Article (Scientific journals)
Cdk6-dependent regulation of g(1) length controls adult neurogenesis.
Beukelaers, Pierre; Vandenbosch, Renaud; Caron, Nicolas et al.
2011In Stem Cells, 29 (4), p. 713-24
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Abstract :
[en] The presence of neurogenic precursors in the adult mammalian brain is now widely accepted, but the mechanisms coupling their proliferation with the onset of neuronal differentiation remain unknown. Here, we unravel the major contribution of the G(1) regulator cyclin-dependent kinase 6 (Cdk6) to adult neurogenesis. We found that Cdk6 was essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Specifically, Cdk6 deficiency prevents the expansion of neuronally committed precursors by lengthening G(1) phase duration, reducing concomitantly the production of newborn neurons. Altogether, our data support G(1) length as an essential regulator of the switch between proliferation and neuronal differentiation in the adult brain and Cdk6 as one intrinsic key molecular regulator of this process. STEM Cells 2011;29:713-724.
Research center :
Giga-Neurosciences - ULiège
Disciplines :
Biochemistry, biophysics & molecular biology
Neurology
Author, co-author :
Beukelaers, Pierre 
Vandenbosch, Renaud   ;  Université de Liège - ULiège > GIGA - Neurosciences
Caron, Nicolas ;  Université de Liège - ULiège > GIGA - Neurosciences
Nguyen, Laurent  ;  Université de Liège - ULiège > Département des sciences cliniques > Neurologie
Belachew, Shibeshih ;  Université de Liège - ULiège > Département des sciences cliniques > Neurologie
Moonen, Gustave  ;  Université de Liège - ULiège > Département des sciences cliniques > Neurologie
Kiyokawa, Hiroaki
Barbacid, Mariano
Santamaria, David
Malgrange, Brigitte  ;  Université de Liège - ULiège > GIGA - Neurosciences
 These authors have contributed equally to this work.
Language :
English
Title :
Cdk6-dependent regulation of g(1) length controls adult neurogenesis.
Publication date :
2011
Journal title :
Stem Cells
ISSN :
1066-5099
eISSN :
1549-4918
Publisher :
Wiley
Volume :
29
Issue :
4
Pages :
713-24
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Fonds Léon Fredericq [BE]
Commentary :
Copyright (c) 2011 AlphaMed Press.
Available on ORBi :
since 12 July 2011

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