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| Reference : Study of the combined effect of 5-ALA-based photodynamic therapy and NF-kappaB inhibiti... |
| Scientific congresses and symposiums : Poster | |||
| Life sciences : Biochemistry, biophysics & molecular biology | |||
| http://hdl.handle.net/2268/99060 | |||
| Study of the combined effect of 5-ALA-based photodynamic therapy and NF-kappaB inhibition on human glioblastoma cell survival | |
| English | |
Coupienne, Isabelle  [Université de Liège - ULg > > GIGA-R : Virologie - Immunologie >] | |
| Fettweis, Grégory [Université de Liège - ULg > > > GIGA - Utilisateurs machines] | |
| Piette, Jacques [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Virologie - Immunologie >] | |
| Jan-2011 | |
| A0 | |
| No | |
| No | |
| International | |
| Cell Signal-omics 2011 Integrated cellular pathology Systems biology of human disease | |
| du 26 au 28 janvier 2011 | |
| Marc Diederich | |
| Luxembourg | |
| Luxembourg | |
| [en] PDT ; glioblastome ; nécrose | |
| [en] Glioblastoma constitute the most frequent and deadliest type of brain tumors in human adults.
They are very resistant to all current therapies and are associated with a huge rate of recurrence. In most cases, this type of tumor is characterized by a constitutive activation of the nuclear factor-kappaB (NF-kappaB). This factor is known to be a key regulator of various physiological processes such as inflammation, immune response, cell growth or apoptosis. In the present study, we explored the role of NF-kappaB activation in the sensitivity of human glioblastoma cells to a treatment by 5-aminolevulinic acid (5-ALA)–based photodynamic therapy (PDT). Our results show that inhibition of NF-kappaB improves glioblastoma cell death in response to 5-ALA-PDT. We then studied the molecular mechanisms underlying the cell death induced by PDT combined or not with NF-kappaB inhibition. We found that PDT mainly induced necrosis in glioblastoma cells and NF-kappaB was found to have anti-necrotic functions in this context. In the second part of this study, we examined the role of the kinase RIP3, recently identified as a key effector of the necrotic pathway, in 5-ALA-PDT-induced necrosis and studied whether NF-kappaB interfered in RIP3-dependent necrosis induction. | |
| Fonds pour la formation à la Recherche dans l'Industrie et dans l'Agriculture (Communauté française de Belgique) - FRIA ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS | |
| http://hdl.handle.net/2268/99060 |
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