Reference : Quality control of Citri reticulatae pericarpium: Exploratory analysis and discrimination.
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/99689
Quality control of Citri reticulatae pericarpium: Exploratory analysis and discrimination.
English
Tistaert, Christophe [> > > >]
Thierry, Line [> > > >]
Szandrach, Andrzej [> > > >]
Dejaegher, B. [> > > >]
Fan, Guorong [> > > >]
Frederich, Michel mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Vander Heyden, Yvan [Université Libre de Bruxelles - ULB > > > >]
2011
Analytica Chimica Acta
Elsevier
705
1-2
111-22
Yes (verified by ORBi)
International
0003-2670
1873-4324
Amsterdam
The Netherlands
[en] Extracts of Citri reticulatae pericarpium (PCR) are commonly used in the Traditional Chinese Medicine. The quality control of PCR is currently performed by single marker analysis, which can hardly describe the complexity of such natural samples. In this study, a fingerprint methodology for PCR based on high-performance liquid chromatography (HPLC) was developed and validated. A total of 69 fingerprints of authenticated PCR samples, commercial PCR samples, mixed peel samples, and other Citrus peels were recorded. Exploratory data analysis allowed optimizing the extraction procedure and detecting mixed peel samples. Once the optimizations were performed and the method validated, discrimination between the authentic PCR samples and all other samples was performed by p-Discriminant Partial Least Squares. The established model was able to differentiate between classes with a high reliability for each sample. Furthermore, evaluation of the score and loading plots of the model indicated nobiletin, tangeretin, naringin and hesperidin as important markers for the quality control of PCR.
http://hdl.handle.net/2268/99689
10.1016/j.aca.2011.04.024
Copyright (c) 2011 Elsevier B.V. All rights reserved.

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