Publications and communications of Nathalie LAYIOS

Khellaf, L., Lemiale, V., Decavèle, M., de Chambrun, M. P., Beurton, A., Kamel, T., Stoclin, A., Mokart, D., Bruneel, F., Vigneron, C., Kouatchet, A., Henry, B., Quenot, J.-P., Jolly, G., Issa, N., Bellal, M., Poissy, J., Pichereau, C., Schmidt, J., ... Joseph, A. (February 2024). Critically Ill Patients with Visceral Nocardia Infection, France and Belgium, 2004-2023. Emerging Infectious Diseases, 30 (2), 345 - 349. doi:10.3201/eid3002.231440

Peetermans, M.* , Matheeussen, V.* , Moerman, C., De Rydt, F., Thieren, S., Pollet, E., Casaer, M., De Backer, B., De Paep, R., Debaveye, Y., Desmet, L., Desmet, S., Duval, E. I. M., Fraipont, V., Geysels, D., Hermans, G., Lahaye, F., Mathy, X., Meersseman, P., ... Jorens, P. G.*. (29 January 2024). Clinical and molecular epidemiological features of critically ill patients with invasive group A Streptococcus infections: a Belgian multicenter case-series. Annals of Intensive Care, 14 (1), 19. doi:10.1186/s13613-024-01249-7
* These authors have contributed equally to this work.

Fontaine, C., Layios, N., Giot, J.-B., Meex, C., & Descy, J. (January 2024). Un antibiogramme rapide optimise-t-il la prise en charge thérapeutique des patients présentant une bactériémie ? Revue Médicale de Liège, 79 (1), 17-22.

Gosset, C., Foguenne, J., SIMUL, M., Layios, N., Massion, P., DAMAS, P., & Gothot, A. (2024). A reactive monocyte subset characterized by low expression of CD91 is expanded during sterile and septic inflammation. Clinical Chemistry and Laboratory Medicine, 1-12. doi:10.1515/cclm-2023-0992

Misset, B., Piagnerelli, M., Hoste, E., Dardenne, N., Grimaldi, D., Michaux, I., De Waele, E., Dumoulin, A., Jorens, P. G., van der Hauwaert, E., Vallot, F., Lamote, S., Swinnen, W., De Schryver, N., Fraipont, V., de Mey, N., Dauby, N., Layios, N., Mesland, J.-B., ... Laterre, P.-F. (26 October 2023). Convalescent Plasma for Covid-19–Induced ARDS in Mechanically Ventilated Patients. New England Journal of Medicine, 389 (17), 1590-1600. doi:10.1056/nejmoa2209502

Misset, B., Nguyet, A. D., BERTRAND, A., Piagnerelli, M., Hoste, E., de Waele, E., Dumoulin, A., Jorens, P., van der Hauwaert, E., Vallot, F., Swinnen, W., De Schryver, N., de Mey, N., Layios, N., Mesland, J., Robinet, S., Cavalier, E., Donneau, A.-F., Moutschen, M., & Laterre, P. F. (24 October 2023). Immunological sub-phenotypes and response to Convalescent-Plasma (CP) in COVID-19 induced ARDS (C-ARDS): a hierarchical cluster analysis [Poster presentation]. ESICM LIVES 2023, Milan, Italy.

Hendrikx, E., Mathieu, D., Mathy, X., Fraipont, V., Misset, B., Meex, C., & Layios, N. (16 June 2023). A Multicenter Case Series of invasive Streptococcus pyogenes A (GAS) Infections from a Tertiary ICU in Liège, Belgium [Poster presentation]. Belgian Society of Intensive Care Medicine annual meeting, Bruxelles, Belgium.

