Reference : Hydrogel nanocomposites: a potential UV/blue light filtering material for ophthalmic len...
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
Engineering, computing & technology : Materials science & engineering
http://hdl.handle.net/2268/95185
Hydrogel nanocomposites: a potential UV/blue light filtering material for ophthalmic lenses
English
Bozukova, Dimitriya [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Pagnoulle, Christophe [Physiol SA, Liège, Belgium > > > >]
De Pauw, Marie-Claire mailto [University of Liège (ULg) > Biomedical Sciences and Preclinical Department > Laboratory of Histology and Cytology > >]
Vertruyen, Bénédicte mailto [University of Liège (ULg) > Department of Chemistry > Laboratory of Structural Inorganic Chemistry > >]
Jérôme, Robert mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Jérôme, Christine mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
2011
Journal of Biomaterials Science. Polymer Edition
VSP
22
1947-1961
Yes (verified by ORBi)
International
0920-5063
Utrecht
The Netherlands
[en] biomaterial ; intraocular lens ; implant
[en] Poly(2-hydroxyethyl methacrylate-co-methyl methacrylate) (poly(HEMA-co-MMA)) and ZnS hydrogel nanocomposites were prepared and characterized. The chemical composition of the inorganic nanoparticles was confirmed by X-ray diffraction, and the homogeneity of their distribution within the hydrogel was assessed by transmission electron microscopy. The influence of the content of ZnS nanoparticles on the optical performances of the nanocomposites was investigated by UV-Vis spectroscopy. The ability of the hydrogel nanocomposites to filter the hazardous UV light and part of the blue light was reported, which makes them valuable candidates for ophthalmic lens application. In contrast to the optical properties, the thermo-mechanical properties of neat poly(HEMA-co-MMA) hydrogels were found to be largely independent of filling by ZnS nanoparticles ( 2 mg/ml co-monomer mixture). Finally, in vitro cell adhesion test with lens epithelial cells (LECs), extracted from porcine lens crystalline capsule, showed that ZnS had no deleterious effect on the biocompatibility of neat hydrogels, at least at low content.
Center for Education and Research on Macromolecules (CERM)
Researchers
http://hdl.handle.net/2268/95185
10.1163/092050610X529173

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