Reference : Auditory processing in the vegetative state.
Scientific journals : Article
Human health sciences : Anesthesia & intensive care
Human health sciences : Neurology
http://hdl.handle.net/2268/9582
Auditory processing in the vegetative state.
English
Laureys, Steven [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
Faymonville, Marie mailto [Centre Hospitalier Universitaire de Liège - CHU > > Anesthésie et réanimation >]
Degueldre, Christian mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Del Fiore, Guy [ > > ]
Damas, Pierre mailto [Centre Hospitalier Universitaire de Liège - CHU > > Soins intensifs >]
Lambermont, Bernard [Centre Hospitalier Universitaire de Liège - CHU > > Frais communs médecine >]
Janssens, Nathalie [> > > >]
Aerts, Joël [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Franck, Georges [> > > >]
Luxen, André mailto [Université de Liège - ULg > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron >]
Moonen, Gustave mailto [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
Lamy, Maurice mailto [Université de Liège - ULg > Département des sciences cliniques > Département des sciences cliniques >]
Maquet, Pierre mailto [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
2000
Brain : A Journal of Neurology
Oxford University Press
123 ( Pt 8)
1589-601
Yes (verified by ORBi)
International
0006-8950
1460-2156
Oxford
United Kingdom
[en] Acoustic Stimulation ; Adult ; Auditory Cortex/pathology/physiopathology/radionuclide imaging ; Auditory Perception ; Cerebrovascular Circulation ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Persistent Vegetative State/diagnosis/physiopathology ; Reference Values ; Tomography, Emission-Computed
[en] H(2)(15)O-PET was used to investigate changes in regional cerebral blood flow in response to auditory stimulation in patients in the vegetative state. Five patients in a vegetative state of hypoxic origin were compared with 18 age-matched controls. In addition, the cerebral metabolism of these patients and 53 age-matched controls was studied using [(18)F]fluorodeoxyglucose. In control subjects, auditory click stimuli activated bilateral auditory cortices [Brodmann areas (BA) 41 and 42] and the contralateral auditory association cortices (BA 22). In the patients, although resting metabolism was decreased to 61% of normal values, bilateral auditory areas 41 and 42 showed activation as seen in the controls, but the temporoparietal junction cortex (BA 22) failed to be activated. Moreover, the auditory association cortex was functionally disconnected from the posterior parietal association area (BA 40), the anterior cingulate cortex (BA 24) and the hippocampus, as revealed by psychophysiological interaction analysis. Thus, despite altered resting metabolism, the auditory primary cortices were still activated during external stimulation, whereas hierarchically higher-order multi- modal association areas were not. Such a cascade of functional disconnections along the auditory cortical pathways, from the primary auditory areas to multimodal and limbic areas, suggests that the residual cortical processing observed in the vegetative state cannot lead to the integrative processes that are thought to be necessary for the attainment of the normal level of awareness.
http://hdl.handle.net/2268/9582

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