ORBi: Ghuysen Jean-Marie - Penicillin-binding proteins. Wall peptidoglycan assembly and resistance to penicillin: Facts, doubts and hopes

Reference : Penicillin-binding proteins. Wall peptidoglycan assembly and resistance to penicillin: F...


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Microbiology Life sciences : Biochemistry, biophysics & molecular biology
	To cite this reference:	http://hdl.handle.net/2268/98932

Title :	Penicillin-binding proteins. Wall peptidoglycan assembly and resistance to penicillin: Facts, doubts and hopes
Language :	English
Author, co-author :	Ghuysen, Jean-Marie [Université de Liège - ULg > > Centre d'Ingéniérie des Protéines > > >]
	Charlier, Paulette [Université de Liège - ULg > > Centre d'Ingéniérie des Protéines > >]
	Coyette, Jacques [Université de Liège - ULg > > Centre d'Ingéniérie des Protéines > >]
	Duez, Colette [Université de Liège - ULg > > Centre d'ingénierie des protéines >]
	Fonzé, Evelyne [Université de Liège - ULg > > Centre d'ingénierie des protéines > >]
	Fraipont, Claudine [Université de Liège - ULg > > Centre d'ingénierie des protéines >]
	Goffin, Colette [Université de Liège - ULg > > Centre d'ingénierie des protéines >]
	Joris, Bernard [Université de Liège - ULg > > Centre d'ingénierie des protéines > >]
	Distèche, Martine [Université de Liège - ULg > > Centre d'ingénierie des protéines >]
Publication date :	1997
Journal title :	International Journal of Antimicrobial Agents
Publisher :	Elsevier Science
Volume :	8
Issue/season :	1
Pages :	45-60
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	0924-8579
City :	Amsterdam
Country :	The Netherlands
Abstract :	[en] The assembly of the bacterial cell wall peptidoglycan relies upon the availability of a ready-made precursor, the lipid II intermediate. This intermediate is taken up by a multifunctional factory that provides the required enzymatic activities for polymer assembly at the exterior of the plasma membrane. Morphogenetic networks regulate the synthesis in a cell-cycle-dependent fashion. As essential components of the cell machinery are targets of beta-lactam antibiotics, safety devices protect the cells against these toxic agents. Controversy and consensus formation lie at the heart of the scientific research. This review focuses on questions that bacterial cell wall biochemists still strive, with increasing success, to answer. (C) 1997 Elsevier Science B.V.
Research units :	Centre d'Ingénierie des Protéines - CIP
Funders :	Fonds de la Recherche Scientifique Médicale - FRSM ; Fonds de la Recherche Fondamentale Collective - FRFC
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/98932

File(s) associated to this reference

Fulltext file(s):

	File	Commentary	Version	Size	Access
Open access	out_132412_72277.pdf		Author postprint	812.39 kB	View/Open

All documents in ORBi are protected by a user license.

Dspace v1.5