Reference : Cdk6-dependent regulation of g(1) length controls adult neurogenesis.
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Human health sciences : Neurology
http://hdl.handle.net/2268/95467
Cdk6-dependent regulation of g(1) length controls adult neurogenesis.
English
Beukelaers, Pierre* [> > > >]
Vandenbosch, Renaud* mailto [Université de Liège - ULg > > GIGA - Neurosciences >]
Caron, Nicolas mailto [Université de Liège - ULg > > GIGA - Neurosciences >]
Nguyen, Laurent mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]
Belachew, Shibeshih mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]
Moonen, Gustave mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]
Kiyokawa, Hiroaki [> > > >]
Barbacid, Mariano [> > > >]
Santamaria, David [> > > >]
Malgrange, Brigitte mailto [Université de Liège - ULg > > GIGA - Neurosciences >]
* These authors have contributed equally to this work.
2011
Stem Cells
Wiley
29
4
713-24
Yes (verified by ORBi)
International
1066-5099
1549-4918
[en] The presence of neurogenic precursors in the adult mammalian brain is now widely accepted, but the mechanisms coupling their proliferation with the onset of neuronal differentiation remain unknown. Here, we unravel the major contribution of the G(1) regulator cyclin-dependent kinase 6 (Cdk6) to adult neurogenesis. We found that Cdk6 was essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Specifically, Cdk6 deficiency prevents the expansion of neuronally committed precursors by lengthening G(1) phase duration, reducing concomitantly the production of newborn neurons. Altogether, our data support G(1) length as an essential regulator of the switch between proliferation and neuronal differentiation in the adult brain and Cdk6 as one intrinsic key molecular regulator of this process. STEM Cells 2011;29:713-724.
Giga-Neurosciences
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Fonds Léon Fredericq
Researchers
http://hdl.handle.net/2268/95467
10.1002/stem.616
Copyright (c) 2011 AlphaMed Press.

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