Reference : Recollection and familiarity processes in probable Alzheimer's disease: an fMRI study

	Document type :	Scientific congresses and symposiums : Paper published in a book
	Discipline(s) :	Social & behavioral sciences, psychology : Neurosciences & behavior
	To cite this reference:	http://hdl.handle.net/2268/99746

Title :	Recollection and familiarity processes in probable Alzheimer's disease: an fMRI study
Language :	English
Author, co-author :	Genon, Sarah [Université de Liège - ULg > Département de Psychologie : cognition et comportement > Neuropsychologie >]
	Collette, Fabienne [Université de Liège - ULg > Département de Psychologie : cognition et comportement > Neuropsychologie >]
	Salmon, Eric [Université de Liège - ULg > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn. >]
	Bastin, Christine [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Publication date :	2011
Main document title :	Proceedings of the 5th International Conference on Memory
Pages :	126
Audience :	International
Event name :	5th International Conference on Memory
Keywords :	[en] episodic memory ; fMRI ; Alzheimer's disease
Abstract :	[en] Cerebral activity associated with recollection and familiarity in 28 patients with Alzheimer’s disease (AD) and 17 healthy controls was directly measured in an event-related fMRI experiment during performance of a recognition memory task with the process dissociation procedure. Brain regions associated to recollection were evidenced by contrasting activations for inclusion and exclusion conditions whereas brain regions related to familiarity were explored with the mean effect of the two conditions (at P < .05 corrected). Twelve patients had null recollection estimates (AD-), whereas 16 patients did experience some recollection although significantly less than controls (AD+). In AD+ and controls, recollection activated the posterior cingulate cortex (PCC). In contrast, familiarity estimates were equivalent in the 3 groups and were associated with brain activations around the intraparietal sulcus (IPS). Thus, in AD, impaired recollection is related to damage of the PCC whereas preserved familiarity is supported by the IPS.
Research units :	Centre de Recherches du Cyclotron - CRC
Permalink :	http://hdl.handle.net/2268/99746

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