Reference : Development of a Chitosan Nanofibrillar Scaffold for Skin Repair and Regeneration.
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/99133
Development of a Chitosan Nanofibrillar Scaffold for Skin Repair and Regeneration.
English
Tchemtchoua Tateu, Victor mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Laboratoire des tissus conjonctifs]
Atanasova, G. [> > > >]
Aqil, Abdelhafid mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Filee, P. [> > > >]
Garbacki, Nancy mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Laboratoire des tissus conjonctifs]
Vanhooteghem, Olivier [Université de Liège - ULg > Département des sciences cliniques > Département des sciences cliniques]
Deroanne, Christophe mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Laboratoire de Biologie des Tissus Conjonctifs > >]
Noël, Agnès mailto [Université de Liège - ULg > Département de chimie (sciences) > Centre d'études et de rech. sur les macromolécules (CERM)]
Jérôme, Christine mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Richelle, Betty mailto [Université de Liège - ULg > Département des Sciences biomédicales et précliniques > Laboratoire de Biologie des Tissus Conjonctifs > >]
Poumay, Y. [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Laboratoire des tissus conjonctifs]
Colige, Alain mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Laboratoire de Biologie des Tissus Conjontifs > >]
2011
Biomacromolecules
American Chemical Society
12
3194-3204
Yes (verified by ORBi)
International
1525-7797
1526-4602
Washington
DC
[en] biomaterial ; scaffold
[en] The final goal of the present study was the development of a 3-D chitosan dressing that would shorten the healing time of skin wounds by stimulating migration, invasion, and proliferation of the relevant cutaneous resident cells. Three-dimensional chitosan nanofibrillar scaffolds produced by electrospinning were compared with evaporated films and freeze-dried sponges for their biological properties. The nanofibrillar structure strongly improved cell adhesion and proliferation in vitro. When implanted in mice, the nanofibrillar scaffold was colonized by mesenchymal cells and blood vessels. Accumulation of collagen fibrils was also observed. In contrast, sponges induced a foreign body granuloma. When used as a dressing covering full-thickness skin wounds in mice, chitosan nanofibrils induced a faster regeneration of both the epidermis and dermis compartments. Altogether our data illustrate the critical importance of the nanofibrillar structure of chitosan devices for their full biocompatibility and demonstrate the significant beneficial effect of chitosan as a wound-healing biomaterial.
Center for Education and Research on Macromolecules (CERM)
Researchers
http://hdl.handle.net/2268/99133
10.1021/bm200680q

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