimie, Mons, Belgium.

Dintilhac, G., Florence, X., Guillotin, F., Chiap, P., Lebrun, P., Pirotte, B., & De Tullio, P. (28 April 2009). Synthèse, étude de la métabolisation et évaluation pharmacologique du 3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxyde (BPDZ 73) et de ses métabolites [Paper presentation]. Forum des jeunes chercheurs du CIRM, Liège, Belgium.

Florence, X., De Tullio, P., Lebrun, P., & Pirotte, B. (03 February 2009). Les canaux potassiques ATP-dépendants : nouvelles cibles potentielles pour le traitement de divers troubles métaboliques [Paper presentation]. Forum des jeunes chercheurs du CIRM, Liège, Belgium.

Hemmer, M., De Tullio, P., Konradowski, E., Frankenne, F., Noël, A., Foidart, J.-M., Bueb, J. L., Tschirhart, E., & Pirotte, B. (03 February 2009). Conception, synthèse et évaluation biologique de dérivés coumariniques en tant qu’agents anti-cancéreux potentiels [Paper presentation]. Forum des jeunes chercheurs du CIRM, Liège, Belgium.

Arrault, A., Rocchi, S., Picard, F., Maurois, P., Pirotte, B., & Vamecq, J. (2009). A short series of antidiabetic sulfonylureas exhibit multiple ligand PPARgamma-binding patterns. Biomedicine and Pharmacotherapy, 63, 56-62. doi:10.1016/j.biopha.2007.12.007

Bissonnette, E. Y., Tremblay, G. M., Turmel, V., Pirotte, B., & Reboud-Ravaux, M. (2009). Coumarinic derivatives show anti-inflamatory effects on alveolor macrophages, but their anti-elastase activity is essential to reduce lung inflammation in vivo. International Immunopharmacology, 9, 49-54. doi:10.1016/j.intimp.2008.09.009

Florence, X., De Tullio, P., Pirotte, B., & Lebrun, P. (2009). Original cromakalim analogues as KATP channel openers. Metabolic and Functional Research on Diabetes, 2, 19-44 (A16.

Florence, X., Sebille, S., De Tullio, P., Lebrun, P., & Pirotte, B. (2009). New R/S-3,4-dihydro-2,2-dimethyl-2H-1-benzopyrans as KATP channel openers: modulation of the 4-position. Bioorganic and Medicinal Chemistry, 17, 7723-7731. doi:10.1016/j.bmc.2009.09.041

Renard, J.-F., Arslan, D., Garbacki, N., Pirotte, B., & de Leval, X. (2009). Pyridine analogues of nimesulide: design, synthesis, and in vitro and in vivo pharmacological evaluation as promising cyclooxygenase 1 and 2 inhibitors. Journal of Medicinal Chemistry, 52, 5864-5871. doi:10.1021/jm900702b

Robert, S., Ghiotto, J., Pirotte, B., David, J.-L., Masereel, B., Pochet, L., & Dogné, J.-M. (2009). Is thrombin generation the new rapid, reliable and relevant pharmacological tool for the development of anticoagulant drugs ? Pharmacological Research, 59, 160-166. doi:10.1016/j.phrs.2008.12.003

Kempen, I., Hemmer, M., Counerotte, S., Pochet, L., De Tullio, P., Foidart, J.-M., Blacher, S., Noël, A., Frankenne, F., & Pirotte, B. (December 2008). 6-Substituted 2-Oxo-2h-1-Benzopyran-3-Carboxylic Acid Derivatives in a New Approach of the Treatment of Cancer Cell Invasion and Metastasis. European Journal of Medicinal Chemistry, 43 (12), 2735-50. doi:10.1016/j.ejmech.2008.01.024

Lambert, V., Frederich, M., Rousseau, R., Detry, B., Peulen, O., Rakic, J.-M., Noël, A., Pirotte, B., Govaert, B., & De Tullio, P. (August 2008). 1H NMR metabolomic approach of the laser-induced choroidal neovascularization in mice [Poster presentation]. 20th International Symposium on Medicinal Chemistry, Vienne, Austria.

Francotte, P., De Tullio, P., Fraikin, P., Counerotte, S., Goffin, E., Danober, L., Lestage, P., Renard, P., Caignard, D. H., & Pirotte, B. (17 May 2008). Design, synthesis and pharmacological evaluation of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides acting as AMPA potentiators [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Liège, Belgium.

Florence, X., De Tullio, P., Lebrun, P., & Pirotte, B. (May 2008). 6-Substituted benzopyran derivatives as potent KATP channel openers: synthesis and biological in vitro evaluation [Poster presentation]. 22èmes Journées Franco-Belges de Pharmacochimie, Caen, France.

Francotte, P., De Tullio, P., Fraikin, P., Goffin, E., Dintilhac, G., Danober, L., Lestage, P., Lesur, B., Botez, I., Caignard, D. H., & Pirotte, B. (May 2008). Development of cognitive enhancers acting through AMPA potentiation: design of novel benzothiadiazine 1,1-dioxides with improved pharmacokinetic profile [Paper presentation]. 22èmes Journées Franco-Belges de Pharmacochimie, Caen, France.

Hemmer, M., Kempen, I., De Tullio, P., Haan, , Lambert, V., Noël, A., Foidart, J.-M., Bueb, J. L., Tschirhart, E., & Pirotte, B. (May 2008). New biological investigations on the anti-angiogenic agent 3-bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate: in search of its original mechanism of action [Poster presentation]. 22èmes Journées Franco-Belges de Pharmacochimie, Caen, France.

Renard, J.-F., Arslan, D., Garbacki, N., De Leval, X., & Pirotte, B. (May 2008). (N-pyridinyl)alkanesulfonamides as potent anti-inflammatory drugs [Poster presentation]. 22èmes Journées Franco-Belges de Pharmacochimie, Caen, France.

Bayot, A., Basse, N., Lee, I., Gareil, M., Pirotte, B., Bulteau, A. L., Friguet, B., & Reboud-Ravaux, M. (2008). Towards the control of intercellular protein turnover: Mitochondrial Lon protease inhibitors versus proteasome inhibitors. Biochimie, 90, 260-269. doi:10.1016/j.biochi.2007.10.010

Franck, T., Kohnen, S., Grulke, S., Neven, P., Goutman, Y., Péters, F., Pirotte, B., Deby, G., & Serteyn, D. (2008). Inhibitory effect of curcuminoids and tetrahydrocurcuminoids on equine activated neutrophils and myeloperoxidase activity. Physiological Research, 57 (4), 577-587.

Francotte, P., De Tullio, P., Podona, T., Diouf, O., Fraikin, P., Lestage, P., Danober, L., Thomas, J.-Y., Caignard, D.-H., & Pirotte, B. (2008). Synthesis and pharmacological evaluation of a second generation of pyridothiadiazine 1,1-dioxides acting as AMPA potentiators. Bioorganic and Medicinal Chemistry, 16 (23), 9948-56. doi:10.1016/j.bmc.2008.10.036

Khelili, S., Florence, X., Bouhadja, M., Abdelaziz, S., Mechouch, N., Mohamed, Y., De Tullio, P., Lebrun, P., & Pirotte, B. (2008). Synthesis and activity on rat aorta rings and rat pancreatic beta-cells of ring-opened analogues of benzopyran-type potassium channel activators. Bioorganic and Medicinal Chemistry, 16, 6124-6130. doi:10.1016/j.bmc.2008.04.043

Lebrun, P., Becker, B., Morel, N., Ghisdal, P., Antoine, M.-H., De Tullio, P., & Pirotte, B. (2008). KATP channel openers: tissue selectivity of original 3-alkylaminopyrido- and 3-alkylaminobenzothiadiazine 1,1 -dioxides. Biochemical Pharmacology, 75, 468-475. doi:10.1016/j.bcp.2007.08.032

Renard, J.-F., Garbacki, N., de Leval, X., & Pirotte, B. (2008). New pyridinic analogues of nimesulide as potent COXs inhibitors [Poster presentation]. XXth International Symposium on Medicinal Chemistry (EFMC – ISMC 2008), Vienne, Austria.

Sebille, S., De Tullio, P., Florence, X., Becker, B., Antoine, M.-H., Michaux, C., Wouters, J., Pirotte, B., & Lebrun, P. (2008). new R/S-3,4-dihydro-2,2-dimethyl-6-halo-4-(phenylainothiocarbonylamino)-2H-1-benzopyrans structually related to (+/-)-cromakalim as tissue-selective pancreatic beta-celle KATP channel openers. Bioorganic and Medicinal Chemistry, 16, 5704-5719.

Florence, X., De Tullio, P., Lebrun, P., & Pirotte, B. (October 2007). Design, synthesis, and pharmacological evaluation of cromakalim analogues as pancreatic β-cell-selective KATP channel openers [Paper presentation]. 13th Forum of Pharmaceutical Sciences, Spa, Belgium.

Francotte, P., Gillotin, F., Van Heuguen, J. C., Frederich, M., Lebrun, P., CHIAP, P., Pirotte, B., & De Tullio, P. (October 2007). Application of LC-SPE-NMR to the structural determination of metabolites of KATP channel openers belonging to 3-alkylamino-4H-1,2,4-arylthiadiazine 1,1-dioxides [Paper presentation]. 13th Forum of Pharmaceutical Sciences, Spa, Belgium.

Hemmer, M., De Tullio, P., Bernard, Y., Konradowski, E., Frankenne, F., Bueb, J. L., Tschirhart, E., & Pirotte, B. (October 2007). Design, synthesis and anticancer activity of novel hydroxylated coumarin derivatives [Paper presentation]. 13th Forum of Pharmaceutical Sciences, Spa, Belgium.

Renard, J.-F., de Leval, X., & Pirotte, B. (October 2007). Development of original pyridinic analogues of nimesulide as cycloxygenase inhibitors [Paper presentation]. 13th Forum of Pharmaceutical Sciences, Spa, Belgium.

Robert, S., Ghiotto, J., Pirotte, B., David, J. L., Masereel, B., Pochet, L., & Dogne, J. M. (October 2007). Thrombin activity profile: a rapid, reliable and relevant ex vivo screening test for the development of anticoagulant drugs [Paper presentation]. 13th Forum of Pharmaceutical Sciences, Spa, Belgium.

Florence, X., De Tullio, P., Lebrun, P., & Pirotte, B. (July 2007). Cromakalim analogues as pancreatic β-cell-selective KATP channel openers [Poster presentation]. 1st International Brussels Islet Symposium, Bruxelles, Belgium.

Robert, S., Ghiotto, J., Pirotte, B., David, J. L., Masereel, B., Pochet, L., & Dogne, J. M. (July 2007). Thrombin activity profile : a powerful ex vivo screening test for the development of anticoagulant drugs [Poster presentation]. XXIst Congress of the International Society on Thrombosis and Haemostasis, Genève, Switzerland.

Florence, X., De Tullio, P., Lebrun, P., & Pirotte, B. (May 2007). Synthèse et évaluation biologique de nouveaux activateurs des canaux potassiques ATP-dépendants en série benzopyrane [Poster presentation]. 21èmes Journées Franco-Belges de Pharmacochimie, Namur, Belgium.

Francotte, P., Fraikin, P., De Tullio, P., Graindorge, E., Dintilhac, G., Counerotte, S., Goffin, E., Danober, L., Lestage, P., Lesur, B., Caignard, D. H., & Pirotte, B. (May 2007). Design, synthèse et évaluation pharmacologique de 1,2,4-thiénothiadiazine 1,1-dioxydes en tant que nouveaux potentialisateurs AMPA [Poster presentation]. 21èmes Journées Franco-Belges de Pharmacochimie, Namur, Belgium.

Hemmer, M., De Tullio, P., Bernard, Y., Konradowski, E., Frankenne, F., Bueb, J. L., Tschirhart, E., & Pirotte, B. (May 2007). Conception, synthèse et évaluation biologique de composés coumariniques en tant qu’agents anti-cancéreux potentiels [Poster presentation]. 21èmes Journées Franco-Belges de Pharmacochimie, Namur, Belgium.

Moray, A. L., Dogne, J. M., Neven, P., Ghiotto, J., Pirotte, B., & Hanson, J. (May 2007). Conception et synthèse d’outils pharmacologiques originaux pour l’étude des récepteurs au thromboxane [Poster presentation]. 21èmes Journées Franco-Belges de Pharmacochimie, Namur, Belgium.

Renard, J.-F., Arslan, D., Garbacki, N., de Leval, X., & Pirotte, B. (May 2007). Conception, synthèse et évaluation pharmacologique in vitro et in vivo d’analogues pyridiniques du nimésulide [Poster presentation]. 21èmes Journées Franco-Belges de Pharmacochimie, Namur, Belgium.

Robert, S., Ghiotto, J., Pirotte, B., David, J. L., Masereel, B., Pochet, L., & Dogne, J. M. (May 2007). Le profil d’activité de thrombine: un puissant test de criblage ex vivo pour le développement d’agents anticoagulants [Poster presentation]. 21èmes Journées Franco-Belges de Pharmacochimie, Namur, Belgium.

Kolh, P., Rolin, S., Tchana-Sato, V., Ghuysen, A., Lambermont, B., D'Orio, V., Limet, R., Pirotte, B., & Dogné, J. M. (21 April 2007). Comparative effects on LV performance, arterial hemodynamics and ventriculo-arterial coupling of two porcine models of coronary artery occlusion [Paper presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Anvers, Belgium.

Francotte, P., De Tullio, P., Goffin, E., Dintilhac, G., Graindorge, E., Fraikin, P., Lestage, P., Danober, L., Thomas, J.-Y., Caignard, D.-H., & Pirotte, B. (2007). Design, synthesis, and pharmacology of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors. Journal of Medicinal Chemistry, 50 (13), 3153-3157. doi:10.1021/jm070120i

Francotte, P., De Tullio, P., & Pirotte, B. (2007). Novel dipyrazoles acting as glutamate modulators. Expert Opinion on Therapeutic Patents, 17 (12), 1489-1493. doi:10.1517/13543776.17.12.1489

Francotte, P., De Tullio, P., & Pirotte, B. (2007). Cholinergic Transmission and Acetylcholine release enhancers. In Protein Misfolding in neuro degenerative Diseases : Mechanisms and Therapeutic Strategies (Eds: H.J. Smith, C. Simons, R.D.E. sewell, CRC Press, pp. 96-103). Routledge.

Francotte, P., De Tullio, P., & Pirotte, B. (2007). AChE Inhibitors and their Clinical Assessment. In Protein Misfolding in Neurodegenerative Diseases: Mechanisms and Therapeutic Strategies (Eds: H.J. Smith, C. Simons, R.D.E. sewell, CRC Press, pp. 114-144).

Gillotin, F., De Tullio, P., VAN HEUGEN, J.-C., Francotte, P., Frederich, M., Lebrun, P., Kremers, P., Pirotte, B., & CHIAP, P. (2007). Coupling of the LC-MS/MS and the LC-SPE-NMR for the structural identification of pancreatic KATP channel openers metabolites following in vitro biotransformation [Poster presentation]. HPLC 2007, Gent, Belgium.

Hanson, J., Dogné, J.-M., Ghiotto, J., Moray, A.-L., Kinsella, B. T., & Pirotte, B. (2007). Design, synthesis, and SAR study of a series of N-alkyl-N'-[2-(aryloxy)-5-nitrobenzenesulfonyl]lureas and -cyanoguanidine as selective antagonists of the TPalpha and TPBeta isoforms of the human thromboxane A2 receptor. Journal of Medicinal Chemistry, 50, 3928-3936. doi:10.1021/jm070427h

Pirotte, B. (2007). Laboratoire de Chimie pharmaceutique - ULg. Chimie Nouvelle, 95, 68-75.

Renard, J.-F., Arslan, D., Garbacki, N., de Leval, X., & Pirotte, B. (2007). Conception, synthèse et évaluation pharmacologique in vitro et in vivo d’analogues pyridiniques du nimésulide [Poster presentation]. 21èmes Journées Franco-Belges de Pharmacochimie, Namur, Belgium.

Francotte, P., De Tullio, P., & Pirotte, B. (14 December 2006). Etude de la métabolisation in vitro d’activateurs des canaux potassiques appurtenant à la classe des 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxydes: utilisation conjuguée de la LC-MS et de la LC-SPE-NMR [Paper presentation]. Forum des jeunes chercheurs du CIRM.

