Article (Scientific journals)
Quality control of Citri reticulatae pericarpium: Exploratory analysis and discrimination.
Tistaert, Christophe; Thierry, Line; Szandrach, Andrzej et al.
2011In Analytica Chimica Acta, 705 (1-2), p. 111-22
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Abstract :
[en] Extracts of Citri reticulatae pericarpium (PCR) are commonly used in the Traditional Chinese Medicine. The quality control of PCR is currently performed by single marker analysis, which can hardly describe the complexity of such natural samples. In this study, a fingerprint methodology for PCR based on high-performance liquid chromatography (HPLC) was developed and validated. A total of 69 fingerprints of authenticated PCR samples, commercial PCR samples, mixed peel samples, and other Citrus peels were recorded. Exploratory data analysis allowed optimizing the extraction procedure and detecting mixed peel samples. Once the optimizations were performed and the method validated, discrimination between the authentic PCR samples and all other samples was performed by p-Discriminant Partial Least Squares. The established model was able to differentiate between classes with a high reliability for each sample. Furthermore, evaluation of the score and loading plots of the model indicated nobiletin, tangeretin, naringin and hesperidin as important markers for the quality control of PCR.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Tistaert, Christophe
Thierry, Line
Szandrach, Andrzej
Dejaegher, B.
Fan, Guorong
Frederich, Michel  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Vander Heyden, Yvan;  Université Libre de Bruxelles - ULB
Language :
English
Title :
Quality control of Citri reticulatae pericarpium: Exploratory analysis and discrimination.
Publication date :
2011
Journal title :
Analytica Chimica Acta
ISSN :
0003-2670
eISSN :
1873-4324
Publisher :
Elsevier, Amsterdam, Netherlands
Volume :
705
Issue :
1-2
Pages :
111-22
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2011 Elsevier B.V. All rights reserved.
Available on ORBi :
since 06 October 2011

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