Reference : Convenient grafting through approach for the preparation of stealth polymeric blood p...
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
Engineering, computing & technology : Materials science & engineering
http://hdl.handle.net/2268/97777
Convenient grafting through approach for the preparation of stealth polymeric blood pool magnetic resonance imaging contrast agents
English
Grogna, Mathurin [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Cloots, Rudi mailto [University of Liège (ULg) > Department of Chemistry > Laboratory of Structural Inorganic Chemistry > >]
Luxen, André mailto [University of Liège (ULg) > Department of Chemistry > Cyclotron Research Center > >]
Jérôme, Christine mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Passirani, Catherine [University of Angers (France) > > INSERM > >]
Lautram, Nolwenn [University of Angers (France) > > INSERM > >]
Desreux, Jean-François mailto [University of Liège (ULg) > Department of Chemistry > Laboratory of Coordination and Radiochemistry > >]
Detrembleur, Christophe mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
1-Sep-2011
Journal of Polymer Science. Part A, Polymer Chemistry
Wiley
49
17
3700-3708
Yes (verified by ORBi)
International
0887-624X
1099-0518
New York
NY
[en] Nuclear Magnetic Resonance Imaging (MRI) contrast agent
[en] New hydrosoluble magnetic resonance imaging (MRI) macrocontrast agents are synthesized by reversible addition fragmentation chain transfer (RAFT) copolymerization of poly(ethylene oxide) methyl ether acrylate (PEOMA) with an acrylamide bearing a ligand for gadolinium, followed by the complexation of Gd3+. This convenient and simple grafting through approach leads to macrocontrast agents with a high relaxivity at high frequency that is imparted by the restricted tumbling of the Gd3+ complex caused by its attachment to the polymer backbone. Importantly a very low protein adsorption is also evidenced by the hemolytic CH50 test. It is the result of the poly(ethylene oxide) (PEO) brush that efficiently hides the gadolinium complex and renders it stealth to the proteins of the immune system. Improved contrast and long blood circulating properties are thus expected for these macrocontrast agents.
Center for Education and Research on Macromolecules (CERM)
Politique Scientifique Fédérale (Belgique) = Belgian Federal Science Policy ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; The "IISN"
Researchers
http://hdl.handle.net/2268/97777
10.1002/pola.24805
http://onlinelibrary.wiley.com/doi/10.1002/pola.24805/pdf

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