Reference : 17-O-Acetyl,10-hydroxycorynantheol, a Selective Antiplasmodial Alkaloid Isolated from St...
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/99598
17-O-Acetyl,10-hydroxycorynantheol, a Selective Antiplasmodial Alkaloid Isolated from Strychnos usambarensis Leaves
English
Cao, Martine mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Muganga, Raymond mailto [Université de Liège - ULg > > > Doct. sc. bioméd. & pharma. (Bologne)]
Tits, Monique mailto [Université de Liège - ULg > Département de pharmacie > Phytochimie et phytothérapie >]
Angenot, Luc mailto [Université de Liège - ULg > Département de pharmacie > Département de pharmacie >]
Frederich, Michel mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Aug-2011
Planta Medica
Georg Thieme Verlag Stuttgart
77
2050-2053
Yes (verified by ORBi)
International
0032-0943
New York
NY
[en] Strychnos usambarensis Gilg. ; Loganiaceae ; Monomeric indole alkaloid ; antiplasmodial ; selectivity
[en] In the course of our investigations on Strychnos usambarensis leaves in order to isolate isostrychnopentamine, the main alkaloid responsible for the antiplasmodial activity of the plant, a new tertiary indolic alkaloid has been isolated: 17-O-acetyl, 10-hydroxycorynantheol 1. Its structure was determined by means of spectroscopic and spectrometric methods such as UV, IR, CD, NMR and ESI-MS. 17-O-acetyl, 10-hydroxycorynantheol 1 is one of the most active monomeric indole alkaloid known to date showing an in vitro activity against Plasmodium falciparum close to 5 µM and a high selectivity.
CIRM
Researchers
http://hdl.handle.net/2268/99598

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