No full text
Article (Scientific journals)
Inhibition of testosterone metabolism in the brain and cloacal gland of the quail by specific inhibitors and antihormones.
Alexandre, Corine; Balthazart, Jacques
1987In Journal of Endocrinology, 112 (2), p. 189-95
Peer Reviewed verified by ORBi
 

Files


Full Text
No document available.

Send to



Details



Keywords :
Androgen Antagonists/pharmacology; Androstanes/pharmacology; Androstatrienes/pharmacology; Animals; Azasteroids/pharmacology; Cloaca/drug effects/metabolism; Coturnix/physiology; Cyproterone/analogs & derivatives/pharmacology; Cyproterone Acetate; Estrogen Antagonists/pharmacology; Flutamide/pharmacology; Hypothalamus/drug effects/metabolism; Male; Nitromifene/pharmacology; Quail/physiology; Tamoxifen/pharmacology; Testosterone/metabolism/pharmacology
Abstract :
[en] The effects of antioestrogens, antiandrogens and of various inhibitors of testosterone metabolism on testosterone metabolism in the quail hypothalamus and cloacal gland were studied by an in-vitro radioenzymatic assay. It was found that antioestrogens and antiandrogens generally had little or no effect on aromatase and 5 alpha- and 5 beta-reductases of testosterone, except when used at very high doses. The 5 alpha-reductase inhibitor, 17 beta-N,N-diethylcarbamoyl-4-methyl-4-aza-5 alpha-androstan-3-one, inhibited both 5 alpha- and 5 beta-dihydrotestosterone production without markedly affecting aromatase activity. Surprisingly, the aromatase inhibitor, 1,4,6-androstatriene-3,17-dione, inhibited not only the production of oestradiol but also that of 5 beta-dihydrotestosterone and, to a lesser extent, 5 alpha-dihydrotestosterone. These unexpected properties should be taken into account when interpreting the results of in-vivo experiments using these compounds.
Disciplines :
Zoology
Neurosciences & behavior
Author, co-author :
Alexandre, Corine
Balthazart, Jacques  
Language :
English
Title :
Inhibition of testosterone metabolism in the brain and cloacal gland of the quail by specific inhibitors and antihormones.
Publication date :
1987
Journal title :
Journal of Endocrinology
ISSN :
0022-0795
eISSN :
1479-6805
Publisher :
Society for Endocrinology, Bristol, United Kingdom
Volume :
112
Issue :
2
Pages :
189-95
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 18 July 2011

Statistics


Number of views
56 (0 by ULiège)
Number of downloads
0 (0 by ULiège)

Scopus citations®
 
22
Scopus citations®
without self-citations
18
OpenCitations
 
21

Bibliography


Similar publications



Contact ORBi