De Tullio, P., Chiap, P., Francotte, P., Van Heugen, J.-C., Florence, X., Frederich, M., Gillotin, F., Kremers, P., Lebrun, P., & Pirotte, B. (18 November 2006). In vitro metabolisation study of several 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel openers : combined use of LC-Q-TOF MS/MS and LC-SPE-NMR [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

Florence, X., De Tullio, P., Lebrun, P., & Pirotte, B. (18 November 2006). New developments in benzopyran derivatives as pancreatic β-cell KATP channel openers [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

Hanson, J., Dogne, J. M., Ghiotto, J., Moray, A. L., Neven, P., Kelley, L. P., Kinsella, B. T., & Pirotte, B. (18 November 2006). Pharmacological evaluation of TP receptor antagonists by differential activity on alpha and beta isoforms [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

De Tullio, P., Frederich, M., Chiap, P., Kremers, P., Francotte, P., Lebrun, P., & Pirotte, B. (17 November 2006). Application of LC-SPE-NMR to the structural determination of KATP channel openers metabolites belonging to the 3-alkylamino-4H-1,2,4-arylthiadiazine 1,1-dioxide derivatives [Paper presentation]. 5th YBMRS, Bruxelles, Belgium.

Dassesse, T., de Leval, X., de Leval, L., Pirotte, B., Castronovo, V., & Waltregny, D. (November 2006). Activation of the thromboxane A2 pathway in human prostate cancer correlates with tumor Gleason score and pathologic stage. European Urology, 50 (5), 1021-31, discussion 1031. doi:10.1016/j.eururo.2006.01.036

de Leval, X., Dassesse, T., Dogné, J.-M., Waltregny, D., Bellahcene, A., Benoit, V., Pirotte, B., & Castronovo, V. (September 2006). Evaluation of original dual thromboxane A2 modulators as antiangiogenic agents. Journal of Pharmacology and Experimental Therapeutics, 318 (3), 1057-1067. doi:10.1124/jpet.106.101188

De Tullio, P., Gillotin, F., Francotte, P., Van Heugen, J.-C., Frederich, M., Lebrun, P., Chiap, P., & Pirotte, B. (August 2006). Combined use of LC-SPE-NMR and LC-MS for the metabolites characterization of ATP-sensitive potassium channel openers belonging to 3-alkylamino-4H-1,2,4-arylthiadiazine 1,1-dioxides [Poster presentation]. XIXth International Symposium on Medicinal Chemistry, Istanbul, Turkey.

Francotte, P., De Tullio, P., Fraikin, P., Counerotte, S., Goffin, E., Danober, L., Lestage, P., Renard, P., Caignard, D. H., & Pirotte, B. (August 2006). Design, synthesis and pharmacological evaluation of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides acting as AMPA potentiators [Poster presentation]. XIXth International Symposium on Medicinal Chemistry, Istanbul, Turkey.

Hanson, J., Dogne, J. M., Kelley, L. P., Kinsella, B. T., & Pirotte, B. (August 2006). Development of a fluorescent microplate cell based assay for the rapid evaluation of human thromboxane A2 receptor modulators acting on α and β isoforms [Poster presentation]. XIXth International Symposium on Medicinal Chemistry, Istanbul, Turkey.

Hanson, J., Ghiotto, J., Neven, P., Kelley, L. P., Kinsella, B. T., Dogne, J. M., & Pirotte, B. (July 2006). Pharmacological evaluation of TP receptor antagonists characterized by differential activity on alpha and beta isoforms. Acta Pharmacologica Sinica, 27, 21.

Cherdon, C., Hanson, J., Pirotte, B., Dogne, J. M., & Defraigne, J.-O. (June 2006). Activité préférentielle de la 8-iso-prostaglandine F2A (8-iso-PGF2A) sur l’isoforme alpha du récepteur au thromboxane A2 [Poster presentation]. 20èmes Journées Franco-Belges de Pharmacochimie, Lille, France.

De Tullio, P., Chiap, P., Francotte, P., Van Heugen, J.-C., Florence, X., Frederich, M., Gillotin, F., Kremers, P., Lebrun, P., & Pirotte, B. (June 2006). Application de la LC-SPE-RMN et de la LC-MS à la détermination structurale des métabolites d’activateurs des canaux KATP de la classe des 3-alkylamino-4H-arylthiadiazine 1,1-dioxydes [Poster presentation]. 20èmes Journées Franco-Belges de Pharmacochimie, Lille, France.

Florence, X., De Tullio, P., Lebrun, P., & Pirotte, B. (June 2006). Nouveaux développements dans le domaine des activateurs des canaux potassiques ATP-dépendants en série benzopyrane [Poster presentation]. 20èmes Journées Franco-Belges de Pharmacochimie, Lille, France.

Francotte, P., Fraikin, P., De Tullio, P., Counerotte, S., Goffin, E., Danober, L., Lestage, P., Renard, P., Caignard, D. H., & Pirotte, B. (June 2006). Design, synthèse et évaluation pharmacologique de 1,2,4-pytridothiadiazine 1,1-dioxydes en tant que nouveaux potentiateurs AMPA [Poster presentation]. 20èmes Journées Franco-Belges de Pharmacochimie, Lille, France.

Hanson, J., Dogne, J. M., Ghiotto, J., Kelley, L. P., Kinsella, B. T., & Pirotte, B. (June 2006). Evaluation pharmacologique d'une série de composés nitrobenzéniques sur les deux isoformes du récepteur au thromboxane A2, TPα et TPβ [Poster presentation]. 20èmes Journées Franco-Belges de Pharmacochimie, Lille, France.

Hanson, J., Reynaud, D., Qiao, N., Devel, P., Moray, A.-L., Renard, J.-F., Kelley, L. P., Winum, J.-Y., Montero, J.-L., Kinsella, B. T., Pirotte, B., Pace-Asciak, C. R., & Dogné, J.-M. (June 2006). Synthesis and pharmacological evaluation of novel thromboxane modulators as antiplatelet agents acting on both the alpha and beta isoforms of the human thromboxane receptor. Journal of Medicinal Chemistry, 49 (12), 3701-3709. doi:10.1021/jm060108a

Hemmer, M., Plancon, S., Bernard, Y., Bueb, J. L., Tschirhart, E., & Pirotte, B. (June 2006). Conception, synthèse et évaluation biologique de composés coumariniques en tant qu’agents anti-cancéreux et anti-angiogéniques potentiels [Poster presentation]. 20èmes Journées Franco-Belges de Pharmacochimie, Lille, France.

Renard, J.-F., De Leval, X., & Pirotte, B. (June 2006). Nouveaux développements dans le domaine des analogues pyridiniques du nimésulide présentant un pont « inter-cycle » aminé [Poster presentation]. 20èmes Journées Franco-Belges de Pharmacochimie, Lille, France.

Gillotin, F., De Tullio, P., Van Heugen, J.-C., Francotte, P., Frederich, M., Lebrun, P., Kremers, P., Chiap, P., & Pirotte, B. (17 May 2006). Application of LC-SPE-NMR and LC-Q-TOF MS/MS to the structural determination of KATP channel openers metabolites belonging to the 3-alkylamino-4H-1,2,4-arylthiadiazine 1,1-dioxides [Poster presentation]. 10th Bioforum, Liège, Belgium.

Hanson, J., Dogne, J. M., Kelley, L. P., Kinsella, B. T., & Pirotte, B. (17 May 2006). Development of a fluorescent microplate cell based assay for the rapid evaluation of human thromboxane A2 receptor modulators acting on α and β isoforms [Poster presentation]. 10th Bioforum, Liège, Belgium.

Pirotte, B., Counerotte, S., Detry, V., Frankenne, F., Foidart, J.-M., & Noël, A. (02 March 2006). Preparation of 5-(1,1'-biphenyl)-4-yl-5-(4-(4-aminoacylphenyl)-piperazin)-1-yl-pyrimidine-2,4,6-triones and their use as inhibitors of zinc metalloendopeptidases.

De Tullio, P., Dupont, L., Francotte, P., Counerotte, S., Lebrun, P., & Pirotte, B. (2006). Three-Dimentional Quantitative Structure-Activity Relationships of ATP-Sensitive Potassium (KATP) Channel Openers Belonging to the 3-Alkylamino-4H-1,2,4-benzo- and 3-Alkylamino-4H-1,2,4-pyridothiadiazine 1,1-Dioxide Families. Journal of Medicinal Chemistry, 49, 6779-6788. doi:10.1021/jm060534w

De Tullio, P., Lebrun, P., Florence, X., Antoine, M. H., Francotte, P., & Pirotte, B. (2006). Selective pancreatic ATP-sensitive potassium channel openers for the treatement of glucose homeostasis disorders. Drugs of the Future, 31, 991-1001. doi:10.1358/dof.2006.031.11.1036837

Dogné, J.-M., Hanson, J., de Leval, X., Pratico, D., Pace-Asciak, C. R., Drion, P., Pirotte, B., & Ruan, K.-H. (2006). From the design to the clinical application of thromboxane modulators [letter to the editor]. Current Pharmaceutical Design, 12 (8), 903-923. doi:10.2174/138161206776055921

Francotte, P., De Tullio, P., Fraikin, P., Counerotte, S., Goffin, E., & Pirotte, B. (2006). In Search of Novel Ampa Potentiators. Recent Patents on CNS Drug Discovery, 1 (3), 239-46. doi:10.2174/157488906778773661

Francotte, P., De Tullio, P., Fraikin, P., & Pirotte, B. (2006). New trends in the design of drugs against Alzheimer disease. Frontiers in Medicinal Chemistry, 3, 249-284.

Khelili, S., Lebrun, P., De Tullio, P., & Pirotte, B. (2006). Synthesis and pharmacological evaluation of some N-arylsulfonyl-N-methyl-N'-(2,2-dimethyl-2-H-1-benzopyran-4-yl)ureas structurally related to cromakalim. Bioorganic and Medicinal Chemistry, 14, 3530-3534. doi:10.1016/j.bmc.2006.01.009

Michaux, C., De Leval, X., Julémont, F., Dogné, J.-M., Pirotte, B., & Durant, F. (2006). Structure-based pharmacophore of COX-2 selective inhibitors and identification of original lead compounds from 3D database searching method. European Journal of Medicinal Chemistry, 41, 1446-1455. doi:10.1016/j.ejmech.2006.07.017

Renard, J.-F., Julémont, F., De Leval, X., & Pirotte, B. (2006). The use of nimesulide and its analogues in cancer chemoprevention. Anti-Cancer Agents in Medicinal Chemistry, 6, 233-237. doi:10.2174/187152006776930855

Sebille, S., Gall, D., De Tullio, P., Florence, X., Lebrun, P., & Pirotte, B. (2006). Design, Synthesis and Pharmacological Evaluation of R/S-3,4-Dihydro-2,2-Dimethyl-6-Halo-4-(Phenylaminocarbonylamino)-2H-1-Benzopyrans: Towards Tissue-Selective Pancreatic Beta-Cells KATP Channel Openers Structually Related to (+/-)-Cromakalim. Journal of Medicinal Chemistry, 49, 4690-4697. doi:10.1021/jm060161z

Sebille, S., Pirotte, B., Boverie, S., De Tullio, P., Lebrun, P., & Antoine, M. H. (18 August 2005). Benzopyran derivatives, method of production and use thereof.

Francotte, P., Fraikin, P., De Tullio, P., Pirotte, B., Lestage, P., Danober, L., Caignard, D.-H., & Renard, P. (27 July 2005). Preparation of fluorinated benzothiadiazine derivatives and their use as AMPA receptor modulators.

Francotte, P., Fraikin, P., De Tullio, P., Pirotte, B., Lestage, P., Danober, L., Caignard, D. H., & Renard, P. (27 July 2005). Fluorinated benzothiadiazine derivatives and their use as AMPA receptor modulators.

De Leval, X., Dassesse, T., Dogne, J. M., Castronovo, V., & Pirotte, B. (May 2005). Développement de modulateurs de la voie du thromboxane A2 en tant qu’agents anti-angiogéniques et anti-métastatiques [Poster presentation]. 19èmes Journées Franco-Belges de Pharmacochimie, Liège, Belgium.

Florence, X., De Tullio, P., Antoine, M. H., Lebrun, P., & Pirotte, B. (May 2005). Synthèse et évaluation biologique d’analogues 6,7-disubstitués du (R)-3-[2-(1-hydroxypropylamino)]-4H-1,2,4-benzothiadiazine 1,1-dioxyde en tant qu’activateurs potentiels des canaux potassiques sensibles à l’ATP et leurs analogues biotinylés en tant qu’outils pharmacologiques [Poster presentation]. 19èmes Journées Franco-Belges de Pharmacochimie, Liège, Belgium.

Francotte, P., Fraikin, P., De Tullio, P., Boverie, S., Danober, L., Lestage, P., Renard, P., Caignard, D. H., & Pirotte, B. (May 2005). Modulateurs allostériques positifs des récepteurs AMPA de la classe des 1,2,4-benzothiadiazine 1,1-dioxydes : conception, synthèse et évaluation pharmacologique [Poster presentation]. 19èmes Journées Franco-Belges de Pharmacochimie, Liège, Belgium.

Hanson, J., Reynaud, D., Qiao, N., Renard, J.-F., Botty, D., Neven, P., Pace-Asciak, C. R., Pirotte, B., & Dogne, J. M. (May 2005). Synthèse et évaluation pharmacologique de composés nitrobenzéniques originaux présentant des affinités différentielles pour les isoformes du récepteur au thromboxane A2 [Poster presentation]. 19èmes Journées Franco-Belges de Pharmacochimie, Liège, Belgium.

Kempen, I., Lambert, V., Melen, L., Noël, A., Foidart, J.-M., & Pirotte, B. (May 2005). Evaluation pharmacologique du 6-acétoxyméthyl-2-oxo-2H-1-benzopyrane-3-carboxylate de 3-bromophényle en tant qu’agent anti-angiogénique [Poster presentation]. 19èmes Journées Franco-Belges de Pharmacochimie, Liège, Belgium.

Khelili, S., Bouider, N., Delarge, J., & Pirotte, B. (May 2005). Synthesis and pharmacological effects of opened analogues of benzothiadiazine 1,1-dioxides with sulfonylurea moieties on diuresis and glycemia [Poster presentation]. 19èmes Journées Franco-Belges de Pharmacochimie, liège, Belgium.

Khelili, S., Lebrun, P., Delarge, J., & Pirotte, B. (May 2005). Synthesis and pharmacological evaluation of ATP-sensitive potassium channel openers related to cromakalim : introduction of N-methylated and non N-methylated arylsulfonylurea moieties [Poster presentation]. 19èmes Journées Franco-Belges de Pharmacochimie, Liège, Belgium.

Sebille, S., Florence, X., Antoine, M. H., Boverie, S., De Tullio, P., Lebrun, P., & Pirotte, B. (May 2005). Vers la découverte d’activateurs sélectifs du canal KATP pancréatique, analogues du cromakalim : synthèse et évaluation pharmacologique du R/S-4-(4-chlorophénylaminothiocarbonylamino)-3,4-dihydro-2,2-diméthyl-6-fluoro-2H-1-benzopyrane [Poster presentation]. 19èmes Journées Franco-Belges de Pharmacochimie, Liège, Belgium.

Lemoine, H., Grittner, D., Kuper, J., Pirotte, B., Schonlau, J., & Weber, H. (March 2005). Die diazoxid-analoge BPDZ44 und BPDZ79 unterscheiden den zwischen verschiedenen KATP-kanälen durch unterscheidliche agonistische wirkung und nicht durch unterschiedliche bindungsaffinität [Poster presentation]. Gesellschaft für Toxikologie, Mainz, Germany.

Boverie, S., Antoine, M.-H., Somers, F., Becker, B., Sebille, S., Ouedraogo, R., Counerotte, S., Pirotte, B., Lebrun, P., & De Tullio, P. (2005). Effect on KATP channel activation properties and tissue selctivity of the nature of the substituent in the 7- and the 3-position of 4H-1,2,4-benzothiadiazine. Journal of Medicinal Chemistry, 48, 3492-3503. doi:10.1021/jm0311339

De Tullio, P., Boverie, S., Becker, B., Antoine, M.-H., Nguyen, Q.-A., Francotte, P., Counerotte, S., Sebille, S., Pirotte, B., & Lebrun, P. (2005). 3-Alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel openers : effect of 6,7-distribution on potency and tissue selectivity. Journal of Medicinal Chemistry, 48, 4990-5000. doi:10.1021/jm0580050

Dogné, J.-M., Rolin, S., Petein, M., Tchana-Sato, V., Ghuysen, A., Lambermont, B., Hanson, J., Magis, D., Segers, P., Pirotte, B., Masereel, B., Drion, P., D'Orio, V., & Kolh, P. (2005). Characterization of an original model of myocardial infarction provoked by coronary artery thrombosis induced by ferric chloride in pig. Thrombosis Research, 116 (5), 431-442. doi:10.1016/j.thromres.2005.02.006

Dupont, L., Boverie, S., De Tullio, P., & Pirotte, B. (2005). Crystal structure of 7-chloro-3-isopropylsulfanyl-4H-1,2,4-benzothiadiazine 1,1-dioxide, C10H11CIN2O2S2. Zeitschrift für Kristallographie. New Crystal Structures, NCS 220, 467-468.

