Reference : NF-kB, stem cells and breast cancer: the links get stronger
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/97913
NF-kB, stem cells and breast cancer: the links get stronger
English
Shostak, Kateryna mailto [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
Chariot, Alain mailto [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
26-Jul-2011
Breast Cancer Research [=BCR]
BioMed Central
13
4
214
Yes (verified by ORBi)
International
1465-5411
1465-542X
London
United Kingdom
[en] Nf kappa B ; Bresat cancer ; Stem cells
[en] Self-renewing breast cancer stem cells are key actors in perpetuating tumour existence and in treatment resistance and relapse. The molecular pathways required for their maintenance are starting to be elucidated. Among them is the transcription factor NF-κB, which is known to play critical roles in cell survival, inflammation and immunity. Recent studies indicate that mammary epithelial NF-κB regulates the self-renewal of breast cancer stem cells in a model of Her2-dependent tumourigenesis. We will describe here the NF-κB-activating pathways that are involved in this process and in which progenitor cells this transcription factor is actually activated.
Unit of Signal Transduction, GIGA
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/97913

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