Article (Scientific journals)
In vivo biocompatibility of three potential intraperitoneal implants
Defrère, Sylvie; Mestdagt, Mélanie; Riva, Raphaël et al.
2011In Macromolecular Bioscience, 11 (10), p. 1335-45
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Keywords :
biocompatibility; implant; polydimethylsiloxane (PDMS); poly(ethylene-co-vinyl acetate) (PEVA); poly(hydroxyethyl methacrylate) (polyHEMA); biomaterial
Abstract :
[en] The intraperitoneal biocompatibility of PDMS, polyHEMA and pEVA was investigated in rats, rabbits and rhesus monkeys. No inflammation was evidenced by hematological analyses and measurement of inflammatory markers throughout the experiment and by post-mortem examination of the pelvic cavity. After 3 or 6 months, histological analysis revealed fibrous tissue encapsulating PDMS and PEVA implants in all species and polyHEMA implants in rabbits and monkeys. Calcium deposits were observed inside polyHEMA implants. The intraperitoneal biocompatibility of all 3 polymers makes them suitable for the design of drug delivery systems, which may be of great interest for pathologies confined to the pelvic cavity.
Research center :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Defrère, Sylvie
Mestdagt, Mélanie ;  Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement
Riva, Raphaël ;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Krier, Fabrice ;  Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique
Van Langendonckt, Anne
Drion, Pierre ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R:Méth. expér.des anim. de labo et éth. en expér. anim.
Jérôme, Christine  ;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Evrard, Brigitte  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique
Dehoux, Paul
Foidart, Jean-Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique
Donnez, Jacques
Language :
English
Title :
In vivo biocompatibility of three potential intraperitoneal implants
Publication date :
2011
Journal title :
Macromolecular Bioscience
ISSN :
1616-5187
eISSN :
1616-5195
Publisher :
John Wiley & Sons, United Kingdom
Volume :
11
Issue :
10
Pages :
1335-45
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 19 July 2011

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