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Study of the combined effect of 5-ALA-based photodynamic therapy and NF-kappaB inhibition on human glioblastoma cell survival
Coupienne, Isabelle; Fettweis, Grégory; Piette, Jacques
2011Cell Signal-omics 2011 Integrated cellular pathology Systems biology of human disease
 

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Keywords :
PDT; glioblastome; nécrose
Abstract :
[en] Glioblastoma constitute the most frequent and deadliest type of brain tumors in human adults. They are very resistant to all current therapies and are associated with a huge rate of recurrence. In most cases, this type of tumor is characterized by a constitutive activation of the nuclear factor-kappaB (NF-kappaB). This factor is known to be a key regulator of various physiological processes such as inflammation, immune response, cell growth or apoptosis. In the present study, we explored the role of NF-kappaB activation in the sensitivity of human glioblastoma cells to a treatment by 5-aminolevulinic acid (5-ALA)–based photodynamic therapy (PDT). Our results show that inhibition of NF-kappaB improves glioblastoma cell death in response to 5-ALA-PDT. We then studied the molecular mechanisms underlying the cell death induced by PDT combined or not with NF-kappaB inhibition. We found that PDT mainly induced necrosis in glioblastoma cells and NF-kappaB was found to have anti-necrotic functions in this context. In the second part of this study, we examined the role of the kinase RIP3, recently identified as a key effector of the necrotic pathway, in 5-ALA-PDT-induced necrosis and studied whether NF-kappaB interfered in RIP3-dependent necrosis induction.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Coupienne, Isabelle ;  Université de Liège - ULiège > GIGA-R : Virologie - Immunologie
Fettweis, Grégory  ;  Université de Liège - ULiège > GIGA - Utilisateurs machines
Piette, Jacques ;  Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Virologie - Immunologie
Language :
English
Title :
Study of the combined effect of 5-ALA-based photodynamic therapy and NF-kappaB inhibition on human glioblastoma cell survival
Publication date :
January 2011
Number of pages :
A0
Event name :
Cell Signal-omics 2011 Integrated cellular pathology Systems biology of human disease
Event organizer :
Marc Diederich
Event place :
Luxembourg, Luxembourg
Event date :
du 26 au 28 janvier 2011
Audience :
International
Funders :
FRIA - Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture [BE]
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Available on ORBi :
since 21 September 2011

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