Reference : Vascularity and fractal dimension of the dermo-epidermal interface in guttate and plaque...
Scientific journals : Article
Human health sciences : Dermatology
http://hdl.handle.net/2268/9673
Vascularity and fractal dimension of the dermo-epidermal interface in guttate and plaque-type psoriasis.
English
Uhoda, Isabelle [> >]
Pierard, Gérald mailto [Université de Liège - ULg > > Dermatopathologie >]
Pierard-Franchimont, Claudine [Université de Liège - ULg > > Dermatopathologie >]
Arrese Estrada, Jorge [Université de Liège - ULg > > Dermatopathologie >]
Goffin, Véronique [Université de Liège - ULg > > Dermatopathologie >]
Nikkels, Arjen mailto [Université de Liège - ULg > > Dermatologie >]
Paquet, Philippe mailto [Université de Liège - ULg > > Dermatopathologie >]
Quatresooz, Pascale mailto [Université de Liège - ULg > > Dermatopathologie >]
2005
Dermatology : International Journal for Clinical & Investigative Dermatology
S. Karger
210
3
189-93
Yes (verified by ORBi)
International
1018-8665
1421-9832
Basel
Switzerland
[en] Biopsy ; Case-Control Studies ; Humans ; Microcirculation ; Neovascularization, Pathologic/pathology/physiopathology ; Psoriasis/pathology/physiopathology ; Skin/blood supply
[en] BACKGROUND: Histological structures of the skin are often irregular in size and shape. Euclidean geometry and fractal analysis are complementary for assessing distinct aspects of their dimensions. OBJECTIVE: To determine and compare the variations in shape of the dermo-epidermal junction and the size of the superficial vessels in psoriatic lesions. METHOD: The relative microvasculature area and the fractal dimension D of the dermo-epidermal interface were measured inside and outside growth-stunted guttate lesions (n = 22) and expanding plaques (n = 37) in psoriasis of the trunk. RESULTS: The median D values of the dermo-epidermal interface were significantly larger (p < 0.01) in psoriatic plaques (D = 1.15) than in guttate lesions (D = 1.08), and these D values on lesional skin were significantly larger (p < 0.01) than in the uninvolved skin (D = 1.03). The microvasculature was significantly (p < 0.01) more developed in lesional (plaque: 13%, guttate: 8.20%) than in uninvolved skin (3.60 and 3.85%). No correlations were found between the relative microvasculature areas and the D values of the dermo-epidermal interface, both in the uninvolved and lesional skins of each psoriatic type. CONCLUSION: The absence of a relationship between modulations of the dermo-epidermal junction and vascular hyperplasia, both in expanding and stable psoriasis lesions, suggests that these events are regulated by different mechanisms and do not depend on each other.
http://hdl.handle.net/2268/9673
10.1159/000083508

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