Reference : Structure Guided Development of Potent Reversibly Binding Penicillin Binding Protein ...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/96174
Structure Guided Development of Potent Reversibly Binding Penicillin Binding Protein Inhibitors
English
Woon, Esther C. Y. [> >]
Zervosen, Astrid mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Sauvage, Eric mailto [Université de Liège - ULg > > Centre d'ingénierie des protéines >]
Simmons, Katie J. [> >]
Zivec, Matej [> >]
Inglis, Steven R. [> >]
Fishwick, Colin W. G. [> >]
Gobec, Stanislav [> >]
Charlier, Paulette mailto [Université de Liège - ULg > Département des sciences de la vie > Cristallographie des macromolécules biologiques >]
Luxen, André mailto [Université de Liège - ULg > Département de chimie (sciences) > Chimie organique de synthèse >]
Schofield, Christopher J. [> >]
2011
ACS Medicinal Chemistry letters
2 (3)
219-223
Yes (verified by ORBi)
International
1948-5875
[en] Penicillin binding proteins, ; boronic acids, ; antibiotics ; antibiotic-resistance, ; β-lactams ; transpeptidase-inhibition
[en] Following from the evaluation of different types of electrophiles, combined modeling and
crystallographic analyses are used to generate potent boronic acid based inhibitors of a penicillin binding
protein. The results suggest that a structurally informed approach to penicillin binding protein inhibition
will be useful for the development of both improved reversibly binding inhibitors, including boronic acids,
and acylating inhibitors, such as β-lactams.
http://hdl.handle.net/2268/96174

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