Reference : Cytokine production from sputum cells in eosinophilic versus non-eosinophilic asthmatics
Scientific journals : Article
Human health sciences : Cardiovascular & respiratory systems
http://hdl.handle.net/2268/9465
Cytokine production from sputum cells in eosinophilic versus non-eosinophilic asthmatics
English
Quaedvlieg, Valérie mailto [Centre Hospitalier Universitaire de Liège - CHU > > Pneumologie-Allergologie >]
Henket, Monique [Centre Hospitalier Universitaire de Liège - CHU > > Pneumologie-Allergologie >]
Sele, Jocelyne [Centre Hospitalier Universitaire de Liège - CHU > > Pneumologie-Allergologie >]
Louis, Renaud mailto [Université de Liège - ULg > Département des sciences cliniques > Pneumologie - Allergologie]
Jan-2006
Clinical & Experimental Immunology
Blackwell Publishing
143
1
161-166
Yes (verified by ORBi)
International
0009-9104
Oxford
[en] asthma ; cytokines ; eosinophils ; phenotypes ; sputum cells
[en] The inflammatory pathways involved in asthma are more complex than the sole Th2-mediated eosinophilic airway inflammation. Different phenotypes of asthma have been recently highlighted and are probably underlied by different immunological profiles. The aim of the study was to assess cytokine production from sputum cells in eosinophilic versus non-eosinophilic asthmatics. Induced sputum was obtained from 48 consecutive stable mild to moderate asthmatics (20 eosinophilic asthmatics, 28 non-eosinophilic asthmatics) and 31 healthy subjects. Cytokine released from sputum cells were measured by a home-made two-step sandwich immunoassay. Cytokines investigated were interleukin (IL)-4, IL-6, IL-10, tumour necrosis factor (TNF)-alpha and interferon (IFN)-gamma. Sputum cells from eosinophilic asthmatics produced more IL-4 than those from both healthy subjects (P < 0.05) and non-eosinophilic asthmatics (P < 0.05). Conversely, sputum cells from eosinophilic asthma were found to release lower amounts of TNF-alpha than those from healthy subjects (P < 0.05). The group of non-eosinophilic asthmatics did not distinguish from healthy subjects with respect to any cytokines measured. Sputum cells from asthmatics exhibiting eosinophilic airway inflammation release more IL-4 and less TNF-alpha than those of healthy subjects. By contrast, non-eosinophilic asthmatics did not distinguish from healthy subjects by abnormal cytokine release from their sputum cells.
http://hdl.handle.net/2268/9465
10.1111/j.1365-2249.2005.02968.x
http://www3.interscience.wiley.com/journal/118579790/issue

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