Article (Scientific journals)
Testosterone-induced brain aromatase is sexually dimorphic.
Schumacher, M.; Balthazart, Jacques
1986In Brain Research, 370 (2), p. 285-93
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Keywords :
Animals; Aromatase/biosynthesis; Brain/enzymology; Coturnix; Enzyme Induction; Estradiol/biosynthesis; Female; Kinetics; Male; Orchiectomy; Organ Specificity; Sex Factors; Testosterone/metabolism/pharmacology
Abstract :
[en] Female quail are less sensitive than males to the activating effects of testosterone (T) on behavior. Testosterone induces hypothalamic aromatase activity more efficiently in males than in females (higher Vmax but similar Km). As the conversion of T to estradiol (E2) is important for the activation of male sexual behavior, we propose that the incapacity of the female hypothalamus to produce behaviorally active E2 contributes to their insensitivity to T. The 5 alpha-reductase, which converts T into 5 alpha-dihydrotestosterone (5 alpha-DHT), is induced by T specifically in the anterior hypothalamus of both sexes.
Disciplines :
Zoology
Endocrinology, metabolism & nutrition
Neurosciences & behavior
Author, co-author :
Schumacher, M.
Balthazart, Jacques  
Language :
English
Title :
Testosterone-induced brain aromatase is sexually dimorphic.
Publication date :
1986
Journal title :
Brain Research
ISSN :
0006-8993
eISSN :
1872-6240
Publisher :
Elsevier Science, Amsterdam, Netherlands
Volume :
370
Issue :
2
Pages :
285-93
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 18 July 2011

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