Dupont, L., Boverie, S., Pirotte, B., & De Tullio, P. (2005). Crystal structure of 7-chloro-3-isopropoxy-4H-1,2,4-benzothiadiazine 1,1-dioxide monohydrate, C10H13CIN2O4S H2O. Zeitschrift für Kristallographie. New Crystal Structures, NCS 220, 565-566.

Dupont, L., Pirotte, B., & De Tullio, P. (2005). Crystal structure of 7-chloro-3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxide, C10H12CIN3O2S. Zeitschrift für Kristallographie. New Crystal Structures, NCS 220, 353-354.

Frederick, R., Robert, S., Charlier, C., De Ruyck, J., Wouters, J., Pirotte, B., Masereel, B., & Pochet, L. (2005). 3,6-Disubstitued coumarins as mechanism-based inhibitors of thrombin and factor Xa. Journal of Medicinal Chemistry, 48, 7592-7603. doi:10.1021/jm050448g

Hanson, J., Rolin, S., Reynaud, D., Qiao, N., Kelley, L. P., Reid, H. M., Valentin, F., Tippins, J., Kinsella, B. T., Masereel, B., Pace-Asciak, C. R., Pirotte, B., & Dogné, J.-M. (2005). In vitro and in vivo pharmacological characterization of BM-613 [N-n-pentyl-N'-[2-(4'-methylphenylamino)-5-nitrobenzenesulfonyl]urea]. Journal of Pharmacology and Experimental Therapeutics, 313, 293-301. doi:10.1124/jpet.104.079301

Michaux, C., Charlier, C., Julémont, F., De Leval, X., Dogné, J.-M., Pirotte, B., & Durant, F. (2005). A new potential cyclooxygenase-2 inhibitor, pyridinic analogue of nimesulide. European Journal of Medicinal Chemistry, 40, 1316-1324. doi:10.1016/j.ejmech.2005.08.003

Pirotte, B., De Tullio, P., Antoine, M.-H., Sebille, S., Florence, X., & Lebrun, P. (2005). New insights into the development pf ATP-sensitive potassium channel openers. Expert Opinion on Therapeutic Patents, 15, 497-504. doi:10.1517/13543776.15.5.497

Sebille, S., De Tullio, P., Becker, B., Antoine, M.-H., Boverie, S., Pirotte, B., & Lebrun, P. (2005). 4,6-Disubstitued 2,2-dimethylchromans structually related to the KATP channel opener cromakalim : design, synthesis, and effect on insulin release and vascular tone. Journal of Medicinal Chemistry, 48, 614-621.

De Tullio, P., Sebille, S., Florence, X., Lebrun, P., & Pirotte, B. (17 November 2004). Utilisation de la spectrométrie RMN dans l’identification de structure de dérivés biotinylés de modulateurs de canaux potassiques ATP-dépendants [Paper presentation]. CREMAN, Séminaire.

Graindorge, E., Francotte, P., Boverie, S., De Tullio, P., Pirotte, B., Lestage, P., Danober, L. P., Renard, P., & Caignard, D. H. (12 November 2004). Novel thiadiazine derivatives useful as AMPA receptor modulators, preparation method, and pharmaceutical compositions containing them.

Michaux, C., Julemont, F., De Leval, X., Dogne, J. M., Pirotte, B., & Durant, F. (07 October 2004). Pharmacophore generation to design new leads for selective cyclooxygenase-2 inhibition [Poster presentation]. Assemblée Générale Annuelle de la Société Royale de Chimie, Liège, Belgium.

De Tullio, P., Dupont, L., Boverie, S., Becker, B., Antoine, M. H., Sebille, S., Lebrun, P., & Pirotte, B. (August 2004). Improvement of the pharmacophoric model for an agonistic activity of arylthiadiazine dioxides on pancreatic KATP channels using the CoMSIA approach [Poster presentation]. XVIIIth ISMC, Copenhague, Denmark.

Francotte, P., Fraikin, P., De Tullio, P., Boverie, S., Danober, L., Lestage, P., Renard, P., Caignard, D. H., & Pirotte, B. (August 2004). Synthesis and biological evaluation of novel 2,3-dihydro-4H-1,2,4-benzothiadiazine 1,1-dioxides acting as AMPA potentiators [Poster presentation]. XVIIIth ISMC, Copenhague, Denmark.

Roland, I., de Leval, X., Evrard, B., Pirotte, B., Dogné, J.-M., & Delattre, L. (August 2004). Modulation of the arachidonic cascade with omega 3 fatty acids or analogues: Potential therapeutic benefits. Mini Reviews in Medicinal Chemistry, 4 (6), 659-668. doi:10.2174/1389557043403738

Boverie, S., De Tullio, P., Sebille, S., Dewalque, D., Damas, J., Lebrun, P., & Pirotte, B. (July 2004). Relaxant effects on the rat uterine smooth muscle of putative K+ATP channel openers [Poster presentation]. EPHAR 2004, Porto, Portugal.

Sebille, S., De Tullio, P., Antoine, M. H., Boverie, S., Pirotte, B., & Lebrun, P. (July 2004). New analogues of the potassium channel opener cromakalim : effects on rat pancreatic B-cells and rat aorta rings [Poster presentation]. EPHAR 2004, Porto, Portugal.

Boverie, S., Antoine, M. H., De Tullio, P., Sebille, S., Dewalque, D., Damas, J., Lebrun, P., & Pirotte, B. (June 2004). Synthèse de nouveaux analogues benzothiadiaziniques en tant qu’activateurs potentiels des canaux KATP et leur évaluation pharmacologique in vitro sur cellules B pancréatiques, aorte et utérus de rats [Poster presentation]. 18èmes Journées Franco-belges de Pharmacochimie, Luxembourg, Luxembourg.

Francotte, P., Boverie, S., Fraikin, P., Lestage, P., Danober, L., Caignard, D. H., De Tullio, P., & Pirotte, B. (June 2004). Prodrogues de modulateurs allostériques positifs des récepteurs AMPA apparentés à l’IDRA-21 : design, synthèse, étude de la stabilité et évaluation pharmacologique [Poster presentation]. 18èmes Journées Franco-belges de Pharmacochimie, Luxembourg, Luxembourg.

Hanson, J., Renard, J.-F., Neven, P., De Leval, X., Rolin, S., Pirotte, B., & Dogne, J. M. (June 2004). Synthèse et évaluation pharmacologique de nouveaux antagonistes du récepteur au thromboxane A2 dérivés du BM-573 [Poster presentation]. 18èmes Journées Franco-belges de Pharmacochimie, Luxembourg, Luxembourg.

Julemont, F., De Leval, X., Dogne, J. M., & Pirotte, B. (June 2004). Synthèse et évaluation pharmacologique d’analogues pyridiniques du nimésulide : variation du pont « inter-cycle [Poster presentation]. 18èmes Journées Franco-belges de Pharmacochimie, Luxembourg, Luxembourg.

Kempen, I., Frankenne, F., Telliez, A., Pommery, N., Henichart, J. P., Foidart, J.-M., & Pirotte, B. (June 2004). Synthèse et évaluation pharmacologique in vitro de nouveaux analogues du 6-acétoxyméthyl-2-oxo-2H-1-benzopyrane-3-carboxylate de 3-bromophényle en tant qu’agents inhibiteurs de l’invasion cellulaire [Poster presentation]. 18èmes Journées Franco-belges de Pharmacochimie, Luxembourg, Luxembourg.

Michaux, C., Julemont, F., De Leval, X., Dogne, J. M., Pirotte, B., & Durant, F. (June 2004). Identification d’un inhibiteur COX-2 sélectif », 18èmes Journées Franco-belges de Pharmacochimie [Poster presentation]. 18èmes Journées Franco-belges de Pharmacochimie, Luxembourg, Luxembourg.

Michaux, C., Julemont, F., De Leval, X., Pirotte, B., & Durant, F. (June 2004). Identification d’inhibiteurs sélectifs de la cyclooxygénase-2 (COX-2) [Paper presentation]. 18èmes Journées Franco-belges de Pharmacochimie, Luxembourg, Luxembourg.

Sebille, S., De Tullio, P., Antoine, M. H., Boverie, S., Lebrun, P., & Pirotte, B. (June 2004). Nouveaux activateurs des canaux KATP analogues du cromakalim : synthèse et évaluation pharmacologique in vitro sur cellules B pancréatiques et aortes de rats [Poster presentation]. 18èmes Journées Franco-belges de Pharmacochimie, Luxembourg, Luxembourg.

De Leval, X., Dassesse, T., Benoit, V., Hanson, J., Dogne, J. M., Castronovo, V., & Pirotte, B. (May 2004). Development of thromboxane A2 modulators as promising anti-metastatic and anti-angiogenic compounds [Paper presentation]. 12th Forum of Pharmaceutical Sciences, Blankenberge, Belgium.

Francotte, P., Boverie, S., Fraikin, P., Lestage, P., Danober, L., Caignard, D. H., De Tullio, P., & Pirotte, B. (May 2004). Prodrugs of AMPA potentiators structurally related to IDRA-21: design, preparation, hydrolysis study and pharmacological evaluation [Paper presentation]. 12th Forum of Pharmaceutical Sciences, Blankenberge, Belgium.

Hanson, J., Rolin, S., De Leval, X., Reynaud, D., Qiao, N., Neven, P., Masereel, B., Pace-Asciak, C. R., Pirotte, B., & Dogné, J.-M. (May 2004). In vivo evaluation of antithrombotic potency of BM-613, a thromboxane A2 receptor antagonist, in a rat model of arterial thrombosis [Paper presentation]. 12th Forum of Pharmaceutical Sciences, Blankenberge, Belgium.

Sebille, S., De Tullio, P., Antoine, M. H., Boverie, S., Lebrun, P., & Pirotte, B. (May 2004). New analogues of the potassium channel opener cromakalim: effects on rat pancreatic B-cells and rat aorta rings [Paper presentation]. 12th Forum of Pharmaceutical Sciences, Blankenberge, Belgium.

De Leval, X., Hanson, J., David, J.-L., Masereel, B., Pirotte, B., & Dogné, J.-M. (2004). New developments on thromboxane and prostacyclin modulators. Part II: prostacyclin modulators. Current Medicinal Chemistry, 11, 1243-1252. doi:10.2174/0929867043365279

De leval, X., Julémont, F., Benoit, V., Frederich, M., Pirotte, B., & Dogné, J.-M. (2004). First and second generations of COX-2 selective inhibitors. Mini Reviews in Medicinal Chemistry, 4, 597-601. doi:10.2174/1389557043403693

Dogné, J.-M., De leval, X., Hanson, J., Frederich, M., Lambermont, B., Ghuysen, A., Casini, A., Masereel, B., Ruan, K. E., Pirotte, B., & Kolh, P. (2004). New developments on thromboxane and prostacyclin modulators. Part I: thromboxane modulators. Current Medicinal Chemistry, 11, 1223-1241. doi:10.2174/0929867043365260

Dogné, J.-M., Hanson, J., De leval, X., Kolh, P., Tchana-Sato, V., de Leval, L., Rolin, S., Ghuysen, A., Segers, P., Lambermont, B., Masereel, B., & Pirotte, B. (2004). Pharmacological characterization of N-tert-butyl-N’-[2-(4’-methylphenylamino)-5-nitrobenzenesulfonyl]urea (BM-573), a novel thromboxane A2 receptor antagonist and thromboxane synthase inhibitor in a rat model of arterial thrombosis and its effects on bleeding time. Journal of Pharmacology and Experimental Therapeutics, 309 (2), 498-505. doi:10.1124/jpet.103.063610

Dogné, J.-M., Hanson, J., De leval, X., Masereel, B., Kolh, P., & Pirotte, B. (2004). New developments on thromboxane modulators. Mini Reviews in Medicinal Chemistry, 649-657. doi:10.2174/1389557043403684

Francotte, P., Boverie, S., Fraikin, P., Lestage, P., Danober, L., Caignard, D.-H., De Tullio, P., & Pirotte, B. (2004). Produgs of AMPA potentiators structurally related to IDRA21 : design, preparation, hydrolysis study and pharmacological evaluation. Fundamental and Clinical Pharmacology, 595.

Francotte, P., Graindorge, E., Boverie, S., De Tullio, P., & Pirotte, B. (2004). New trends in the design of drugs against Alzheimer's disease. Current Medicinal Chemistry, 11 (13), 1757-1778. doi:10.2174/0929867043364946

Graindorge, E., Francotte, P., Boverie, S., De Tullio, P., & Pirotte, B. (2004). New trends in the development of positive allosteric modulators of AMPA receptors. Current Medicinal Chemistry - Central Nervous System Agents, 4, 95-103.

Hanson, J., De Leval, X., David, J.-L., Supuran, C., Pirotte, B., & Dogné, J.-M. (2004). Progress in the field of GPIIb/IIIa antagonists. Current Medicinal Chemistry - Cardiovascular and Hematological Agents, 2, 157-167. doi:10.2174/1568016043477224

Hanson, J., Kolh, P., Rolin, S., Tchana-Sato, V., De Leval, X., Petein, M., Masereel, B., Pirotte, B., Dogné, J.-M., Lambermont, B., David, J. L., & GHUYSEN, A. (2004). In vivo pharmacological evaluation of BM-573, an original thromboxane A2 receptor antagonist and thromboxane synthase inhibitor. Fundamental and Clinical Pharmacology, 270.

Hanson, J., Renard, J.-F., Neven, P., De leval, X., Rolin, S., Pirotte, B., & Dogné, J.-M. (2004). Synthésis and pharmacological evaluation of original thromboxane A2 receptor antagonists derived from BM-573. Fundamental and Clinical Pharmacology, 596.

Hanson, J., Rolin, S., De Leval, X., Neven, P., Masereel, B., Pirotte, B., & Dogné, J.-M. (2004). Characterization of preferential activity on platelet thromboxane A2 receptors of BM-613, a new thromboxane A2 antagonist. Fundamental and Clinical Pharmacology, 269.

Julémont, F., de Leval, X., Michaux, C., Renard, J.-F., Winum, J.-Y., Montero, J.-L., Damas, J., Dogné, J.-M., & Pirotte, B. (2004). Design, synthesis and pharmacological evaluation of pyridinic analogues of nimesulide as cyclooxygenase-2 selective inhibitors. Journal of Medicinal Chemistry, 47, 6749-6759. doi:10.1021/jm049480l

Julémont, F., Dogné, J.-M., Pirotte, B., & de Leval, X. (2004). Recent development in the field of dual COX / 5-LOX inhibitors. Mini Reviews in Medicinal Chemistry, 4, 633-638. doi:10.2174/1389557043403747

Kempen, I., Counerotte, S., Frankenne, F., Noël, A., Foidart, J.-M., & Pirotte, B. (2004). Effects of recently developed 6-substituted 3-bromophenyl 2-oxo-2H-1-benzopyran-3-carboxylate derivatives on HT1080 cell invasion in vitro. Fundamental and Clinical Pharmacology, 271.

Kempen, I., Frankenne, F., Telliez, A., Pommery, N., Henichart, J. P., Foidart, J.-M., & Pirotte, B. (2004). Design and pharmacological evaluation of recently developed 6-substituted 3-bromophenyl 2-oxo-2H-1-benzopyran 3-carboxylate derivatives as putative inhibitors of cell invasion. Fundamental and Clinical Pharmacology, 596.

Michaux, C., Julémont, F., de Leval, X., Dogné, J.-M., Pirotte, B., & Durant, F. (2004). Identification of COX-2 selective inhibitor. Fundamental and Clinical Pharmacology, 598.

Mouithys-Mickalad, A., Deby, G., Dogné, J.-M., de Leval, X., Kohnen, S., Navet, R., Sluse, F., Hoebeke, M., Pirotte, B., & Lamy, M. (2004). Effects of COX-2 inhibitors on ROS produced by Chlamydia pneumoniae-primed human promonocytic cells (THP-1). Biochemical and Biophysical Research Communications, 325 (4), 1122-1130. doi:10.1016/j.bbrc.2004.10.155

Sebille, S., Boverie, S., Becker, B., Antoine, M. H., De Tullio, P., Lebrun, P., & Pirotte, B. (2004). Effects of cromakalim analogues on rat pancreatic B-cells, rat aorta rings and rat uterus. Study of their mechanism of action as potassium channel activators. Fundamental and Clinical Pharmacology, 271.

