Reference : Extensive Deposition of Basement Membrane by Tumours: A Prognostic Factor? A Reappraisal
Scientific journals : Article
Life sciences : Anatomy (cytology, histology, embryology...) & physiology
http://hdl.handle.net/2268/9938
Extensive Deposition of Basement Membrane by Tumours: A Prognostic Factor? A Reappraisal
English
Noël, Agnès mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme >]
Fontes, R. [> > > >]
Emonard, H. [> > > >]
Foidart, Jean-Michel mailto [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique >]
Oct-1993
Epithelial Cell Biology
Springer Verlag London Ltd
2
4
150-4
Yes (verified by ORBi)
International
0940-9912
London
United Kingdom
[en] A loss of the continuous linear deposit of basement membrane around invasive carcinomas has been suggested to correlate with their increased invasiveness. In contrast, extensive basement membrane deposition would represent a more favourable prognosis. The Engelbreth-Holm-Swarm (EHS) tumour, a transplantable neoplasm, is widely used for its ability to synthesize and deposit large amounts of basement membrane components. We have evaluated the metastatic potential of this neoplasm 2 months after subcutaneous inoculation. Histological examination of lung sections revealed the presence of numerous metastatic foci. The metastatic cells retained their organization into clusters surrounded by extracellular matrix. Both the 72 kDa and the 92 kDa type IV collagenases were detected by zymography in Triton or urea extract (matrigel) of primary tumour. These results cast doubt on the hypothesis that the extensiveness of basement membrane deposition might always be of prognostic value by being inversely correlated with the degree of invasiveness of a carcinoma.
http://hdl.handle.net/2268/9938

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