Reference : Effect of the injection solvent on steroid activity.
Scientific journals : Article
Life sciences : Zoology
Social & behavioral sciences, psychology : Neurosciences & behavior
Human health sciences : Endocrinology, metabolism & nutrition
Effect of the injection solvent on steroid activity.
Deviche, P. [> > > >]
Balthazart, Jacques mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau >]
General and Comparative Endocrinology
Yes (verified by ORBi)
New York
[en] Androgens/administration & dosage ; Androstenedione/administration & dosage ; Animals ; Cloaca/drug effects/growth & development ; Dihydrotestosterone/administration & dosage ; Injections, Intramuscular ; Luteinizing Hormone/blood ; Male ; Muscle Development ; Muscles/drug effects ; Quail ; Solvents ; Testosterone/administration & dosage
[en] The effects of testosterone, 5 alpha-dihydrotestosterone, and androstenedione on cloacal gland and sternotracheal muscle growth and on luteinizing hormone plasma levels were studied in Japanese quail. The steroids were given to the animals in daily intramuscular injections and were dissolved either in propylene glycol or in ethanol:saline (1:1). The three steroids had significant effects on the responses which were measured, but the magnitude of this effect was clearly related to the type of vehicle in which the steroids were dissolved. Furthermore there was a significant interaction between the effects of solvents and of steroid; for example, testosterone was much less androgenic than 5 alpha-dihydrotestosterone when dissolved in propylene glycol, but both had similar effects when dissolved in ethanol:saline. The effects of the mode of administration of different steroids on a given physiological response should be taken into consideration.

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