Sebille, S., De Tullio, P., Antoine, M. H., Boverie, S., Lebrun, P., & Pirotte, B. (2004). New analogues of the KATP channel opener cromakalim : synthesis and pharmacological evaluation on rat pancreatic B-cells and rat aorta rings. Fundamental and Clinical Pharmacology, 599.

Sebille, S., De Tullio, P., Boverie, S., Antoine, M.-H., Lebrun, P., & Pirotte, B. (2004). Recent developments in the chemistry of potassium channel activators : the cromakalim analogues. Current Medicinal Chemistry, 11, 1213-1222. doi:10.2174/0929867043365378

De Leval, X., Dassesse, T., Benoît, V., Pirotte, B., Merville, M.-P., David, J. L., Castronovo, V., & Dogne, J. M. (December 2003). Pharmacological evaluation of BM-573, a dual thromboxane A2 receptor antagonist and thromboxane synthase inhibitor, as potential anti-metastatic agent [Poster presentation]. 45th ASH Annual Meeting, San Diego, United States.

Dogne, J. M., Kolh, P., Rolin, S., Tchana-Sato, V., Hanson, J., De Leval, X., Lambermont, B., Ghuysen, A., Petein, M., De Leval, X., Masereel, B., & Pirotte, B. (December 2003). Antithrombotic activity of BM-573, a novel thromboxane modulator, in rat arterial thrombosis model, pig myocardial infarction model and its effect on bleeding time [Poster presentation]. 45th ASH Annual Meeting, San Diego, United States.

Hanson, J., Rolin, S., De Leval, X., Neven, P., Masereel, B., Pirotte, B., & Dogne, J. M. (December 2003). BM-613, a new thromboxane A2 antagonist, is characterized by a preferential activity on platelet thromboxane A2 receptors [Poster presentation]. 45th ASH Annual Meeting, san Diego, United States.

Hanson, J., Rolin, S., De Leval, X., Neven, P., Masereel, B., Pirotte, B., & Dogne, J. M. (22 November 2003). BM-613, a new thromboxane A2 antagonist, is characterized by a preferential activity on platelet thromboxane A2 receptors [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Liège, Belgium.

Kempen, I., Counerotte, S., Frankenne, F., Noël, A., Foidart, J.-M., & Pirotte, B. (22 November 2003). Effects of recently developed 6-substituted 3-bromophenyl 2-oxo-2H-1-benzopyran-3-carboxylate derivatives on HT1080 cell invasion in vitro [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Liège, Belgium.

Sebille, S., Boverie, S., Becker, B., Antoine, M. H., De Tullio, P., Lebrun, P., & Pirotte, B. (22 November 2003). Effects of cromakalim analogues on rat pancreatic B-cells, rat aorta rings and rat uterus. Study of their mechanism of action as potassium channel activators [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Liège, Belgium.

de Leval, X. J., Dassesse, T., Benoit, V., Pirotte, B., Merville, M.-P., David, J.-L., Castronovo, V., & Dogné, J.-M. (16 November 2003). Pharmacological evaluation of BM-573, a dual thromboxane A(2) receptor antagonist and thromboxane synthase inhibitor, as potential anti-metastatic agent. Blood, 102 (11, Part 2), 72.

Hanson, J., Kolh, P., Rolin, S., Tchana-Sato, V., De Leval, X., Lambermont, B., Ghuysen, A., Petein, M., Masereel, B., Pirotte, B., & Dogne, J. M. (November 2003). Antithrombotic activity of BM-573, a novel thromboxane modulator, in rat arterial thrombosis model, pig myocardial infarction model and its effects on bleeding time [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Liège, Belgium.

Lebrun, P., Antoine, M. H., Dabrowski, M., Bondo-Hansen, J., Pirotte, B., & De Tullio, P. (July 2003). Towards tissue-selective KATP channel openers [Poster presentation]. 3rd F.E.P.S. - European Physiological Society, Nice, France.

De Leval, X., Dogne, J. M., Pirotte, B., Scozzafava, A., Casini, A., & Supuran, C. T. (June 2003). Fluorine containing aromatic/heterocyclic sulfonamides as topical intraocular pressure lowering agents with prolonged duration of action.

Frederick, R., Pochet, L., Pirotte, B., & Masereel, B. (May 2003). Conception, synthèse et évaluation biologique d’amino et de guanidino-coumarines inhibiteurs potentiels de thrombine [Poster presentation]. XVIIèmes Journées Franco-Belges de Pharmacochimie, Woluwe-Saint-Lambert, Belgium.

Hanson, J., Rolin, S., De Leval, X., Neven, P., Devel, P., Masereel, B., Pirotte, B., & Dogne, J. M. (May 2003). Synthesis and pharmacological evaluation of BM-613, an original thromboxane A2 antagonist [Poster presentation]. 11th Forum of pharmaceutical sciences, Spa, Belgium.

Hanson, J., Rolin, S., De Leval, X., Neven, P., Devel, P., Masereel, B., Pirotte, B., & Dogne, J. M. (May 2003). Pharmacological evaluation of the thromboxane A2 receptor antagonist BM-613 [Poster presentation]. XVIIèmes Journées Franco-Belges de Pharmacochimie, Woluwe-Saint-Lambert, Belgium.

Julemont, F., De Leval, X., Damas, J., Michaux, C., Durant, F., Pirotte, B., & Dogne, J. M. (May 2003). Pyridinic sulfonamides as potential COX-2 inhibitors [Poster presentation]. 11th Forum of pharmaceutical sciences, Spa, Belgium.

Julemont, F., De Leval, X., Michaux, C., Pirotte, B., & Dogne, J. M. (May 2003). Synthèse et évaluation pharmacologique de N-pyridinyl-alkanesulfonamides apparentés au nimésulide [Poster presentation]. XVIIèmes Journées Franco-Belges de Pharmacochimie, Woluwe-Saint-Lambert, Belgium.

Kempen, I., Counerotte, S., Frankenne, F., Foidart, J.-M., Noël, A., & Pirotte, B. (May 2003). Anti-invasive and anti-migrative properties of recently developed 6-substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives [Poster presentation]. 11th Forum of pharmaceutical sciences, Spa, Belgium.

Michaux, C., De Leval, X., Julemont, F., Pirotte, B., & Durant, F. (May 2003). Pharmacophore generation to design new leads for selective cyclooxygenase-2 (COX-2) inhibition [Poster presentation]. XVIIèmes Journées Franco-Belges de Pharmacochimie, Woluwe-Saint-Lambert, Belgium.

Pochet, L., Rolin, S., Morel, M., Pirotte, B., Frederick, R., & Masereel, B. (May 2003). Synthèse et évaluation biologique de nouvelles coumarines en tant qu’anticoagulants potentiels [Poster presentation]. XVIIèmes Journées Franco-Belges de Pharmacochimie, Woluwe-Saint-Lambert, Belgium.

Sebille, S., Becker, B., Boverie, S., De Tullio, P., Antoine, M. H., Lebrun, P., & Pirotte, B. (May 2003). 3,4-Dihydro-2,2-dimethylchromans structurally related to the KATP channel opener cromakalim: design, synthesis, effect on insulin release and vascular tone [Poster presentation]. 11th Forum of pharmaceutical sciences, Spa, Belgium.

Sebille, S., Becker, B., De Tullio, P., Boverie, S., Antoine, M. H., Lebrun, P., & Pirotte, B. (May 2003). Evaluation pharmacologique et étude du mécanisme d’action de molécules structurellement apparentées au cromakalim en tant qu’activateurs des canaux KATP [Poster presentation]. XVIIèmes Journées Franco-Belges de Pharmacochimie, Woluwe-Saint-Lambert, Belgium.

Delarge, J., Pirotte, B., Dogné, J. M., de Leval, X., & Julémont, F. (10 April 2003). Pyridinic sulfonamide derivatives, method of production and use thereof.

Kempen, I., Papapostolou, D., Thierry, N., Pochet, L., Counerotte, S., Masereel, B., Foidart, J.-M., Reboud-Ravaux, M., Noël, A., & Pirotte, B. (07 April 2003). 3-Bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate inhibits cancer cell invasion in vitro and tumour growth in vivo. British Journal of Cancer, 88 (7), 1111-1118. doi:10.1038/sj.bjc.6600856

Francotte, P., Graindorge, E., Kempen, I., Boverie, S., De Tullio, P., Caignard, D. H., Lestage, P., & Pirotte, B. (31 January 2003). Préparation et évaluation pharmacologique de modulateurs allostériques positifs des récepteurs AMPA : les 2,3-dihydro-4H-1,2,4-pyridothiadiazine 1,1-dioxydes [Poster presentation]. 10ème Journée Jeunes Chercheurs, Paris, France.

Graindorge, E., Francotte, P., Boverie, S., Kempen, I., De Tullio, P., Caignard, D. H., Lestage, P., & Pirotte, B. (31 January 2003). Nouveaux composés agissant en tant que modulateurs allostériques positifs des récepteurs glutamatergiques de sous-type AMPA : les 2,3-dihydro-4H-1,2,4-benzothiadiazine 1,1-dioxydes [Poster presentation]. 10éme Journée Jeunes Chercheurs, Paris, France.

Hanson, J., Rolin, S., De Leval, X., Neven, P., Devel, P., Masereel, B., Pirotte, B., & Dogne, J. M. (31 January 2003). Etude de la sélectivité tissulaire d’un nouvel antagoniste des récepteurs au thromboxane A2, le BM-613 [Poster presentation]. 10éme Journée Jeunes Chercheurs, Paris, France.

Kempen, I., Counerotte, S., Frankenne, F., Foidart, J.-M., Noël, A., & Pirotte, B. (31 January 2003). Les esters du 6-hydroxymethyl-2-oxo-2H-1-benzopyrane-3-carboxylate de 3-bromophényle inhibent l’invasion des cellules de fibrosarcome humain in vitro [Poster presentation]. 10ème Journée Jeunes Chercheurs, Paris, France.

Sebille, S., Boverie, S., De Tullio, P., Antoine, M. H., Lebrun, P., & Pirotte, B. (31 January 2003). Nouveaux analogues du cromakalim en tant qu’agents pharmacologiques potentials de la classe des activateurs des canaux KATP [Paper presentation]. 10éme Journée Jeunes Chercheurs, Paris, France.

De Leval, X., Benoit, V., Delarge, J., Julémont, F., Masereel, B., Pirotte, B., Merville, M.-P., David, J. L., & Dogné, J.-M. (2003). Pharmacological evaluation of the novel thromboxane modulator BM-567 (II/II). Effects of BM-567 on osteogenic sarcoma-cell-induced platelet aggregation. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 55-59. doi:10.1016/S0952-3278(02)00235-1

De Leval, X., Dassesse, T., Benoit, V., Pirotte, B., David, J.-L., Merville, M.-P., Castronovo, V., & Dogné, J.-M. (2003). Pharmacological evaluation of BM-573, a dual thromboxane A2 receptor antagonist and thromboxane synthase inhibitor, as potential anti-metastatic agent. Blood, 72.

De Tullio, P., Becker, B., Boverie, S., Dabrowski, M., Wahl, P., Antoine, M.-H., Somers, F., Sebille, S., Ouedraogo, R., Hansen, J. B., Lebrun, P., & Pirotte, B. (2003). Toward tissue-selective pancreatic B-cells KATP channel openers belonging to 3-alkylamino-7-halo-4H-1,2,4-benzothiadiazine 1,1-dioxides. Journal of Medicinal Chemistry, 46, 3342-3353. doi:10.1021/jm021117w

Dogné, J.-M., de Leval, X., Kolh, P., Sanna, V., Rolin, S., Michaux, C., Mauer, M., David, J.-L., Masereel, B., & Pirotte, B. (January 2003). Pharmacological evaluation of the novel thromboxane modulator BM-567 (I/II). Effects of BM-567 on platelet function. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 68 (1), 49-54. doi:10.1016/S0952-3278(02)00236-3

Dogné, J.-M., Kolh, P., Rolin, S., Tchana-Sato, V., Hanson, J., De Leval, X., Lambermont, B., Ghuysen, A., Petein, M., de Leval, L., Masereel, B., & Pirotte, B. (2003). Antithrombotic activity of BM-573, a novel thromboxane modulator, in rat arterial thrombosis model, pig myocardial infarction model and its effect on bleeding time. Blood, 106.

Dupont, L., Somers, F., De Tullio, P., & Pirotte, B. (2003). 3-Isopropylamino-7-nitro-1,4,2-benzodithiazine 1,1-dioxide. Acta Crystallographica, 1509-o1511. doi:10.1107/S1600536803020324

Hanson, J., De Leval, X., Kolh, P., Supuran, C., Pirotte, B., & Dogné, J.-M. (2003). Update on GPIIb/IIIa antagonists. Expert Opinion on Therapeutic Patents, 13, 1173-1188. doi:10.1517/13543776.13.8.1173

Hanson, J., Rolin, S., De Leval, X., Neven, P., De Leval, L., Masereel, B., Pirotte, B., & Dogné, J.-M. (2003). BM-613, a new thromboxane A2 antagonist, is characterized by a preferential activity on platelet thromboxane A2 receptors. Blood, 813a-814.

Julémont, F., Dogné, J.-M., Laeckmann, D., Pirotte, B., & de Leval, X. (2003). Recent developments in 5-lipoxygenase inhibitors. Expert Opinion on Therapeutic Patents, 13, 1-13. doi:10.1517/13543776.13.1.1

Pochet, L., Dieu, M., Frederick, R., Murray, A. M., Kempen, I., Pirotte, B., & Masereel, B. (2003). Investigation of the inhibition mechanism of coumarins on chymotrypsin by mass spectrometry. Tetrahedron, 4557-4561. doi:10.1016/S0040-4020(03)00660-4

Kempen, I., Frankenne, F., Noël, A., Foidart, J.-M., & Pirotte, B. (15 November 2002). Effects of 6-substituted 2-oxo-2H-1-benzopyran-3-carbowylic acide derivatives on cellular invasion in vitro [Poster presentation]. Drug Hunting: New Targets, New Tools, New Drugs, Bruxelles, Belgium.

Michaux, C., Charlier, C., Julémont, F., de Leval, X., Dogné, J.-M., Pirotte, B., & Durant, F. (15 November 2002). Rationalization of the binding mode of pyridinic compounds derived from nimesulide, a preferential cyclooxygenase-2 inhibitor [Poster presentation]. Drug Hunting: New Targets, New Tools, New Drugs, Bruxelles, Belgium.

Sebille, S., Boverie, S., De Tullio, P., Becker, B., Antoine, M. H., Lebrun, P., & Pirotte, B. (15 November 2002). Synthesis and pharmacological evaluation of cromakalim analogues as potassium channel activators [Poster presentation]. Drug Hunting: New Targets, New Tools, New Drugs, Bruxelles, Belgium.

De Leval, X., Benoît, V., Neven, P., Benoît, P., Michaux, C., Masereel, B., Pirotte, B., David, J. L., & Dogne, J. M. (October 2002). Effects of thromboxane A2 receptor antagonists and thromboxane synthase inhibitors on osteogenic sarcoma cell induced platelet aggregation [Poster presentation]. 17th International Congress on Thrombosis, Bologne, Italy.

Michaux, C., Charlier, C., Julémont, F., de Leval, X., Dogné, J.-M., Pirotte, B., & Durant, F. (26 September 2002). Rationalization of the binding mode of pyridinic compounds derived from nimesulide, a preferential cyclooxygenase-2 inhibitor [Poster presentation]. Assemblée générale annuelle de la Société Royale de Chimie, Namur, Belgium.

Boverie, S., De Tullio, P., Dewalque, D., Sebille, S., Damas, J., & Pirotte, B. (September 2002). Relaxant effects on the rat uterine smooth muscle of K+ATP channel openers compared to ritodrine, diltiazem and verapamil : development of new pharmacological in vitro models [Poster presentation]. XVIIth International Symposium on Medicinal Chemistry, Barcelone, Spain.

Cosgrove, K. E., Lee, A. T., Hussain, K., Clayton, P. E., Rahier, J., Saudubray, J. M., Aynsley-Green, A., Pirotte, B., Lebrun, P., & Dunne, M. J. (September 2002). BPDZ 154 is a novel and potent activator of ATP-sensitive potassium channels in pancreatic B-cells; implications for hyperinsulinism [Paper presentation]. European Society for Paediatric Endocrinology Meeting.

De Tullio, P., Boverie, S., Becker, B., Antoine, M. H., Sebille, S., Lebrun, P., & Pirotte, B. (September 2002). 6,7-Disubstituted 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides: new potent ATP-sensitive potassium channel openers [Poster presentation]. XVIIth International Symposium on Medicinal Chemistry, Barcelone, Spain.

