Reference : Cdk2 loss accelerates precursor differentiation and remyelination in the adult central n...
Scientific journals : Article
Human health sciences : Neurology
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/95469
Cdk2 loss accelerates precursor differentiation and remyelination in the adult central nervous system.
English
Caillava, Céline [Université Pierre et Marie Curie-Paris 6 > Centre de Recherche de l’Institut du Cerveau et de la Moelle Epinière > > >]
Vandenbosch, Renaud mailto [Université de Liège - ULg > > GIGA - Neurosciences >]
Jablonska, Beata [Center for Neuroscience Research (Washington DC) > Children’s National Medical Center > > >]
Deboux, Cyrille [Université Pierre et Marie Curie-Paris 6 > Centre de Recherche de l’Institut du Cerveau et de la Moelle Epinière > > >]
Spigoni, Giulia [Université Pierre et Marie Curie-Paris 6 > Centre de Recherche de l’Institut du Cerveau et de la Moelle Epinière > > >]
Gallo, Vittorio [Center for Neuroscience Research (Washington DC) > Children’s National Medical Center > > >]
Malgrange, Brigitte mailto [Université de Liège - ULg > > GIGA - Neurosciences >]
Baron-Van Evercooren, Anne [Université Pierre et Marie Curie-Paris 6 > Centre de Recherche de l’Institut du Cerveau et de la Moelle Epinière > > >]
2011
Journal of Cell Biology
Rockefeller University Press
193
2
397-407
Yes
International
0021-9525
1540-8140
New York
NY
[en] Animals ; Axons/metabolism ; Central Nervous System/metabolism ; Cyclin-Dependent Kinase 2/genetics ; Demyelinating Diseases/genetics/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Mutant Strains ; Nerve Regeneration/physiology ; Neural Stem Cells/metabolism ; Neurogenesis/genetics ; Oligodendroglia/metabolism
[en] The specific functions of intrinsic regulators of oligodendrocyte progenitor cell (OPC) division are poorly understood. Type 2 cyclin-dependent kinase (Cdk2) controls cell cycle progression of OPCs, but whether it acts during myelination and repair of demyelinating lesions remains unexplored. Here, we took advantage of a viable Cdk2(-/-) mutant mouse to investigate the function of this cell cycle regulator in OPC proliferation and differentiation in normal and pathological conditions. During central nervous system (CNS) development, Cdk2 loss does not affect OPC cell cycle, oligodendrocyte cell numbers, or myelination. However, in response to CNS demyelination, it clearly alters adult OPC renewal, cell cycle exit, and differentiation. Importantly, Cdk2 loss accelerates CNS remyelination of demyelinated axons. Thus, Cdk2 is dispensable for myelination but is important for adult OPC renewal, and could be one of the underlying mechanisms that drive adult progenitors to differentiate and thus regenerate myelin.
Giga-Neurosciences
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers
http://hdl.handle.net/2268/95469
10.1083/jcb.201004146

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