|Reference : Study of the combined effect of 5-ALA-based photodynamic therapy and NF-kappaB inhib...|
|Scientific congresses and symposiums : Poster|
|Life sciences : Biochemistry, biophysics & molecular biology|
|Study of the combined effect of 5-ALA-based photodynamic therapy and NF-kappaB inhibition on human glioblastoma cell survival|
|Coupienne, Isabelle [Université de Liège - ULg > > GIGA-R : Virologie - Immunologie >]|
|Fettweis, Grégory [Université de Liège - ULg > > > GIGA - Utilisateurs machines]|
|Piette, Jacques [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Virologie - Immunologie >]|
|Cell Signal-omics 2011 Integrated cellular pathology Systems biology of human disease|
|du 26 au 28 janvier 2011|
|[en] PDT ; glioblastome ; nécrose|
|[en] Glioblastoma constitute the most frequent and deadliest type of brain tumors in human adults.
They are very resistant to all current therapies and are associated with a huge rate of
recurrence. In most cases, this type of tumor is characterized by a constitutive activation of
the nuclear factor-kappaB (NF-kappaB). This factor is known to be a key regulator of various
physiological processes such as inflammation, immune response, cell growth or apoptosis. In
the present study, we explored the role of NF-kappaB activation in the sensitivity of human
glioblastoma cells to a treatment by 5-aminolevulinic acid (5-ALA)–based photodynamic
therapy (PDT). Our results show that inhibition of NF-kappaB improves glioblastoma cell
death in response to 5-ALA-PDT. We then studied the molecular mechanisms underlying the
cell death induced by PDT combined or not with NF-kappaB inhibition. We found that PDT
mainly induced necrosis in glioblastoma cells and NF-kappaB was found to have anti-necrotic
functions in this context. In the second part of this study, we examined the role of the kinase
RIP3, recently identified as a key effector of the necrotic pathway, in 5-ALA-PDT-induced
necrosis and studied whether NF-kappaB interfered in RIP3-dependent necrosis induction.
|Fonds pour la formation à la Recherche dans l'Industrie et dans l'Agriculture (Communauté française de Belgique) - FRIA ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS|
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