Misset, B., Piagnerelli, M., Hoste, E., Dardenne, N., Grimaldi, D., Michaux, I., De Waele, E., Dumoulin, A., Jorens, P., Layios, N., Moutschen, M., Desmecht, D., Gothot, A., & Laterre, P. F. (14 June 2023). Proceedings of Reanimation 2023, the French Intensive Care Society International CongressCO‐59 Secondary outcomes of the CONFIDENT randomized trial of convalescent plasma therapy with high titers of neutralizing antibodies (NAb) in COVID-ARDS patients [Poster presentation]. SRLF annual meeting 2023, Paris, France. doi:10.1186/s13613-023-01131-y

Layios, N., Mathieu, D., Dumont, R., & GILLARD, R. (2023). Fulminant hepatic failure: An unusual suspect. JACEP: Journal of the American College of Emergency Physicians. doi:10.1002/emp2.12912

Tabah, A., Buetti, N., Staiquly, Q., Ruckly, S., Akova, M., Aslan, A. T., Leone, M., Conway Morris, A., Bassetti, M., Arvaniti, K., Lipman, J., Ferrer, R., Qiu, H., Paiva, J.-A., Povoa, P., De Bus, L., De Waele, J., Zand, F., Gurjar, M., ... Layios, N. (Other coll.). (February 2023). Epidemiology and outcomes of hospital-acquired bloodstream infections in intensive care unit patients: the EUROBACT-2 international cohort study. Intensive Care Medicine, 49 (2), 178 - 190. doi:10.1007/s00134-022-06944-2

Layios, N., Gosset, C., Maes, N., Delierneux, C., Hego, A., Huart, J., LECUT, C., DAMAS, P., Oury, C., & Gothot, A. (2023). Prospective flow cytometry analysis of leucocyte subsets in critically ill patients who develop sepsis: a pilot study. Infection. doi:10.1007/s15010-023-01983-3

Layios, N. (2022). Streamlining antimicrobial stewardship tools in critically ill patients [Doctoral thesis, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/299325

De Voeght, A., WILLEMS, E., Servais, S., Seidel, L., Pirotte, M., Massion, P., Layios, N., Pereira, M., Misset, B., CANIVET, J.-L., Beguin, Y., & Baron, F. (31 August 2022). Overall Survival Rate in Allogeneic Stem Cell Transplanted Patients Requiring Intensive Care Can Be Predicted by the Prognostic Index for Critically Ill Allogeneic Transplantation Patients (PICAT) and the Sequential Organ Failure Assessment (SOFA) Scores. Cancers, 14 (17), 4266. doi:10.3390/cancers14174266

GREGOIRE, C.* , LAYIOS, N.* , LAMBERMONT, B., LECHANTEUR, C., BRIQUET, A., Bettonville, V., BAUDOUX, E., THYS, M., Dardenne, N., Misset, B.* , & BEGUIN, Y.*. (04 July 2022). Bone Marrow-Derived Mesenchymal Stromal Cell Therapy in Severe COVID-19: Preliminary Results of a Phase I/II Clinical Trial. Frontiers in Immunology, 13, 932360. doi:10.3389/fimmu.2022.932360
* These authors have contributed equally to this work.

Robba, C., Giovannini, M., Meyfroidt, G., van der Jagt, M., Citerio, G., Smith, M., & Layios, N. (Other coll.). (01 July 2022). Intensive Care Admission and Management of Patients With Acute Ischemic Stroke: A Cross-sectional Survey of the European Society of Intensive Care Medicine. Journal of Neurosurgical Anesthesiology, 34 (3), 313 - 320. doi:10.1097/ANA.0000000000000761

Misset, B., Piagnerelli Michaël, Hoste Eric, Dardenne, N., Grimaldi D., Michaux, I., Dumoulin, A., Jorens, P., van der Hauwaert, E., de Waele, E., Vallot, F., Lamote, S., Swinnen, W., Fraipont, V., de Mey, N., de Schryver, N., de Wit, S., Layios, N., Mesland, J., ... Laterre, P. F. (June 2022). Convalescent plasma therapy with high titers of neutralizing antibodies to reduce mortality in patients with COVID-19 associated ARDS: the Belgian randomized CONFIDENT trial [Poster presentation]. SIZ Annual Meeting, Bruxelles, Belgium.

