Reference : Design and synthesis of novel DOTA(Gd3+)–polymer conjugates as potential MRI contrast...
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
Engineering, computing & technology : Materials science & engineering
http://hdl.handle.net/2268/97779
Design and synthesis of novel DOTA(Gd3+)–polymer conjugates as potential MRI contrast agents
English
Grogna, Mathurin [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Cloots, Rudi mailto [University of Liège (ULg) > Department of Chemistry > Laboratory of Structural Inorganic Chemistry > >]
Luxen, André mailto [University of Liège (ULg) > Department of Chemistry > Cyclotron Research Center > >]
Jérôme, Christine mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Desreux, Jean-François mailto [University of Liège (ULg) > Department of Chemistry > Laboratory of Coordination and Radiochemistry > >]
Detrembleur, Christophe mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
27-Jul-2011
Journal of Materials Chemistry
Royal Society of Chemistry
21
34
12917-12926
Yes (verified by ORBi)
International
0959-9428
1364-5501
Cambridge
United Kingdom
[en] Nuclear Magnetic Resonance Imaging (MRI) contrast agent
[en] Conventional low molecular weight gadolinium based Magnetic Resonance Imaging (MRI) contrast agents such as Magnevist® are very useful for imaging tissues. However, at the high magnetic fields used in modern MRI equipments, their relaxivity (contrasting efficiency) is rather poor. The grafting of the gadolinium complex onto macromolecules is a way to enhance their relaxivity provided that the rotational motion of the complex is decreased significantly. Here we report the design of novel Gd3+ based MRI contrast agents with improved relaxivity and potential long blood circulation life-time. We investigate the grafting of 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid, 1,4,7-tris(1,1-dimethylethyl) ester (DO3AtBu-NH2; a precursor of Gd3+ ligand) onto well-defined functional copolymers bearing activated esters (succinimidyl esters) and poly(ethylene oxide) (PEO) chains required for stealthiness. The tert-butyl groups of grafted DO3AtBu-NH2 are then deprotected by trifluoroacetic acid followed by complexation of Gd3+. Addition of free DOTA at the end of the reaction is necessary to leave the pure and stable water soluble macrocontrast agent. Importantly it shows a relaxivity at high frequencies that is 300% higher than that of the ungrafted gadolinium complex. These novel functional copolymers are therefore promising candidates as macromolecular contrast agents for MRI applications.
Center for Education and Research on Macromolecules (CERM)
Politique Scientifique Fédérale (Belgique) = Belgian Federal Science Policy ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; The "IISN"
Researchers
http://hdl.handle.net/2268/97779
10.1039/c1jm00005e
http://pubs.rsc.org/en/content/articlepdf/2011/jm/c1jm00005e?page=search

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