ORBi: Tchemtchoua Tateu Victor - Development of a Chitosan Nanofibrillar Scaffold for Skin Repair and Regeneration.

Reference : Development of a Chitosan Nanofibrillar Scaffold for Skin Repair and Regeneration.


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Biochemistry, biophysics & molecular biology
	To cite this reference:	http://hdl.handle.net/2268/99133

Title :	Development of a Chitosan Nanofibrillar Scaffold for Skin Repair and Regeneration.
Language :	English
Author, co-author :	Tchemtchoua Tateu, Victor [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Laboratoire des tissus conjonctifs]
	Atanasova, G. [> > > >]
	Aqil, Abdelhafid [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
	Filee, P. [> > > >]
	Garbacki, Nancy [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Laboratoire des tissus conjonctifs]
	Vanhooteghem, Olivier [Université de Liège - ULg > Département des sciences cliniques > Département des sciences cliniques]
	Deroanne, Christophe [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Laboratoire de Biologie des Tissus Conjonctifs > >]
	Noël, Agnès [Université de Liège - ULg > Département de chimie (sciences) > Centre d'études et de rech. sur les macromolécules (CERM)]
	Jérôme, Christine [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
	Richelle, Betty [Université de Liège - ULg > Département des Sciences biomédicales et précliniques > Laboratoire de Biologie des Tissus Conjonctifs > >]
	Poumay, Y. [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Laboratoire des tissus conjonctifs]
	Colige, Alain [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Laboratoire de Biologie des Tissus Conjontifs > >]
Publication date :	2011
Journal title :	Biomacromolecules
Publisher :	American Chemical Society
Volume :	12
Pages :	3194-3204
Audience :	International
ISSN :	1525-7797
e-ISSN :	1526-4602
City :	Washington
Country :	DC
Keywords :	[en] biomaterial ; scaffold
Abstract :	[en] The final goal of the present study was the development of a 3-D chitosan dressing that would shorten the healing time of skin wounds by stimulating migration, invasion, and proliferation of the relevant cutaneous resident cells. Three-dimensional chitosan nanofibrillar scaffolds produced by electrospinning were compared with evaporated films and freeze-dried sponges for their biological properties. The nanofibrillar structure strongly improved cell adhesion and proliferation in vitro. When implanted in mice, the nanofibrillar scaffold was colonized by mesenchymal cells and blood vessels. Accumulation of collagen fibrils was also observed. In contrast, sponges induced a foreign body granuloma. When used as a dressing covering full-thickness skin wounds in mice, chitosan nanofibrils induced a faster regeneration of both the epidermis and dermis compartments. Altogether our data illustrate the critical importance of the nanofibrillar structure of chitosan devices for their full biocompatibility and demonstrate the significant beneficial effect of chitosan as a wound-healing biomaterial.
Research units :	Center for Education and Research on Macromolecules (CERM)
Target :	Researchers
Permalink :	http://hdl.handle.net/2268/99133
DOI :	10.1021/bm200680q

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