Reference : Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and...
Scientific journals : Article
Human health sciences : Laboratory medicine & medical technology
http://hdl.handle.net/2268/9687
Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors
English
Li, X. R. [> > > >]
Tjwa, M. [> > > >]
Moons, L. [> > > >]
Fons, P. [> > > >]
Noël, Agnès mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme >]
Ny, A. [> > > >]
Zhou, J. M. [> > > >]
Lennartsson, J. [> > > >]
Li, H. [> > > >]
Luttun, A. [> > > >]
Ponten, A. [> > > >]
Devy, L. [> > > >]
Bouche, A. [> > > >]
Oh, H. [> > > >]
Manderveld, A. [> > > >]
Blacher, Silvia mailto [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
Communi, D. [> > > >]
Savi, P. [> > > >]
Bono, F. [> > > >]
Dewerchin, M. [> > > >]
Foidart, Jean-Michel mailto [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique >]
Autiero, M. [> > > >]
Herbert, J. M. [> > > >]
Collen, D. [> > > >]
Heldin, C. H. [> > > >]
Eriksson, U. [> > > >]
Carmeliet, P. [> > > >]
Jan-2005
Journal of Clinical Investigation
American Society for Clinical Investigation
115
1
118-127
Yes (verified by ORBi)
International
0021-9738
Ann Arbor
MI
[en] The angiogenic mechanism and therapeutic potential of PDGF-CC, a recently discovered member of the VEGF/PDGF superfamily, remain incompletely characterized. Here we report that PDGF-CC mobilized endothelial progenitor cells in ischemic conditions; induced differentiation of bone marrow cells into ECs; and stimulated migration of ECs. Furthermore, PDGF-CC induced the differentiation of bone marrow cells into smooth muscle cells and stimulated their growth during vessel sprouting. Moreover, delivery of PDGF-CC enhanced postischemic revascularization of the heart and limb. Modulating the activity of PDGF-CC may provide novel opportunities for treating ischemic diseases.
http://hdl.handle.net/2268/9687
10.1172/JCI200519189

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