Article (Scientific journals)
L'etude clinique du mois. L'etude FIELD de protection cardio-vasculaire avec le fenofibrate chez le patient diabetique de type 2.
Radermecker, Régis; Scheen, André
2005In Revue Médicale de Liège, 60 (12), p. 957-61
Peer reviewed
 

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Keywords :
Aged; Antilipemic Agents/therapeutic use; Cardiovascular Diseases/etiology/prevention & control; Diabetes Mellitus, Type 2/complications; Dyslipidemias/drug therapy; Humans; Middle Aged; Procetofen/therapeutic use
Abstract :
[en] FIELD ("Fenofibrate Intervention and Events Lowering in Diabetes") study compared the incidence of coronary and cardiovascular events in 4895 patients with type 2 diabetes treated with fenofibrate (micronized fomulation, 200 mg/day) and in 4900 patients treated with placebo. After a mean 5-year follow-up, the fenofibrate group did not have less coronary events (primary endpoint), neither present a significant reduction in cardiovascular or total mortality as compared to the placebo group. However, it had significantly less non-fatal myocardial infarctions and cardiovascular events in general as well as less coronary and total revascularization procedures (secondary endpoints). The higher rate of starting statin therapy in patients allocated placebo might have masked a larger treatment benefit of fenofibrate on macrovascular complications. The tolerance of fenofibrate was good, even in combination with statins. More surprisingly, fenofibrate exerted a favourable effect on microangiopathy complications, with less albuminuria progression and less retinopathy needing laser treatment (tertiary endpoints).
Disciplines :
Pharmacy, pharmacology & toxicology
Cardiovascular & respiratory systems
Author, co-author :
Radermecker, Régis ;  Centre Hospitalier Universitaire de Liège - CHU > Diabétologie,nutrition, maladies métaboliques
Scheen, André  ;  Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale
Language :
French
Title :
L'etude clinique du mois. L'etude FIELD de protection cardio-vasculaire avec le fenofibrate chez le patient diabetique de type 2.
Alternative titles :
[en] Field, a randomized clinical trial of cardiovascular prevention with fenofibrate in type 2 diabetes
Publication date :
2005
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Université de Liège. Revue Médicale de Liège, Liège, Belgium
Volume :
60
Issue :
12
Pages :
957-61
Peer reviewed :
Peer reviewed
Additional URL :
Available on ORBi :
since 26 March 2009

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