Article (Scientific journals)
Brain perfusion patterns in familial frontotemporal lobar degeneration.
Seelaar, H.; Papma, J. M.; Garraux, Gaëtan et al.
2011In Neurology, 77 (4), p. 384-92
Peer Reviewed verified by ORBi
 

Files


Full Text
Seelaar Neurology 2011.pdf
Publisher postprint (894.24 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
dementia; brain imaging; perfusion; frontotemporal; genetic
Abstract :
[en] OBJECTIVE: Frontotemporal lobar degeneration (FTLD) is a clinically, genetically, and pathologically heterogeneous disorder. The aim of this study was to compare clinical features and perfusion patterns on SPECT of patients with familial FTLD-TAR DNA binding protein 43 kDa (TDP) and MAPT mutations. METHODS: Patients were included if they had MAPT or GRN mutations, positive family history with pathologically proven FTLD in the patient or first-degree relative, or were part of FTD-MND families. All patients and 10 age- and gender-matched controls underwent measurement of brain perfusion using (99m)Tc-HMPAO SPECT. We used SPM8 to perform image processing and voxel-based group analyses (p < 0.001). Gender and age were included as nuisance variables in the design matrices. RESULTS: Of the 29 patients with familial FTLD, 19 had familial FTLD-TDP (GRN mutations in 6), and 10 had MAPT mutations. At clinical presentation, familial FTLD-TDP patients were older at onset (p = 0.030) and had more memory deficits (p = 0.011), whereas patients with MAPT had more naming deficits (p < 0.001) and obsessive-compulsive behavior (p = 0.001). The between-groups SPECT analyses revealed significantly less perfusion in the right frontal lobe, precuneus, cuneus, and inferior parietal lobule in familial FTLD-TDP, whereas significantly less perfusion was found in the left temporal and inferior frontal gyri in MAPT. Post hoc analysis of familial FTLD-TDP with unknown genetic defect vs MAPT revealed less perfusion in the right frontal and parietal lobe. CONCLUSION: Familial FTLD-TDP shows relatively more posterior hypoperfusion, including the precuneus and inferior parietal lobule, possibly related to significant memory impairment. Patients with MAPT were characterized by impaired perfusion of the temporal regions and naming deficits.
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Genetics & genetic processes
Neurology
Radiology, nuclear medicine & imaging
Author, co-author :
Seelaar, H.
Papma, J. M.
Garraux, Gaëtan  ;  Université de Liège - ULiège > Département des sciences cliniques > Neurologie
de Koning, I.
Reijs, A. E.
Valkema, R.
Rozemuller, A. J. M.;  Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.
Salmon, Eric  ;  Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.
van Swieten, J. C.
Language :
English
Title :
Brain perfusion patterns in familial frontotemporal lobar degeneration.
Publication date :
2011
Journal title :
Neurology
ISSN :
0028-3878
eISSN :
1526-632X
Publisher :
Lippincott Williams & Wilkins, Hagerstown, United States - Maryland
Volume :
77
Issue :
4
Pages :
384-92
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 15 September 2011

Statistics


Number of views
57 (0 by ULiège)
Number of downloads
0 (0 by ULiège)

Scopus citations®
 
18
Scopus citations®
without self-citations
13
OpenCitations
 
13

Bibliography


Similar publications



Contact ORBi