Reference : Plasma myeloperoxidase and vitamin E levels in head injury: preliminary results relat...
Scientific journals : Article
Human health sciences : Anesthesia & intensive care
Human health sciences : Surgery
Human health sciences : Multidisciplinary, general & others
http://hdl.handle.net/2268/9639
Plasma myeloperoxidase and vitamin E levels in head injury: preliminary results related to outcome.
English
Hans, Pol [Centre Hospitalier Universitaire de Liège - CHU > > Anesthésie et réanimation >]
Franssen, Colette mailto [Centre Hospitalier Universitaire de Liège - CHU > > Anesthésie et réanimation >]
Pincemail, Joël mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie cardio-vasculaire >]
Bertrand, Yve [Centre Hospitalier Universitaire de Liège - CHU > >]
Hannique, Geneviève [> > > >]
Damas, Pierre mailto [Centre Hospitalier Universitaire de Liège - CHU > > Soins intensifs >]
Lamy, Maurice mailto [Université de Liège - ULg > Département des sciences cliniques > Département des sciences cliniques >]
1992
Journal of Neurosurgical Anesthesiology
Lippincott Williams & Wilkins
4
1
26-30
Yes (verified by ORBi)
International
0898-4921
1537-1921
Hagerstown
MD
[en] This preliminary study was designed to assess a possible role of neutrophil activation and to determine the prognostic value of plasma myeloperoxidase (MPO) and vitamin E (Vit. E) levels in severe head injury. Plasma MPO and Vit. E levels were measured in nine severely head-injured patients (Glasgow Coma Score </=8) (ages 12-80 years) 6, 12. 18, 24, and 30 h after trauma. Patients were classified into two groups according to outcome after discharge from the ICU: group D (death; n = 5) and group S (survival; n = 4). Plasma MPO levels were increased immediately after trauma and then decreased. The MPO peak observed after 6 h was significantly higher (p < 0.05) in group D (mean +/- SEM: 1,237 +/- 122 ng/ml) than in group S (mean +/- SEM: 543 +/- 148 ng/ml). Plasma Vit. E levels were lower than normal values and decreased over time. They were always significantly lower (p < 0.05) in group D than in group S, except for the first sample. These differences cannot be explained entirely by total plasma lipid (TL) values since no statistical difference in TL concentrations was found between the two groups during the course of study. The ratio of Vit. E to TL. considered as the best index of Vit. E status, was lower in group D than in group S. and the difference reached statistical significance (p < 0.05) 12 h after trauma. In conclusion, in spite of the limited number of patients included in this study, it appears that severe head injury is associated with an increase in MPO and a decrease in Vit. E levels. These biochemical changes are of greater magnitude in group D than in group S; they suggest neutrophil activation and lipoperoxidation processes. Finally, plasma MPO and Vit. E seem to be new discriminant factors of outcome in head-injured patients.
http://hdl.handle.net/2268/9639

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