Frederick, R., Pochet, L., Pirotte, B., Doucet, C., Reboud-Ravaux, M., & Masereel, B. (31 May 2002). Design et synthèse de nouveaux dérivés coumariniques inhibiteurs de thrombine [Poster presentation]. XVIemes Journées Franco-Belges de Pharmacochimie, Bagnoles de l’Orne, France.

De Leval, X., Benoît, V., Neven, P., Benoît, P., Michaux, C., Masereel, B., Pirotte, B., David, J. L., & Dogne, J. M. (May 2002). Effects of thromboxane A2 receptor antagonists and thromboxane synthase inhibitors on osteogenic sarcoma cell induced platelet aggregation [Poster presentation]. XVIemes Journées Franco-Belges de Pharmacochimie, Bagnoles de l’Orne, France.

Francotte, P., Graindorge, E., Kempen, I., Boverie, S., De Tullio, P., Caignard, D. H., Lestage, P., & Pirotte, B. (May 2002). Synthèse et évaluation biologique de 2,3-dihydro-4H-1,2,4-pyridothiadiazine 1,1-dioxydes en tant que modulateurs allostériques positifs des récepteurs AMPA [Poster presentation]. XVIemes Journées Franco-Belges de Pharmacochimie, Bagnoles de l’Orne, France.

Graindorge, E., Francotte, P., Boverie, S., Kempen, I., De Tullio, P., Caignard, D. H., Lestage, P., & Pirotte, B. (May 2002). Les 2,3-dihydro-4H-1,2,4-benzothiadiazine 1,1-dioxydes en tant que modulateurs allostériques positifs des récepteurs glutamatergiques de sous-type AMPA [Poster presentation]. XVIemes Journées Franco-Belges de Pharmacochimie, Bagnoles de l’Orne, France.

Kempen, I., Counerotte, S., Frankenne, F., Noël, A., Foidart, J.-M., & Pirotte, B. (May 2002). Les esters du 6-hydroxyméthyl-2-oxo-2H-1-benzopyrane-3-carboxylate de 3-bromophényle en tant qu’agents inhibiteurs de l’invasion cellulaire in vitro [Poster presentation]. XVIemes Journées Franco-Belges de Pharmacochimie, Bagnoles de l’Orne, France.

Sebille, S., Becker, B., De Tullio, P., Boverie, S., Antoine, M. H., Lebrun, P., & Pirotte, B. (May 2002). Synthèse et évaluation pharmacologique in vitro de nouveaux analogues du cromakalim en tant qu’activateurs potentiels des canaux KATP [Poster presentation]. XVIemes Journées Franco-Belges de Pharmacochimie, Bagnoles de l’Orne, France.

Lee, A. T., Cosgrove, K. E., Barnes, P. B., Lindley, K. J., Aynsley-Green, A., De Tullio, P., Pirotte, B., Lebrun, P., & Dunne, M. J. (April 2002). BPDZ 154 is a potent activator of ATP-sensitive potassium channels in pancreatic β-cells [Poster presentation]. 21th Joint Meeting of the British Endocrine Societies, Harrogate, United Kingdom.

Boverie, S., Becker, B., Sebille, S., Antoine, M. H., Pirotte, B., Lebrun, P., & De Tullio, P. (02 March 2002). Development of 4H-1,2,4-benzothiadiazine 1,1-dioxides as putative tocolytic agents: pharmacological evaluation on different smooth muscle preparations [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Liège, Belgium.

De Leval, X., Benoit, V., Neven, P., Benoit, P., Michaux, C., Masereel, B., Pirotte, B., David, J. L., & Dogne, J. M. (02 March 2002). Effects of thromboxane A2 receptor antagonists and thromboxane synthase inhibitors on osteogenic sarcoma cell-induced platelet aggregation [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Liège, Belgium.

De Tullio, P., Boverie, S., Dewalque, D., Damas, J., Sebille, S., & Pirotte, B. (02 March 2002). Relaxant effect of K+ATP channel openers on the uterine smooth muscle: pharmacological in vitro models [Paper presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Liège, Belgium.

De Tullio, P., Boverie, S., Dewalque, D., Sebille, S., Damas, J., & Pirotte, B. (02 March 2002). Relaxant effect of K+ATP channel openers on the uterine smooth muscle: pharmacological in vitro models [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Liège, Belgium.

Julémont, F., de Leval, X., Neven, P., Michaux, C., Charlier, C., Pirotte, B., & Dogné, J.-M. (02 March 2002). Evaluation of pyridinic sulfonamides related to nimesulide as COX-2 selective inhibitors [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Liège, Belgium.

Sebille, S., Becker, B., Antoine, M. H., Boverie, S., De Tullio, P., Lebrun, P., & Pirotte, B. (02 March 2002). Pharmacological evaluation of cromakalim analogues: towards the discovery of new inhibitors of insulin secretion from rat pancreatic β-cells [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Liège, Belgium.

Lee, A. T., Cosgrove, K. E., Barnes, P. B., Lindley, K. J., Aynsley-Green, A., De Tullio, P., Pirotte, B., Lebrun, P., & Dunne, M. J. (March 2002). BPDZ 154: a novel activator of KATP channels in β-cells [Poster presentation]. U.K.-German Joint Physiological Society Meeting, Tuebingen, Germany.

Boverie, S., Dewalque, D., Sebille, S., Damas, J., Pirotte, B., & De Tullio, P. (25 January 2002). Action myorelâchante sur la fibre musculaire lisse utérine de nouveaux dérivés de type 4H-1,2,4-benzothiadiazine 1,1-dioxyde diversement substitués en position 3 et 7 [Paper presentation]. Journée Jeunes Chercheurs, Paris, France.

Kempen, I., Counerotte, S., Frankenne, F., Foidart, J.-M., & Pirotte, B. (25 January 2002). Synthèse et évaluation pharmacologique de dérivés de l'acide 2-oxo-2H-1-benzopyrane-3-carboxylique en tant qu'agents inhibiteurs de l'invasion cellulaire in vitro [Poster presentation]. Journée Jeunes Chercheurs, Paris, France.

Sebille, S., Becker, B., Antoine, M. H., De Tullio, P., Lebrun, P., & Pirotte, B. (25 January 2002). Synthèse et évaluation pharmacologique in vitro sur cellules B pancréatiques de rats, aortes de rats et utérus de rates de molécules apparentées au cromakalim en tant qu'activateurs des canaux KATP [Poster presentation]. Journée Jeunes Chercheurs, Paris, France.

Becker, B., Sebille, S., Antoine, M. H., Pirotte, B., Lebrun, P., De Tullio, P., & Boverie, S. (2002). Development of 4H-1,2,4-benzothiadiazine 1,1-dioxides as putative tocolytic agents: pharmacological evaluation on different smooth muscle preparations. Fundamental and Clinical Pharmacology, 246.

Benoit, P., De Leval, X., Pirotte, B., & Dogné, J.-M. (2002). Latest discoveries in prostaglandin receptor modulators. Expert Opinion on Therapeutic Patents, 12, 1225-1235. doi:10.1517/13543776.12.8.1225

Boverie, S., Becker, B., Sebille, S., Antoine, M. H., Pirotte, B., Lebrun, P., & De Tullio, P. (2002). development of 4H-1,2,4-benzothiadiazine 1,1-dioxides as putative tocolytic agents: pharmacological evaluation on diferent smooth muscle preparations. Fundamental and Clinical Pharmacology, 246.

Boverie, S., Becker, B., Somers, F., Nguyen, Q. A., Ouedraogo, R., Antoine, M. H., Lebrun, P., Pirotte, B., & De Tullio, P. (2002). 3-R/S-(hydroxyalkylamino)-4H-1,2,4-benzothiadiazine 1,1-dioxides as potential K+ATP channel activators: influence of stereochemistry on biological activity and tissue selectivity. Fundamental and Clinical Pharmacology, 69.

Cosgrove, K. E., Antoine, M.-H., Lee, A. T., Barnes, P. D., De Tullio, P., Clayton, P., McCloy, R., De Lonlay, P., Nihoul-Fekete, C., Robert, J. J., Saudubray, J.-M., Rahier, J., Lindley, K. J., Hussain, K., Aynsley-Green, A., Pirotte, B., Lebrun, P., & Dunne, M. J. (2002). BPDZ 154 Activates Adenosine 5’-Triphosphate-Sensitive Potassium Channels; In Vitro Studies Using Rodent Insulin-Secreting Cells and Islets Isolated from Patients with Hyperinsulinism. Journal of Clinical Endocrinology and Metabolism, 87, 4860-4868. doi:10.1210/jc.2002-020439

Cosgrove, K. E., Gonzalez, A. M., Lee, A. T., Barnes, P., Hussain, K., Aynsley-Green, A., Lindley, K. J., Pirotte, B., Lebrun, P., & Dunne, M. J. (2002). In vitro recovery of ATP-sensitive potassium channels in Beta-cells from patients with hyperinsulinism in infancy; effects of low temperature and BPDZ 154. Journal of Physiology, 544, 229.

Dabrowski, M., Ashcroft, F. M., Ashfield, R., Lebrun, P., Pirotte, B., Egebjerg, J., Hansen, J. B., & Wahl, P. (2002). The novel diazoxide analog 3-isopropylamino-7-methoxy-4H-1,2,4-benzothiadiazine 1,1-dioxide is a selective Kir6.2/SUR1 channel opener. Diabetes, 51, 1896-1906. doi:10.2337/diabetes.51.6.1896

De Leval, X., Benoit, V., Neven, P., Benoit, P., Michaux, C., Masereel, B., Pirotte, B., David, J. L., & Dogné, J.-M. (2002). Effects of thromboxane A2 receptor antagonists and thromboxane synthase inhibitors on osteogenic sarcoma cell-induced platelet aggregation. Fundamental and Clinical Pharmacology, 245.

De Leval, X., Benoit, V., Neven, P., Benoit, P., Michaux, C., Masereel, B., Pirotte, B., David, J.-L., & Dogné, J.-M. (2002). Effects of thromboxane A2 receptor antagonists and thromboxane synthase inhibitors on osteogenic sarcoma cell-induced platelet aggregation. Fundamental and Clinical Pharmacology, 16, 245.

De Leval, X., Julémont, F., Delarge, J., Pirotte, B., & Dogné, J.-M. (2002). New trends in dual 5-LOX/COX inhibition. Current Medicinal Chemistry, 9, 941-962. doi:10.2174/0929867024606713

De Leval, X., Julémont, F., Delarge, J., Sanna, V., Pirotte, B., & Dogné, J.-M. (2002). Advances in the field of COX-2 inhibition. Expert Opinion on Therapeutic Patents, 12, 969-989. doi:10.1517/13543776.12.7.969

De Tullio, P., Boverie, S., Dewalque, D., Sebille, S., Damas, J., & Pirotte, B. (2002). Relaxant effect of K+ATP channel openers on the uterine smooth muscle; phrmacological in vitro models. Fundamental and Clinical Pharmacology, 245.

De Tullio, P., Boverie, S., Dewalque, D., Sebille, S., Damas, J., & Pirotte, B. (2002). Relaxant effect of K+ATP channel openers on the uterine smooth muscle: pharmacological in vitro models. Fundamental and Clinical Pharmacology, 245.

De Tullio, P., Ouedraogo, R., Becker, B., Boverie, S., Somers, F., Antoine, M. H., Pirotte, B., & Lebrun, P. (2002). 2-N-alkylation of 3-alkylamino-substituted 2H-benzo- and 2H-pyridothiadiazine 1,1-dioxides: from K+ATP channel openers to Ca++ channel blockers? Fundamental and Clinical Pharmacology, 68.

Dogné, J.-M., De Leval, X., Benoit, P., Rolin, S., Pirotte, B., & Masereel, B. (2002). Therapeutic potential of thromboxane inhibitors in asthma. Expert Opinion on Investigational Drugs, 275-281. doi:10.1517/13543784.11.2.275

Erb, B., Rigo, B., Pirotte, B., & Couturier, D. (2002). Synthesis of 2-amino-1,4-dihydro-4-quinolinones and diaminomethylene Meldrum’s acids derivatives as potential potassium channel openers. Journal of Heterocyclic Chemistry, 39, 15-28. doi:10.1002/jhet.5570390102

Julémont, F., de Leval, X., Michaux, C., Damas, J., Charlier, C., Durant, F., Pirotte, B., & Dogné, J.-M. (2002). Spectral and crystallographic study of pyridinic analogues of nimesulide : determination of the active form of methanesulfonamides as COX-2 selective inhibitors. Journal of Medicinal Chemistry, 45, 5182-5185. doi:10.1021/jm020920n

Julémont, F., de Leval, X., Neven, P., Michaux, C., Charlier, C., Pirotte, B., & Dogné, J.-M. (2002). Evaluation of pyridinic sulfonamides related to nimesulide as COX-2 selective inhibitors. Fundamental and Clinical Pharmacology, 246.

Lee, A. T., Cosgrove, K. E., Barnes, P. D., Lindley, K. J., Aynsley-Green, A., De Tullio, P., Pirotte, B., Lebrun, P., & Dunne, M. J. (2002). BPDZ 154 is a potent activator of ATP-sensitive potassium channels in pancreatic Beta-cells. Endocrine Abstracts, 16.

Lee, A. T., Cosgrove, K. E., Barnes, P. D., Lindley, K. J., Aynsley-Green, A., De Tullio, P., Pirotte, B., Lebrun, P., & Dunne, M. J. (2002). BPDZ 154 is a potent activator of ATP-sensitive potassium channels in pancreatic b-cells. Endocrine abstracts 2002, 16.

Lee, A. T., Cosgrove, K. E., Barnes, P. D., Lindley, K. J., Aynsley-Green, A., De Tullio, P., Pirotte, B., Lebrun, P., & Dunne, M. J. (2002). BPDZ 154: a novel activator of KATP channels in beta-cells. Pflügers Archiv: European Journal of Physiology, 338.

Lee, A. T., Cosgrove, K. E., Barnes, P. D., Lindley, K. J., Aynsley-Green, A., De Tullio, P., Pirotte, B., Lebrun, P., & Dunne, M. J. (2002). BPDZ 154: a novel activator of K ATP channels in Beta-cells. Pflugers Archiv für die Gesamte Physiologie des Menschen und der Tiere, 338.

Michaux, C., Charlier, C., Julémont, F., Dogné, J.-M., de Leval, X., Norberg, B., Pirotte, B., & Durant, F. (2002). N-(3-Phenoxy-4-pyridinio)methanesulfonamidate. Acta Crystallographica, 88-89. doi:10.1107/S0108270101018595

Nguyen, Q. A., Antoine, M. H., Ouedraogo, R., Hermann, M., Sergooris, J., Pirotte, B., & Lebrun, P. (2002). In vitro and in vivo effects of new insulin releasing agents. Biochemical Pharmacology, 515-521. doi:10.1016/S0006-2952(01)00880-2

Ouedraogo, R., Becker, B., Boverie, S., Somers, F., Antoine, M.-H., Pirotte, B., Lebrun, P., & De Tullio, P. (2002). 2-Alkyl-3-alkylamino-2H-benzo- and pyridothiadiazine 1,1-dioxides: from K+ATP channel openers to Ca++ channel blockers? Biological Chemistry, 383, 1759-1768. doi:10.1515/BC.2002.197

Sebille, S., Becker, B., Antoine, M. H., Boverie, S., De Tullio, P., Lebrun, P., & Pirotte, B. (2002). Pharmacological evaluation of cromakalim analogues: towards the discovery of new inhibitors of insulin secretion from rat pancreatic -cells. Fundamental and Clinical Pharmacology, 245.

Sebille, S., becker, B., Antoine, M. H., Boverie, S., De Tullio, P., Lebrun, P., & Pirotte, B. (2002). Pharmacological evaluation of cromakalim analogues: towards the discovery of new inhibitors of insulin secretion from rat pancreatic Beta-cells. Fundamental and Clinical Pharmacology, 246.

Sebille, S., Becker, B., Antoine, M. H., Boverie, S., De Tullio, P., Lebrun, P., & Pirotte, B. (2002). Pharmacological evaluation of cromakalim analogues: towards the discovery of new inhibitors of insulin secretion from rat pancreatic Beta-cells. Fundamental and Clinical Pharmacology, 246.

Sebille, S., Becker, B., Antoine, M. H., Lebrun, P., & Pirotte, B. (2002). Effects on rat pancreatic B-cells and rat aorta rings of 4,6-disubstituted 2,2-dimethylchromans structurally related to the potassium channel opener cromakalim. Fundamental and Clinical Pharmacology, 69.

Sebille, S., Becker, B., Antoine, M.-H., Lebrun, P., & Pirotte, B. (2002). Effects on rat pancreatic B-cells and rat aorta rings of 4,6-disubstituted 2,2-dimethylchromans structurally related to the potassium channel opener cromakalim. Fundamental and Clinical Pharmacology, 16, 69.

