Reference : Fluorescent labeling of degradable poly(lactide-co-glycolide) for cellular nanopartic...
Scientific journals : Article
Engineering, computing & technology : Materials science & engineering
Physical, chemical, mathematical & earth Sciences : Chemistry
http://hdl.handle.net/2268/97858
Fluorescent labeling of degradable poly(lactide-co-glycolide) for cellular nanoparticles tracking in living cells
English
Freichels, Hélène [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Danhier, Fabienne [Université catholique de Louvain (UCL), Brussels > > Unité de Pharmacie Galénique / Louvain Drug Research Institute (LDRI) > >]
Préat, Véronique [Université catholique de Louvain (UCL), Brussels > > Unité de Pharmacie Galénique / Louvain Drug Research Institute (LDRI) > >]
Lecomte, Philippe mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Jérôme, Christine mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Feb-2011
International Journal of Artificial Organs
Wichtig Editore
34
2
152-160
Yes (verified by ORBi)
International
0391-3988
Milano
Italy
[en] biomaterial ; nanomedecine
[en] Fluorescent-labeled aliphatic polyesters are essential materials for in vitro and in vivo studies of the behavior of these biodegradable polymers in interaction with cells or in a body. In particular, the direct cellular localization of drug delivery systems based on these materials allows better understanding of the internalization mechanism and determination of the pharmacokinetics. Polylactide-co-glycolide (PLGA) is a rapidly degradable copolymer widely used in pharmaceutics and nanomedecine. It was prepared by ring-opening polymerization of lactide and glycolide in order to obtain a well-defined material to investigate conditions allowing the covalent linkage of a fluorescent dye (fluorescein) while preserving the macromolecular characteristics of the polymer. The success of the functionalization was ascertained by proton nuclear magnetic resonance (1H NMR), size-exclusion chromatography (SEC) and fluorescence spectroscopy.
Center for Education and Research on Macromolecules (CERM)
Politique Scientifique Fédérale (Belgique) = Belgian Federal Science Policy ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; The "Walloon Region" in the frame of the VACCINOR project
Researchers
http://hdl.handle.net/2268/97858
10.5301/IJAO.2011.6420
http://www.artificial-organs.com/public/IJAO/Issue/Article.action?cmd=navigate&urlkey=Public_Details&uid=41EF8759-DBC5-4456-926C-E5DE1C0E13C6&t=IJAO

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