Article (Scientific journals)
Effect of the injection solvent on steroid activity.
Deviche, P.; Balthazart, Jacques
1987In General and Comparative Endocrinology, 65 (2), p. 199-202
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Keywords :
Androgens/administration & dosage; Androstenedione/administration & dosage; Animals; Cloaca/drug effects/growth & development; Dihydrotestosterone/administration & dosage; Injections, Intramuscular; Luteinizing Hormone/blood; Male; Muscle Development; Muscles/drug effects; Quail; Solvents; Testosterone/administration & dosage
Abstract :
[en] The effects of testosterone, 5 alpha-dihydrotestosterone, and androstenedione on cloacal gland and sternotracheal muscle growth and on luteinizing hormone plasma levels were studied in Japanese quail. The steroids were given to the animals in daily intramuscular injections and were dissolved either in propylene glycol or in ethanol:saline (1:1). The three steroids had significant effects on the responses which were measured, but the magnitude of this effect was clearly related to the type of vehicle in which the steroids were dissolved. Furthermore there was a significant interaction between the effects of solvents and of steroid; for example, testosterone was much less androgenic than 5 alpha-dihydrotestosterone when dissolved in propylene glycol, but both had similar effects when dissolved in ethanol:saline. The effects of the mode of administration of different steroids on a given physiological response should be taken into consideration.
Disciplines :
Endocrinology, metabolism & nutrition
Neurosciences & behavior
Zoology
Author, co-author :
Deviche, P.
Balthazart, Jacques  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau
Language :
English
Title :
Effect of the injection solvent on steroid activity.
Publication date :
1987
Journal title :
General and Comparative Endocrinology
ISSN :
0016-6480
eISSN :
1095-6840
Publisher :
Elsevier, New York, United States - New York
Volume :
65
Issue :
2
Pages :
199-202
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 18 July 2011

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