Article (Scientific journals)
Actin-targeting natural compounds as tools to study the role of actin cytoskeleton in signal transduction.
Kustermans, Gaëlle; Piette, Jacques; Legrand, Sylvie
2008In Biochemical Pharmacology, 76(11), p. 1310-1322
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Keywords :
actin cytoskeleton; signal transduction
Abstract :
[en] Actin cytoskeleton controls a vast range of cellular processes such as motility, cytokinesis, differentiation, vesicle transport, phagocytosis, muscle contraction. A growing literature clearly demonstrated that actin cytoskeleton can play a regulating role in several signalling pathways. Cells tightly regulate actin dynamics through numerous specific proteins in order to rapidly and locally respond to various stimuli. An obvious approach to determine the involvement of actin cytoskeleton in signalling pathways is the use of actin-targeting natural compounds. These drugs modulate actin dynamics, accelerating either polymerization or depolymerization, through various mechanisms. This review focus on the use of these actin-targeting drugs as tools to demonstrate the role of actin cytoskeleton in several signal transduction pathways such as those initiated from antigen receptor in T and B cells or those involving mitogen-activated protein kinases (MAPKs) or transcription factors NF-kB and SRF (serum response factor). In this last case (SRF), the use of various actin-targeting drugs participated in the elucidation of the molecular mechanism by which actin regulates SRF-mediated transcription.
Research center :
Giga-Signal Transduction - ULiège
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Kustermans, Gaëlle ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Piette, Jacques ;  Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Virologie - Immunologie - GIGA-Research
Legrand, Sylvie ;  Université de Liège - ULiège > GIGA-R : Virologie - Immunologie
Language :
English
Title :
Actin-targeting natural compounds as tools to study the role of actin cytoskeleton in signal transduction.
Publication date :
01 December 2008
Journal title :
Biochemical Pharmacology
ISSN :
0006-2952
eISSN :
1873-2968
Publisher :
Elsevier Science, Oxford, United Kingdom
Volume :
76(11)
Pages :
1310-1322
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 24 March 2009

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