Reference : Obesite, insulinoresistance et diabete de type 2: facteurs de risque du cancer du sein.
Scientific journals : Article
Human health sciences : Oncology
Human health sciences : Endocrinology, metabolism & nutrition
http://hdl.handle.net/2268/99487
Obesite, insulinoresistance et diabete de type 2: facteurs de risque du cancer du sein.
French
[en] Obesity, insulin resistance and type 2 diabetes: risk factors for breast cancer
SCHEEN, André mailto [Centre Hospitalier Universitaire de Liège - CHU > > Diabétologie,nutrition, maladies métaboliques]
Beck, Emmanuel mailto [Université de Liège - ULg > Département des sciences cliniques > Département des sciences cliniques]
DE FLINES, Jenny mailto [Centre Hospitalier Universitaire de Liège - CHU > > Diabétologie,nutrition, maladies métaboliques]
RORIVE, Marcelle mailto [Centre Hospitalier Universitaire de Liège - CHU > > Diabétologie,nutrition, maladies métaboliques]
2011
Revue Médicale de Liège
66
5-6
Le cancer du sein
238-44
Yes (verified by ORBi)
0370-629X
Belgium
[en] Breast cancer ; Type 2 diabetes ; Estrogen ; Obesity ; Metformin ; Insulin
[en] Obesity and type 2 diabetes are two risk factors of breast cancer, especially after menopause. Underlying mechanisms are multiple and include hyperinsulinism due to insulin resistance (insulin, as insulin-like-growth factor -IGF-, is a growth factor), hyperleptinaemia associated with hypoadiponectinaemia, and high levels of estrogens resulting from aromatization of androgens in adipose tissue. In presence of type 2 diabetes associated with obesity, hyperglycaemia might provide energy substrate promoting tumour growth. These data have therapeutic implications with expected favourable effects of weight loss, resulting in a reduction of fat mass and insulin resistance, and the promising results recently reported with metformin contrasting with the negative effects of exogenous administration of high doses of insulin.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/99487
http://www.rmlg.ulg.ac.be

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