ORBi: Li X. R. - Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors

Reference : Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and th...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Laboratory medicine & medical technology
	To cite this reference:	http://hdl.handle.net/2268/9687

Title :	Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors
Language :	English
Author, co-author :	Li, X. R. [> > > >]
	Tjwa, M. [> > > >]
	Moons, L. [> > > >]
	Fons, P. [> > > >]
	Noël, Agnès [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme >]
	Ny, A. [> > > >]
	Zhou, J. M. [> > > >]
	Lennartsson, J. [> > > >]
	Li, H. [> > > >]
	Luttun, A. [> > > >]
	Ponten, A. [> > > >]
	Devy, L. [> > > >]
	Bouche, A. [> > > >]
	Oh, H. [> > > >]
	Manderveld, A. [> > > >]
	Blacher, Silvia [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
	Communi, D. [> > > >]
	Savi, P. [> > > >]
	Bono, F. [> > > >]
	Dewerchin, M. [> > > >]
	Foidart, Jean-Michel [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique >]
	Autiero, M. [> > > >]
	Herbert, J. M. [> > > >]
	Collen, D. [> > > >]
	Heldin, C. H. [> > > >]
	Eriksson, U. [> > > >]
	Carmeliet, P. [> > > >]
Publication date :	Jan-2005
Journal title :	Journal of Clinical Investigation
Publisher :	American Society for Clinical Investigation
Volume :	115
Issue/season :	1
Pages :	118-127
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	0021-9738
City :	Ann Arbor
Country :	MI
Abstract :	[en] The angiogenic mechanism and therapeutic potential of PDGF-CC, a recently discovered member of the VEGF/PDGF superfamily, remain incompletely characterized. Here we report that PDGF-CC mobilized endothelial progenitor cells in ischemic conditions; induced differentiation of bone marrow cells into ECs; and stimulated migration of ECs. Furthermore, PDGF-CC induced the differentiation of bone marrow cells into smooth muscle cells and stimulated their growth during vessel sprouting. Moreover, delivery of PDGF-CC enhanced postischemic revascularization of the heart and limb. Modulating the activity of PDGF-CC may provide novel opportunities for treating ischemic diseases.
Permalink :	http://hdl.handle.net/2268/9687
DOI :	10.1172/JCI200519189

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