Article (Scientific journals)
Diabete sucre iatrogene: l'exemple des anti-psychotiques atypiques.
Scheen, André; De Hert, M.
2005In Revue Médicale de Liège, 60 (5-6), p. 455-60
Peer reviewed
 

Files


Full Text
20050506_35.pdf
Publisher postprint (595.76 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Antipsychotic Agents/adverse effects/therapeutic use; Diabetes Mellitus/chemically induced; Humans; Iatrogenic Disease; Insulin/secretion; Insulin Resistance; Pancreatitis; Risk Factors; Weight Gain
Abstract :
[en] As an example of iatrogenic diabetes, we discuss the problem of diabetes mellitus in patients receiving atypical antipsychotics. The risk of diabetes mellitus appears to be different according to various molecules with, by decreasing order, clozapine, olanzapine, risperidone and quetiapine, and finally amisulpride, aripiprazole and ziprasidone. A careful analysis of published case reports and series indicates the existence of two different problems: 1) the rather common development of impaired glucose tolerance or diabetes mellitus (often associated with metabolic syndrome) related to weight gain in individuals at risk for type 2 diabetes; and 2) the occurrence of rare cases of acute metabolic episodes with severe ketoacidosis and/or pancreatitis whose pathophysiological mechanisms remain largely unknown. Generally speaking, the pathophysiology involves both increased insulin resistance and deficient insulin secretion. Cautious metabolic monitoring of patients receiving atypical antipsychotics is recommended, and the selection of the appropriate drug should be influenced by the metabolic profile of the various molecules and the metabolic risk of the patients who should be treated with atypical antipsychotics.
Disciplines :
Endocrinology, metabolism & nutrition
Psychiatry
Author, co-author :
Scheen, André  ;  Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale
De Hert, M.
Language :
French
Title :
Diabete sucre iatrogene: l'exemple des anti-psychotiques atypiques.
Alternative titles :
[en] Drug-induced diabetes mellitus: the exemple of atypical antipsychotics
Publication date :
2005
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Université de Liège. Revue Médicale de Liège, Liège, Belgium
Special issue title :
Le diabète sucré dans tous ses états
Volume :
60
Issue :
5-6
Pages :
455-60
Peer reviewed :
Peer reviewed
Additional URL :
Available on ORBi :
since 26 March 2009

Statistics


Number of views
459 (2 by ULiège)
Number of downloads
516 (2 by ULiège)

Scopus citations®
 
21
Scopus citations®
without self-citations
6

Bibliography


Similar publications



Contact ORBi