Reference : Actin-targeting natural compounds as tools to study the role of actin cytoskeleton in...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Actin-targeting natural compounds as tools to study the role of actin cytoskeleton in signal transduction.
Kustermans, Gaëlle mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Piette, Jacques mailto [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Virologie - Immunologie - GIGA-Research >]
Legrand, Sylvie mailto [Université de Liège - ULg > > GIGA-R : Virologie - Immunologie >]
Biochemical Pharmacology
Elsevier Science
Yes (verified by ORBi)
United Kingdom
[en] actin cytoskeleton ; signal transduction
[en] Actin cytoskeleton controls a vast range of cellular processes such as motility, cytokinesis,
differentiation, vesicle transport, phagocytosis, muscle contraction. A growing literature
clearly demonstrated that actin cytoskeleton can play a regulating role in several signalling
pathways. Cells tightly regulate actin dynamics through numerous specific proteins in order
to rapidly and locally respond to various stimuli. An obvious approach to determine the
involvement of actin cytoskeleton in signalling pathways is the use of actin-targeting
natural compounds. These drugs modulate actin dynamics, accelerating either polymerization
or depolymerization, through various mechanisms. This review focus on the use of
these actin-targeting drugs as tools to demonstrate the role of actin cytoskeleton in several
signal transduction pathways such as those initiated from antigen receptor in T and B cells
or those involving mitogen-activated protein kinases (MAPKs) or transcription factors NF-kB
and SRF (serum response factor). In this last case (SRF), the use of various actin-targeting
drugs participated in the elucidation of the molecular mechanism by which actin regulates
SRF-mediated transcription.
Giga-Signal Transduction

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