Article (Scientific journals)
Effects of metabolism inhibitors, antiestrogens and antiandrogens on the androgen and estrogen induced sexual behavior in Japanese quail.
Alexandre, Corine; Balthazart, Jacques
1986In Physiology and Behavior, 38 (4), p. 581-91
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Keywords :
Androgens/physiology; Androstatrienes/pharmacology; Animals; Coturnix/physiology; Cyproterone/analogs & derivatives/pharmacology; Cyproterone Acetate; Diethylstilbestrol/pharmacology; Estrogens/physiology; Flutamide/pharmacology; Male; Orchiectomy; Quail/physiology; Sexual Behavior, Animal/physiology; Tamoxifen/pharmacology; Testosterone/pharmacology
Abstract :
[en] The relative contribution of androgenic and estrogenic metabolites of testosterone to the activation of sexual behavior was studied in Japanese quail by using inhibitors of testosterone metabolism, antiestrogens and antiandrogens. These compounds were tested in castrated birds whose sexual behavior had been activated by silastic implants of testosterone (T) or daily injections of testosterone propionate (TP) or diethylstilboestrol (DES). The aromatase inhibitor ATD only depressed T-induced behavior when injected at high doses and the 5 alpha-reductase inhibitor, 4MA was inactive in this respect. The antiestrogens, tamoxifen (TAM) and nitromifene citrate (CI-628) strongly depressed sexual behavior but they also drastically reduced the crowing behavior which is typically androgen-dependent which throws some doubts on the specificity of their action. The antiandrogens, flutamide and cyproterone acetate (CA), only had limited inhibitory effects on the copulatory behavior but similarly decreased only marginally the crowing. As they strongly depressed the cloacal gland growth, it can be ascertained that they were injected in sufficient amounts and their lack of action on crowing questions the ability of these compounds to inhibit brain processes even when they are androgen-dependent. Taken together with the results of previous experiments which tested the behavioral effects of the testosterone metabolites, the present data confirm the implication of both androgenic and estrogenic metabolites of testosterone in the activation of behavior. Their interaction remains, however, poorly defined and its understanding will probably require the identification of the biochemical processes which in the brain mediate the behavior.
Disciplines :
Zoology
Neurosciences & behavior
Author, co-author :
Alexandre, Corine
Balthazart, Jacques  
Language :
English
Title :
Effects of metabolism inhibitors, antiestrogens and antiandrogens on the androgen and estrogen induced sexual behavior in Japanese quail.
Publication date :
1986
Journal title :
Physiology and Behavior
ISSN :
0031-9384
eISSN :
1873-507X
Publisher :
Elsevier Science, New York, United States - New York
Volume :
38
Issue :
4
Pages :
581-91
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 18 July 2011

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