Wouters, J., Huygens, M., Pochet, L., Pirotte, B., Durant, F., & Masereel, B. (2002). Structural approach of the mechanism of inhibition of -chymotrypsin by coumarins. Bioorganic and Medicinal Chemistry Letters, 12, 1109-1112. doi:10.1016/S0960-894X(02)00073-2

De Tullio, P., Becker, B., Ouedraogo, R., Boverie, S., Somers, F., Pirotte, B., Lebrun, P., & Antoine, M. H. (08 December 2001). 2-Alkyl-3-alkylamino-2H-benzo- and pyridothiadiazine 1,1-dioxides: Ca++ channel blockers rather than K+ATP channel openers? [Poster presentation]. Workshop on the Endocrine Pancreas, Bruxelles, Belgium.

De Leval, X., David, J. L., Neven, P., Benoit, V., Pirotte, B., Merville, M.-P., Bours, V., & Dogne, J. M. (December 2001). Effects of BM-573, a dual thromboxane A2 receptor antagonist and thromboxane synthase inhibitor, on osteogenic sarcoma cell-induced platelet aggregation [Poster presentation]. The 43rd ASH Annual Meeting, Orlando, United States.

Boverie, S., Becker, B., Somers, F., Nguyen, Q. A., Ouedraogo, R., Antoine, M. H., Lebrun, P., Pirotte, B., & De Tullio, P. (17 November 2001). 3-R/S-(hydroxyalkylamino)-4H-1,2,4-benzothiadiazine 1,1-dioxides as potential K+ATP channel activators: influence of stereochemistry on biological activity and tissue selectivity [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

De Tullio, P., Ouedraogo, R., Becker, B., Boverie, S., Somers, F., Antoine, M. H., Pirotte, B., & Lebrun, P. (17 November 2001). 2-N-alkylation of 3-alkylamino-substituted 2H-benzo- and 2H-pyridothiadiazine 1,1-dioxides: from K+ATP channel openers to Ca++ channel blockers? [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

Sebille, S., Becker, B., Antoine, M. H., Lebrun, P., & Pirotte, B. (17 November 2001). Effects on rat pancreatic B-cells and rat aorta rings of 4,6-disubstituted 2,2-dimethylchromans structurally related to the potassium channel opener cromakalim [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

de Leval, X., David, J.-L., Neven, P., Benoit, V., Pirotte, B., Merville, M.-P., Bours, V., & Dogné, J.-M. (16 November 2001). Effects of BM-573, a dual thromboxane A(2) receptor antagonist and thromboxane synthase inhibitor, on osteogenic sarcoma cell-induced platelet aggregation. Blood, 98 (11, Part 2), 43.

Julemont, F., De Leval, X., Neven, P., Michaux, C., Pirotte, B., & Dogne, J. M. (16 November 2001). Synthesis and pharmacological evaluation of pyridinic sulfonamides related to nimesulide [Poster presentation]. One Day Symposium; Drug Discovery Strategies: from Leads to Drugs, Louvain-la-Neuve, Belgium.

Kempen, I., Pochet, L., Papapostolou, D., Counerotte, S., Masereel, B., Foidart, J.-M., Reboud-Ravaux, M., Frankenne, F., & Pirotte, B. (16 October 2001). Effects on in vitro and in vivo cellular invasion of two 6-(acetoxymethyl)-2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives [Poster presentation]. Molecular Mechanisms in Cancer and Alzheimer’s disease, Bruxelles, Belgium.

Becker, B., Antoine, M. H., Nguyen, Q. A., Rigo, B., Cosgrove, K. E., Barnes, P. D., Dunne, M. J., Pirotte, B., & Lebrun, P. (September 2001). ATP-sensitive K+ channels activated by a quinolinone derivative [Poster presentation]. Annual meeting of the EASD islets study group, Glasgow, United Kingdom.

Kibirev, V. K., Lacan, F., Bourdel, F., Pochet, L., Caflish, A., Doucet, C., Masereel, B., Pirotte, B., & Reboud-Ravaux, M. (July 2001). Inhibition of thrombin by oxobenzopyran derivatives: structure-activity relationships [Poster presentation]. Congrès ISTH, Paris, France.

Pirotte, B., De Tullio, P., Boverie, S., Kempen, I., & Lestage, P. (07 June 2001). Novel benzothiadiazine derivatives, preparation method and pharmaceutical compositions containing them.

Boverie, S., De Tullio, P., Becker, B., Antoine, M. H., Dewalque, D., Damas, J., Lebrun, P., & Pirotte, B. (01 June 2001). Propriétés biologiques des 7-chloro-4H-1,2,4-benzothiadiazine 1,1-dioxydes diversement substitués en position 3: nouveaux analogues du diazoxide [Poster presentation]. XVémes Journées Franco-Belges de Pharmacochimie, Namur, Belgium.

De Leval, X., Delarge, J., Neven, P., Michaux, C., Masereel, B., Pirotte, B., David, J. L., & Dogne, J. M. (01 June 2001). Effects of thromboxane A2 receptor antagonists and COX inhibitors on osteogenic sarcome cell-induced platelet aggregation [Poster presentation]. XVémes Journées Franco-Belges de Pharmacochimie, Namur, Belgium.

De Tullio, P., Ouedraogo, R., Boverie, S., Antoine, M. H., Becker, B., Delarge, J., Lebrun, P., & Pirotte, B. (01 June 2001). Les 3-alkylamino-2-méthyl-2H-benzo- et pyridothiadiazine dioxydes en tant qu’activateurs potentiels des canaux potassiques sensibles à l’ATP [Poster presentation]. XVémes Journées Franco-Belges de Pharmacochimie, Namur, Belgium.

Julemont, F., De Leval, X., Neven, P., Devel, P., Pirotte, B., Delarge, J., Masereel, B., Michaux, C., & Dogne, J. M. (01 June 2001). Synthèse et évaluation pharmacologique d’un méthanesulfonamide pyridinique apparenté à l’acide niflumique [Poster presentation]. XVémes Journées Franco-Belges de Pharmacochimie, Namur, Belgium.

Kempen, I., Pochet, L., Papapostolou, D., Counerotte, S., Masereel, B., Foidart, J.-M., Reboud-Ravaux, M., Frankenne, F., & Pirotte, B. (01 June 2001). Comparaison de l’effet de deux dérivés de l’acide 6-(acetoxymethyl)-2-oxo-2H-1-benzopyrane-3-carboxylique sur l’inhibition de l’invasion cellulaire in vitro et in vivo [Poster presentation]. XVémes Journées Franco-Belges de Pharmacochimie, Namur, Belgium.

Lux, C., Delarge, J., De Leval, X., Kempen, I., Pirotte, B., & Dogne, J. M. (01 June 2001). Evaluation d’inhibiteurs de cyclooxygénases et d’antagonistes du TXA2 sur la migration des cellules endothéliales in vitro [Poster presentation]. XVémes Journées Franco-Belges de Pharmacochimie, Namur, Belgium.

Pochet, L., Doucet, C., Pirotte, B., Frederick, R., Delarge, J., Reboud-Ravaux, M., & Masereel, B. (01 June 2001). Synthèse et évaluation enzymatique de nouvelles coumarines en tant qu’inhibiteurs de thrombine [Poster presentation]. XVémes Journées Franco-Belges de Pharmacochimie, Namur, Belgium.

Sebille, S., Becker, B., Antoine, M. H., Lebrun, P., & Pirotte, B. (01 June 2001). Conception, synthèse et évaluation pharmacologique de composés structuralement apparentés au cromakalim en tant qu’activateurs des canaux KATP [Poster presentation]. XVémes Journées Franco-Belges de Pharmacochimie, Namur, Belgium.

Julémont, F., de Leval, X., Neven, P., Devel, P., Pirotte, B., Delarge, J., Masereel, B., Michaux, C., & Dogné, J. M. (24 May 2001). Synthesis and pharmacological evaluation of pyridinic methanesulfonamides as potential COX-2 inhibitors [Paper presentation]. 10th Forum of Pharmaceutical Sciences, Montréal, Canada.

Boverie, S., De Tullio, P., Becker, B., Antoine, M. H., Dewalque, D., Damas, J., Lebrun, P., & Pirotte, B. (May 2001). Preparation and biological properties of chemically diverse 3-substituted 7-chloro-4H-1,2,4-benzothiadiazine 1,1-dioxides structurally related to the potassium channel opener diazoxide [Paper presentation]. 10th Forum of Pharmaceutical Sciences, Montréal, Canada.

Julemont, F., De Leval, X., Neven, P., Devel, P., Pirotte, B., Delarge, J., Masereel, B., Michaux, C., & Dogne, J. M. (May 2001). Synthesis and pharmacological evaluation of pyridinic methanesulfonamides as potential COX-2 inhibitors [Paper presentation]. 10th Forum of Pharmaceutical Sciences, Montréal, Canada.

Kempen, I., Papapostolou, D., Pochet, L., Counerotte, S., Masereel, B., Foidart, J.-M., Reboud-Ravaux, M., Noël, A., & Pirotte, B. (May 2001). Effects on cellular invasion of two synthetic coumarins [Paper presentation]. 10th Forum of Pharmaceutical Sciences, Montréal, Canada.

Pochet, Doucet, C., Dieu, M., Alin, V., Pirotte, B., Reboud-Ravaux, M., & Masereel, B. (May 2001). Inhibition mechanism of serine protease by coumarin derivatives [Paper presentation]. 10th Forum of Pharmaceutical Sciences, Montréal, Canada.

Sebille, S., Becker, B., Boverie, S., Antoine, M.-H., Lebrun, P., & Pirotte, B. (May 2001). Synthesis and pharmacological evaluation of 4,6-disubstituted 2,2-dimethylchromans structurally related to the KATP channel opener cromakalim [Paper presentation]. 10th Forum of Pharmaceutical Sciences, Montréal, Canada.

Kempen, I., Pochet, L., Papapostolu, D., Counerotte, S., Masereel, B., Foidart, J.-M., Reboud-Ravaux, M., Noël, A., & Pirotte, B. (21 April 2001). Effects on cellular invasion of 6-(acetoxymethyl)-2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives [Poster presentation]. Spring Meeting Angiogenesis, Liège, Belgium.

Pirotte, B. (2001). Les Benzo- et les Pyridothiadiazine Dioxydes en Chimie Thérapeutique: Conception, Synthèse et Evaluation Pharmacologique [Post doctoral thesis, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/31250

Julémont, F., De Leval, X., Neven, P., Devel, P., Masereel, B., Michaux, C., Pirotte, B., Delarge, J., & Dogne, J. M. (26 January 2001). Conception, synthèse et évaluation pharmacologique d’analogues pyridiniques du Nimésulide en tant qu’inhibiteurs potentiels des cyclooxygénases [Poster presentation]. Journée Jeunes Chercheurs, Paris, France.

Kempen, I., Pochet, L., Papapostolu, D., Masereel, B., Foidart, J.-M., Reboud-Ravaux, M., Frankenne, F., & Pirotte, B. (26 January 2001). Comparaison de l’effet de deux coumarines sur l’inhibition de l’invasion cellulaire in vitro et in vivo [Poster presentation]. Journée Jeunes Chercheurs, Paris, France.

Sebille, S., Becker, B., Antoine, M. H., Boverie, S., Arkhammar, P., Hansen, J. B., Lebrun, P., & Pirotte, B. (26 January 2001). Synthèse et évaluation pharmacologique de composés structuralement apparentés au cromakalim en tant qu’activateurs des canaux KATP [Poster presentation]. Journée Jeunes Chercheurs, Paris, France.

Somers, F., De Tullio, P., Boverie, S., Nguyen, Q. A., Becker, B., Antoine, M. H., Pirotte, B., & Lebrun, P. (26 January 2001). Les 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxydes diversement substitués par un atome de chlore en tant qu’activateurs des canaux KATP [Poster presentation]. Journée Jeunes Chercheurs, Paris, France.

Becker, B., Antoine, M.-H., Nguyen, Q.-A., Rigo, B., Cosgrove, K. E., Barnes, P. D., Dunne, M. J., Pirotte, B., & Lebrun, P. (2001). Synthesis and characterisation of a quinolinonic compound activating ATP-sensitive K+ channels in endocrine and smooth muscle tissues. British Journal of Pharmacology, 134, 375-385. doi:10.1038/sj.bjp.0704266

Boverie, S., Antoine, M.-H., De Tullio, P., Somers, F., Becker, B., Sebille, S., Lebrun, P., & Pirotte, B. (2001). Effect on insulin release of compounds structurally related to the potassium channel opener 7-chloro-3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxide (BPDZ 73): introduction of heteroatoms on the 3-alkylamino side chain of the benzothiadiazine 1,1-dioxide ring. Journal of Pharmacy and Pharmacology, 53, 973-980. doi:10.1211/0022357011776216

De Leval, X., Delarge, J., Devel, P., Neven, P., Michaux, C., Masereel, B., Pirotte, B., David, J. L., Henrotin, Y., & Dogne, J.-M. (2001). Evaluation of classical NSAIDs and COX-2 selective inhibitors on purified ovine enzymes and human whole blood. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 64, 211-216. doi:10.1054/plef.2001.0262

Dupont, L., De Tullio, P., Boverie, S., & Pirotte, B. (2001). 3-Amino-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxide. Acta Crystallographica, E57, 602-o603. doi:10.1107/S1600536801009904

Dupont, L., De Tullio, P., Tinant, B., & Pirotte, B. (2001). (R/S)-3-(3-Methyl-2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide mono-hydrate. Acta Crystallographica, E57, 1050-o1051.

Dupont, L., Khellili, S., Pirotte, B., Tinant, B., & De Tullio, P. (2001). Absolute configuration of N-[(R)-3-methyl-2-butyl]-(S)-2-(6-methoxy-2-naphthyl)-propionamide. Acta Crystallographica, E57, 650-o651. doi:10.1107/S1600536801010285

Dupont, L., Somers, F., Boverie, S., Pirotte, B., Tinant, B., & De Tullio, P. (2001). 7-Chloro-2-methyl-3-methylamino-2H-1,2,4-benzothiadiazine 1,1-dioxide. Acta Crystallographica, E57, 652-o654.

Somers, F., Ouedraogo, R., Antoine, M.-H., De Tullio, P., Becker, B., Fontaine, J., Damas, J., Dupont, L., Rigo, B., Delarge, J., Lebrun, P., & Pirotte, B. (2001). Original 2-alkylamino-6-halogenoquinazolin-4(3H)-ones and KATP channel activity. Journal of Medicinal Chemistry, 44, 2575-2585. doi:10.1021/jm0004648

Boverie, S., Becker, B., Somers, F., De Tullio, P., Dewalque, D., Antoine, M. H., Arkhammar, Nielsen, F. E., Hansen, J. B., Damas, J., Delarge, J., Lebrun, P., & Pirotte, B. (01 December 2000). New 3-alkylamino-7-chloro-4H-1,2,4-benzothiadiazine 1,1-dioxides related to BPDZ 73 as putative KATP channel openers: design, synthesis and pharmacological evaluation [Poster presentation]. One Day Symposium : Drug Discovery Strategies: Hit and Lead Finding, Mont-St-Guibert, Belgium.

De Tullio, P., Boverie, S., Somers, F., Ouedraogo, J., Antoine, M. H., Becker, B., Nielsen, F. E., Arkhammar, P., Hansen, J. B., Delarge, J., Lebrun, P., & Pirotte, B. (01 December 2000). Preparation and biological evaluation of new 7-substituted 3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides, analogues of the KATP channel opener BPDZ 73 [Poster presentation]. One Day Symposium : Drug Discovery Strategies: Hit and Lead Finding, Mont-St-Guibert, Belgium.

Becker, B., Antoine, M. H., Nguyen, Q. A., Rigo, B., Pirotte, B., & Lebrun, P. (18 November 2000). A quinolinone derivative activating ATP-sensitive K+ channels [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Leuven, Belgium.

Damas, J., & Pirotte, B. (18 November 2000). Heart rate decrease induced by BPDZ 259, a diazoxide analogue [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Leuven, Belgium.

Sebille, S., Becker, B., Antoine, M. H., Arkhammar, P., Hansen, J. B., Lebrun, P., & Pirotte, B. (18 November 2000). Pharmacological evaluation of 4,6-disubstituted 2,2-dimethylchromans structurally related to the KATP channel opener cromakalim [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Leuven, Belgium.

Antoine, M. H., Arkhammar, P., Nguyen, Q. A., Bondo Hansen, J., Pirotte, B., & Lebrun, P. (September 2000). A potent diazoxide analogue activating ATP-sensitive K+ channels and inhibiting insulin release [Poster presentation]. 36Th Annual Meeting of the EASD.

