Reference : Sugar-labeled and PEGylated (bio)degradable polymers intended for targeted drug deliv...
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
Engineering, computing & technology : Materials science & engineering
http://hdl.handle.net/2268/98104
Sugar-labeled and PEGylated (bio)degradable polymers intended for targeted drug delivery systems
English
Freichels, Hélène [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Jérôme, Robert mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Jérôme, Christine mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
30-Aug-2011
Carbohydrate Polymers
Elsevier Science
86
3
1093-1106
Yes (verified by ORBi)
International
0144-8617
[en] biomaterial ; nanomedicine ; review
[en] This paper aims at giving a comprehensive view of the research effort devoted to the preparation of sugar coated long-circulating degradable polymers intended for drug delivery applications. In the recent past, many research projects have focused on the controlled drug delivery and, therefore, on the design of drug carriers. Among them, polymeric carriers have great potential because they can be chemically modified to a large extent and so endowed with specific properties. For instance, depending on the selected polymer, either the circulation time in the bloodstream can be increased very significantly (long-circulating polymer) or the drug carrier can be completely degraded after administration. Moreover, active targeting, i.e., carriers bearing a ligand known for specific affinity for one tissue, has emerged as a method of choice in targeting the delivery of drugs. This concept is of the utmost importance because the large variety of receptors present in the body makes the selective targeting a must in order to prevent any healthy tissue from being damaged irreversibly. The purpose of this paper is to emphasize that carbohydrates are very promising pilot molecules for the next generation of drug delivery
Center for Education and Research on Macromolecules (CERM)
Politique Scientifique Fédérale (Belgique) = Belgian Federal Science Policy ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; The "Région Wallonne" in the frame of the VACCINOR project
Researchers
http://hdl.handle.net/2268/98104
10.1016/j.carbpol.2011.06.004
http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6TFD-532WM6G-2-1&_cdi=5224&_user=532038&_pii=S0144861711004504&_origin=gateway&_coverDate=08%2F30%2F2011&_sk=999139996&view=c&wchp=dGLbVlW-zSkWl&md5=92d37494f93c155d835816a5e29bd947&ie=/sdarticle.pdf

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