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| Reference : Structure Guided Development of Potent Reversibly Binding Penicillin Binding Protein Inh... |
| Scientific journals : Article | |||
| Life sciences : Biochemistry, biophysics & molecular biology | |||
| http://hdl.handle.net/2268/96174 | |||
| Structure Guided Development of Potent Reversibly Binding Penicillin Binding Protein Inhibitors | |
| English | |
| Woon, Esther C. Y. [> >] | |
Zervosen, Astrid  [Université de Liège - ULg > > Centre de recherches du cyclotron >] | |
| Sauvage, Eric [Université de Liège - ULg > > Centre d'ingénierie des protéines >] | |
| Simmons, Katie J. [> >] | |
| Zivec, Matej [> >] | |
| Inglis, Steven R. [> >] | |
| Fishwick, Colin W. G. [> >] | |
| Gobec, Stanislav [> >] | |
| Charlier, Paulette [Université de Liège - ULg > Département des sciences de la vie > Cristallographie des macromolécules biologiques >] | |
| Luxen, André [Université de Liège - ULg > Département de chimie (sciences) > Chimie organique de synthèse >] | |
| Schofield, Christopher J. [> >] | |
| 2011 | |
| ACS Medicinal Chemistry letters | |
| 2 (3) | |
| 219-223 | |
| International | |
| 1948-5875 | |
| [en] Penicillin binding proteins, ; boronic acids, ; antibiotics ; antibiotic-resistance, ; β-lactams ; transpeptidase-inhibition | |
| [en] Following from the evaluation of different types of electrophiles, combined modeling and
crystallographic analyses are used to generate potent boronic acid based inhibitors of a penicillin binding protein. The results suggest that a structurally informed approach to penicillin binding protein inhibition will be useful for the development of both improved reversibly binding inhibitors, including boronic acids, and acylating inhibitors, such as β-lactams. | |
| http://hdl.handle.net/2268/96174 |
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