Layios, N., Visée, C., Mistretta, V., Denooz, R., Maes, N., Descy, J., Frippiat, F., Marchand, S., & Grégoire, N. (2022). Modelled target attainment after temocillin treatment in severe pneumonia: systemic and epithelial lining fluid pharmacokinetics of continuous versus intermittent infusions. Antimicrobial Agents and Chemotherapy, 0205221. doi:10.1128/AAC.02052-21

Gosset, C., FOGUENNE, J., SIMUL, M., TOMSIN, O., AMMAR, H., LAYIOS, N., MASSION, P., DAMAS, P., & GOTHOT, A. (13 October 2021). Machine learning identification of specific changes in myeloid cell phenotype during bloodstream infections. Scientific Reports, 11, 20288. doi:10.1038/s41598-021-99628-8

GONCETTE, V., Layios, N., DESCY, J., & FRIPPIAT, F. (September 2021). Continuous infusion, therapeutic drug monitoring and outpatient parenteral antimicrobial therapy with ceftazidime/avibactam: a retrospective cohort study. Journal of Global Antimicrobial Resistance, 26, 15 - 19. doi:10.1016/j.jgar.2021.04.015

Heilmann, E., Gregoriano, C., Annane, D., Reinhart, K., Bouadma, L., Wolff, M., Chastre, J., Luyt, C.-E., Tubach, F., Branche, A. R., Briel, M., Christ-Crain, M., Welte, T., Corti, C., de Jong, E., Nijsten, M., de Lange, D. W., van Oers, J. A. H., Beishuizen, A., ... Schuetz, P. (2021). Duration of antibiotic treatment using procalcitonin-guided treatment algorithms in older patients: a patient-level meta-analysis from randomized controlled trials. Age and Ageing, 50 (5), 1546-1556. doi:10.1093/ageing/afab078

Lambermont, B., Seidel, L., THYS, M., CAVALLERI, J., Delanaye, P., Canivet, J.-L., KISOKA, G., Layios, N., & Misset, B. (2021). Comparison of Covid‐19 patient management and outcome in a tertiary care center during the first and second waves of the pandemic. Annals of Intensive Care.

DE VOEGHT, A., CALMES, D., BECK, F., SYLVESTRE, J.-B., DELVENNE, P., PETERS, P., VERTENOEIL, G., BARON, F., LAYIOS, N., & CANIVET, J.-L. (2020). Thrombotic microvascular injury is not mediated by thrombotic microangiopathy despite systemic complement activation in Covid-19 patients. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/256301.

Alessandri, C., & Layios, N. (2020). Actualités et guide pratique d'utilisation de la procalcitonine dans les bactériémies. Vaisseaux, Coeur, Poumons.

FRIPPIAT, F., Vercheval, C., & Layios, N. (2020). Meropenem: continuous or extended infusion? Critical care (London, England), 24 (1), 192. doi:10.1186/s13054-020-02883-w

GONCETTE, V., Layios, N., & Frippiat, F. (2020). Continuous infusion and outpatient parenteral antimicrobial therapy with ceftazidime-avibactam: evaluation of efficacy based on therapeutic drug monitoring [Paper presentation]. ECCMID 2020.

LAMBERMONT, B., ERNST, M., DEMARET, P., BOCCAR, S., FRAIPONT, V., GURDEBEKE, C., VAN BRUSSEL, C., QUINONEZ, M., DUBOIS, C., LEMINEUR, T., NJAMBOU, T., AKANDO, B., WERTZ, D., THYS, M., MAES, N., CANIVET, J.-L., KISOKA, G., LAYIOS, N., LEDOUX, D., ... HIGNY, J. (2020). Corticosteroids are associated with a decrease in mortality in a multicenter cohort of mechanically ventilated COVID-19 patients [Poster presentation]. ESICM 2020.

