Reference : Stealth macromolecular platforms for the design of MRI blood pool contrast agents
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
Engineering, computing & technology : Materials science & engineering
http://hdl.handle.net/2268/97775
Stealth macromolecular platforms for the design of MRI blood pool contrast agents
English
Grogna, Mathurin [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Cloots, Rudi mailto [University of Liège (ULg) > Department of Chemistry > Laboratory of Structural Inorganic Chemistry > >]
Luxen, André mailto [University of Liège (ULg) > Department of Chemistry > Cyclotron Research Center > >]
Jérôme, Christine mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Passirani, Catherine [University of Angers (France) > > INSERM > >]
Lautram, Nolwenn [University of Angers (France) > > INSERM > >]
Desreux, Jean-François mailto [University of Liège (ULg) > Department of Chemistry > Laboratory of Coordination and Radiochemistry > >]
Collodoro, Mike [University of Liège (ULg) > Biomedical Sciences and Preclinical Department > Laboratory of Histology and Cytology > >]
Gillet, Marie-Claire mailto [University of Liège (ULg) > Biomedical Sciences and Preclinical Department > Laboratory of Histology and Cytology > >]
Detrembleur, Christophe mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Oct-2011
Polymer Chemistry
2
10
2316-2327
Yes (verified by ORBi)
International
1759-9954
[en] Nuclear Magnetic Resonance Imaging (MRI) contrast agent
[en] Stealth macromolecular platforms bearing alkyne groups and poly(ethylene oxide) brushes were synthesized by reversible addition fragmentation chain transfer (RAFT) polymerization. The anchoring of Gd3+-chelates bearing an azide group was then carried out by the Huisgen 1,3-dipolar cycloaddition (“click”) reaction in mild conditions, leading to macrocontrast agents for MRI applications. The gadolinium complex is hidden in the PEO shell that renders the macrocontrast agents free of any cytotoxicity and stealth to proteins of the immune system. Relaxometry measurements have evidenced an improved relaxivity of the macrocontrast agent compared to ungrafted gadolinium chelate. Moreover, this relaxivity is further enhanced when the spacer length between the Gd3+-chelate and the polymer backbone is shorter, as the result of its decreased tumbling rate. These novel products are therefore promising candidates for MRI applications.
Center for Education and Research on Macromolecules (CERM)
Politique Scientifique Fédérale (Belgique) = Belgian Federal Science Policy ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; The "IISN"
Researchers
http://hdl.handle.net/2268/97775
10.1039/C1PY00198A
http://pubs.rsc.org/en/content/articlepdf/2011/py/c1py00198a

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