Article (Scientific journals)
Clinical experience with antithrombin III concentrates in critically ill patients with sepsis and multiple organ failure.
Eisele, Bernd; Lamy, Maurice
1998In Seminars in Thrombosis and Hemostasis, 24 (1), p. 71-80
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Keywords :
Antithrombin III/therapeutic use; Clinical Trials as Topic; Critical Illness; Humans; Incidence; Multiple Organ Failure/complications/drug therapy; Prevalence; Sepsis/complications/drug therapy/epidemiology; Serine Proteinase Inhibitors/therapeutic use
Abstract :
[en] Despite improvements in critical care medicine and the development and aggressive use of potent broad-spectrum anti-microbial agents, mortality due to severe sepsis has not changed during the recent years and still comes to 35% to 45%. For quite a long time our understanding of the pathophysiology of sepsis was mainly focused on endotoxin and proinflammatory cytokines like tumor necrosis factor or interleukin-1. Now it is generally accepted that many signs and symptoms of sepsis are not directly mediated by cytokines but are transmitted through other mediator systems. The coagulation system comes into play especially when the septic process progresses to malperfusion and organ failure. Antithrombin III is an important inhibitor of the intrinsic, extrinsic and common pathway of coagulation. Recently, evidence has been accumulating that there is an additional anti-inflammatory potential of the drug. Currently there are several clinical trials ongoing to investigate whether this effect is of clinical relevance in the treatment of patients with severe sepsis.
Disciplines :
Anesthesia & intensive care
Author, co-author :
Eisele, Bernd
Lamy, Maurice ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Language :
English
Title :
Clinical experience with antithrombin III concentrates in critically ill patients with sepsis and multiple organ failure.
Publication date :
1998
Journal title :
Seminars in Thrombosis and Hemostasis
ISSN :
0094-6176
eISSN :
1098-9064
Publisher :
Thieme Medical Publishing Inc., New York, United States - New York
Volume :
24
Issue :
1
Pages :
71-80
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 25 March 2009

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