LAMBERMONT, B., ERNST, M., DEMARET, P., FRAIPONT, V., GURDEBEKE, C., SOTTIAUX, T., QUINONEZ, M., DUBOIS, C., NJAMBOU, T., AKANDO, B., LEMINEUR, T., WERTZ, D., FORET, F., ROUSSEAU, A.-F., LEDOUX, D., LAYIOS, N., ROBINET, S., MORIMONT, P., & Misset, B. (2020). Corticosteroid therapy is associated with a decrease in mortality in a multicenter cohort of mechanically ventilated COVID-19 patients. Intensive Care Medicine Experimental, 8 (Suppl 2), 001357.

MARCHETTA, S., LAMBERMONT, B., MASSION, P., ROUSSEAU, A.-F., LAYIOS, N., ROBINET, S., CANIVET, J.-L., KISOKA, G., LEDOUX, D., MORIMONT, P., PIRET, S., WIESEN, P., & Misset, B. (2020). La première vague de la COVID-19 aux Soins intensifs. Revue Médicale de Liège.

Perot, A., Misset, B., MASSION, P., PIRET, S., ROUSSEAU, A.-F., WIESEN, P., ROBINET, S., LAMBERMONT, B., MORIMONT, P., LEDOUX, D., CANIVET, J.-L., & LAYIOS, N. (2020). Low incidence of thrombotic events in SARS-CoV-2 mechanically ventilated anticoagulated patients. Intensive Care Medicine Experimental, 8 (Suppl 2), 001583.

Uyttendaele, V., Knopp, J. L., PIROTTE, M., BAYET, M., MORIMONT, P., LAYIOS, N., LAMBERMONT, B., Shaw, G. M., Chase, J. G., & Desaive, T. (2020). STAR-Liège: Modulating Insulin AND Nutrition Improves Glycaemic Control [Poster presentation]. e-ISICEM - International Symposium on Intensive Care & Emergency Medicine.

Parzibut, G., CANIVET, J.-L., GUIOT, J., Lambermont, B., Layios, N., LEDOUX, D., Massion, P., MORIMONT, P., PIRET, S., ROBINET, S., Rousseau, A.-F., Verscheure, S., WIESEN, P., & Misset, B. (2019). Le syndrome de detresse respiratoire aigue. Revue Médicale de Liège, 74 (10), 514-520.

Skripkina, E., Canivet, A., Wautier, M., Martiny, D., Hallin, M., MEEX, C., & LAYIOS, N. (2019). Méningite à Campylobacter jejuni. Revue Médicale de Liège, 74 (7-8), 420-423.

DESCY, J., VISEE, C., FRIPPIAT, F., MEEX, C., LAYIOS, N., VAN BAMBEKE, F., & MELIN, P. (21 April 2018). Temocillin susceptibility testing with Vitek2® system and E-test® Are these methods reliable to determine temocillin MIC ? [Poster presentation]. ECCMID 2018.

Alves, J., Alp, E., Koulenti, D., Zhang, Z., Ehrmann, S., Blot, S., Bassetti, M., Conway-Morris, A., Reina, R., Teran, E., Sole-Lleonart, C., Ruiz-Rodríguez, M., Rello, J., SANEME-2 investigators, & Layios, N. (April 2018). Nebulization of antimicrobial agents in mechanically ventilated adults in 2017: an international cross-sectional survey. European Journal of Clinical Microbiology and Infectious Diseases, 37 (4), 785 - 794. doi:10.1007/s10096-017-3175-5

Montague, S.* , Delierneux, C.* , LECUT, C., LAYIOS, N., Dinsdale, R., Lee, C., Poulter, N., Andrews, R., Hampson, P., Wearn, C., MAES, N., Bishop, J., Bamford, A., Gardiner, C., Lee, W., Iqbal, T., Moiemen, N., Watson, S., Oury, C.* , ... Gardiner, E.*. (February 2018). Soluble GPVI is elevated in injured patients: shedding is mediated by fibrin activation of GPVI. Blood, 2 (3), 240/251. doi:10.1182/bloodadvances.2017011171
* These authors have contributed equally to this work.

