Article (Scientific journals)
Cdk2 loss accelerates precursor differentiation and remyelination in the adult central nervous system.
Caillava, Céline; Vandenbosch, Renaud; Jablonska, Beata et al.
2011In Journal of Cell Biology, 193 (2), p. 397-407
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Keywords :
Animals; Axons/metabolism; Central Nervous System/metabolism; Cyclin-Dependent Kinase 2/genetics; Demyelinating Diseases/genetics/metabolism; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Nerve Regeneration/physiology; Neural Stem Cells/metabolism; Neurogenesis/genetics; Oligodendroglia/metabolism
Abstract :
[en] The specific functions of intrinsic regulators of oligodendrocyte progenitor cell (OPC) division are poorly understood. Type 2 cyclin-dependent kinase (Cdk2) controls cell cycle progression of OPCs, but whether it acts during myelination and repair of demyelinating lesions remains unexplored. Here, we took advantage of a viable Cdk2(-/-) mutant mouse to investigate the function of this cell cycle regulator in OPC proliferation and differentiation in normal and pathological conditions. During central nervous system (CNS) development, Cdk2 loss does not affect OPC cell cycle, oligodendrocyte cell numbers, or myelination. However, in response to CNS demyelination, it clearly alters adult OPC renewal, cell cycle exit, and differentiation. Importantly, Cdk2 loss accelerates CNS remyelination of demyelinated axons. Thus, Cdk2 is dispensable for myelination but is important for adult OPC renewal, and could be one of the underlying mechanisms that drive adult progenitors to differentiate and thus regenerate myelin.
Research center :
Giga-Neurosciences - ULiège
Disciplines :
Neurology
Biochemistry, biophysics & molecular biology
Author, co-author :
Caillava, Céline;  Université Pierre et Marie Curie-Paris 6 > Centre de Recherche de l’Institut du Cerveau et de la Moelle Epinière
Vandenbosch, Renaud  ;  Université de Liège - ULiège > GIGA - Neurosciences
Jablonska, Beata;  Center for Neuroscience Research (Washington DC) > Children’s National Medical Center
Deboux, Cyrille;  Université Pierre et Marie Curie-Paris 6 > Centre de Recherche de l’Institut du Cerveau et de la Moelle Epinière
Spigoni, Giulia;  Université Pierre et Marie Curie-Paris 6 > Centre de Recherche de l’Institut du Cerveau et de la Moelle Epinière
Gallo, Vittorio;  Center for Neuroscience Research (Washington DC) > Children’s National Medical Center
Malgrange, Brigitte  ;  Université de Liège - ULiège > GIGA - Neurosciences
Baron-Van Evercooren, Anne;  Université Pierre et Marie Curie-Paris 6 > Centre de Recherche de l’Institut du Cerveau et de la Moelle Epinière
Language :
English
Title :
Cdk2 loss accelerates precursor differentiation and remyelination in the adult central nervous system.
Publication date :
2011
Journal title :
Journal of Cell Biology
ISSN :
0021-9525
eISSN :
1540-8140
Publisher :
Rockefeller University Press, New York, United States - New York
Volume :
193
Issue :
2
Pages :
397-407
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Available on ORBi :
since 12 July 2011

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