Bourdel, F., Lacan, F., Doucet, C., Pochet, L., Calfish, A., Masereel, B., Pirotte, B., & Reboud-Ravaux, M. (September 2000). Oxobenzopyran derivatives as thrombin inhibitors [Poster presentation]. XVIth International Symposium on Medicinal Chemistry, Bologne, Italy.

Boverie, S., Antoine, M. H., Becker, B., De Tullio, P., Somers, F., Sebille, S., Lebrun, P., & Pirotte, B. (September 2000). Effect on the pancreatic endocrine system of 3-alkylamino-7-chloro-4H-1,2,4-benzothiadiazine 1,1-dioxides structurally related to diazoxide [Poster presentation]. 68ème Congrès de la Société de Physiologie, Liège, Belgium.

Boverie, S., Becker, B., Somers, F., De Tullio, P., Dewalque, D., Antoine, M. H., Arkhammar, P., Nielsen, F. E., Hansen, J. B., Damas, J., Delarge, J., Lebrun, P., & Pirotte, B. (September 2000). Synthesis and biological evaluation of 3-alkylamino-7-chloro-4H-1,2,4-benzothiadiazine 1,1-dioxides as KATP channel openers structurally related to BPDZ 73 [Poster presentation]. XVIth International Symposium on Medicinal Chemistry, Bologne, Italy.

De Tullio, P., Somers, F., Ouedraogo, J., Boverie, S., Antoine, M. H., Becker, B., Nielsen, F. E., Arkhammar, P., Hansen, J. B., Delarge, J., Lebrun, P., & Pirotte, B. (September 2000). 7-Substituted 3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as potent KATP channel openers: synthesis and bioloigical in vitro evaluation [Poster presentation]. XVIth International Symposium on Medicinal Chemistry, Bologne, Italy.

Kempen, I., Pochet, L., Papapostulu, D., Boggetto, N., Doucet, C., Masereel, B., Foidart, J.-M., Reboud-Ravaux, M., Frankenne, F., & Pirotte, B. (September 2000). Inhibition of cellular invasion by 3-chlorophenyl 6-(acetoxymethyl)-2-oxo-2H-1-benzopyran-3-carboxylate [Poster presentation]. 68ème Congrès de la Société de Physiologie, Liège, Belgium.

Reboud-Ravaux, M., Pochet, L., Doucet, C., Thierry, N., Masereel, B., Delarge, J., & Pirotte, B. (August 2000). Specific inhibitors of human leukocyte elastase [Poster presentation]. World Congress on Lung Health, Florence, Italy.

Pochet, L., Doucet, C., Dieu, M., Alin, V., Pirotte, B., Reboud-Ravaux, M., & Masereel, B. (June 2000). Activity and inhibition mechanism of coumarin-based derivatives as protease inhibitor [Poster presentation]. 27th National Medicinal Chemistry Symposium, Kansas, United States.

Boverie, S., Antoine, M. H., De Tullio, P., Somers, F., Lebrun, P., & Pirotte, B. (May 2000). Synthèse et évaluation biologique de composés structuralement apparentés au 7-chloro-3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxyde (BPDZ 73): introduction d’hétéroatomes au niveau de la chaîne latérale en position 3 du cycle benzothiadiazine 1,1-dioxyde [Poster presentation]. 14èmes Journées Franco-Belges de Pharmacochimie, Lille, France.

De Leval, X., Delarge, J., Devel, P., Damas, J., Henrotin, Y., Michaux, C., Pirotte, B., Masereel, B., & Dogne, J. M. (May 2000). Evaluation de la selectivité COX-1/COX-2 de drogues à visée anti-inflammatoire sur sang humain [Poster presentation]. 14èmes Journées Franco-Belges de Pharmacochimie, Lille, France.

De Tullio, P., Boverie, S., Nguyen, Q. A., Ouedraogo, R., Somers, F., Sebille, S., Antoine, M. H., Becker, B., Nielsen, F., Arkhammar, P., Hansen, J. B., Delarge, J., Lebrun, P., & Pirotte, B. (May 2000). Les 3-R/S-(hydroxyalkylamino)-4H-1,2,4-benzothiadiazine 1,1-dioxydes en tant qu’activateurs potentiels des canaux KATP: Influence de la stéréochimie sur l’activité pharmacologique et la sélectivité tissulaire [Poster presentation]. 14èmes Journées Franco-Belges de Pharmacochimie, Lille, France.

Julemont, F., Neven, P., De Leval, X., Masereel, B., Michaux, C., Pirotte, B., Delarge, J., & Dogne, J. M. (May 2000). Conception, synthèse et évaluation pharmacologique de l’analogue pyridinique du nimésulide en tant qu’inhibiteur des cyclooxygénases [Poster presentation]. 14èmes Journées Franco-Belges de Pharmacochimie, Lille, France.

Kempen, I., Papapostolu, D., Pochet, L., Boggetto, N., Doucet, C., Masereel, B., Foidart, J.-M., Reboud-Ravaux, M., Noël, A., & Pirotte, B. (May 2000). Le 6-(acetoxymethyl)-2-oxo-2H-1-benzopyrane-3-carboxylate de 3-chlorophényle agissant en tant qu’inhibiteur potentiel de l’invasion tumorale [Poster presentation]. 14èmes Journées Franco-Belges de Pharmacochimie, Lille, France.

Khelili, S., Nguyen, Q. A., Faury, G., Leclerc, G., Pirotte, B., & Lebrun, P. (May 2000). Etude de quelques dérivés benzothiadiaziniques apparentés au diazoxide et aux thiazides en tant qu’activateurs de canaux potassiques [Poster presentation]. 14èmes Journées Franco-Belges de Pharmacochimie, Lille, France.

Somers, F., Boverie, S., Nguyen, Q. A., Antoine, M. H., Dogne, J. M., Lebrun, P., Pirotte, B., & De Tullio, P. (May 2000). 3-Alkylamino-6,7-dichloro-4H-1,2,4-benzothiadiazine 1,1-dioxydes: synthèse et évaluation pharmacologique en tant qu’activateurs potentiels du canal potassique ATP-dépendant [Poster presentation]. 14èmes Journées Franco-Belges de Pharmacochimie, lille, France.

Boverie, S., Somers, F., Ouedraogo, R., Antoine, M. H., Dogne, J. M., De Leval, X., De Tullio, P., Pirotte, B., & Lebrun, P. (04 March 2000). 7-Substituted alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as new analogues of diazoxide: effects on the insulin releasing process in vitro [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

De Leval, X., Delarge, J., Devel, P., Damas, J., Henrotin, Y., Neven, P., Masereel, B., Pirotte, B., Somers, F., Wouters, J., Michaux, C., & Dogne, J. M. (04 March 2000). Evaluation of classical NSAIDs in a model of human whole blood assay [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

Dogne, J. M., De Leval, X., Neven, P., Somers, F., Delarge, J., Rolin, S., Michaux, C., Wauters, J., Pirotte, B., Damas, J., & Masereel, B. (04 March 2000). Pharmacological evaluation of original sulfonylureas as thromboxane A2 antagonists [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

Pirotte, B., De Tullio, P., Podona, T., Diouf, O., & Lestage, P. (04 March 2000). New chemical and pharmacological developments in the field of positive allosteric modulators of AMPA receptors structurally related to cyclothiazide and diazoxide [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

Kempen, I., Pochet, L., Doucet, C., Lacan, F., Bourdel, F., Reboud-Ravaux, M., Noël, A., Foidart, J.-M., & Pirotte, B. (29 January 2000). Inhibition of cancer cells invasion by coumarin derivatives [Poster presentation]. A.B.E.C., Invasion and metastasis, Gand, Belgium.

Boverie, S., De Tullio, P., Ouedraogo, R., Nguyen, Q. A., Somers, F., Damas, J., Lebrun, P., & Pirotte, B. (28 January 2000). Les 3-alkylsulfanyl- et 3-alkoxy-4H-1,2,4-benzothiadiazine 1,1-dioxydes structuralement apparentés aux 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxydes en tant qu’activateurs potentiels des canaux potassiques sensibles à l’ATP [Poster presentation]. Journée Jeunes Chercheurs, Paris, France.

Kempen, I., Pochet, L., Doucet, C., Lacan, F., Bourdel, F., Masereel, B., Frankenne, F., Foidart, J.-M., Reboud-Ravaux, M., & Pirotte, B. (28 January 2000). Les esters de l’acide 6-(acétoxyméthyl)-2-oxo-2H-1-benzopyrane-3-carboxylique en tant qu’agents antiinvasifs potentiels dans le traitement du cancer [Paper presentation]. Journée Jeunes Chercheurs, Paris, France.

Kempen, I., Pochet, L., Doucet, C., Lacan, F., Bourdel, F., Masereel, F., Masereel, B., Frankenne, F., Foidart, J.-M., Reboud-Ravaux, M., & Pirotte, B. (28 January 2000). Les esters de l’acide 6-(acétoxyméthyl)-2-oxo-2H-1-benzopyrane-3-carboxylique en tant qu’agents antiinvasifs potentiels dans le traitement du cancer [Poster presentation]. Journée Jeunes Chercheurs, Paris, France.

Somers, F., Boverie, S., Ouedraogo, R., Antoine, M. H., Dogne, J. M., De Leval, X., Lebrun, P., Pirotte, B., & De Tullio, P. (28 January 2000). Nouveaux 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxydes: synthèse et évaluation pharmacologique en tant qu’inhibiteurs potentiels du processus insulino-sécrétoire [Poster presentation]. Journée Jeunes Chercheurs, Paris, France.

Boverie, S., Antoine, M.-H., Becker, B., De Tullio, P., Somers, F., Sebille, S., Lebrun, P., & Pirotte, B. (2000). Effect on the pancreatic endocrine system of 3-alkylamino-7-chloro-4H-1,2,4-benzothiadiazine 1,1-dioxides structurally related to diazoxide. Pflügers Archiv: European Journal of Physiology, 439, 220-R221.

Boverie, S., Somers, F., Ouedraogo, R., Antoine, M.-H., Dogne, J.-M., De Leval, X., De Tullio, P., Pirotte, B., & Lebrun, P. (2000). 7-Substituted alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as new analogues of diazoxide: effects on the insulin releasing process in vitro. Fundamental and Clinical Pharmacology, 14, 299.

De Leval, X., Delarge, J., Somers, F., De Tullio, P., Henrotin, Y., Pirotte, B., & Dogne, J.-M. (2000). Recent advances in inducible cyclooxygenase (COX-2) inhibition. Current Medicinal Chemistry, 7 (10), 1041-1062. doi:10.2174/0929867003374417

De Leval, X., Dogné, J.-M., Delarge, J., Pirotte, B., Dupont, G., Mathy-Hartert, M., Chahboune, J., Labasse, A., Neven, P., Reginster, J.-Y., & Henrotin, Y. (2000). Comparative effects of nimesulide, nimesulide L-lysine and nimesulide L-lysine L-arginine on human articular chondrocytes in vitro. Mediators of Inflammation, 9, 51.

De Leval, X., Dogne, J.-M., Masereel, B., Pirotte, B., Reginster, J.-Y., Neven, P., Labasse, A., Delarge, J., & Henrotin, Y. (2000). Profile of nimesulide and nimesulide-L-lysine-β-cyclodextrin on chondrocyte metabolism. Fundamental and Clinical Pharmacology, 14, 167.

De Leval, X., Henrotin, Y., Labasse, A., Reginster, J.-Y., Neven, P., Delarge, J., Somers, F., Masereel, B., Pirotte, B., & Dogne, J.-M. (2000). Comparison of the effects of nimesulide and nimesulide-L-lysine on PGE2 production by COX-1 and COX-2 and on chondrocyte metabolism in vitro. Pharmacy and Pharmacology Communications, 6, 83-87. doi:10.1211/146080800128735683

De Leval, X., Henrotin, Y., Masereel, B., Pirotte, B., Somers, F., Neven, P., Devel, P., Delarge, J., & Dogne, J.-M. (2000). Evaluation of classical NSAIDs on COX-1 and COX-2 purified enzymes and prognosis of their effects on physiological responses. Fundamental and Clinical Pharmacology, 14, 167.

De Tullio, P., Delarge, J., & Pirotte, B. (2000). Therapeutic and chemical developments of cholecystokinin receptor ligands. Expert Opinion on Investigational Drugs, 9, 129-146. doi:10.1517/13543784.9.1.129

Dogne, J.-M., De Leval, X., Delarge, J., Dupont, G., Mathy-Hartert, M., Chahboune, J., Labasse, A., Neven, P., Somers, F., Pirotte, B., Reginster, J.-Y., & Henrotin, Y. (2000). Synthesis and evaluation of non-carboxylic pyridinic derivatives as cyclooxygenase inhibitors. Mediators of Inflammation, 9, 52.

Dogne, J.-M., De Leval, X., Neven, P., Rolin, S., Pirotte, B., David, J.-L., Delarge, J., & Masereel, B. (2000). Characterization of antiplatelet activity of ticlopidine and acetylsalicylic acid by PFA-100. Fundamental and Clinical Pharmacology, 14, 168.

Dogne, J.-M., De Leval, X., Neven, P., Somers, F., Delarge, J., Rolin, S., Michaux, C., Wauters, J., Pirotte, B., Damas, J., & Masereel, B. (2000). Pharmacological evaluation of original sulfonylureas as thromboxane A2 antagonists. Fundamental and Clinical Pharmacology, 14, 300.

Erb, B., Akue, R., Rigo, B., Pirotte, B., & Couturier, D. (2000). Synthesis of 2-aminoquinazoline-4(3H)-one derivatives as potential potassium channel openers. Journal of Heterocyclic Chemistry, 37, 253-260. doi:10.1002/jhet.5570370206

Kempen, I., Doucet, C., Pochet, L., Lacan, F., Bourdel, F., Noël, A., Foidart, J.-M., Reboud-Ravaux, M., & Pirotte, B. (2000). Coumarin derivatives as putative antiinvasive agents in cancer. Fundamental and Clinical Pharmacology, 14, 169.

Kempen, I., Pochet, L., Papapostulu, D., Boggetto, N., Doucet, C., Masereel, B., Foidart, J.-M., Reboud-Ravaux, M., Frankenne, F., & Pirotte, B. (2000). Inhibition of cellular invasion by 3-chlorophenyl 6-(acetoxymethyl)-2-oxo-2H-1-benzopyran-3-carboxylate. Pflügers Archiv: European Journal of Physiology, 439, 252.

Lebrun, P., Arkhammar, P., Antoine, M.-H., Nguyen, Q.-A., Bondo Hansen, J., & Pirotte, B. (2000). A potent diazoxide analogue activating ATP-sensitive K+ channels and inhibiting insulin release. Diabetologia, 43, 723-732. doi:10.1007/s001250051370

Ouedraogo, R., Fontaine, J., Antoine, M.-H., Pirotte, B., & Lebrun, P. (2000). Effects of 3-alkylamino-7-chloro-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxides on smooth muscle contractile activity. Pharmacy and Pharmacology Communications, 6, 97-100.

Pirotte, B., Ouedraogo, R., De Tullio, P., Khelili, S., Somers, F., Boverie, S., Dupont, L., Fontaine, J., Damas, J., & Lebrun, P. (2000). 3-Alkylamino-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxides structurally related to diazoxide and pinacidil as potassium channel openers acting on vascular smooth muscle cells: design, synthesis and pharmacological evaluation. Journal of Medicinal Chemistry, 43, 1456-1466. doi:10.1021/jm991069o

Pochet, L., Doucet, C., Dive, G., Wouters, J., Masereel, B., Reboud-Ravaux, M., & Pirotte, B. (2000). Coumarinic derivatives as mechanism-based inhibitors of α-chymotrypsin and human leukocyte elastase. Bioorganic and Medicinal Chemistry, 8 (6), 1489-1501. doi:10.1016/S0968-0896(00)00071-7

Somers, F., De Tullio, P., Boverie, S., Dogne, J.-M., de Leval, X., Antoine, M.-H., Lebrun, P., & Pirotte, B. (2000). Synthesis and biological effects of new 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides on insulin-secreting cells. Pharmacy and Pharmacology Communications, 6, 89-95. doi:10.1211/096089296765556980

Somers, F., Ouedraogo, R., De Tullio, P., Antoine, M.-H., Boverie, S., Fontaine, J., Damas, J., Pirotte, B., & Lebrun, P. (2000). Comparison between the effects of 3-aralkylamino-/3-cycloalkylalkylamino-substituted benzothiadiazine dioxides and their corresponding quinazolinone isosteres on different smooth muscle preparations. Fundamental and Clinical Pharmacology, 14, 171.

