ORBi: Goffin Frédéric - Expression pattern of metalloproteinases and tissue inhibitors of matrix-metalloproteinases in cycling human endometrium

Reference : Expression pattern of metalloproteinases and tissue inhibitors of matrix-metalloproteina...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Reproductive medicine (gynecology, andrology, obstetrics)
	To cite this reference:	http://hdl.handle.net/2268/9691

Title :	Expression pattern of metalloproteinases and tissue inhibitors of matrix-metalloproteinases in cycling human endometrium
Language :	English
Author, co-author :	Goffin, Frédéric [Centre Hospitalier Universitaire de Liège - CHU > > Gynécologie-Obstétrique CHR >]
	Munaut, Carine [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
	Frankenne, Francis [ > > ]
	PERRIER d'HAUTERIVE, Sophie [Université de Liège - ULg > > Gynécologie-Obstétrique CHR >]
	Beliard, Aude [Centre Hospitalier Universitaire de Liège - CHU > > Gynécologie-Obstétrique CHR >]
	Fridman, Viviana [Centre Hospitalier Universitaire de Liège - CHU > > Anatomie pathologique >]
	Nervo, Patricia [Centre Hospitalier Universitaire de Liège - CHU > > Gynécologie-Obstétrique CHR >]
	Colige, Alain [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Protéines et glycoprot. de matr.extracell. et membran.basal. >]
	Foidart, Jean-Michel [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique >]
Publication date :	Sep-2003
Journal title :	Biology of Reproduction
Publisher :	Society for the Study of Reproduction
Volume :	69
Issue/season :	3
Pages :	976-984
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	0006-3363
e-ISSN :	1529-7268
City :	Madison
Country :	WI
Keywords :	[en] female reproductive tract ; gene regulation ; menstrual cycle
Abstract :	[en] The cyclic growth, differentiation, and cell death of endometrium represents the most dynamic example of steroid-driven tissue turnover in human adults. Key effectors in these processes-matrix metalloproteinases (MMPs) and their specific inhibitors (TIMPs)-are regulated by ovarian steroids and, locally, by cytokines. We used reverse transcription-polymerase chain reaction to evaluate the expression of both transcriptionally regulated molecules such as estrogen receptor-alpha, progesterone receptor, and prolactin and a large array of MMPs and TIMPs (MMP-1, -2, -3, -7, -8, -9, -11, -12, -19, -26, MT1-MMP, MT2-MMP, MT3-MMP, TIMP-1, -2, -3). Altogether, three distinct patterns of MMP and two patterns of TIMP expression were detected in cycling endometrium: 1). MMPs restricted to the menstrual period (MMPs-1, -3, -8, -9, -12); 2). MMPs and TIMPs expressed throughout the cycle (MMP-2, MT1-MMP, MT2-MMP, MMP-19, TIMP-1, and TIMP-2); 3). MMPs predominantly expressed during the proliferative phase (MMP-7, MMP-11, MMP-26, and MT3-MMP); and 4). TIMP-3, which, contrary to the other TIMPs, shows significant modulations, with maximum expression during the late secretory and menstrual phases. These specific patterns of MMP expression associated with each phase of the cycle may point to specific roles in the processes of menstruation, housekeeping activities, angiogenesis, tissue growth, and extracellular matrix remodeling.
Permalink :	http://hdl.handle.net/2268/9691
DOI :	10.1095/biolreprod.103.015933

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