NF-kB, stem cells and breast cancer: the links get stronger

[en] Self-renewing breast cancer stem cells are key actors in perpetuating tumour existence and in treatment resistance and relapse. The molecular pathways required for their maintenance are starting to be elucidated. Among them is the transcription factor NF-κB, which is known to play critical roles in cell survival, inflammation and immunity. Recent studies indicate that mammary epithelial NF-κB regulates the self-renewal of breast cancer stem cells in a model of Her2-dependent tumourigenesis. We will describe here the NF-κB-activating pathways that are involved in this process and in which progenitor cells this transcription factor is actually activated.

Research center :

Unit of Signal Transduction, GIGA

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Shostak, Kateryna ; Université de Liège - ULiège > Département de pharmacie > Chimie médicale

Chariot, Alain ; Université de Liège - ULiège > Département de pharmacie > Chimie médicale

Language :

English

Title :

NF-kB, stem cells and breast cancer: the links get stronger

Publication date :

26 July 2011

Journal title :

Breast Cancer Research

ISSN :

1465-5411

eISSN :

1465-542X

Publisher :

BioMed Central, London, United Kingdom

Volume :

Issue :

Pages :

214

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]

Available on ORBi :

since 29 August 2011

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Scopus citations^®

149

Scopus citations^®
without self-citations

149

OpenCitations

140

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