LAYIOS, N., Delierneux, C., Hego, A., HUART, J., GOSSET, C., LECUT, C., MAES, N., Geurts, P., Joly, A., LANCELLOTTI, P., Albert, A., DAMAS, P., GOTHOT, A., & Oury, C. (December 2017). Sepsis prediction in critically ill patients by platelet activation markers on ICU admission: a prospective pilot study. Intensive Care Medicine Experimental, 5 (1), 32. doi:10.1186/s40635-017-0145-2

VISEE, C., LAYIOS, N., MISTRETTA, V., MAES, N., VAN BAMBEKE, F., & FRIPPIAT, F. (23 April 2017). Epithelial lining fluid penetration of temocillin administered by continuous infusion in critically ill patients with nosocomial pneumonia [Paper presentation]. 27th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Vienne, Austria.

VISEE, C., FRIPPIAT, F., DESCY, J., MEEX, C., MELIN, P., MISTRETTA, V., VAN BAMBEKE, F., & LAYIOS, N. (22 April 2017). Are Vitek2 system and E-test relevant and reliable for determining susceptibility to temocillin? [Poster presentation]. 27th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Vienne, Austria.

HAYETTE, M.-P., WERY, M., BOREUX, R., PEETERS, S., STIRLING, E., STEVENSON, R., & LAYIOS, N. (25 April 2015). Evaluation of a commercially developed semi-automated PCR-surface enhanced raman scattering assay for the detection of Candida species in blood [Poster presentation]. ECCMID, Copenhagen, Denmark.

LAYIOS, N., Delierneux, C., Hego, A., HUART, J., Joly, A., Geurts, P., DAMAS, P., LECUT, C., Gothot, A., & Oury, C. (2015). Erratum: Elevated basal levels of circulating activated platelets predict ICU-acquired sepsis and mortality: a prospective study. Critical Care, 19 (1), 301. doi:10.1186/s13054-015-1005-7

LAYIOS, N., GOSSET, C., Delierneux, C., Hego, A., HUART, J., DAMAS, P., Oury, C., & GOTHOT, A. (2015). Prospective immune profiling in critically ill adults : before, during and after severe sepsis shock. Critical Care, 19 (1).

LAYIOS, N., GOSSET, C., Delierneux, C., Hego, A., HUART, J., Joly, A., Geurts, P., DAMAS, P., Oury, C., & Gothot, A. (2015). Erratum: Prospective immune profiling in critically ill adults: before, during and after severe sepsis and septic shock. Critical Care, 19 (1), 300. doi:10.1186/s13054-015-1006-6

Frippiat, F., Seidel, L., Denooz, R., DAMAS, P., Layios, N., & Moutschen, M. (2014). Pharmacokinetics of Extended vs Intermittent Intravenous Infusion of Meropenem in Critically Ill Patients Receiving Continuous Veno-Venous Haemofiltration. Open Forum Infectious Diseases. doi:10.1093/ofid/ofu052

LAYIOS, N., CANIVET, J.-L., Baron, F., Moutschen, M., & Hayette, M.-P. (2014). Mortierella wolfii-Associated Invasive Disease. Emerging Infectious Diseases, 20 (9), 1591-2. doi:10.3201/eid2009.140469

LAYIOS, N., & LAMBERMONT, B. (2013). Procalcitonin for antibiotic treatment in intensive care unit patients. Current Infectious Disease Reports, 15 (5), 394-9. doi:10.1007/s11908-013-0360-2

DAMAS, P., LAYIOS, N., SEIDEL, L., NYS, M., MELIN, P., & LEDOUX, D. (July 2011). Severity of ICU-acquired pneumonia according to infectious microorganisms. Intensive Care Medicine, 37 (7), 1128-35. doi:10.1007/s00134-011-2255-8

LAYIOS, N. (2009). La décontamination digestive sélective: vieux démons ou .... jeune fiancée? Réanimation, 18, 467-469. doi:10.1016/j.reaurg.2009.06.007