Reference : In vivo biocompatibility of three potential intraperitoneal implants
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/95844
In vivo biocompatibility of three potential intraperitoneal implants
English
Defrère, Sylvie [ > > ]
Mestdagt, Mélanie [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
Riva, Raphaël mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Krier, Fabrice mailto [Université de Liège - ULg > Département de pharmacie > Pharmacie galénique >]
Van Langendonckt, Anne [ > > ]
Drion, Pierre mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > GIGA-R:Méth. expér.des anim. de labo et éth. en expér. anim. >]
Jérôme, Christine mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Evrard, Brigitte mailto [Université de Liège - ULg > Département de pharmacie > Pharmacie galénique >]
Dehoux, Paul [ > > ]
Foidart, Jean-Michel mailto [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique >]
Donnez, Jacques [ > > ]
2011
Macromolecular Bioscience
11
10
1335-45
Yes (verified by ORBi)
International
1616-5187
1616-5195
[en] biocompatibility ; implant ; polydimethylsiloxane (PDMS) ; poly(ethylene-co-vinyl acetate) (PEVA) ; poly(hydroxyethyl methacrylate) (polyHEMA) ; biomaterial
[en] The intraperitoneal biocompatibility of PDMS, polyHEMA and pEVA was investigated in rats, rabbits and rhesus monkeys. No inflammation was evidenced by hematological analyses and measurement of inflammatory markers throughout the experiment and by post-mortem examination of the pelvic cavity. After 3 or 6 months, histological analysis revealed fibrous tissue encapsulating PDMS and PEVA implants in all species and polyHEMA implants in rabbits and monkeys. Calcium deposits were observed inside polyHEMA implants. The intraperitoneal biocompatibility of all 3 polymers makes them suitable for the design of drug delivery systems, which may be of great interest for pathologies confined to the pelvic cavity.
Center for Education and Research on Macromolecules (CERM)
http://hdl.handle.net/2268/95844
10.1002/mabi.201100077

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