Reference : Testosterone-induced brain aromatase is sexually dimorphic.
Scientific journals : Article
Life sciences : Zoology
Social & behavioral sciences, psychology : Neurosciences & behavior
Human health sciences : Endocrinology, metabolism & nutrition
http://hdl.handle.net/2268/95779
Testosterone-induced brain aromatase is sexually dimorphic.
English
Schumacher, M. [> > > >]
Balthazart, Jacques mailto [ > > ]
1986
Brain Research
Elsevier Science
370
2
285-93
Yes (verified by ORBi)
International
0006-8993
Amsterdam
The Netherlands
[en] Animals ; Aromatase/biosynthesis ; Brain/enzymology ; Coturnix ; Enzyme Induction ; Estradiol/biosynthesis ; Female ; Kinetics ; Male ; Orchiectomy ; Organ Specificity ; Sex Factors ; Testosterone/metabolism/pharmacology
[en] Female quail are less sensitive than males to the activating effects of testosterone (T) on behavior. Testosterone induces hypothalamic aromatase activity more efficiently in males than in females (higher Vmax but similar Km). As the conversion of T to estradiol (E2) is important for the activation of male sexual behavior, we propose that the incapacity of the female hypothalamus to produce behaviorally active E2 contributes to their insensitivity to T. The 5 alpha-reductase, which converts T into 5 alpha-dihydrotestosterone (5 alpha-DHT), is induced by T specifically in the anterior hypothalamus of both sexes.
http://hdl.handle.net/2268/95779

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