De Tullio, P., Felekidis, A., Liégeois, J.-F., Pirotte, B., Stachow, M., Kempen, I., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (26 November 1999). Enantiomeric resolution of pirlindole at the preparative scale: derivatization and chromatographic methods [Poster presentation]. Chirality: Impact in Drug Design and Development, Braine l'Alleud, Belgium.

De Tullio, P., Felekidis, A., Liégeois, J.-F., Pirotte, B., Stachow, M. H., Kempen, I., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (26 November 1999). Enantiomeric resolution of pirlindole at the preparative scale: derivatization and chromatographic methods [Poster presentation]. Chirality: Impact in Drug Design and Development, Braine l’Alleud, Belgium.

Somers, F., De Tullio, P., Ouedraogo, R., Antoine, M. H., Boverie, S., Fontaine, J., Damas, J., Lebrun, P., & Pirotte, B. (26 November 1999). New 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides and 2-alkylamino 3H-quinazolin-4-ones as putative KATP channel openers: influence of stereochemistry on biological activity [Poster presentation]. Chirality: Impact in Drug Design and Development, Braine l'Alleud, Belgium.

Boverie, S., De Tullio, P., Ouedraogo, R., Nguyen, Q. A., Somers, F., Damas, J., Lebrun, P., & Pirotte, B. (20 November 1999). 3-Alkylsulfanyl- and 3-alkoxy-substituted benzothiadiazines structurally related to 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as putative KATP channel openers [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

De Leval, X., Dogne, J. M., Masereel, B., Pirotte, B., Reginster, J.-Y., Neven, P., Labasse, A., Delarge, J., & Henrotin, Y. (20 November 1999). Profile of nimesulide and nimesulide-L-lysine-β-cyclodextrin on chondrocyte metabolism [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

De Leval, X., Henrotin, Y., Masereel, B., Pirotte, B., Somers, F., Neven, P., Devel, P., Delarge, J., & Dogne, J. M. (20 November 1999). Evaluation of classical NSAIDs on COX-1 and COX-2 purified enzymes and prognosis of their effects on physiological responses [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

Dogne, J. M., De Leval, X., Neven, P., Rolin, S., Pirotte, B., David, J. L., Delarge, J., & Masereel, B. (20 November 1999). Characterization of antiplatelet activity of ticlopidine and acetylsalicylic acid by PFA-100 [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

Kempen, I., Doucet, C., Pochet, L., Lacan, F., Bourdel, F., Noël, A., Foidart, J.-M., Reboud-Ravaux, M., & Pirotte, B. (20 November 1999). Coumarin derivatives as putative antiinvasive agents in cancer [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

Somers, F., Ouedraogo, R., De Tullio, P., Antoine, M. H., Boverie, S., Fontaine, J., Damas, J., Pirotte, B., & Lebrun, P. (20 November 1999). Comparison between the effects of 3-aralkylamino-/3-cycloalkylalkylamino-substituted benzothiadiazine dioxides and their corresponding quinazolinone isosteres on different smooth muscle preparations [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

Dupont, L., De Tullio, P., Khelili, S., Somers, F., Delarge, J., & Pirotte, B. (28 October 1999). Crystal structures of R- and S-7-chloro-3-[1-(cyclohexyl)ethylamino]-4H-1,2,4-benzothiadiazine 1,1-dioxide (absolute configurations) [Poster presentation]. First Belgian Crystallography Symposium, Bruxelles, Belgium.

De Leval, X., Dogne, J. M., Delarge, J., Pirotte, B., Dupont, G., Mathy-Hartert, M., Chahboune, J., Labasse, A., Neven, P., Reginster, J.-Y., & Henrotin, Y. (17 September 1999). Comparative effects of nimesulide, nimesulide L-lysine and nimesulide L-lysine L-arginine on human articular chondrocytes in vitro [Poster presentation]. Groupe de Contact FNRS/FRSM “Mécanismes Cellulaires de l’Inflammation", Bruxelles, Belgium.

Dogne, J. M., De Leval, X., Delarge, J., Dupont, G., Mathy-Hartert, M., Chahboune, J., Labasse, A., Neven, P., Somers, F., Pirotte, B., Reginster, J.-Y., & Henrotin, Y. (17 September 1999). Synthesis and evaluation of non-carboxylic pyridinic derivatives as cyclooxygenase inhibitors [Poster presentation]. Groupe de Contact FNRS/FRSM “Mécanismes Cellulaires de l’Inflammation", Bruxelles, Belgium.

De Tullio, P., Boverie, S., Somers, F., Lebrun, P., Pirotte, B., Nielsen, F., & Hansen, J. B. (01 July 1999). Pyrido 1,2,4-thiadiazine derivatives, their preparation and use.

De Tullio, P., Nielsen, F. E., Hansen, J. B., Hansen, H. C., Pirotte, B., Boverie, S., Somers, F., Lebrun, P., & Mogensen, J. P. (01 July 1999). 1,2,4-Benzothiadiazine derivatives, their preparation and use.

Lebrun, P., Ouedraogo, R., Nguyen, Q. A., Antoine, M. H., Dunne, M. J., Pirotte, B., & Masereel, B. (July 1999). In vivo et in vitro effect of new glibenclamide isosteres [Poster presentation]. Second European Congress of Pharmacology, Budapest, Budapest, Hungary.

Lebrun, P., Ouedraogo, R., Nguyen, Q. A., Antoine, M. H., Dunne, M. J., Pirotte, B., & Masereel, B. (July 1999). In vivo et in vitro effect of new glibenclamide isosteres [Poster presentation]. Second European Congress of Pharmacology, Budapest, Budapest, Hungary.

Pirotte, B., De Tullio, P., Podona, T., Diouf, O., Morain, P., Lestage, P., & Lebrun, P. (July 1999). Pyrido- and benzothiadiazine dioxides related to diazoxide: structural requirements leading to a KATP channel activator or to an allosteric modulator of the AMPA receptors [Poster presentation]. Second European Congress of Pharmacology, Budapest, Budapest, Hungary.

Boverie, S., Nguyen, Q. A., De Tullio, P., Somers, F., Pirotte, B., & Lebrun, P. (12 June 1999). Pharmacological evaluation of 3-alkylsulfanyl-4H-1,2,4-benzothiadiazine 1,1-dioxides structurally related to the KATP channel opener diazoxide [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Gand, Belgium.

Somers, F., De Tullio, P., Boverie, S., Dogne, J. M., Antoine, M. H., Lebrun, P., & Pirotte, B. (12 June 1999). New 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as putative KATP channel openers: design, synthesis and pharmacological evaluation [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Gand, Belgium.

Boverie, S., De Tullio, P., Somers, F., Lebrun, P., & Pirotte, B. (May 1999). Les 3-alkylsulfanyl-4H-1,2,4-benzothiadiazine 1,1-dioxydes structuralement apparentés au diazoxide en tant qu’activateurs potentiels des canaux potassiques sensibles à l’ATP [Poster presentation]. Treizièmes Journées Franco-Belges de Pharmacochimie, Liège, Belgium.

De Leval, X., Dogne, J. M., Neven, P., Labasse, A., Masreel, B., Somers, F., Pirotte, B., De Tullio, P., Delarge, J., Reginster, J.-Y., & Henrotin, Y. (May 1999). Evaluation de la sélectivité COX-1 vs COX-2 de drogues à potentialités anti-inflammatoires [Poster presentation]. Treizièmes Journées Franco-Belges de Pharmacochimie, Liège, Belgium.

Dogne, J. M., Neven, P., Rolin, S., De Leval, X., Somers, F., David, J. L., Delarge, J., De Tullio, P., Pirotte, B., & Masereel, B. (May 1999). Impact d’antagonistes du thromboxane A2 dérivés du torasémide sur la fonction plaquettaire [Poster presentation]. Treizièmes Journées Franco-Belges de Pharmacochimie, Liège, Liège, Belgium.

Ouedraogo, R., Fontaine, J., Antoine, M. H., Pirotte, B., & Lebrun, P. (May 1999). Synthèse et évaluation pharmacologique de 3-alkylamino-7-chloro-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxydes [Poster presentation]. Treizièmes Journées Franco-Belges de Pharmacochimie, Liège, Liège, Belgium.

Pochet, L., Dive, G., Alin, V., Pirotte, B., Doucet, C., Delarge, J., Reboud-Ravaux, M., & Masereel, B. (May 1999). Mécanisme d’inactivation de l’α-chymotrypsine par les dérivés coumariniques: étude de l’ouverture de la lactone [Poster presentation]. Treizièmes Journées Franco-Belges de Pharmacochimie, Liège, Liège, Belgium.

Somers, F., De Tullio, P., Boverie, S., Dogne, J. M., Antoine, M. H., Lebrun, P. H., & Pirotte, B. (May 1999). Conception, synthèse et évaluation pharmacologique de nouveaux 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxydes en tant qu’activateurs potentiels des canaux potassiques ATP-dépendants [Poster presentation]. Treizièmes Journées Franco-Belges de Pharmacochimie, Liège, Liège, Belgium.

Dorwald, F. Z., Hansen, J. B., Mogensen, J. P., Tagmose, T. M., Pirotte, B., Lebrun, P., De Tullio, P., Boverie, S., & Delarge, J. (08 February 1999). Derivatives of 2,5- and 3,5-disubstituted anilines, their preparation and use.

Boverie, S., Nguyen, Q.-A., De Tullio, P., Somers, F., Pirotte, B., & Lebrun, P. (1999). Pharmacological evaluation of 3-alkylsulfanyl-4H-1,2,4-benzothiadiazine 1,1-dioxides structurally related to the KATP channel opener diazoxide. Fundamental and Clinical Pharmacology, 13, 605.

De Tullio, P., Ceccato, A., Liégeois, J.-F., Pirotte, B., Felekidis, A., Stachow, M., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (1999). Effective resolution of racemic pirlindole at the preparative scale. Chirality, 11, 261-266. doi:10.1002/(SICI)1520-636X(1999)11:4<261::AID-CHIR1>3.0.CO;2-S

De Tullio, P., Delarge, J., & Pirotte, B. (1999). Recent advances in the chemistry of cholecystokinin receptor ligands (agonists and antagonists). Current Medicinal Chemistry, 6, 433-455.

De Tullio, P., Khelili, S., Ouedraogo, R., Somers, F., Boverie, S., Dupont, L., Fontaine, J., Antoine, M.-H., Delarge, J., Lebrun, P., & Pirotte, B. (1999). 3-Alkylamino-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as potent KATP-channel activators: structural study and influence of stereochemistry. Pharmacy and Pharmacology Communications, 5, 195-198.

De Tullio, P., Ouedraogo, R., Dupont, L., Somers, F., Boverie, S., Dogne, J.-M., Delarge, J., & Pirotte, B. (1999). Synthesis and structural studies of 3-alkylamino-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides: a new class of heterocyclic compounds with therapeutical promises. Tetrahedron, 55, 5419-5432. doi:10.1016/S0040-4020(99)00231-8

Doucet, C., Pochet, L., Thierry, N., Pirotte, B., Delarge, J., & Reboud-Ravaux, M. (1999). 6-Substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid as a core structure for selective inhibitors of human leucocyte elastase. Journal of Medicinal Chemistry, 42, 4161-4171. doi:10.1021/jm990070k

Dupont, L., De Tullio, P., Khelili, S., Somers, F., Delarge, J., & Pirotte, B. (1999). 7-Chloro-(R)-3-[1-(cyclohexyl)ethylamino]-4H-1,2,4-benzothiadiazine 1,1-dioxide and 7-chloro-(S)-3-[1-(cyclohexyl)ethylamino]-4H-1,2,4-benzothiadiazine 1,1-dioxide. Acta Crystallographica, C55, 1945-1947. doi:10.1107/S0108270199010069

Dupont, L., Pirotte, B., & De Tullio, P. (1999). 7-Iodo-3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxide. Acta Crystallographica, C55, 1152-1154. doi:10.1107/S0108270199000669

Dupont, L., Pirotte, B., Podona, T., Diouf, O., Delarge, J., & De Tullio, P. (1999). 4-Ethyl-2,3-dihydro-4H-pyrido[3,2-e]-1,2,4-thiadiazine 1,1-dioxide and 4-ethyl-2,3-dihydro-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide. Acta Crystallographica, C55, 461-464. doi:10.1107/S0108270198013894

Khelili, S., De Tullio, P., Lebrun, P., Fillet, M., Antoine, M.-H., Ouedraogo, R., Dupont, L., Fontaine, J., Felekidis, A., Leclerc, G., Delarge, J., & Pirotte, B. (1999). Preparation and pharmacological evaluation of the R- and S-enantiomers of 3-(2’-butylamino)-4H- and 3-(3’-methyl-2’-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide, two tissue selective ATP-sensitive potassium channel openers. Bioorganic and Medicinal Chemistry, 7 (8), 1513-1520. doi:10.1016/S0968-0896(99)00082-6

Khelili, S., Nguyen, Q.-A., Lebrun, P., Delarge, J., & Pirotte, B. (1999). Synthesis and pharmacological evaluation of KATP-channel openers related to cromakalim: introduction of arylsulphonylurea moieties. Pharmacy and Pharmacology Communications, 5, 189-193.

Lebrun, P., Ouedraogo, R., Nguyen, Q.-A., Antoine, M.-H., Dunne, M. J., Pirotte, B., & Masereel, B. (1999). In vivo et in vitro effect of new glibenclamide isosteres. Fundamental and Clinical Pharmacology, 13, Suppl. 1, 381.

Ouedraogo, R., Nguyen, Q.-A., Antoine, M.-H., Fontaine, J., Somers, F., De Tullio, P., Pirotte, B., & Lebrun, P. (1999). Pharmacological study of original 3-alkylamino-2-methyl-2H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides. Fundamental and Clinical Pharmacology, 13, 245.

Pirotte, B., De Tullio, P., Podona, T., Diouf, O., Morain, P., Lestage, P., & Lebrun, P. (1999). Pyrido- and benzothiadiazine dioxides related to diazoxide: structural requirements leading to a KATP channel activator or to an allosteric modulator of the AMPA receptors. Fundamental and Clinical Pharmacology, 13, Suppl. 1, 134.

Somers, F., De Tullio, P., Boverie, S., Dogne, J.-M., Antoine, M.-H., Lebrun, P., & Pirotte, B. (1999). New 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as putative KATP channel openers: design, synthesis and pharmacological evaluation. Fundamental and Clinical Pharmacology, 13, 607.

Nguyen, Q. A., Ouedraogo, R., Antoine, M. H., Pirotte, B., Pochet, L., Masereel, B., & Lebrun, P. (12 December 1998). In vivo and in vitro effect of new glibenclamide isosteres [Paper presentation]. Annual Meeting of the FRSM Contact Group Endocrine Pancreas, Liège, Belgium.

Reboud-Ravaux, M., Pochet, L., Doucet, C., Pirotte, B., Boggetto, N., & Delarge, J. (10 December 1998). Coumarin derivatives, methods of preparation and application as medicines.

Dogne, J. M., De Leval, X., Damas, J., Nuhrich, A., Fontaine, J., De Tullio, P., Somers, F., Pirotte, B., Neven, P., Delarge, J., & Masereel, B. (27 November 1998). Design, synthesis and biological evaluation of sulfonylureas as original non-prostanoïd thromboxane A2 receptor antagonists [Paper presentation]. Annual Meeting of the Belgian Society on Thrombosis and Haemostasis, Zemst, Belgium.

Dogne, J. M., De Leval, X., Damas, J., Nuhrich, A., Fontaine, J., De Tullio, P., Somers, F., Pirotte, B., Neven, P., Delarge, J., & Masereel, B. (27 November 1998). Design, synthesis and biological evaluation of sulfonylureas as original non-prostanoid thromboxane A2 receptor antagonists [Poster presentation]. Annual meeting of the Belgian Society on thrombosis and haemostasis, Zemst, Belgium.

Ouedraogo, R., Nguyen, Q. A., Antoine, M. H., Fontaine, J., Somers, F., De Tullio, P., Pirotte, B., & Lebrun, P. (21 November 1998). Pharmacological study of original 3-alkylamino-2-methyl-2H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Anvers, Belgium.

De Tullio, P., Ceccato, A., Liégeois, J.-F., Pirotte, B., Felekidis, A., Stachow, M., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (September 1998). Preparative resolution of racemic pirlindole: chromatographic methods and determination of the absolute configuration [Poster presentation]. Fourth European Congress of Pharmaceutical Sciences, Milan, Italy.

De Tullio, P., Ceccato, A., Liégeois, J.-F., Pirotte, B., Felekidis, A., Stachow, M., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (September 1998). Effective resolution of racemic pirlindole at the preparative scale: derivatization method and absolute configuration [Poster presentation]. XVth EFMC International Symposium on Medicinal Chemistry.