Reference : 6-Substituted 2-Oxo-2h-1-Benzopyran-3-Carboxylic Acid Derivatives in a New Approach of t...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/9663
6-Substituted 2-Oxo-2h-1-Benzopyran-3-Carboxylic Acid Derivatives in a New Approach of the Treatment of Cancer Cell Invasion and Metastasis
English
Kempen, I. [> > > >]
Hemmer, Marc mailto [Université de Liège - ULg > Département de pharmacie > Chimie pharmaceutique >]
Counerotte, Stéphane mailto [Université de Liège - ULg > > Chimie pharmaceutique >]
Pochet, L. [> > > >]
De Tullio, Pascal mailto [Université de Liège - ULg > > Chimie pharmaceutique >]
Foidart, Jean-Michel mailto [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique >]
Blacher, Silvia mailto [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
Noël, Agnès mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme >]
Frankenne, Francis [ > > ]
Pirotte, Bernard mailto [Université de Liège - ULg > > Chimie pharmaceutique >]
Dec-2008
European Journal of Medicinal Chemistry
Elsevier
43
12
2735-50
Yes (verified by ORBi)
International
0223-5234
Paris
France
[en] Coumarin derivatives ; Cancer ; Cell invasion ; Anti-cancer
[en] Novel 6-substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives were synthesized and their potency in reducing the invasive behaviour of HT 1080 fibrosarcoma cells was evaluated. Structure-activity relationships were deduced from biological results and will be used in further design of new active compounds. In particular, the acetoxymethyl substituent found at the 6-position of previously described active compounds can be replaced by an acetamidomethyl substituent without loss of potency; while the presence of an aryl ester function at the 3-position was preferred to a thioester or an amide function to induce marked biological activity. This work confirms the interest of aryl esters of 6-substituted coumarin-3-carboxylic acids as potential new anti-cancer agents.
http://hdl.handle.net/2268/9663
10.1016/j.ejmech.2008.01.024

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
Kempen I EJMC 2008.pdf.pdfAuthor postprint472.57 kBView/Open

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.