You are here:
| Reference : Hormones modulate the concentration of cytoplasmic progestin receptors in the brain of m... |
| Scientific journals : Article | |||
| Human health sciences : Endocrinology, metabolism & nutrition Life sciences : Zoology Social & behavioral sciences, psychology : Neurosciences & behavior | |||
| http://hdl.handle.net/2268/95757 | |||
| Hormones modulate the concentration of cytoplasmic progestin receptors in the brain of male ring doves (Streptopelia risoria). | |
| English | |
Balthazart, Jacques  [> > > >] | |
| Blaustein, J. D. [> > > >] | |
| Cheng, M. F. [> > > >] | |
| Feder, H. H. [ > > ] | |
| 1980 | |
| Journal of Endocrinology | |
| Society for Endocrinology | |
| 86 | |
| 2 | |
| 251-61 | |
| 0022-0795 | |
| 1479-6805 | |
| Bristol | |
| United Kingdom | |
| [en] Animals ; Binding, Competitive ; Brain/drug effects/metabolism ; Castration ; Columbidae/metabolism ; Cytoplasm/metabolism ; Dihydrotestosterone/pharmacology ; Gonadal Steroid Hormones/pharmacology ; Male ; Progestins ; Promegestone/metabolism ; Receptors, Progesterone/drug effects/metabolism | |
| [en] A cytoplasmic progestin receptor has been characterized in the brain of castrated ring doves using an in-vitro assay that measures the binding of a synthetic progestin, [3H]17 alpha,21-dimethyl-19-nor-pregna-4,9-diene-3,20-dione(promegestone; R5020). The affinity of the receptor was similar in both the hyperstriatum and the hypothalamus (Kd approximately equal to 4 X 10(-10) mol/l). Its concentration was higher in the anterior hypothalamus-preoptic area (63 +/- 4 fmol/mg (S.E.M.) protein) than in other brain regions (posterior hypothalamus, 33 +/- 5; hyperstriatum, 28 +/- 3; midbrain, 17 +/- 4 fmol/mg protein; n = 7). Progesterone and R5020 competed well for binding but oestradiol and 5 beta-dihydrotestosterone did not. Corticosterone and, to a lesser extent, testosterone and 5 alpha-dihydrotestosterone completed for binding but much higher concentrations were required than for progestins. Injections of testosterone (200 micrograms testosterone propionate daily for 7 days) significantly increased the concentration of progestin receptors in the anterior and posterior hypothalamus without having any significant effect on other brain areas. Shorter treatment, lasting for 2 days, with testosterone propionate (200 micrograms daily), 5 alpha-dihydrotestosterone (200 micrograms daily) or oestradiol benzoate (50 micrograms daily) did not always cause this increase but seven injections of oestradiol benzoate (50 micrograms daily for 7 days) were even more effective than seven injections of testosterone propionate (200 micrograms daily for 7 days). These data suggested that the sensitivity to progesterone of the brain of the bird changes as a consequence of increases in the level of testosterone in the circulation. | |
| http://hdl.handle.net/2268/95757 |
There is no file associated with this reference.
All documents in ORBi are protected by a user license.
